目的探讨水迷宫训练对老年性痴呆大鼠的防治作用及其机制。方法 48只SD大鼠随机分为对照组、模型组、水迷宫短期训练组(short-term drill group of water-maze,WMDS)和水迷宫长期训练组(long-term drill group of water-maze,WMDL);以穹...目的探讨水迷宫训练对老年性痴呆大鼠的防治作用及其机制。方法 48只SD大鼠随机分为对照组、模型组、水迷宫短期训练组(short-term drill group of water-maze,WMDS)和水迷宫长期训练组(long-term drill group of water-maze,WMDL);以穹隆-海马伞切断进行"老年性痴呆"造模,水迷宫训练后,断头取脑制备海马匀浆,酶联免疫吸附法(ELISA)测定海马区TNF-α的水平,比色法检测海马组织匀浆中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量,并评价大鼠的学习能力。结果模型组大鼠的TNF-α水平、MDA含量较对照组明显增加(P<0.01),而SOD活性明显降低(P<0.05);水迷宫短期和长期训练组大鼠的TNF-α、MDA较对照组均明显增高(P<0.05),而SOD活性均明显降低(P<0.01);水迷宫短期和长期训练组大鼠的TNF-α较模型组均明显降低(P<0.05),而SOD活性均明显增加(P<0.01);而且短期训练组与长期训练组TNF-α、MDA和SOD活性之间均有显著性差异(P<0.05)。结论水迷宫训练可增强动物海马部位SOD含量,可能通过减少炎症介质TNF-α以及发挥抗氧化的作用,在一定程度上有利于老年性痴呆的改善。展开更多
In order to carry out an integrated assessment of sea water quality objectively, this paper based on the concept and principle of artificial neural network, generated appropriate training samples for BP artificial neu...In order to carry out an integrated assessment of sea water quality objectively, this paper based on the concept and principle of artificial neural network, generated appropriate training samples for BP artificial neural network model through the method of producing samples to the concentration of various pollution index of sea water quality from the viewpoint of threshold, established the BP artificial neural network model of sea water quality assessment using multi-layer neural network with error back-propagation algorithm. This model was used to assess water environment and obtain sea water quality categories of offshore area in Bohai Bay through calculating. The calculations shown that pollution index in river＇s wet season was higher than that in dry season from 2004 to 2007, and the pollution was particularly serious in 2005 and 2006, but a little better in 2007. The assessed results of cases shown that the model was reasonable in design and higher in generalization, meanwhile, it was common, objective and practical to sea water quality assessment.展开更多
A superimposed training （ST） based channel estimation method is presented that provides accurate estimation of a sparse underwater acoustic orthogonal frequency-division multiplexing （OFDM） channel while improving...A superimposed training （ST） based channel estimation method is presented that provides accurate estimation of a sparse underwater acoustic orthogonal frequency-division multiplexing （OFDM） channel while improving bandwidth transmission efficiency. A periodic low power training sequence is superimposed on the information sequence at the transmitter. The channel parameters can be estimated without consuming any extra system bandwidth, but an unknown information sequence can interfere with the ST channel estimation method, so in this paper, an iterative method was adopted to improve estimation performance. An underwater acoustic channel＇s properties include large channel dimensions and a sparse structure, so a matching pursuit （MP） algorithm was used to estimate the nonzero taps, allowing the performance loss caused by additive white Gaussian noise （AWGN） to be reduced. The results of computer simulations show that the proposed method has good channel estimation performance and can reduce the peak-to-average ratio of the OFDM channel as well.展开更多
The purpose of this systematic review was to identify the effects of weight-lifting or resistance exercise on breast cancer-related lymphedema.Published articles written in English were retrieved from electronic datab...The purpose of this systematic review was to identify the effects of weight-lifting or resistance exercise on breast cancer-related lymphedema.Published articles written in English were retrieved from electronic databases,including ScienceDirect,PubMed,Scopus,and CINAHL databases.Hand-searches for unpublished papers were also completed.Content analysis was used to examine articles that met the inclusion criteria.Among 525 searched papers,15 papers met the inclusion criteria:13 trials evaluated weight-lifting or resistance exercise alone and two trials evaluated weight-lifting or resistance exercise plus aerobic exercise.The results of the review showed that no arm volume change was observed for either exercise modality.In addition,six included studies showed that weight-lifting or resistance exercise did not cause lymphedema or adverse events in patients at risk of breast cancer-related lymphedema.For patients with breast cancer-related lymphedema,six studies reported that change of swelling outcome measures were not significantly different between the weight-lifting or resistance exercise group and the control group.However,three included studies reported that volume of arm was significantly more reduced in the weight-lifting or resistance exercise group than those in the control group.The findings suggest that supervised resistance exercise may be safe,feasible,and beneficial in patients with breast cancer-related lymphedema or at risk for breast cancer-related lymphedema.However,the limitation of small sample size implies that further research is needed to confirm these findings.展开更多
Failure depth of coal seam floors is one of the important considerations that must be kept in mind when mining is carried out above a confined aquifer. In order to study the factors that affect the failure depth of co...Failure depth of coal seam floors is one of the important considerations that must be kept in mind when mining is carried out above a confined aquifer. In order to study the factors that affect the failure depth of coal seam floors such as mining depth, coal seam pitch, mining thickness, workface length and faults, we propose a combined artificial neural networks (ANN) prediction model for failure depth of coal seam floors on the basis of existing engineering data by using genetic algorithms to train the ANN. A practical engineering application at the Taoyuan Coal Mine indicates that this method can effectively determine the network struc- ture and training parameters, with the predicted results agreeing with practical measurements. Therefore, this method can be applied to relevant engineering projects with satisfactory results.展开更多
Purpose： The purpose of this study was to determine if antioxidant supplementation, moderate exercise, and the combination of both treatments could ameliorate cognitive performance in adult mice and whether the apoli...Purpose： The purpose of this study was to determine if antioxidant supplementation, moderate exercise, and the combination of both treatments could ameliorate cognitive performance in adult mice and whether the apolipoprotein E （APOE） genotype as well as sex could influence the functional outcomes of the treatments. Methods： For a period of 16 weeks, separate groups of male and female mice expressing either the human APOE3 or APOE4 isoforms were fed either a control diet （NIH-31） or the control diet supplemented with vitamins E and C （1.12 IU/g diet a-tocopheryl acetate and 1.65 mg/g ascorbic acid）. The mice were further separated into a sedentary group or a group that followed a daily exercise regimen. After 8 weeks on the treatments, the mice were administered a battery of functional tests including tests to measure cognitive and affective function. Results： There was no effect of genotype or treatment on the learning performance in the Morris water maze. In the discriminated avoidance task, APOE4 mice performed better in learning the discrimination component of the task. Overall, exercise improved performance of APOE4 and APOE3 mice on various aspects of the active avoidance task. Antioxidant supplementation improved performance only in the APOE4 mice. On the test for anxiety, APOE4 mice spent more time in the open arms and supplementation with antioxidant reversed that effect. Conclusion： Exercise was the most effective treatment at improving cognitive function in both genotypes and sex, while antioxidants seemed to be effective only in the APOE4. In young adult mice only non-spatial learning and memory were improved. The combination of the two treatments did not yield further improvement in cognition, and there was no antagonistic action of the antioxidant supplementation on the beneficial effects of exercise.展开更多
In the field of underwater survey, there is a variety of methods which differ from each other in terms of the operating environment and the purpose that each method is used. Hence, some of the state-of-the-art methods...In the field of underwater survey, there is a variety of methods which differ from each other in terms of the operating environment and the purpose that each method is used. Hence, some of the state-of-the-art methods, that have many applications in the various scientific fields nowadays, are introduced in this paper. Additionally, the application of the procedures for an underwater survey in shallow depths is analyzed in accordance with the training standards of the PADI Underwater Survey Diver distinctive specialty. The main goal is to demonstrate not only the theoretical background of underwater surveys but also their operational issues, in order to facilitate the development of knowledge and skills during a training course. Finally, a case study for the recording and 3D modeling of the seabeds＇ morphology in shallow water is presented as it has been organized and accomplished by the participants of such a training course. By this way, it is expected that the reader will understand explicitly the application of the procedures prior, during and after the dive for an underwater survey in shallow depths.展开更多
OBJECTIVE:To observe the effect of lit-moxa stimulating acupoint Guanyuan(CV 4) on lactic acid and super-oxide dismutase(SOD) in skeletal muscle after exercise exhaustion.METHODS:Twenty-eight adult male Sprague-Dawley...OBJECTIVE:To observe the effect of lit-moxa stimulating acupoint Guanyuan(CV 4) on lactic acid and super-oxide dismutase(SOD) in skeletal muscle after exercise exhaustion.METHODS:Twenty-eight adult male Sprague-Dawley rats were randomly divided into normal control group,exhausted control group,exercise group and moxibustion group using exercise training and mild heating with lit-moxa stick as treatment methods.The exhausted control group,moxibustion group and exercise group received an exhaustive swimming after 20 days of intervention.Swimming exhausted times were recorded.Lactic acid and SOD concentration in soleus muscle were detected and compared between every two groups.RESULTS:The swimming exhausted times of the moxibustion group and the exercise group were significantly increased compare to the exhausted control group(P < 0.05).The lactic acid of the exhausted control group was significantly increased comparing with the normal control group(P <0.05),and the lactic acid of the moxibustion group and the exercise group were significantly lower than that of the exhausted control group(P < 0.05).The SOD level of the exhausted control group was significantly decreased comparing with the normal control group(P < 0.05),and the SOD level of the moxibustion group and the exercise group were significantly higher than that of the exhausted control group(both,P < 0.05).There was no statistical difference between the moxibustion group and the exercise group.CONCLUSION:With lit moxa stick,heat stimulating acupoint of Guanyuan(CV 4) decreased the levels of lactic acid and SOD in rat's skeletal muscle.展开更多
文摘目的探讨水迷宫训练对老年性痴呆大鼠的防治作用及其机制。方法 48只SD大鼠随机分为对照组、模型组、水迷宫短期训练组(short-term drill group of water-maze,WMDS)和水迷宫长期训练组(long-term drill group of water-maze,WMDL);以穹隆-海马伞切断进行"老年性痴呆"造模,水迷宫训练后,断头取脑制备海马匀浆,酶联免疫吸附法(ELISA)测定海马区TNF-α的水平,比色法检测海马组织匀浆中超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量,并评价大鼠的学习能力。结果模型组大鼠的TNF-α水平、MDA含量较对照组明显增加(P<0.01),而SOD活性明显降低(P<0.05);水迷宫短期和长期训练组大鼠的TNF-α、MDA较对照组均明显增高(P<0.05),而SOD活性均明显降低(P<0.01);水迷宫短期和长期训练组大鼠的TNF-α较模型组均明显降低(P<0.05),而SOD活性均明显增加(P<0.01);而且短期训练组与长期训练组TNF-α、MDA和SOD活性之间均有显著性差异(P<0.05)。结论水迷宫训练可增强动物海马部位SOD含量,可能通过减少炎症介质TNF-α以及发挥抗氧化的作用,在一定程度上有利于老年性痴呆的改善。
文摘In order to carry out an integrated assessment of sea water quality objectively, this paper based on the concept and principle of artificial neural network, generated appropriate training samples for BP artificial neural network model through the method of producing samples to the concentration of various pollution index of sea water quality from the viewpoint of threshold, established the BP artificial neural network model of sea water quality assessment using multi-layer neural network with error back-propagation algorithm. This model was used to assess water environment and obtain sea water quality categories of offshore area in Bohai Bay through calculating. The calculations shown that pollution index in river＇s wet season was higher than that in dry season from 2004 to 2007, and the pollution was particularly serious in 2005 and 2006, but a little better in 2007. The assessed results of cases shown that the model was reasonable in design and higher in generalization, meanwhile, it was common, objective and practical to sea water quality assessment.
基金Supported by the National Natural Science Foundation of China under Grant No.60572039
文摘A superimposed training （ST） based channel estimation method is presented that provides accurate estimation of a sparse underwater acoustic orthogonal frequency-division multiplexing （OFDM） channel while improving bandwidth transmission efficiency. A periodic low power training sequence is superimposed on the information sequence at the transmitter. The channel parameters can be estimated without consuming any extra system bandwidth, but an unknown information sequence can interfere with the ST channel estimation method, so in this paper, an iterative method was adopted to improve estimation performance. An underwater acoustic channel＇s properties include large channel dimensions and a sparse structure, so a matching pursuit （MP） algorithm was used to estimate the nonzero taps, allowing the performance loss caused by additive white Gaussian noise （AWGN） to be reduced. The results of computer simulations show that the proposed method has good channel estimation performance and can reduce the peak-to-average ratio of the OFDM channel as well.
文摘The purpose of this systematic review was to identify the effects of weight-lifting or resistance exercise on breast cancer-related lymphedema.Published articles written in English were retrieved from electronic databases,including ScienceDirect,PubMed,Scopus,and CINAHL databases.Hand-searches for unpublished papers were also completed.Content analysis was used to examine articles that met the inclusion criteria.Among 525 searched papers,15 papers met the inclusion criteria:13 trials evaluated weight-lifting or resistance exercise alone and two trials evaluated weight-lifting or resistance exercise plus aerobic exercise.The results of the review showed that no arm volume change was observed for either exercise modality.In addition,six included studies showed that weight-lifting or resistance exercise did not cause lymphedema or adverse events in patients at risk of breast cancer-related lymphedema.For patients with breast cancer-related lymphedema,six studies reported that change of swelling outcome measures were not significantly different between the weight-lifting or resistance exercise group and the control group.However,three included studies reported that volume of arm was significantly more reduced in the weight-lifting or resistance exercise group than those in the control group.The findings suggest that supervised resistance exercise may be safe,feasible,and beneficial in patients with breast cancer-related lymphedema or at risk for breast cancer-related lymphedema.However,the limitation of small sample size implies that further research is needed to confirm these findings.
基金Projects 50874103 supported by the National Natural Science Foundation of China2006CB202210 by the National Basic Research Program of China+1 种基金BK2008135 by the Natural Science Foundation of Jiangsu Provincethe Qing-lan Project of Jiangsu Province
文摘Failure depth of coal seam floors is one of the important considerations that must be kept in mind when mining is carried out above a confined aquifer. In order to study the factors that affect the failure depth of coal seam floors such as mining depth, coal seam pitch, mining thickness, workface length and faults, we propose a combined artificial neural networks (ANN) prediction model for failure depth of coal seam floors on the basis of existing engineering data by using genetic algorithms to train the ANN. A practical engineering application at the Taoyuan Coal Mine indicates that this method can effectively determine the network struc- ture and training parameters, with the predicted results agreeing with practical measurements. Therefore, this method can be applied to relevant engineering projects with satisfactory results.
基金supported by grant MRG-10-173988 and donation from the Pine Family Foundation
文摘Purpose： The purpose of this study was to determine if antioxidant supplementation, moderate exercise, and the combination of both treatments could ameliorate cognitive performance in adult mice and whether the apolipoprotein E （APOE） genotype as well as sex could influence the functional outcomes of the treatments. Methods： For a period of 16 weeks, separate groups of male and female mice expressing either the human APOE3 or APOE4 isoforms were fed either a control diet （NIH-31） or the control diet supplemented with vitamins E and C （1.12 IU/g diet a-tocopheryl acetate and 1.65 mg/g ascorbic acid）. The mice were further separated into a sedentary group or a group that followed a daily exercise regimen. After 8 weeks on the treatments, the mice were administered a battery of functional tests including tests to measure cognitive and affective function. Results： There was no effect of genotype or treatment on the learning performance in the Morris water maze. In the discriminated avoidance task, APOE4 mice performed better in learning the discrimination component of the task. Overall, exercise improved performance of APOE4 and APOE3 mice on various aspects of the active avoidance task. Antioxidant supplementation improved performance only in the APOE4 mice. On the test for anxiety, APOE4 mice spent more time in the open arms and supplementation with antioxidant reversed that effect. Conclusion： Exercise was the most effective treatment at improving cognitive function in both genotypes and sex, while antioxidants seemed to be effective only in the APOE4. In young adult mice only non-spatial learning and memory were improved. The combination of the two treatments did not yield further improvement in cognition, and there was no antagonistic action of the antioxidant supplementation on the beneficial effects of exercise.
文摘In the field of underwater survey, there is a variety of methods which differ from each other in terms of the operating environment and the purpose that each method is used. Hence, some of the state-of-the-art methods, that have many applications in the various scientific fields nowadays, are introduced in this paper. Additionally, the application of the procedures for an underwater survey in shallow depths is analyzed in accordance with the training standards of the PADI Underwater Survey Diver distinctive specialty. The main goal is to demonstrate not only the theoretical background of underwater surveys but also their operational issues, in order to facilitate the development of knowledge and skills during a training course. Finally, a case study for the recording and 3D modeling of the seabeds＇ morphology in shallow water is presented as it has been organized and accomplished by the participants of such a training course. By this way, it is expected that the reader will understand explicitly the application of the procedures prior, during and after the dive for an underwater survey in shallow depths.
基金Supported by State Administration of Traditional Chinese Medicine Key Lab of Specialized Acupuncture and Moxibustion Therapy Evaluation:research on the Mechanism of Preventive Moxibustion on Exercise Intolerance of RatInnovation Team Project(No.2011-CXTD-19)of Beijing University of Chinese Medicine:research on the Preventive Effect of Moxibustion+1 种基金Ministry of Education Key Lab of Tcm Health Care:Moxibustion and TCM Health CareBeijing Key Lab of TCM Health Care:Moxibustion and TCM Health Care
文摘OBJECTIVE:To observe the effect of lit-moxa stimulating acupoint Guanyuan(CV 4) on lactic acid and super-oxide dismutase(SOD) in skeletal muscle after exercise exhaustion.METHODS:Twenty-eight adult male Sprague-Dawley rats were randomly divided into normal control group,exhausted control group,exercise group and moxibustion group using exercise training and mild heating with lit-moxa stick as treatment methods.The exhausted control group,moxibustion group and exercise group received an exhaustive swimming after 20 days of intervention.Swimming exhausted times were recorded.Lactic acid and SOD concentration in soleus muscle were detected and compared between every two groups.RESULTS:The swimming exhausted times of the moxibustion group and the exercise group were significantly increased compare to the exhausted control group(P < 0.05).The lactic acid of the exhausted control group was significantly increased comparing with the normal control group(P <0.05),and the lactic acid of the moxibustion group and the exercise group were significantly lower than that of the exhausted control group(P < 0.05).The SOD level of the exhausted control group was significantly decreased comparing with the normal control group(P < 0.05),and the SOD level of the moxibustion group and the exercise group were significantly higher than that of the exhausted control group(both,P < 0.05).There was no statistical difference between the moxibustion group and the exercise group.CONCLUSION:With lit moxa stick,heat stimulating acupoint of Guanyuan(CV 4) decreased the levels of lactic acid and SOD in rat's skeletal muscle.
