Objective： Conventional external beam irradiation techniques for nasopharyngeal carcinoma have limitations, and improving external beam irradiation techniques is needed to enhance the curative rate. This study was de...Objective： Conventional external beam irradiation techniques for nasopharyngeal carcinoma have limitations, and improving external beam irradiation techniques is needed to enhance the curative rate. This study was designed to cvaluate the difference in dose distribution of three dimensional conformal radiotherapy （3D CRT） and conventional treatment plan in early untreated nasopharyngeal carcinoma using a three dimensional treatment planning system. Methods： Twenty-two patients with early untreated nasopharyngeal carcinoma were selected. Conventional and 3D CRT plans were made for each of them and compared with respect to target volume coverage （V95）,normal tissue sparing （D50, D33 and D5, etc）, normal tissue complication probability （NTCP）. Results： The average volumetric dose comparison indicated that the V95 of PTVnx70 were 98.22% and 99.99% （P=0.06）, and PTVnd60, 98.41% and 99.63% （P=1.00）, PTV,x60, 98.44% and 99.98% （P=0.03）, PTVnx50, 98.85% and 99.63% （P=0.02） in conventional and 3DCRT treatment plans respectively. With respect to normal tissue sparing, the average D50 of unilateral parotid glands were 51.91 Gy and 64.30 Gy （P=0.00） respectively, and the unilateral temporomandibular joints, 49.98 Gy and 64.47 Gy （P=0.00）, the Dlcc of spinal cords, 44.98 Gy and 48.09 Gy （P=0.00） in 3D CRT and conventional plans. Conclusion： Though only a little bit better dose coverage of target volume in subclinical lesion region was reached in 3D CRT plans, it spared more normal tissues e.g. parotid glands and temporomandibular joints etc and decreased their NTCP while it got the similar dose distribution in target volumes as conventional plans did for these early nasopharyngeal carcinoma cases.展开更多
In this research,a commercial CFD code ＂Fluent＂ was applied to optimization of bulbous bow shape for a non ballast water ships（NBS）.The ship was developed at the Laboratory of the authors in Osaka Prefecture Unive...In this research,a commercial CFD code ＂Fluent＂ was applied to optimization of bulbous bow shape for a non ballast water ships（NBS）.The ship was developed at the Laboratory of the authors in Osaka Prefecture University,Japan.At first,accuracy of the CFD code was validated by comparing the CFD results with experimental results at towing tank of Osaka Prefecture University.In the optimizing process,the resistances acting on ships in calm water and in regular head waves were defined as the object function.Following features of bulbous bow shapes were considered as design parameters： volume of bulbous bow,height of its volume center,angle of bow bottom,and length of bulbous bow.When referring to the computed results given by the CFD like resistance,pressure and wave pattern made by ships in calm water and in waves,an optimal bow shape for ships was discovered by comparing the results in the series of bow shapes.In the computation on waves,the ship is in fully captured condition because shorter waves,λ/Lpp 0.6,are assumed.展开更多
Objective： To review literature from 1956 to 2007 and explore regularities in points selection and methods for acupuncture-moxibustion treatment of allergic rhinitis. Methods： A comprehensive analysis was made by a ...Objective： To review literature from 1956 to 2007 and explore regularities in points selection and methods for acupuncture-moxibustion treatment of allergic rhinitis. Methods： A comprehensive analysis was made by a method of metrological analysis according to the data from ＂China Modem Acupuncture-moxibustion Information Databank＂. Results： Points Yingxiang （LI 20） and Feishu （BL 13） were most frequently used. Acupuncture and hydro-acupuncture were the major treatment methods. Conclusion： It is suggested that Yingxiang （LI 20）, Yintang （Ex-HN 3）, Feishu （BL 13） and Dazhui （GV 14） be used as a basic prescription for acupuncture-moxibustion treatment of allergic rhinitis, which is combined with point selection based on syndrome differentiation.展开更多
With the speed upgrade of the high-speed train,the aerodynamic drag becomes one of the key factors to restrain the train speed and energy saving.In order to reduce the aerodynamic drag of train head,a new parametric a...With the speed upgrade of the high-speed train,the aerodynamic drag becomes one of the key factors to restrain the train speed and energy saving.In order to reduce the aerodynamic drag of train head,a new parametric approach called local shape function(LSF) was adopted based on the free form surface deformation(FFD) method and a new efficient optimization method based on the response surface method(RSM) of GA-GRNN.The optimization results show that the parametric method can control the large deformation with a few design parameters,and can ensure the deformation zones smoothness and smooth transition of different deformation regions.With the same sample points for training,GA-GRNN performs better than GRNN to get the global optimal solution.As an example,the aerodynamic drag for a simplified shape with head + one carriage + tail train is reduced by 8.7%.The proposed optimization method is efficient for the engineering design of high-speed train.展开更多
基金This project was supported by a grant from Guangdong Medical Research Foundation (No.Al999214).
文摘Objective： Conventional external beam irradiation techniques for nasopharyngeal carcinoma have limitations, and improving external beam irradiation techniques is needed to enhance the curative rate. This study was designed to cvaluate the difference in dose distribution of three dimensional conformal radiotherapy （3D CRT） and conventional treatment plan in early untreated nasopharyngeal carcinoma using a three dimensional treatment planning system. Methods： Twenty-two patients with early untreated nasopharyngeal carcinoma were selected. Conventional and 3D CRT plans were made for each of them and compared with respect to target volume coverage （V95）,normal tissue sparing （D50, D33 and D5, etc）, normal tissue complication probability （NTCP）. Results： The average volumetric dose comparison indicated that the V95 of PTVnx70 were 98.22% and 99.99% （P=0.06）, and PTVnd60, 98.41% and 99.63% （P=1.00）, PTV,x60, 98.44% and 99.98% （P=0.03）, PTVnx50, 98.85% and 99.63% （P=0.02） in conventional and 3DCRT treatment plans respectively. With respect to normal tissue sparing, the average D50 of unilateral parotid glands were 51.91 Gy and 64.30 Gy （P=0.00） respectively, and the unilateral temporomandibular joints, 49.98 Gy and 64.47 Gy （P=0.00）, the Dlcc of spinal cords, 44.98 Gy and 48.09 Gy （P=0.00） in 3D CRT and conventional plans. Conclusion： Though only a little bit better dose coverage of target volume in subclinical lesion region was reached in 3D CRT plans, it spared more normal tissues e.g. parotid glands and temporomandibular joints etc and decreased their NTCP while it got the similar dose distribution in target volumes as conventional plans did for these early nasopharyngeal carcinoma cases.
文摘In this research,a commercial CFD code ＂Fluent＂ was applied to optimization of bulbous bow shape for a non ballast water ships（NBS）.The ship was developed at the Laboratory of the authors in Osaka Prefecture University,Japan.At first,accuracy of the CFD code was validated by comparing the CFD results with experimental results at towing tank of Osaka Prefecture University.In the optimizing process,the resistances acting on ships in calm water and in regular head waves were defined as the object function.Following features of bulbous bow shapes were considered as design parameters： volume of bulbous bow,height of its volume center,angle of bow bottom,and length of bulbous bow.When referring to the computed results given by the CFD like resistance,pressure and wave pattern made by ships in calm water and in waves,an optimal bow shape for ships was discovered by comparing the results in the series of bow shapes.In the computation on waves,the ship is in fully captured condition because shorter waves,λ/Lpp 0.6,are assumed.
文摘Objective： To review literature from 1956 to 2007 and explore regularities in points selection and methods for acupuncture-moxibustion treatment of allergic rhinitis. Methods： A comprehensive analysis was made by a method of metrological analysis according to the data from ＂China Modem Acupuncture-moxibustion Information Databank＂. Results： Points Yingxiang （LI 20） and Feishu （BL 13） were most frequently used. Acupuncture and hydro-acupuncture were the major treatment methods. Conclusion： It is suggested that Yingxiang （LI 20）, Yintang （Ex-HN 3）, Feishu （BL 13） and Dazhui （GV 14） be used as a basic prescription for acupuncture-moxibustion treatment of allergic rhinitis, which is combined with point selection based on syndrome differentiation.
基金supported by the National Basic Research Program of China ("973" Project) (Grant No. 2011CB711100)the National Hi-Tech Research and Development Program of China ("863" Project) (Grant No.2009BAQG12A03)Computing Facility for Computational Mechanics,Institute of Mechanics,Chinese Academy of Sciences
文摘With the speed upgrade of the high-speed train,the aerodynamic drag becomes one of the key factors to restrain the train speed and energy saving.In order to reduce the aerodynamic drag of train head,a new parametric approach called local shape function(LSF) was adopted based on the free form surface deformation(FFD) method and a new efficient optimization method based on the response surface method(RSM) of GA-GRNN.The optimization results show that the parametric method can control the large deformation with a few design parameters,and can ensure the deformation zones smoothness and smooth transition of different deformation regions.With the same sample points for training,GA-GRNN performs better than GRNN to get the global optimal solution.As an example,the aerodynamic drag for a simplified shape with head + one carriage + tail train is reduced by 8.7%.The proposed optimization method is efficient for the engineering design of high-speed train.
