校地共生--设计助力乡村振兴对策研究

结合国家所制定的相应指导意见,分析乡村建设现状,合理规划校地共生,完善设计助力乡村振兴的措施,使得乡村可以得到结构性的改革与发展,合理的运用好创新设计,积极主动地参与到设计扶贫活动中,真正做到校地共生,切实推动设计助力乡村振兴的发展进程。

“校地共生理念”下设计助力乡村振兴路径研究

设计服务和乡村振兴相互融合已成为时代的发展趋势,在相关政策指引下,属地高校基于校地共生理念,与在地乡村紧密结合,发挥属地高校自身设计类专业及人才等方面的优势,与在地政府、企业联合组建设计创新团队,发挥设计整合、协同创新的作用,用设计将乡村的发展资源转化为生命力,帮助地方政府打造生态宜居美丽乡村,贡献出属地高校的设计力量,完成属地高校设计服务乡村振兴的担当和使命。文章梳理了三年以来的国家、部委关于高校设计助力乡村振兴的相关政策文件,通过文献分析了高校设计助力乡村振兴的时代背景、现实需求和研究基础。针对乡村振兴人才匮乏的问题,提出属地高校和当地乡村互融共生,阐述了校地共生理念下设计助力乡村振兴的实施路径,为属地高校深度参与地建设生态宜居美丽乡村提供可资借鉴的路径。

设计助力会展品牌构建的整合性策略研究

会展品牌构建是当前会展业发展的大势所趋,会展设计作为会展项目工作中的一个环节,理应与行业发展趋势保持同向。文章尝试运用整合设计的理念,来梳理会展品牌构建与会展设计之间的联系,力求用设计助力会展品牌构建,提升中国会展品质。

Optimal design and applicability of electric power steering system for automotive platform

The ongoing need for better fuel economy and lower exhaust pollution of vehicles has increased the employment of electric power steering(EPS)in automotives.Optimal design of EPS for a product family reduces the development and fabrication costs significantly.In this paper,the TOPSIS method along with the NSGA-Ⅱis employed to find an optimum family of EPS for an automotive platform.A multi-objective optimization problem is defined considering road feel,steering portability,RMS of Ackerman error,and product family penalty function(PFPF)as the conflicting objective functions.The results for the single objective optimization problems and the ones for the multi-objective optimization problem,as well as two suggested trade-off design points are presented,compared and discussed.For the two suggested points,performance at one objective function is deteriorated by about 1%,while the commonality is increased by 20%–40%,which shows the effectiveness of the proposed method in first finding the non-dominated design points and then selecting the trade-off among the obtained points.The results indicate that the obtained trade-off points have superior performance within the product family with maximum number of common parts.

Substitution for In Vitro and In Vivo Tests:Computational Models from Cell Attachment to Tissue Regeneration

To get an optimal product of orthopaedic implant or regenerative medicine needs to follow trialand-error analyses to investigate suitable product’s material,structure,mechanical properites etc.The whole process from in vivo tests to clinical trials is expensive and time-consuming.Computational model is seen as a useful analysis tool to make the product development.A series of models for simulating tissue engineering process from cell attachment to tissue regeneration are reviewed.The challenging is that models for simulating tissue engineering processes are developed separately.From cell to tissue regeneration,it would go through blood injection after moving out the defect;to cell disperse and attach on the scaffold;to proliferation,migration and differentiation;and to the final part-becoming mature tissues.This paper reviewed models that related to tissue engineering process,aiming to provide an opportunity for researchers to develop a mature model for whole tissue engineering process.This article focuses on the model analysis methods of cell adhesion,nutrient transport and cell proliferation,differentiation and migration in tissue engineering.In cell adhesion model,one of the most accurate method is to use discrete phase model to govern cell movement and use Stanton-Rutland model for simulating cell attachment.As for nutrient transport model,numerical model coupling with volume of fluid model and species transport model together is suitable for predicting nutrient transport process.For cell proliferation,differentiation and migration,finite element method with random-walk algorithm is one the most advanced way to simulate these processes.Most of the model analysis methods require further experiments to verify the accuracy and effectiveness.Due to the lack of technology to detect the rate of nutrient diffusion,there are especially few researches on model analysis methods in the area of blood coagulation.Therefore,there is still a lot of work to be done in the research of the whole process model method of tissue engineering.In the future,the numerical model would be seen as an optimal way to investigate tissue engineering products bioperformance and also enable to optimize the parameters and material types of the tissue engineering products.

Stress Analysis of the Sarafix External Fixator Design

A stress analysis of the Sarafix external fixator design was performed using finite element analysis （FEA） and experimental tensometric measurements. The study was conducted at one of the Sarafix fixator configurations that have a clinical application in the treatment of tibia fractures. The intensity of principal and yon Mises stresses generated at two measuring points （MP） on the fixator connecting rod were monitored and analyzed during the testing on axial compression on the fixator design and its finite element model （FEM）. The 3D geometrical and FEM model of the fixator was formed using the computer aided design/computer aided engineering （CAD/CAE） software system CATIA. Verification of the results for the dominant principal stresses obtained from FEA was carried out through tensometric measurements. The measuring chain consisted of strain gauges connected into two Wheatstone half-bridges, digital measuring amplifier system and a computer with software for acquisition and monitoring of measurement results. A quite good agreement was observed between the results obtained on the basis of FEA and results of experimental tensometric analysis,

非遗·乡村振兴研讨会纪要

近年来,非遗传承与保护、乡村振兴都是颇受关注的话题,为探讨二者的关系以及设计在其中能够发挥的作用,本刊召开了研讨会,邀请从事相关研究和参与实践的专家,就这一话题展开讨论,并推介相关优秀案例。

Potential application of FoldX force field based protein modeling in zinc finger nucleases design

Engineered sequence-specific zinc finger nucleases (ZFNs) make the highly efficient modification of eukaryotic genomes possible.However,most current strategies for developing zinc finger nucleases with customized sequence specificities require the construction of numerous tandem arrays of zinc finger proteins (ZFPs),and subsequent largescale in vitro validation of their DNA binding affinities and specificities via bacterial selection.The labor and expertise required in this complex process limits the broad adoption of ZFN technology.An effective computational assisted design strategy will lower the complexity of the production of a pair of functional ZFNs.Here we used the FoldX force field to build 3D models of 420 ZFP-DNA complexes based on zinc finger arrays developed by the Zinc Finger Consortium using OPEN (oligomerized pool engineering).Using nonlinear and linear regression analysis,we found that the calculated protein-DNA binding energy in a modeled ZFP-DNA complex strongly correlates to the failure rate of the zinc finger array to show significant ZFN activity in human cells.In our models,less than 5% of the three-finger arrays with calculated protein-DNA binding energies lower than 13.132 kcal mol 1 fail to form active ZFNs in human cells.By contrast,for arrays with calculated protein-DNA binding energies higher than 5 kcal mol 1,as many as 40% lacked ZFN activity in human cells.Therefore,we suggest that the FoldX force field can be useful in reducing the failure rate and increasing efficiency in the design of ZFNs.

Multi-objective optimization of shock control bump on a supercritical wing

Based on the supercritical ＂wingl＂ which was released in the DPW-III conference, multi-objective optimization has been done to increase the lift-drag ratio at cruise condition and improve transonic buffet boundary and drag-rise performance. Hicks-Henne shape functions are used to represent the bump shape. In the design optimization to increase lift-drag ratio, the objectives involve the cruise point and three other off-design points nearby. In the other optimization process to improve buffet and drag-rise performance, three buffet onset points near the cruise point and one drag-rise point are selected as the design points. Non-dominating sort genetic algorithm II （NSGA-II） is used in both processes. Additionally, individual analysis for every selected point on the Pareto frontier is conducted in order to avoid local convergence and achieve global optimum. Re- sults of optimization for aerodynamic efficiency show a decrease of 11 counts in drag at the cruise point. Drag at nearby off-design points are also reduced to some extent. Similar approaches are made to improve buffet and drag-rise characteristics, resulting in significant improvements in both ways.