Objective:Cetuximab combined with chemotherapy has been used to treat non-small cell lung cancer (NSCLC) in recent years, most of them were first line setting.This study was to summarize our experiences in treating NS...Objective:Cetuximab combined with chemotherapy has been used to treat non-small cell lung cancer (NSCLC) in recent years, most of them were first line setting.This study was to summarize our experiences in treating NSCLC patients with cetuximab in the non-first line setting.Methods:From October 1st 2006 to December 31st 2009, six NSCLC patients were treated with cetuximab combined standard chemotherapy as non-first line setting in Sun Yat-sen University Cancer Center, China.The short-term efficacies and safeties were analyzed.Results:1.A total of 18 cycles of cetuximab treatment, with a median of two cycles in the whole group.2.There were 6 patients treated as non-first line setting, overall response rate (ORR) was 33.3% (2/6), disease control rate (DCR) was 33.3% (2/6), median time to progression (TTP) was 3.5 (3-4) months, and median OS was 18 (4-28) months.3.There were 50% (3/6) patients occurred acne-like rash within three weeks, their ORR was 66.7% (2/3), and DCR was 66.7% (2/3), however, both of ORR and DCR in patients who didn't occurred acne-like rash were 0% (0/3), the differences of ORR, DCR between two groups were in significant different (P=0.143).4.There was no treatment-associated death and no cetuximab-associated discontinuation.The incidence of acne-like rash was 50% occurred within three weeks, there were two patients suffered side effects associated with chemotherapy.Conclusion:The data of cetuximab application in non-first line setting for patients with NSCLC were rare, and the addition of cetuximab in those population was safe.展开更多
Leading Company in the field of ceramic floor and wall, has different areas of workforce development, in this research, we will focus the tone adjustment area that is committed to the quality of the final product beca...Leading Company in the field of ceramic floor and wall, has different areas of workforce development, in this research, we will focus the tone adjustment area that is committed to the quality of the final product because this depends on the tone and color appearance tile. Since there is a need to standardize the procedure of work in the area pitch adjustment so that the head of the area and adjusters have precise specifications when developing the activities. To standardize the procedure proposed and implemented tools and formats to help in practical ways to the adjuster also raised the activities of the head of the area and the setting of tone and adjusters.展开更多
Existing optimization methodologies for intersection operations assumes a fixed geometric design, however the geometry and operational system should be simultaneously optimized to produce the best performance. Signali...Existing optimization methodologies for intersection operations assumes a fixed geometric design, however the geometry and operational system should be simultaneously optimized to produce the best performance. Signalized crosswalks are complex and critical pedestrian facilities. Their geometry and configuration directly affect the safety, cycle length and resulting delays for all users. As crosswalks become wider or they are placed further upstream, the cycle length will increase due to the all-red time requirement, which deteriorates the overall mobility levels of signalized intersections. In contrast, when crosswalk width decreases, the required minimum pedestrian crossing time increases due to the bi-directional pedestrian flow effects, which leads to longer cycle length. Furthermore, existing manuals and guidelines do not offer any specification for the required crosswalk width under various pedestrian demand conditions. This study aims to propose new criteria for designing crosswalk width at signalized intersections, which can optimize the performance from the viewpoint of vehicular traffic and pedestrians. The proposed methodology considers pedestrian demand and its characteristics （such as bi-directional flow effects）, vehicle demand and the geometric characteristics of the intersection The concept of optimized crosswalk width is proposed and demonstrated through a case study. Moreover, a comprehensive discussion regarding the merits and drawbacks of existing strategies on positioning crosswalks is presented. It was found that at signalized intersections, which are characterized by low pedestrian and high vehicle demands, crosswalk width of 2 meters is appropriate to minimize cycle length and resulting delays for all users including pedestrians.展开更多
基金Supported by a grant of Major Science and Technology Project of "National Significant New Drug Creation" (No.2008ZX09312-002)
文摘Objective:Cetuximab combined with chemotherapy has been used to treat non-small cell lung cancer (NSCLC) in recent years, most of them were first line setting.This study was to summarize our experiences in treating NSCLC patients with cetuximab in the non-first line setting.Methods:From October 1st 2006 to December 31st 2009, six NSCLC patients were treated with cetuximab combined standard chemotherapy as non-first line setting in Sun Yat-sen University Cancer Center, China.The short-term efficacies and safeties were analyzed.Results:1.A total of 18 cycles of cetuximab treatment, with a median of two cycles in the whole group.2.There were 6 patients treated as non-first line setting, overall response rate (ORR) was 33.3% (2/6), disease control rate (DCR) was 33.3% (2/6), median time to progression (TTP) was 3.5 (3-4) months, and median OS was 18 (4-28) months.3.There were 50% (3/6) patients occurred acne-like rash within three weeks, their ORR was 66.7% (2/3), and DCR was 66.7% (2/3), however, both of ORR and DCR in patients who didn't occurred acne-like rash were 0% (0/3), the differences of ORR, DCR between two groups were in significant different (P=0.143).4.There was no treatment-associated death and no cetuximab-associated discontinuation.The incidence of acne-like rash was 50% occurred within three weeks, there were two patients suffered side effects associated with chemotherapy.Conclusion:The data of cetuximab application in non-first line setting for patients with NSCLC were rare, and the addition of cetuximab in those population was safe.
文摘Leading Company in the field of ceramic floor and wall, has different areas of workforce development, in this research, we will focus the tone adjustment area that is committed to the quality of the final product because this depends on the tone and color appearance tile. Since there is a need to standardize the procedure of work in the area pitch adjustment so that the head of the area and adjusters have precise specifications when developing the activities. To standardize the procedure proposed and implemented tools and formats to help in practical ways to the adjuster also raised the activities of the head of the area and the setting of tone and adjusters.
文摘Existing optimization methodologies for intersection operations assumes a fixed geometric design, however the geometry and operational system should be simultaneously optimized to produce the best performance. Signalized crosswalks are complex and critical pedestrian facilities. Their geometry and configuration directly affect the safety, cycle length and resulting delays for all users. As crosswalks become wider or they are placed further upstream, the cycle length will increase due to the all-red time requirement, which deteriorates the overall mobility levels of signalized intersections. In contrast, when crosswalk width decreases, the required minimum pedestrian crossing time increases due to the bi-directional pedestrian flow effects, which leads to longer cycle length. Furthermore, existing manuals and guidelines do not offer any specification for the required crosswalk width under various pedestrian demand conditions. This study aims to propose new criteria for designing crosswalk width at signalized intersections, which can optimize the performance from the viewpoint of vehicular traffic and pedestrians. The proposed methodology considers pedestrian demand and its characteristics （such as bi-directional flow effects）, vehicle demand and the geometric characteristics of the intersection The concept of optimized crosswalk width is proposed and demonstrated through a case study. Moreover, a comprehensive discussion regarding the merits and drawbacks of existing strategies on positioning crosswalks is presented. It was found that at signalized intersections, which are characterized by low pedestrian and high vehicle demands, crosswalk width of 2 meters is appropriate to minimize cycle length and resulting delays for all users including pedestrians.
