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DNA甲基转移酶基因多态性与SLT治疗脑卒中失语症疗效的关联性
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作者 张静洁 邹郝晶 +1 位作者 徐酩 邢影 《贵州医科大学学报》 CAS 2021年第9期1024-1030,共7页
目的探讨DNA甲基转移酶(DNMTs)基因多态性与SLT治疗脑卒中失语症患者疗效的关联性。方法将42例脑卒中后(包括缺血性和出血性)的失语症患者进行标准言语—语言治疗(SLT),采用Amsterdam-Nijmegen日常语言测试(ANELT)和Boston命名测试(BNT... 目的探讨DNA甲基转移酶(DNMTs)基因多态性与SLT治疗脑卒中失语症患者疗效的关联性。方法将42例脑卒中后(包括缺血性和出血性)的失语症患者进行标准言语—语言治疗(SLT),采用Amsterdam-Nijmegen日常语言测试(ANELT)和Boston命名测试(BNT)对治疗效果进行评估,分为治疗有效组和治疗无效组,对两组患者的一般特征、临床特征及DNMTs变异进行基因分型,区分其携带的特定单核苷酸多态性(SNPs)类型。结果STL治疗效果与DNMTs SNPs的基因多态性关联分析显示,DNMT 1基因rs 2228612 C等位基因对应的脑卒中失语症患者治疗无效的风险较高(OR=4.46,95%CI=1.27~15.60,P=0.019),分层分析表明男性患者中该效应更为明显(35.17,95%CI=1.68~735.28,P=0.022);对脑卒中失语症患者的DNMTs多态性进行单体型分析,SLT治疗有效和无效患者的DNMT 1基因SNPs位点的单倍型比较,差异无统计学意义(P>0.05)。结论rs 2228612 C等位基因可能与脑卒中失语症患者STL无效相关。 展开更多
关键词 DNA甲基转移酶 多态性 单核苷酸 失语症 脑卒中 言语—语言治疗
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Visualizing Aphasia in Linguistics From 2000 to 2019
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作者 Huili WANG Shurong ZHANG +1 位作者 Hanning GUO Bo LIU 《Chinese Journal of Applied Linguistics》 2024年第4期541-568,687,共29页
This paper aims to visualize the research of aphasia from a linguistic perspective for the two decades from 2000 to 2019,identifying the changes in research focus and the future emerging trends of aphasia studies in l... This paper aims to visualize the research of aphasia from a linguistic perspective for the two decades from 2000 to 2019,identifying the changes in research focus and the future emerging trends of aphasia studies in linguistics.Applying the bibliometric approach,the present study reviewed 3,004 publications with the topic word“aphasia”in the framework of linguistics.The dataset was created from the Web of Science database ranging from 2000 to 2019.Using the CiteSpace tool,document co-citation analysis,betweenness centrality(BC)measurement and citation burst detection were conducted to explore and determine the thematic patterns,critical studies,and emerging trends of this knowledge domain.Twelve thematic patterns in these two decades were identified,indicating that researchers have focused on language impairment in aphasia,aphasia therapy and other topics associated with aphasia.Meanwhile,papers with high BC reveal the connections among different research clusters.In addition,bursts of detected citations demonstrate that treatment aiming at the enhanced quality of daily life,the utilization of discourse tasks and treatments at the discourse level,deeper exploration of primary progressive aphasia in terms of clinical data and the application of working memory assessment,and the role of working memory(WM)training in rehabilitation will possibly attract more attention in the future.On the basis of the cluster landscape,BC and citation bursts,the review found that scholars paid extensive attention to the alleviation of communication deficits in the linguistic exploration of aphasia. 展开更多
关键词 CITESPACE APHASIA LINGUISTICS language impairment aphasia therapy COMMUNICATION bibliometric review
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Constraint-induced aphasia therapy for patients with aphasia: A systematic review 被引量:2
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作者 Guandong Wang Li Ge +2 位作者 Qingxiang Zheng Pingping Huang Jing Xiang 《International Journal of Nursing Sciences》 CSCD 2020年第3期349-358,共10页
Objectives:This study aimed to systematically evaluate the effects of constraint-induced aphasia therapy(OAT)for aphasic patients reported by randomized controlled trials.Methods:Relevant randomized controlled trials ... Objectives:This study aimed to systematically evaluate the effects of constraint-induced aphasia therapy(OAT)for aphasic patients reported by randomized controlled trials.Methods:Relevant randomized controlled trials were retrieved from 11 electronic databases.A methodological quality assessment was conducted in accordance with the Cochrane Handbook,and metaanalyses were performed by using RevMan 5.2.A descriptive analysis was conducted when the included trials were not suitable for a meta-analysis.Results:A total of 12 trials were included.A statistically significant group difference was shown from the meta-analysis in the results measured by the Western Aphasia Battery(random-effects model,MD=1.23,95%CI=0.31 to 2.14,P<0.01).However,there were no statistically significant differences shown in the results of the Boston Naming Test(fixed-effects model,MD=-1.79,95%CI=-11.19 to Z62,P>0.05)and Aachen Aphasia Test(fixed-effects model,MD=-1.11,95%CI=-4.49 to 2.27,P>0.05).The descriptive analysis showed positive results in language performances of naming,repetition,and comprehension.Conclusion:This systematic review indicated that CIAT was efficient for improving language performance with regard to naming,comprehension,repetition,written language,and oral language based on the current evidence.And this review provides some meaningful guides for clinical practice:expand the therapy duration to 2 or 3 h per day,focus on naming,and choose the best assessment tool.It also indicates a need for more rigorous,large-scale,and high-quality trials in the future. 展开更多
关键词 APHASIA Constraint-induced aphasia therapy Descriptive analysis Language tests
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