Pain is a complex experience consisting of sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Now it has been gradually known that noxious information is processed by a widely-distrib...Pain is a complex experience consisting of sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Now it has been gradually known that noxious information is processed by a widely-distributed, hierarchically- interconnected neural network, referred to as neuromatrix, in the brain. Thus, identifying the multiple neural networks subserving these functional aspects and harnessing this knowledge to manipulate the pain response in new and beneficial ways are challenging tasks. Albeit with elaborate research efforts on the cortical responses to painful stimuli or clinical pain, involvement of the hippocampal formation （HF） in pain is still a matter of controversy. Here, we integrate previous animal and human studies from the viewpoint of HF and pain, sequentially representing anatomical, behavioral, electrophysiological, molecular/ biochemical and functional imaging evidence supporting the role of HF in pain processing. At last, we further expound on the relationship between pain and memory and present some unresolved issues.展开更多
Acupoints are particular areas on the surface of the body through which the Qi and blood of the Zang-fu organs and meridians flow.Acupoints can respond to stimuli and reflect syndromes.Research on the essential morpho...Acupoints are particular areas on the surface of the body through which the Qi and blood of the Zang-fu organs and meridians flow.Acupoints can respond to stimuli and reflect syndromes.Research on the essential morphology of acupoints has two key focuses:anatomical structure and physiological function.The structure is the material and anatomical basis for the function,while the function is the manifestation of the structure.The two factors not only have profound significance for our understanding of the essence of acupoints,but also have great value for clinical acupuncture and moxibustion practice.Based on the structural and functional characteristics of meridians under different physiological and pathological conditions,this paper illustrates the essence of acupoints and explores the rules and biological basis of the acupoint functions induced by acupuncture and moxibustion.展开更多
基金supported by the National Basic Research (973) Program of China (No.2006CB500800)National Innovation Team Program of Ministry of Education, China (No. IRT0560)National Natural Science Foundation of China (No. 30670692 and 30770668)
文摘Pain is a complex experience consisting of sensory-discriminative, affective-motivational, and cognitive-evaluative dimensions. Now it has been gradually known that noxious information is processed by a widely-distributed, hierarchically- interconnected neural network, referred to as neuromatrix, in the brain. Thus, identifying the multiple neural networks subserving these functional aspects and harnessing this knowledge to manipulate the pain response in new and beneficial ways are challenging tasks. Albeit with elaborate research efforts on the cortical responses to painful stimuli or clinical pain, involvement of the hippocampal formation （HF） in pain is still a matter of controversy. Here, we integrate previous animal and human studies from the viewpoint of HF and pain, sequentially representing anatomical, behavioral, electrophysiological, molecular/ biochemical and functional imaging evidence supporting the role of HF in pain processing. At last, we further expound on the relationship between pain and memory and present some unresolved issues.
基金supported by the Key Project of National Natural Science Foundation of China(81130063)the 973 Project(2012CB 518503)
文摘Acupoints are particular areas on the surface of the body through which the Qi and blood of the Zang-fu organs and meridians flow.Acupoints can respond to stimuli and reflect syndromes.Research on the essential morphology of acupoints has two key focuses:anatomical structure and physiological function.The structure is the material and anatomical basis for the function,while the function is the manifestation of the structure.The two factors not only have profound significance for our understanding of the essence of acupoints,but also have great value for clinical acupuncture and moxibustion practice.Based on the structural and functional characteristics of meridians under different physiological and pathological conditions,this paper illustrates the essence of acupoints and explores the rules and biological basis of the acupoint functions induced by acupuncture and moxibustion.
