The problem of spatial mathematical basis has been encountered by both large scale GIS and spatial digital products theoretically and practically.It is also a basic problem in the development of the whole geo_informat...The problem of spatial mathematical basis has been encountered by both large scale GIS and spatial digital products theoretically and practically.It is also a basic problem in the development of the whole geo_information science.After analyzing the status quo and the limitations of the space mathematical base of GIS,this paper points out definitely that the geodetic coordinate system is uniform,which can show the location of any point of the global exactly and uniquely in form of ( B,L,H ) and is the most proper reference system of large_scale GIS and Digital Earth.Moreover,this paper also puts forward a set of practical model of the standard "map projection".Finally,this paper introduces a DRG system based on this model.展开更多
The principle of an automatic piecing device is presented, and the mathematic model of a specific combined mechanism of the automatic piecing device is analysed. The kinematics and dynamics equation of the combined me...The principle of an automatic piecing device is presented, and the mathematic model of a specific combined mechanism of the automatic piecing device is analysed. The kinematics and dynamics equation of the combined mechanism is established on the basis of the mathematic model. By the virtual prototype technology, the motion of this mechanism is simulated, whose result is post-processed by ADAMS. To improve the output motion, according to the simulation output and automatic piecing device's practical working condition, the optimisation of the cam mechanism is carried out by finite difference method. The simulation result of this combined mechanism turns out in accordance with its theoretical analysis of virtual prototype in this research, which, therefore, lays a principle basis for the further study of automatic piecing device.展开更多
The paper discusses the importance of computer as a supporting approach in architecture. This approach is expected to foster the students' design skills in design studios. The approach is an educational tool for tuto...The paper discusses the importance of computer as a supporting approach in architecture. This approach is expected to foster the students' design skills in design studios. The approach is an educational tool for tutors that could guide the students and increase their creativity in their design. It considers the concepts and the practice of digital architectural design that influence architectural education. The approach is a catalyst for creativity, experimentation, critical thinking and the sustained growth of creative communities. The core of design studio is the notions, methods and skills of digital architectural design. The instruments used for this research was an investigation that made for the work of the fourth year students designs at the architectural department at University of Jordan, by testing design process and product of students' work: first using manual skills, and then using computer-aided programs. The results revealed that the computer-based design approach was able to foster students' design skills as well as to develop their creativity in design. Ninety-one percent of 44 students were found improved in design process using computer-based approach that depends on computer programs. This was done in design studio by improving students' way of thinking, developing their abilities to direct their own learning and pushing them for new definitions in developing their future work.展开更多
Difficulty discrimination is an important step in autonomous design and interpreting teaching materials development, which is related to scientifi c nature of the materials, teaching effectiveness, and sequential teac...Difficulty discrimination is an important step in autonomous design and interpreting teaching materials development, which is related to scientifi c nature of the materials, teaching effectiveness, and sequential teaching progress. In this paper, we focus on the diffi culty discrimination of interpretation teaching materials on the basis of analytic hierarchy process and natural language processing. We analyze several factors which affect interpretation teaching materials, and we introduce theories of analytic hierarchy process and natural language processing which is intuitive and credible operation basis.展开更多
Based on the idea of adjoint method and the dynamic evolution method,a new optimum aerodynamic design technique is presented in this paper.It can be applied to the optimum problems with a large number of design variab...Based on the idea of adjoint method and the dynamic evolution method,a new optimum aerodynamic design technique is presented in this paper.It can be applied to the optimum problems with a large number of design variables and is time saving.The key of the new method lies in that the optimization process is regarded as an unsteady evolution,i.e.,the optimization is executed,simultaneously with solving the unsteady flow governing equations and adjoint equations.Numerical examples for both the inverse problem and drag minimization using Euler equations have been presented,and the results show that the method presented in this paper is more efficient than the optimum methods based on the steady flow solution and the steady solution of adjoint equations.展开更多
The low flow coefficient centrifugal impeller(LFCCI)gives a relatively low efficiency and a special treatment is required for the design of this kind of impeller.This paper investigates the influences of cavity leakag...The low flow coefficient centrifugal impeller(LFCCI)gives a relatively low efficiency and a special treatment is required for the design of this kind of impeller.This paper investigates the influences of cavity leakage on the performance prediction and design of LFCCI based on Computational Fluid Dynamics(CFD)techniques.The results show that,the reduction in the effi-ciency of impeller due to the introduction of cavity leakage varies with the blade shape of impeller in a wide range since there is a strong and complex interaction of main flow and leakage flow in the LFCCI.To get a credible optimization result,the backside and foreside cavities should be considered in the CFD-based design of LFCCI.展开更多
In recent years, the silica-on-silicon based multimode interference (MMI) optical waveguide is an interesting research topic. It is being advanced various researches on the silica based MMI coupler. This paper repre...In recent years, the silica-on-silicon based multimode interference (MMI) optical waveguide is an interesting research topic. It is being advanced various researches on the silica based MMI coupler. This paper represents the considerations of the optimal design of the silica-on-silicon based MMI optical coupler for better performance. For that, we have illustrated the simulation results on a particular case of the 4x4 silica-on-silicon based MMI coupler. From the simulation results, it is seen that the performance of the MMI coupler depends on multiple width and length combinations of the MMI waveguide. The results also show that the width of the multimode waveguide could not be too small or too large for optimal performance, and at the widths, 100~tm, 120~tm and 130~tm, the performance could be optimized and be almost 0.62 - 0.64 in a given length range. Finally, the results have been compared with the optical coupler presently available in the market and show that the silica-on-silicon based MMI coupler is much more efficient in terms of losses and the performance associated with it and the size of the coupler.展开更多
Interests in intracellular peptide delivery have continued to grow,significantly fueled by the importance of peptides and their mimetics in modern cell biology and pharmaceutical industry.However,efficient intracellul...Interests in intracellular peptide delivery have continued to grow,significantly fueled by the importance of peptides and their mimetics in modern cell biology and pharmaceutical industry.However,efficient intracellular delivery of membrane-impermeable peptides of different polarities remains a challenging task.In this study,we develop a general and robust strategy for intracellular peptide delivery by using a boronic acid-rich dendrimer.The designed material is capable of transporting peptides with different polarities and charge properties into the cytosol of various cell lines without inducing additional cytotoxicity.The transduction efficacy and proteolytic stability of cargo peptides delivered by the boronic acid-rich dendrimer are much superior to peptides conjugated with cell penetrant peptides such as octaarginine.In addition,the bioactivities of pro-apoptotic peptides are maintained after intracellular delivery.This study provides a versatile and robust platform for the intracellular delivery of membrane-impermeable peptides.展开更多
文摘The problem of spatial mathematical basis has been encountered by both large scale GIS and spatial digital products theoretically and practically.It is also a basic problem in the development of the whole geo_information science.After analyzing the status quo and the limitations of the space mathematical base of GIS,this paper points out definitely that the geodetic coordinate system is uniform,which can show the location of any point of the global exactly and uniquely in form of ( B,L,H ) and is the most proper reference system of large_scale GIS and Digital Earth.Moreover,this paper also puts forward a set of practical model of the standard "map projection".Finally,this paper introduces a DRG system based on this model.
文摘The principle of an automatic piecing device is presented, and the mathematic model of a specific combined mechanism of the automatic piecing device is analysed. The kinematics and dynamics equation of the combined mechanism is established on the basis of the mathematic model. By the virtual prototype technology, the motion of this mechanism is simulated, whose result is post-processed by ADAMS. To improve the output motion, according to the simulation output and automatic piecing device's practical working condition, the optimisation of the cam mechanism is carried out by finite difference method. The simulation result of this combined mechanism turns out in accordance with its theoretical analysis of virtual prototype in this research, which, therefore, lays a principle basis for the further study of automatic piecing device.
文摘The paper discusses the importance of computer as a supporting approach in architecture. This approach is expected to foster the students' design skills in design studios. The approach is an educational tool for tutors that could guide the students and increase their creativity in their design. It considers the concepts and the practice of digital architectural design that influence architectural education. The approach is a catalyst for creativity, experimentation, critical thinking and the sustained growth of creative communities. The core of design studio is the notions, methods and skills of digital architectural design. The instruments used for this research was an investigation that made for the work of the fourth year students designs at the architectural department at University of Jordan, by testing design process and product of students' work: first using manual skills, and then using computer-aided programs. The results revealed that the computer-based design approach was able to foster students' design skills as well as to develop their creativity in design. Ninety-one percent of 44 students were found improved in design process using computer-based approach that depends on computer programs. This was done in design studio by improving students' way of thinking, developing their abilities to direct their own learning and pushing them for new definitions in developing their future work.
文摘Difficulty discrimination is an important step in autonomous design and interpreting teaching materials development, which is related to scientifi c nature of the materials, teaching effectiveness, and sequential teaching progress. In this paper, we focus on the diffi culty discrimination of interpretation teaching materials on the basis of analytic hierarchy process and natural language processing. We analyze several factors which affect interpretation teaching materials, and we introduce theories of analytic hierarchy process and natural language processing which is intuitive and credible operation basis.
文摘Based on the idea of adjoint method and the dynamic evolution method,a new optimum aerodynamic design technique is presented in this paper.It can be applied to the optimum problems with a large number of design variables and is time saving.The key of the new method lies in that the optimization process is regarded as an unsteady evolution,i.e.,the optimization is executed,simultaneously with solving the unsteady flow governing equations and adjoint equations.Numerical examples for both the inverse problem and drag minimization using Euler equations have been presented,and the results show that the method presented in this paper is more efficient than the optimum methods based on the steady flow solution and the steady solution of adjoint equations.
基金supported by the National Natural Science Foundation of China(Grant No.50725621)
文摘The low flow coefficient centrifugal impeller(LFCCI)gives a relatively low efficiency and a special treatment is required for the design of this kind of impeller.This paper investigates the influences of cavity leakage on the performance prediction and design of LFCCI based on Computational Fluid Dynamics(CFD)techniques.The results show that,the reduction in the effi-ciency of impeller due to the introduction of cavity leakage varies with the blade shape of impeller in a wide range since there is a strong and complex interaction of main flow and leakage flow in the LFCCI.To get a credible optimization result,the backside and foreside cavities should be considered in the CFD-based design of LFCCI.
文摘In recent years, the silica-on-silicon based multimode interference (MMI) optical waveguide is an interesting research topic. It is being advanced various researches on the silica based MMI coupler. This paper represents the considerations of the optimal design of the silica-on-silicon based MMI optical coupler for better performance. For that, we have illustrated the simulation results on a particular case of the 4x4 silica-on-silicon based MMI coupler. From the simulation results, it is seen that the performance of the MMI coupler depends on multiple width and length combinations of the MMI waveguide. The results also show that the width of the multimode waveguide could not be too small or too large for optimal performance, and at the widths, 100~tm, 120~tm and 130~tm, the performance could be optimized and be almost 0.62 - 0.64 in a given length range. Finally, the results have been compared with the optical coupler presently available in the market and show that the silica-on-silicon based MMI coupler is much more efficient in terms of losses and the performance associated with it and the size of the coupler.
基金supported by the National Natural Science Foundation of China (21725402)the Science and Technology Commission of Shanghai Municipality (17XD1401600)+1 种基金Guangdong Innovative and Entrepreneurial Research Team Program (2016ZT06C322)supports from the Flow Cytometry Core Facility and the Confocal Microscopy Facility at ECNU
文摘Interests in intracellular peptide delivery have continued to grow,significantly fueled by the importance of peptides and their mimetics in modern cell biology and pharmaceutical industry.However,efficient intracellular delivery of membrane-impermeable peptides of different polarities remains a challenging task.In this study,we develop a general and robust strategy for intracellular peptide delivery by using a boronic acid-rich dendrimer.The designed material is capable of transporting peptides with different polarities and charge properties into the cytosol of various cell lines without inducing additional cytotoxicity.The transduction efficacy and proteolytic stability of cargo peptides delivered by the boronic acid-rich dendrimer are much superior to peptides conjugated with cell penetrant peptides such as octaarginine.In addition,the bioactivities of pro-apoptotic peptides are maintained after intracellular delivery.This study provides a versatile and robust platform for the intracellular delivery of membrane-impermeable peptides.