Third generation DNA sequencing relies on monitoring the ionic current blockage during the DNA molecule’s threading through a nanoscale pore.It is still really tough to attain the single base discrimination on a DNA ...Third generation DNA sequencing relies on monitoring the ionic current blockage during the DNA molecule’s threading through a nanoscale pore.It is still really tough to attain the single base discrimination on a DNA strand by merely analyzing the ionic current due to speedy DNA translocation and low spatial resolution.More integrated configurations are pursued to present versatile comparative dissimilarities of the four bases by enhancing the spatial resolution within a DNA molecule translocation event,such as transverse tunneling current,local potential change,and capacitance oriented voltage resonance.In this mini review,the insight is provided into the status quo on several functionalized techniques and methodologies for DNA sequencing and furthermore concluding remark and outlook are presented.展开更多
The aim of the Daya Bay reactor antineutrino experiment is to determine the neutrino mixing angle 813 with a sensitivity of 0.01 or better at 90% confidence level. In order to improve the position resolution of both t...The aim of the Daya Bay reactor antineutrino experiment is to determine the neutrino mixing angle 813 with a sensitivity of 0.01 or better at 90% confidence level. In order to improve the position resolution of both the positron interaction and the neu- tron capture, the inside of the antineutrino detectors should be as unreflecting as possible. A black matt fluorocarbon paint is coated on the inner surface of the detectors made of 304L stainless steel to meet the physical requirement. This paint is com- patible with mineral oil, has low radioactivity, is easy to spray and fast curing at normal temperatures. The coating has excel- lent performance such as good adhesive force, uniformity, compact, scratch and wear resistance, and so on. It is the first appli- cation of such paint to large physical devices.展开更多
基金supported by the National Basic Research Program of China(Grant No.2011CB707605)National Natural Science Foundation of China(Grant Nos.50925519 and 51375092)G.S.Wu was supported by the Scientific Research Foundation of Graduate School of Southeast University
文摘Third generation DNA sequencing relies on monitoring the ionic current blockage during the DNA molecule’s threading through a nanoscale pore.It is still really tough to attain the single base discrimination on a DNA strand by merely analyzing the ionic current due to speedy DNA translocation and low spatial resolution.More integrated configurations are pursued to present versatile comparative dissimilarities of the four bases by enhancing the spatial resolution within a DNA molecule translocation event,such as transverse tunneling current,local potential change,and capacitance oriented voltage resonance.In this mini review,the insight is provided into the status quo on several functionalized techniques and methodologies for DNA sequencing and furthermore concluding remark and outlook are presented.
基金supported in part by the Ministry of Science and Technology of China (Gramt No. 2006CB808100)supported by the National Natural Science Foundation of China(Grant No. 11005117)
文摘The aim of the Daya Bay reactor antineutrino experiment is to determine the neutrino mixing angle 813 with a sensitivity of 0.01 or better at 90% confidence level. In order to improve the position resolution of both the positron interaction and the neu- tron capture, the inside of the antineutrino detectors should be as unreflecting as possible. A black matt fluorocarbon paint is coated on the inner surface of the detectors made of 304L stainless steel to meet the physical requirement. This paint is com- patible with mineral oil, has low radioactivity, is easy to spray and fast curing at normal temperatures. The coating has excel- lent performance such as good adhesive force, uniformity, compact, scratch and wear resistance, and so on. It is the first appli- cation of such paint to large physical devices.
