China now is in an important period of social transformation, it puts forward unique requirements for changes from the ethics community to the legal social, and also for law operation, legal developments and public aw...China now is in an important period of social transformation, it puts forward unique requirements for changes from the ethics community to the legal social, and also for law operation, legal developments and public awareness of the laws. Law globalization both is a result of globalization in other areas, but also a tool to promote other areas of globalization, and its essence is the performance of the laws of all countries in the world being more interdependent to further strengthen. From a legal point to analysis, to identify the root causes and find ways to solve and to provide a useful reference for the current socialist harmonious society is very necessary.展开更多
An optimized recombinant HPV16 E6E7 fusion gene (HPV16 ofE6E7) was constructed according to codon usage for mammalian cell expression, and a mutant of HPV16 ofE6E7 fusion gene (HPV16 omfE6E7) was generated by site-dir...An optimized recombinant HPV16 E6E7 fusion gene (HPV16 ofE6E7) was constructed according to codon usage for mammalian cell expression, and a mutant of HPV16 ofE6E7 fusion gene (HPV16 omfE6E7) was generated by site-directed mutagenesis at L57G, C113R for the E6 protein and C24G, E26G for the E7 protein for HPV16 ofE6E7 [patent pending (CN 101100672)]. The HPV16 omfE6E7 gene constructed in this work not only lost the transformation capability to NIH 3T3 cells and tumorigenicity in SCID mice, but also maintained very good stability and antigenicity. These results suggests that the HPV16 omfE6E7 gene should undergo further study for application as a safe antigen-specific therapeutic vaccine for HPV16-associated tumors.展开更多
In this paper, it explained the process of demographic aging in Republic of Macedonia. There is relevant information for the gradually process of aging. At the end of the text, there are few charts. Macedonia gained i...In this paper, it explained the process of demographic aging in Republic of Macedonia. There is relevant information for the gradually process of aging. At the end of the text, there are few charts. Macedonia gained independence in 1991, in the course of transition from planned to market economy, many socio-economic parameters changed： Demography become evident that fertility rate dropped significantly. In the previous 20 years, number of infants born decreased somewhat 5-6 times compared to 1980. Number of divorce grew rapidly. Also, in the Republic of Macedonia, there followed a parallel process of immigration to western countries, especially western Europe, USA and Australia as well as other countries from the developed world. This migration happened as a result of mainly economic reasons, i.e., countries in which Macedonians migrate have much higher real incomes when compared with Macedonia, and comparatively much higher living standard. One also can find reason for migration in political reasons also, and family reunification. Low fertility is associated with low income and unemployment. People in Macedonia had suffered greatly in transition times with high unemployment, low wages, and corruption, which largely derogated their chances of better future and career and contributed to the demographic aging and low fertility rates.展开更多
The theoretical light curves of contact binaries are calculated with and without putting in the contact binary evolution model.Firstly,we do not use the contact binary evolution model.A comparison of the light curve i...The theoretical light curves of contact binaries are calculated with and without putting in the contact binary evolution model.Firstly,we do not use the contact binary evolution model.A comparison of the light curve is performed with and without the deformation caused by rotation and tides.It shows that the light curve presents many differences,especially on the bottom and top.Secondly,we adopt the contact binary model [Huang R Q,et al.Chin J Astron Astrophys,2007,7:235-244;Song H F,et al.Chin J Astron Astrophys,2007,7:539-550] and compute the theoretical light curve with and without rotational and tidal effects by studying three binary systems(with low-,intermediate-and high-mass components).The bottom and top of the theoretical light curves are discussed and compared to observations.The results show that taking into account the rotational effect has a better agreement with observations than without it.Therefore,the deformation of the light curve of contact binaries caused by rotation and tides is very important.Meanwhile,the rotational and tidal effect can advance the start of the semi-detached,contact phase and the time of mass-reversal.展开更多
文摘China now is in an important period of social transformation, it puts forward unique requirements for changes from the ethics community to the legal social, and also for law operation, legal developments and public awareness of the laws. Law globalization both is a result of globalization in other areas, but also a tool to promote other areas of globalization, and its essence is the performance of the laws of all countries in the world being more interdependent to further strengthen. From a legal point to analysis, to identify the root causes and find ways to solve and to provide a useful reference for the current socialist harmonious society is very necessary.
基金National 863 Program(2007AA021107)Beijing Municipal Commission of Education Research Projects(KM201010005008)Doctoral Start-up Foundation of Beijing University of Technology
文摘An optimized recombinant HPV16 E6E7 fusion gene (HPV16 ofE6E7) was constructed according to codon usage for mammalian cell expression, and a mutant of HPV16 ofE6E7 fusion gene (HPV16 omfE6E7) was generated by site-directed mutagenesis at L57G, C113R for the E6 protein and C24G, E26G for the E7 protein for HPV16 ofE6E7 [patent pending (CN 101100672)]. The HPV16 omfE6E7 gene constructed in this work not only lost the transformation capability to NIH 3T3 cells and tumorigenicity in SCID mice, but also maintained very good stability and antigenicity. These results suggests that the HPV16 omfE6E7 gene should undergo further study for application as a safe antigen-specific therapeutic vaccine for HPV16-associated tumors.
文摘In this paper, it explained the process of demographic aging in Republic of Macedonia. There is relevant information for the gradually process of aging. At the end of the text, there are few charts. Macedonia gained independence in 1991, in the course of transition from planned to market economy, many socio-economic parameters changed： Demography become evident that fertility rate dropped significantly. In the previous 20 years, number of infants born decreased somewhat 5-6 times compared to 1980. Number of divorce grew rapidly. Also, in the Republic of Macedonia, there followed a parallel process of immigration to western countries, especially western Europe, USA and Australia as well as other countries from the developed world. This migration happened as a result of mainly economic reasons, i.e., countries in which Macedonians migrate have much higher real incomes when compared with Macedonia, and comparatively much higher living standard. One also can find reason for migration in political reasons also, and family reunification. Low fertility is associated with low income and unemployment. People in Macedonia had suffered greatly in transition times with high unemployment, low wages, and corruption, which largely derogated their chances of better future and career and contributed to the demographic aging and low fertility rates.
基金supported by the National Natural Science Foundation of China (Grant No.10933002)
文摘The theoretical light curves of contact binaries are calculated with and without putting in the contact binary evolution model.Firstly,we do not use the contact binary evolution model.A comparison of the light curve is performed with and without the deformation caused by rotation and tides.It shows that the light curve presents many differences,especially on the bottom and top.Secondly,we adopt the contact binary model [Huang R Q,et al.Chin J Astron Astrophys,2007,7:235-244;Song H F,et al.Chin J Astron Astrophys,2007,7:539-550] and compute the theoretical light curve with and without rotational and tidal effects by studying three binary systems(with low-,intermediate-and high-mass components).The bottom and top of the theoretical light curves are discussed and compared to observations.The results show that taking into account the rotational effect has a better agreement with observations than without it.Therefore,the deformation of the light curve of contact binaries caused by rotation and tides is very important.Meanwhile,the rotational and tidal effect can advance the start of the semi-detached,contact phase and the time of mass-reversal.
