Chronic viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are major global health problems affecting more than 500 million people worldwide. Virus-specifi...Chronic viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are major global health problems affecting more than 500 million people worldwide. Virus-specific CD8+ T cells play an important role in the course and outcome of these viral infections and it is hypothesized that altered or impaired differentiation of virus- specific CD8+ T cells contributes to the development of persistence and/or disease progression. A deeper understanding of the mechanisms responsible for functional differentiation of CD8+ T cells is essential for the generation of successful therapies aiming to strengthen the adaptive component of the immune system.展开更多
In a recent comparative confrontation between the Peloponnesian war and the Polynesian war, the anthropologist Marshall Sahlins asked for the agents of history： individuals？ communities？ the social classes？ the ec...In a recent comparative confrontation between the Peloponnesian war and the Polynesian war, the anthropologist Marshall Sahlins asked for the agents of history： individuals？ communities？ the social classes？ the economic structures？ the social structures？ Actually, for the American anthropologist, ＂no history without culture.＂ But the question is to focus on the different discursive forms which transforms the events of history in historiography, in a （referential and not fictional） story; these different （often poetic） forms of historiography shape a collective and cultural memory. The Greek case is particularly significant under that point of view as far as historiography is always situated between oral tradition and written tradition （Jack Goody）, between poetic forms and forms of prose, with an important political, social, religious, and ideological impact.展开更多
基金NIH National Center for Research Resources K12 RR017643 and NIH K08 AI072191 (HR)the National Institutes of Health through the Grand Challenges in Global Health Initiative, Cancer Research Institute Investigator Award, Woodruff Health Sciences Fund, Yerkes Research Center Base Grant RR-00165 and NIH AI070101 (AG)
文摘Chronic viral infections such as hepatitis B virus (HBV), hepatitis C virus (HCV) and human immunodeficiency virus (HIV) are major global health problems affecting more than 500 million people worldwide. Virus-specific CD8+ T cells play an important role in the course and outcome of these viral infections and it is hypothesized that altered or impaired differentiation of virus- specific CD8+ T cells contributes to the development of persistence and/or disease progression. A deeper understanding of the mechanisms responsible for functional differentiation of CD8+ T cells is essential for the generation of successful therapies aiming to strengthen the adaptive component of the immune system.
文摘In a recent comparative confrontation between the Peloponnesian war and the Polynesian war, the anthropologist Marshall Sahlins asked for the agents of history： individuals？ communities？ the social classes？ the economic structures？ the social structures？ Actually, for the American anthropologist, ＂no history without culture.＂ But the question is to focus on the different discursive forms which transforms the events of history in historiography, in a （referential and not fictional） story; these different （often poetic） forms of historiography shape a collective and cultural memory. The Greek case is particularly significant under that point of view as far as historiography is always situated between oral tradition and written tradition （Jack Goody）, between poetic forms and forms of prose, with an important political, social, religious, and ideological impact.
