With the assistance of the symbolic computation system Maple,rich higher order polynomial-type conservation laws and a sixth order t/x-dependent conservation law are constructed for a generalized seventh order nonline...With the assistance of the symbolic computation system Maple,rich higher order polynomial-type conservation laws and a sixth order t/x-dependent conservation law are constructed for a generalized seventh order nonlinear evolution equation by using a direct algebraic method.From the compatibility conditions that guaranteeing the existence of conserved densities,an integrable unnamed seventh order KdV-type equation is found.By introducing some nonlinear transformations,the one-,two-,and three-solition solutions as well as the solitary wave solutions are obtained.展开更多
Chronic alcohol consumption induces hepatic steatosis, the early stage of alcoholic liver disease （ALD）. The aim ofpresent study is to investigate the protective effect ofPanax notoginseng saponins （PNS） against c...Chronic alcohol consumption induces hepatic steatosis, the early stage of alcoholic liver disease （ALD）. The aim ofpresent study is to investigate the protective effect ofPanax notoginseng saponins （PNS） against chronic ethanol-induced hepaticsteatosis in vivo. Mice were pair-fed a modified Lieber-DeCarli liquid diet containing alcohol or isocaloric maltose dextrin ascontrol diet with or without PNS （200 mg/kg, BW） for 8 weeks. Animals supplemented with PNS were protected against hepaticlipid accumulation induced by chronic ethanol exposure. Accordingly, PNS could significantly decrease the elevation of plasmatriglyceride, plasma enzyme activities, i.e. alanine aminotransferase （ALT） and aspartate aminotransferase （AST）, and hepaticTNF-ct and IL-6 levels which were induced by chronic alcohol exposure. In addition, PNS markedly reduced the lipolysis ofwhite adipose tissue （WAT） that stimulated by alcohol feeding through the inhibiting protein expression of phosphorylation ofhormone-sensitive lipase （p-HSL）, rather than total HSL. Furthermore, alcohol exposure also enhanced fatty acid uptake capacityin liver by elevated hepatic CD36 expression, which could attenuated by PNS treatment. These results demonstrate that PNSsupplementation protects against chronic ethanol-induced hepatic steatosis, which is associated with ameliorating dysfunctionallipid metabolism of WAT and the reduced inflammatory cytokines. Our findings suggested that PNS might be potential to bedeveloped as an effective agent for the treatment of chronic alcoholic steatosis.展开更多
文摘With the assistance of the symbolic computation system Maple,rich higher order polynomial-type conservation laws and a sixth order t/x-dependent conservation law are constructed for a generalized seventh order nonlinear evolution equation by using a direct algebraic method.From the compatibility conditions that guaranteeing the existence of conserved densities,an integrable unnamed seventh order KdV-type equation is found.By introducing some nonlinear transformations,the one-,two-,and three-solition solutions as well as the solitary wave solutions are obtained.
基金Research Committee of the University of Macao(Grant No.MYRG123-ICMS12 and MYRG111-ICMS13)from Macao Science and Technology Development Fund(Grant No.010/2013/A1)
文摘Chronic alcohol consumption induces hepatic steatosis, the early stage of alcoholic liver disease （ALD）. The aim ofpresent study is to investigate the protective effect ofPanax notoginseng saponins （PNS） against chronic ethanol-induced hepaticsteatosis in vivo. Mice were pair-fed a modified Lieber-DeCarli liquid diet containing alcohol or isocaloric maltose dextrin ascontrol diet with or without PNS （200 mg/kg, BW） for 8 weeks. Animals supplemented with PNS were protected against hepaticlipid accumulation induced by chronic ethanol exposure. Accordingly, PNS could significantly decrease the elevation of plasmatriglyceride, plasma enzyme activities, i.e. alanine aminotransferase （ALT） and aspartate aminotransferase （AST）, and hepaticTNF-ct and IL-6 levels which were induced by chronic alcohol exposure. In addition, PNS markedly reduced the lipolysis ofwhite adipose tissue （WAT） that stimulated by alcohol feeding through the inhibiting protein expression of phosphorylation ofhormone-sensitive lipase （p-HSL）, rather than total HSL. Furthermore, alcohol exposure also enhanced fatty acid uptake capacityin liver by elevated hepatic CD36 expression, which could attenuated by PNS treatment. These results demonstrate that PNSsupplementation protects against chronic ethanol-induced hepatic steatosis, which is associated with ameliorating dysfunctionallipid metabolism of WAT and the reduced inflammatory cytokines. Our findings suggested that PNS might be potential to bedeveloped as an effective agent for the treatment of chronic alcoholic steatosis.
