咳喘宁口服液质量标准的研究

目的建立咳喘宁口服液的质量标准。方法利用薄层色谱法鉴别咳喘宁口服液中的麻黄、黄芩、金银花、连翘。进行微生物限度检查计数方法学验证。结果对处方中的麻黄、黄芩、金银花、连翘药材进行了薄层色谱分析,斑点清晰,相互分离良好,专属性强。空白试验表明阴性,样品对药材的鉴别没有干扰。本品按2010年版《中国药典》要求进行检查,对各试验菌的回收率逐一进行验证,回收率大于70%,确认常规方法适用于本品的微生物测定。结论该方法简便可行,重现性好。可用于咳喘宁口服液的质量控制。

双滤膜过滤方法在药品微生物限度检查中的应用研究

目的:建立药品微生物限度检查双滤膜过滤方法,验证其消除供试液抑菌活性的有效性。方法:采用枯草芽孢杆菌、大肠埃希菌、金黄色葡萄球菌、白色念珠菌和黑曲霉为挑战菌株,以中国药典收载的离心沉淀法和培养基稀释法为对照方法,考察双滤膜过滤方法的准确度、精密度、定量限、线性、范围、重现性和耐用性等。结果:采用双滤膜过滤方法处理具抑菌活性的供试品,准确度、精密度、定量限和线性等检测结果优于或与现行中国药典收载的方法持平,并具有良好的重现性和耐用性。结论:双滤膜过滤方法处理具有抗菌活性的供试品,实验过程符合中国药典微生物限度检查法相关规定,试验结果有效,可用于药品的微生物限度检查试验。

Adjusting principle of gas jet controlling inlet and numerical verification

To improve the inlet performance of a ramjet working under variable conditions,a design is proposed by controlling the inlet with jet controlling,which combines the method of reducing the sealing Mach number of the external waves and the technique of controlling inlet by jet controlling.Three inlets were designed to analyze the feasibility and a numerical simulation method was used to simulate the three inlet flow fields.The adjustment mechanism of the design was studied through analysis of the simulation results.The design was verified by comparing the performances of the three inlets.The study showed that the method of reducing the sealing Mach number of the external wave system can improve the flow coefficient when the inlet works at low Mach numbers.The technique of controlling inlet by jet controlling can homogenize inlet flow fields at high Mach numbers,reduce effective throat area and increase the total pressure recovery(TPR).Adjustable inlets controlled by jet controlling demonstrate good performance at certain working ranges.