Factors for determining the spindle size are the shaft diameter, positions of bearing and motor, and entire length of the spindle. Then, it is important to find the assembling of the optimal design variables, which sa...Factors for determining the spindle size are the shaft diameter, positions of bearing and motor, and entire length of the spindle. Then, it is important to find the assembling of the optimal design variables, which satisfy the stiffimss and rotational speed required to the spindle. A general full factorial design method was used to verify some factors that affect the natural frequency of a spindle. It is verified that the shorter shaft length and bearing span length represent the higher natural frequency, and there are some effects according to the change in the levels of factors. The detailed spindle dimension is determined by applying an EVD method, which can define the optimal bearing position through considering the limiting condition. Based on the estimated regression model, the optimal spindle size and bearing distance that can improve the primary natural frequency are obtained, and the influence of design factors on the natural frequency is also analyzed.展开更多
Improving the efficiency of ship optimization is crucial for modem ship design. Compared with traditional methods, multidisciplinary design optimization (MDO) is a more promising approach. For this reason, Collabora...Improving the efficiency of ship optimization is crucial for modem ship design. Compared with traditional methods, multidisciplinary design optimization (MDO) is a more promising approach. For this reason, Collaborative Optimization (CO) is discussed and analyzed in this paper. As one of the most frequently applied MDO methods, CO promotes autonomy of disciplines while providing a coordinating mechanism guaranteeing progress toward an optimum and maintaining interdisciplinary compatibility. However, there are some difficulties in applying the conventional CO method, such as difficulties in choosing an initial point and tremendous computational requirements. For the purpose of overcoming these problems, optimal Latin hypercube design and Radial basis function network were applied to CO. Optimal Latin hypercube design is a modified Latin Hypercube design. Radial basis function network approximates the optimization model, and is updated during the optimization process to improve accuracy. It is shown by examples that the computing efficiency and robustness of this CO method are higher than with the conventional CO method.展开更多
The heat exchanger network(HEN) synthesis problem based on entransy theory is analyzed. According to the characteristics of entransy representation of thermal potential energy, the entransy dissipation represents the ...The heat exchanger network(HEN) synthesis problem based on entransy theory is analyzed. According to the characteristics of entransy representation of thermal potential energy, the entransy dissipation represents the irreversibility of the heat transfer process, the temperature difference determines the entransy dissipation, and four HEN design steps based on entransy theory are put forward. The present study shows how it is possible to set energy targets based on entransy and achieve them with a network of heat exchangers by an example of heat exchanger network design for four streams. In order to verify the correctness of the heat exchanger networks design method based on entransy theory, the synthesis of the HEN for the diesel hydrogenation unit is studied. Using the heat exchange networks design method based on entransy theory, the HEN obtained is consistent with energy targets. The entransy transfer efficiency of HEN based on entransy theory is 92.29%, higher than the entransy transfer efficiency of the maximum heat recovery network based on pinch technology.展开更多
The concepts of floating structure plays a very important role in deepwater projects; and the design of the floating structure is one of the most important tasks in the project. The importance of the floating structur...The concepts of floating structure plays a very important role in deepwater projects; and the design of the floating structure is one of the most important tasks in the project. The importance of the floating structure in offshore projects can be demonstrated in the following several areas: the substantial dynamic structure responses due to wave loading and current loading; the limited motion requirements of risers in deep water; and the increasing difficulty of installation for different components of the system. Three major technical aspects have to be considered, i.e. the strength of structure, the fatigue resistance capacity of the system, and local and global stability of the structure. This paper reviews the current design practice of floating structures, evaluates the main tasks during the design and associated major technical requirements, and addresses the major technical challenges encountered during the design. As a close-out of the paper, the authors discuss some potential future developments in the design of floating structures.展开更多
Demand for large vibrating screen is huge in the mineral processing industry. As bending and random vibration are not considered in a traditional design method for beam structures of a large vibrating screen, fatigue ...Demand for large vibrating screen is huge in the mineral processing industry. As bending and random vibration are not considered in a traditional design method for beam structures of a large vibrating screen, fatigue damage occurs frequently to affect the screening performance. This work aims to conduct a systematic mechanics analysis of the beam structures and improve the design method. Total motion of a beam structure in screening process can be decomposed into the traditional followed rigid translation(FRT), bending vibration(BV) and axial linear-distributed random rigid translation(ALRRT) excited by the side-plates. When treated as a generalized single-degree-of-freedom(SDOF) elastic system analytically, the BV can be solved by the Rayleigh's method. Stochastic analysis for random process is conducted for the detailed ALRRT calculation. Expressions for the mechanics property, namely, the shearing force and bending-moment with respect to BV and ALRRT, are derived, respectively. Experimental and numerical investigations demonstrate that the largest BV exists at the beam center and can be nearly ignored in comparison with the FRT during a simplified engineering design. With the BV and FRT considered, the mechanics property accords well with the practical situation with the maximum error of 6.33%, which is less than that obtained by traditional method.展开更多
Additive manufacturing (AM) permits the fabrication of functionally optimized components with high geometrical complexity. The opportunity of using porous infill as an integrated part of the manufactur- ing process ...Additive manufacturing (AM) permits the fabrication of functionally optimized components with high geometrical complexity. The opportunity of using porous infill as an integrated part of the manufactur- ing process is an example of a unique AM feature. Automated design methods are still incapable of fully exploiting this design freedom. In this work, we show how the so-called coating approach to topology optimization provides a means for designing infill-based components that possess a strongly improved buckling load and, as a result, improved structural stability. The suggested approach thereby addresses an important inadequacy of the standard minimum compliance topology optimization approach, in which buckling is rarely accounted for; rather, a satisfactory buckling load is usually assured through a post-processing step that may lead to sub-optimal components. The present work compares the stan- dard and coating approaches to topology optimization for the MBB beam benchmark case. The opti- mized structures are additively manufactured using a filamentary technique. This experimental study validates the numerical model used in the coating approach. Depending on the properties of the infill material, the buckling load may be more than four times higher than that of solid structures optimized under the same conditions.展开更多
The typical industry practice for Tension Leg Platform (TLP) design focuses on a conventional short-term design recipe, which assumes that an N-year design environment leads to an N-year response. In the response-ba...The typical industry practice for Tension Leg Platform (TLP) design focuses on a conventional short-term design recipe, which assumes that an N-year design environment leads to an N-year response. In the response-based design method, the TLP is designed to withstand N-year responses rather than respond to N-year environmental conditions. In this paper, we present an overview and a general procedure for the response-based design method and use a case study to compare the critical TLP responses between the two methods. The results of our comparison show that the conventional short-term design method often contains an element of conservatism and that the response-based design method can reduce the design conditions and thereby achieve cost savings.展开更多
Uncertainties in engineering design may lead to low reliable solutions that also exhibit high sensitivity to uncontrollable variations. In addition, there often exist several conflicting objectives and constraints in ...Uncertainties in engineering design may lead to low reliable solutions that also exhibit high sensitivity to uncontrollable variations. In addition, there often exist several conflicting objectives and constraints in various design environments. In order to obtain solutions that are not only "multi-objectively" optimal, but also reliable and robust, a probabilistic optimization method was presented by integrating six sigma philosophy and multi-objective genetic algorithm. With this method, multi-objective genetic algorithm was adopted to obtain the global Pareto solutions, and six sigma method was used to improve the reliability and robustness of those optimal solutions. Two engineering design problems were provided as examples to illustrate the proposed method.展开更多
A new system for relaxed cocoercive non-linear variational inequalities in uniformly smooth Banach spaces is introduced and studied using the convergence of projection methods.Our results generalize and improve the co...A new system for relaxed cocoercive non-linear variational inequalities in uniformly smooth Banach spaces is introduced and studied using the convergence of projection methods.Our results generalize and improve the corresponding results of recent works.展开更多
A fuzzy phenomenon has been found between design elements when their classifications were researched. It is hard to separate them since they are interrelated so tight. An explanation between design elements and design...A fuzzy phenomenon has been found between design elements when their classifications were researched. It is hard to separate them since they are interrelated so tight. An explanation between design elements and design thoughts in fashion design based on the fuzzy theory is presented in this paper. I hope this will be a breakthrough for people to enlarge their design thoughts and control their design works.展开更多
A collection of k-matchings of bipartite graph Kn,n with the property thatevery pair of independent edges lies in exactly λ of the k-matchings is called aBIMATCH(n,k,λ)-design. Existences and constructions for vario...A collection of k-matchings of bipartite graph Kn,n with the property thatevery pair of independent edges lies in exactly λ of the k-matchings is called aBIMATCH(n,k,λ)-design. Existences and constructions for various BIMATCH (n,k,λ)designs are given.展开更多
The paper discusses the importance of computer as a supporting approach in architecture. This approach is expected to foster the students' design skills in design studios. The approach is an educational tool for tuto...The paper discusses the importance of computer as a supporting approach in architecture. This approach is expected to foster the students' design skills in design studios. The approach is an educational tool for tutors that could guide the students and increase their creativity in their design. It considers the concepts and the practice of digital architectural design that influence architectural education. The approach is a catalyst for creativity, experimentation, critical thinking and the sustained growth of creative communities. The core of design studio is the notions, methods and skills of digital architectural design. The instruments used for this research was an investigation that made for the work of the fourth year students designs at the architectural department at University of Jordan, by testing design process and product of students' work: first using manual skills, and then using computer-aided programs. The results revealed that the computer-based design approach was able to foster students' design skills as well as to develop their creativity in design. Ninety-one percent of 44 students were found improved in design process using computer-based approach that depends on computer programs. This was done in design studio by improving students' way of thinking, developing their abilities to direct their own learning and pushing them for new definitions in developing their future work.展开更多
A new hydraulic system of a novel automatic transmission (AT) was designed. The dimension and structure of valves and cylinders were designed by theoretical calculation. The dynamic simulation model of hydraulic syste...A new hydraulic system of a novel automatic transmission (AT) was designed. The dimension and structure of valves and cylinders were designed by theoretical calculation. The dynamic simulation model of hydraulic system of AT was established by ITI-SimulationX. Simulation results and theoretical design results were compared to confirm the simulation model. Based on the confirmed simulation model, the simulation results of pressure and flow of the hydraulic system were analyzed. The dynamic simulation method is very helpful for designing and analyzing the performance of hydraulic system and further optimization design. The theoretical design method and dynamic simulation model are feasible for the real industrial applications. The research results can be used in hydraulic system design and optimization.展开更多
A new method of virtual ship assembly modeling which integrates ship three-dimensional design and ship construction planning was described in this paper. A workflow model of simulation modeling based on the virtual sh...A new method of virtual ship assembly modeling which integrates ship three-dimensional design and ship construction planning was described in this paper. A workflow model of simulation modeling based on the virtual ship assembly process was also established; furthermore, a method of information transformation between the ship three-dimensional design and ship construction plan was formulated. To meet the requirements of information sharing between different systems in the ship virtual assembly, a simulation database was created by using the software engineering design method and the relational data model. With the application of this database, the information of ship three-dimensional design, construction planning, and virtual assembly can be integrated into one system. Subsequently, this new method was applied as a tool to simulate the virtual assembly of a ship, and the results guarantee its rationality and reliability.展开更多
The idea of millimeter-wave (MMW) radiometer virtual prototyping is discussed in this paper. Designing environment, designing method and the main modeling components of virtual MMW radiometer are researched. Important...The idea of millimeter-wave (MMW) radiometer virtual prototyping is discussed in this paper. Designing environment, designing method and the main modeling components of virtual MMW radiometer are researched. Important external parameters, which have significant influence to composing system, are used to components modeling, and then components are taken to buildup virtual MMW radiometer system. Moreover, the effect to output is contrasted whether there is a low-noise amplifier or not.展开更多
As for the theory and method in garment structural design according to human figures,a principle for garment design,i.e.body-fitting without added allowance,and a combination of draping and planar design (DPD hereunde...As for the theory and method in garment structural design according to human figures,a principle for garment design,i.e.body-fitting without added allowance,and a combination of draping and planar design (DPD hereunder) for young ladies has been put forward,and,also,a DPD garment prototype for them has been established.And the applied formulae for extensively-practicing operation have been set up,which proves to be,with actual samples,a systematic and practical garment structural designing theory and approach.展开更多
The implementation of molecular profiling technologies in oncology deepens our knowledge for the molecular landscapes of cancer diagnoses, identifying aberrations that could be linked with specific therapeutic vulnera...The implementation of molecular profiling technologies in oncology deepens our knowledge for the molecular landscapes of cancer diagnoses, identifying aberrations that could be linked with specific therapeutic vulnerabilities. In particular, there is an increasing list of molecularly targeted anticancer agents undergoing clinical development that aim to block specific molecular aberrations. This leads to a paradigm shift, with an increasing list of specific aberrations dictating the treatment of patients with cancer. This paradigm shift impacts the field of clinical trials, since the classical approach of having clinico-pathological disease characteristics dictating the patients' enrolment in oncology trials shifts towards the implementation of molecular profiling as prescreening step. In order to facilitate the successful clinical development of these new anticancer drugs within specific molecular niches of cancer diagnoses, there have been developed new, innovative trial designs that could be classified as follows: i)longitudinal cohort studies that implement(or not) "nested" downstream trials, 2) studies that assess the clinical utility of molecular profiling, 3) "master" protocol trials, iv) "basket" trials, v) trials following an adaptive design. In the present article, we review these innovative study designs, providing representative examples from each category and we discuss the challenges that still need to be addressed in this era of new generation oncology trials implementing molecular profiling. Emphasis is put on the field of breast cancer clinical trials.展开更多
Post-modernism began to rise in the mid 20th century, and also rapidly played an influence on the cultures of all the countries in the world. Its combination with the design of art in the development process has broug...Post-modernism began to rise in the mid 20th century, and also rapidly played an influence on the cultures of all the countries in the world. Its combination with the design of art in the development process has brought about a new idea for the aesthetic appreciation of people. The combination of postmodernism with fashion design was mainly reflected in sublation. This has exerted a profound influence on the development of fashion design, which is demonstrated in design theme, design idea, and design methods. In this paper, this is introduced from the concept and characteristics of postmodernism, the influence of postmodernism on fashion design, and the reflection of postmodernism in fashion design. It is found that the post-modernism ideological trend plays a certain role in promoting fashion design.展开更多
Presented is a convenient and timesaving design method for illuminating light being used as a pint-sized searchlight usually,based on white light emitting diode(LED) source.The process of design is studied mostly in a...Presented is a convenient and timesaving design method for illuminating light being used as a pint-sized searchlight usually,based on white light emitting diode(LED) source.The process of design is studied mostly in advanced system analysis program(ASAP).The analyses on this kind of design method reveal the factors that would affect the luminous flux distribution of light,including the number of LED chips,the focus of reflecor and refractor,the corresponding position of reflector and refractor with the source.The zone cofficient method and point-by point method are discussed respectively to determine the LED source and the illuminace distribution of light.The desired parallel light output is gained after being optimized in ASAP at last.展开更多
基金Project(RTI04-01-03) supported by the Regional Technology Innovation Program of the Ministry of Knowledge Economy (MKE) of Korea
文摘Factors for determining the spindle size are the shaft diameter, positions of bearing and motor, and entire length of the spindle. Then, it is important to find the assembling of the optimal design variables, which satisfy the stiffimss and rotational speed required to the spindle. A general full factorial design method was used to verify some factors that affect the natural frequency of a spindle. It is verified that the shorter shaft length and bearing span length represent the higher natural frequency, and there are some effects according to the change in the levels of factors. The detailed spindle dimension is determined by applying an EVD method, which can define the optimal bearing position through considering the limiting condition. Based on the estimated regression model, the optimal spindle size and bearing distance that can improve the primary natural frequency are obtained, and the influence of design factors on the natural frequency is also analyzed.
文摘Improving the efficiency of ship optimization is crucial for modem ship design. Compared with traditional methods, multidisciplinary design optimization (MDO) is a more promising approach. For this reason, Collaborative Optimization (CO) is discussed and analyzed in this paper. As one of the most frequently applied MDO methods, CO promotes autonomy of disciplines while providing a coordinating mechanism guaranteeing progress toward an optimum and maintaining interdisciplinary compatibility. However, there are some difficulties in applying the conventional CO method, such as difficulties in choosing an initial point and tremendous computational requirements. For the purpose of overcoming these problems, optimal Latin hypercube design and Radial basis function network were applied to CO. Optimal Latin hypercube design is a modified Latin Hypercube design. Radial basis function network approximates the optimization model, and is updated during the optimization process to improve accuracy. It is shown by examples that the computing efficiency and robustness of this CO method are higher than with the conventional CO method.
基金Supported the National Natural Science Foundation of China(21406124)
文摘The heat exchanger network(HEN) synthesis problem based on entransy theory is analyzed. According to the characteristics of entransy representation of thermal potential energy, the entransy dissipation represents the irreversibility of the heat transfer process, the temperature difference determines the entransy dissipation, and four HEN design steps based on entransy theory are put forward. The present study shows how it is possible to set energy targets based on entransy and achieve them with a network of heat exchangers by an example of heat exchanger network design for four streams. In order to verify the correctness of the heat exchanger networks design method based on entransy theory, the synthesis of the HEN for the diesel hydrogenation unit is studied. Using the heat exchange networks design method based on entransy theory, the HEN obtained is consistent with energy targets. The entransy transfer efficiency of HEN based on entransy theory is 92.29%, higher than the entransy transfer efficiency of the maximum heat recovery network based on pinch technology.
基金Supported by China National 111 Project Under Grant No.B07109
文摘The concepts of floating structure plays a very important role in deepwater projects; and the design of the floating structure is one of the most important tasks in the project. The importance of the floating structure in offshore projects can be demonstrated in the following several areas: the substantial dynamic structure responses due to wave loading and current loading; the limited motion requirements of risers in deep water; and the increasing difficulty of installation for different components of the system. Three major technical aspects have to be considered, i.e. the strength of structure, the fatigue resistance capacity of the system, and local and global stability of the structure. This paper reviews the current design practice of floating structures, evaluates the main tasks during the design and associated major technical requirements, and addresses the major technical challenges encountered during the design. As a close-out of the paper, the authors discuss some potential future developments in the design of floating structures.
基金Project(51221462) supported by the National Natural Science Foundation of ChinaProject(20120095110001) supported by the Ph D Programs Foundation of Ministry of Education of China
文摘Demand for large vibrating screen is huge in the mineral processing industry. As bending and random vibration are not considered in a traditional design method for beam structures of a large vibrating screen, fatigue damage occurs frequently to affect the screening performance. This work aims to conduct a systematic mechanics analysis of the beam structures and improve the design method. Total motion of a beam structure in screening process can be decomposed into the traditional followed rigid translation(FRT), bending vibration(BV) and axial linear-distributed random rigid translation(ALRRT) excited by the side-plates. When treated as a generalized single-degree-of-freedom(SDOF) elastic system analytically, the BV can be solved by the Rayleigh's method. Stochastic analysis for random process is conducted for the detailed ALRRT calculation. Expressions for the mechanics property, namely, the shearing force and bending-moment with respect to BV and ALRRT, are derived, respectively. Experimental and numerical investigations demonstrate that the largest BV exists at the beam center and can be nearly ignored in comparison with the FRT during a simplified engineering design. With the BV and FRT considered, the mechanics property accords well with the practical situation with the maximum error of 6.33%, which is less than that obtained by traditional method.
文摘Additive manufacturing (AM) permits the fabrication of functionally optimized components with high geometrical complexity. The opportunity of using porous infill as an integrated part of the manufactur- ing process is an example of a unique AM feature. Automated design methods are still incapable of fully exploiting this design freedom. In this work, we show how the so-called coating approach to topology optimization provides a means for designing infill-based components that possess a strongly improved buckling load and, as a result, improved structural stability. The suggested approach thereby addresses an important inadequacy of the standard minimum compliance topology optimization approach, in which buckling is rarely accounted for; rather, a satisfactory buckling load is usually assured through a post-processing step that may lead to sub-optimal components. The present work compares the stan- dard and coating approaches to topology optimization for the MBB beam benchmark case. The opti- mized structures are additively manufactured using a filamentary technique. This experimental study validates the numerical model used in the coating approach. Depending on the properties of the infill material, the buckling load may be more than four times higher than that of solid structures optimized under the same conditions.
文摘The typical industry practice for Tension Leg Platform (TLP) design focuses on a conventional short-term design recipe, which assumes that an N-year design environment leads to an N-year response. In the response-based design method, the TLP is designed to withstand N-year responses rather than respond to N-year environmental conditions. In this paper, we present an overview and a general procedure for the response-based design method and use a case study to compare the critical TLP responses between the two methods. The results of our comparison show that the conventional short-term design method often contains an element of conservatism and that the response-based design method can reduce the design conditions and thereby achieve cost savings.
基金The National Natural Science Foundation of China(No. 50475020)
文摘Uncertainties in engineering design may lead to low reliable solutions that also exhibit high sensitivity to uncontrollable variations. In addition, there often exist several conflicting objectives and constraints in various design environments. In order to obtain solutions that are not only "multi-objectively" optimal, but also reliable and robust, a probabilistic optimization method was presented by integrating six sigma philosophy and multi-objective genetic algorithm. With this method, multi-objective genetic algorithm was adopted to obtain the global Pareto solutions, and six sigma method was used to improve the reliability and robustness of those optimal solutions. Two engineering design problems were provided as examples to illustrate the proposed method.
基金Funded by the Natural Science Foundation of Chongqing(No.CSTC 2009BB8240)
文摘A new system for relaxed cocoercive non-linear variational inequalities in uniformly smooth Banach spaces is introduced and studied using the convergence of projection methods.Our results generalize and improve the corresponding results of recent works.
文摘A fuzzy phenomenon has been found between design elements when their classifications were researched. It is hard to separate them since they are interrelated so tight. An explanation between design elements and design thoughts in fashion design based on the fuzzy theory is presented in this paper. I hope this will be a breakthrough for people to enlarge their design thoughts and control their design works.
文摘A collection of k-matchings of bipartite graph Kn,n with the property thatevery pair of independent edges lies in exactly λ of the k-matchings is called aBIMATCH(n,k,λ)-design. Existences and constructions for various BIMATCH (n,k,λ)designs are given.
文摘The paper discusses the importance of computer as a supporting approach in architecture. This approach is expected to foster the students' design skills in design studios. The approach is an educational tool for tutors that could guide the students and increase their creativity in their design. It considers the concepts and the practice of digital architectural design that influence architectural education. The approach is a catalyst for creativity, experimentation, critical thinking and the sustained growth of creative communities. The core of design studio is the notions, methods and skills of digital architectural design. The instruments used for this research was an investigation that made for the work of the fourth year students designs at the architectural department at University of Jordan, by testing design process and product of students' work: first using manual skills, and then using computer-aided programs. The results revealed that the computer-based design approach was able to foster students' design skills as well as to develop their creativity in design. Ninety-one percent of 44 students were found improved in design process using computer-based approach that depends on computer programs. This was done in design studio by improving students' way of thinking, developing their abilities to direct their own learning and pushing them for new definitions in developing their future work.
基金Project(911901204) supported by Youth Innovation Foundation of Beijing University of Aeronautics and Astronautics
文摘A new hydraulic system of a novel automatic transmission (AT) was designed. The dimension and structure of valves and cylinders were designed by theoretical calculation. The dynamic simulation model of hydraulic system of AT was established by ITI-SimulationX. Simulation results and theoretical design results were compared to confirm the simulation model. Based on the confirmed simulation model, the simulation results of pressure and flow of the hydraulic system were analyzed. The dynamic simulation method is very helpful for designing and analyzing the performance of hydraulic system and further optimization design. The theoretical design method and dynamic simulation model are feasible for the real industrial applications. The research results can be used in hydraulic system design and optimization.
基金Supported by Key National Science & Technology Specific Projects under Grant No. 2008ZX05027-005-002
文摘A new method of virtual ship assembly modeling which integrates ship three-dimensional design and ship construction planning was described in this paper. A workflow model of simulation modeling based on the virtual ship assembly process was also established; furthermore, a method of information transformation between the ship three-dimensional design and ship construction plan was formulated. To meet the requirements of information sharing between different systems in the ship virtual assembly, a simulation database was created by using the software engineering design method and the relational data model. With the application of this database, the information of ship three-dimensional design, construction planning, and virtual assembly can be integrated into one system. Subsequently, this new method was applied as a tool to simulate the virtual assembly of a ship, and the results guarantee its rationality and reliability.
文摘The idea of millimeter-wave (MMW) radiometer virtual prototyping is discussed in this paper. Designing environment, designing method and the main modeling components of virtual MMW radiometer are researched. Important external parameters, which have significant influence to composing system, are used to components modeling, and then components are taken to buildup virtual MMW radiometer system. Moreover, the effect to output is contrasted whether there is a low-noise amplifier or not.
文摘As for the theory and method in garment structural design according to human figures,a principle for garment design,i.e.body-fitting without added allowance,and a combination of draping and planar design (DPD hereunder) for young ladies has been put forward,and,also,a DPD garment prototype for them has been established.And the applied formulae for extensively-practicing operation have been set up,which proves to be,with actual samples,a systematic and practical garment structural designing theory and approach.
文摘The implementation of molecular profiling technologies in oncology deepens our knowledge for the molecular landscapes of cancer diagnoses, identifying aberrations that could be linked with specific therapeutic vulnerabilities. In particular, there is an increasing list of molecularly targeted anticancer agents undergoing clinical development that aim to block specific molecular aberrations. This leads to a paradigm shift, with an increasing list of specific aberrations dictating the treatment of patients with cancer. This paradigm shift impacts the field of clinical trials, since the classical approach of having clinico-pathological disease characteristics dictating the patients' enrolment in oncology trials shifts towards the implementation of molecular profiling as prescreening step. In order to facilitate the successful clinical development of these new anticancer drugs within specific molecular niches of cancer diagnoses, there have been developed new, innovative trial designs that could be classified as follows: i)longitudinal cohort studies that implement(or not) "nested" downstream trials, 2) studies that assess the clinical utility of molecular profiling, 3) "master" protocol trials, iv) "basket" trials, v) trials following an adaptive design. In the present article, we review these innovative study designs, providing representative examples from each category and we discuss the challenges that still need to be addressed in this era of new generation oncology trials implementing molecular profiling. Emphasis is put on the field of breast cancer clinical trials.
文摘Post-modernism began to rise in the mid 20th century, and also rapidly played an influence on the cultures of all the countries in the world. Its combination with the design of art in the development process has brought about a new idea for the aesthetic appreciation of people. The combination of postmodernism with fashion design was mainly reflected in sublation. This has exerted a profound influence on the development of fashion design, which is demonstrated in design theme, design idea, and design methods. In this paper, this is introduced from the concept and characteristics of postmodernism, the influence of postmodernism on fashion design, and the reflection of postmodernism in fashion design. It is found that the post-modernism ideological trend plays a certain role in promoting fashion design.
文摘Presented is a convenient and timesaving design method for illuminating light being used as a pint-sized searchlight usually,based on white light emitting diode(LED) source.The process of design is studied mostly in advanced system analysis program(ASAP).The analyses on this kind of design method reveal the factors that would affect the luminous flux distribution of light,including the number of LED chips,the focus of reflecor and refractor,the corresponding position of reflector and refractor with the source.The zone cofficient method and point-by point method are discussed respectively to determine the LED source and the illuminace distribution of light.The desired parallel light output is gained after being optimized in ASAP at last.