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苁蓉精联合卡左双多巴控释片治疗早期帕金森病的疗效观察 被引量:15
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作者 许清水 肖绍坚 +6 位作者 陈少强 林友宁 陈诗雅 覃威 许茜 张宏伟 蔡晶 《中西医结合心脑血管病杂志》 2016年第23期2832-2835,共4页
目的探讨苁蓉精联合卡左双多巴控释片治疗早期帕金森病(PD)病人的临床疗效。方法 PD病人根据意愿,选择采用西药治疗或西药加苁蓉精治疗,分为对照组和治疗组。对照组给予卡左双多巴控释片初始剂量250 mg,每日两次口服治疗;治疗组在对照... 目的探讨苁蓉精联合卡左双多巴控释片治疗早期帕金森病(PD)病人的临床疗效。方法 PD病人根据意愿,选择采用西药治疗或西药加苁蓉精治疗,分为对照组和治疗组。对照组给予卡左双多巴控释片初始剂量250 mg,每日两次口服治疗;治疗组在对照组基础上加用苁蓉精(肉苁蓉、淫羊藿、黄精组成)治疗,疗程均为3个月。观察治疗前后进行统一帕金森病评定量表(UPDRS)评分、中医证候量化评分表评分。结果治疗组治疗后UPDRS总分为15.68分±6.32分,对照组治疗后UPDRS总分为16.12分±4.55分,两组比较差异无统计学意义(P>0.05);治疗组治疗后中医证候量化评分与治疗前相比显著降低(P<0.05),中医证候量化评分总有效率治疗组为71.4%,对照组为60.0%,差异有统计学意义(P<0.05)。结论苁蓉精联合卡左双多巴控释片治疗早期PD病人可明显改善中医证候评分。 展开更多
关键词 帕金森病 补肾中药 中西医结合疗法 苁蓉精 卡左双多巴控释片 帕金森病评定量表 中医证候量压评分
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经络病机与证候新药评价 被引量:5
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作者 汪海 祝捷 +3 位作者 由凤鸣 严然 郑川 夏孟蛟 《中华中医药杂志》 CAS CSCD 北大核心 2021年第5期2453-2455,共3页
经络病机以经络学说为依据,横向参合脏腑、气血津液等理论,反映疾病发生发展及变化转归的机制,能更好体现证候的时空转化轨迹。证候新药是以证候为基点纵向贯穿多种疾病的一类新药,其常用评价方式存在评价指标量化的问题,不能反映证候... 经络病机以经络学说为依据,横向参合脏腑、气血津液等理论,反映疾病发生发展及变化转归的机制,能更好体现证候的时空转化轨迹。证候新药是以证候为基点纵向贯穿多种疾病的一类新药,其常用评价方式存在评价指标量化的问题,不能反映证候动态演进等,制约其进一步发展。笔者在完善证候新药评价模式的探索中发现,经络病机契合证候新药评价发展的内在要求,但前人未予以重视,淡化其临床地位。发展基于经络病机的证候新药评价,并结合现代临床科研方法学,有利于构建综合多维的评价体系,有利于形成互为印证的评价模式,有利于证候新药研发与技术审评体系的建设。 展开更多
关键词 经络病机 候新药 候新药评价 证候量
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Efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency of heart and gallbladder:a randomized,double-blind,controlled trial 被引量:8
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作者 Ye Qing Zhou Jie +2 位作者 Yuan Xiaolei Yuan Canxing Yang Xuming 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2015年第4期381-388,共8页
OBJECTIVE: To evaluate the clinical efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency of heart and gallbladder.METHODS: We conducted a double-blind,randomized,controlled trial involving 100... OBJECTIVE: To evaluate the clinical efficacy of Zhenjingdingzhi decoction in treating insomnia with Qi-deficiency of heart and gallbladder.METHODS: We conducted a double-blind,randomized,controlled trial involving 100 patients with insomnia of Qi-deficiency of heart and gallbladder.Patients were randomly divided into the treatment group(n = 50) and the control group(n = 50) according to a random number table. The treatment group was given Zhenjingdingzhi decoction,while the control group was treated with Suanzaoren decoction. the pharmacological treatment lasted for 8weeks. The clinical efficacy was assessed by using Spiegel scale,Pittsburgh sleep quality index(PSQI)and Traditional Chinese Medicine(TCM) syndrome scores.RESULTS: Comparing Spiegel scores between the two groups at 4 and 8 weeks,the differences in curative effect between the two groups were both significant(both P < 0.05). The total effective rate was46% in the treatment group and 27.7% in the control group at 4 weeks,and 80% and 53.2% at 8weeks,respectively; After 8 weeks,PSQI scores showed that the total effective rates differed significantly between the two groups(P < 0.01): 84% in the treatment group and 59.6% in the control group; In improving sleep quality and sleep duration,the curative effect of the treatment group was better than that of the control group(P < 0.05).TCM syndrome,especially insomnia and palpitation,was improved better in the treatment group after 8 weeks as compared to that in the control group(P < 0.05). The total effective rate of the two groups was 84% and 66%,respectively.CONCLUSION: Zhenjingdingzhi decoction is effective and safe for the treatment of insomnia with Qi-deficiency of heart and gallbladder,especially for improving sleep quality and sleep duration. 展开更多
关键词 Sleep initiation and maintenance disorders Shyness Heart Qi deficiency Zhenjingdingzhi decoction Randomized controlled trial Double-blind method
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A quantification model of Traditional Chinese Medicine syndromes in children with idiopathic precocious puberty and early puberty 被引量:9
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作者 Yanyan Lin Yuanyuan Xue +6 位作者 Jian Yu Yonghong Wang Wen Sun Yanyan Sun Yumin Shi Yiqun Zhang Hong Hu 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2013年第5期630-636,共7页
OBJECTIVE:To establish a quantification model of Traditional Chinese Medicine(TCM)syndromes by sampling patients undergoing idiopathic precocious puberty(IPP)and early puberty.METHODS:A questionnaire for classifying a... OBJECTIVE:To establish a quantification model of Traditional Chinese Medicine(TCM)syndromes by sampling patients undergoing idiopathic precocious puberty(IPP)and early puberty.METHODS:A questionnaire for classifying and quantifying TCM syndromes was designed and administered.All the results were analyzed;the relationship between 3 types of syndrome and 47symptoms were summated.Meanwhile,the frequency distribution of each symptom or sign was aggregated.Fuzzy mathematics was used to develop a quantification model ofTCM syndromes.RESULTS:We found that precocious puberty had 3types of syndrome,including hyperactivity of fire due to Yin deficiency(Syndrome I),depressed liver Qi transforming into fire(Syndrome II),and end retention of damp heat(Syndrome III).In the IPP group,Syndrome I was the most common principal syndrome(100%).Forty-six patients(43.81%)werediagnosed with Syndrome I accompanied by Syndrome II and 11(10.48%)were diagnosed with Syndrome I accompanied by Syndrome III.In the early puberty group,Syndrome I was also the main syndrome(98.39%).The degrees of most symptoms were mild to moderate.Reddened tongue was the most common tongue manifestation(62.86%prevalence)in the IPP group.The most common pulse manifestations were slippery pulse,thread pulse,and taut pulse.The Asymptotic Normalization Coefficient(ANC)method was used to quantify the TCM syndromes in 167 cases.Diagnostic accuracy rate reached 91%,comparable to expert diagnosis.CONCLUSION:We find that there are 3 types of syndrome in the IPP group and in the early puberty group.Syndrome I(hyperactivity of fire due to Yin deficiency)is the main syndrome in the two groups.ANC may be an appropriate for quantification model ofTCM syndromes. 展开更多
关键词 Puberty precocious Medicine Chinese traditional Symptom complex Fuzzy mathematics Cluster analysis Asymptotic normalization coefficient
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