D-S evidence theory provides a good approach to fuse uncertain inlbrmation. In this article, we introduce seismic multi-attribute fusion based on D-S evidence theory to predict the coalbed methane (CBM) concentrated...D-S evidence theory provides a good approach to fuse uncertain inlbrmation. In this article, we introduce seismic multi-attribute fusion based on D-S evidence theory to predict the coalbed methane (CBM) concentrated areas. First, we choose seismic attributes that are most sensitive to CBM content changes with the guidance of CBM content measured at well sites. Then the selected seismic attributes are fused using D-S evidence theory and the fusion results are used to predict CBM-enriched area. The application shows that the predicted CBM content and the measured values are basically consistent. The results indicate that using D-S evidence theory in seismic multi-attribute fusion to predict CBM-enriched areas is feasible.展开更多
In order to overcome the limitation that rock mass instability warnings are caused by a lack of deep consideration of the inherent mechanism of disaster formation, early warning signs of rock mass instability were det...In order to overcome the limitation that rock mass instability warnings are caused by a lack of deep consideration of the inherent mechanism of disaster formation, early warning signs of rock mass instability were detected and multi-field coupling was analyzed. A multi-field coupling model of a damaged rock mass was established. The relationship between microseismic activity parameters and rock mass stability was analyzed, and a multi-parameter early warning index system was established and its solution program was compiled. Based on the D-S data fusion theory,an early warning model of rock mass instability combining multi-field coupling analysis and microseismic monitoring was constructed. Taking an underground mine stope as an object, the multi-field coupling model and its solution program were used to analyze mining response characteristics. The seismic field data were used to verify the accuracy of the multi-field coupling analysis. The early warning model was used to predict the instability of stope rock mass,and the early warning result is consistent with a real-world scenario.展开更多
Stomach cancer is still the fourth most common cancer;thus,it remains an important public health burden worldwide,especially in developing countries.The remarkable geographic variations in the rates of stomach cancer ...Stomach cancer is still the fourth most common cancer;thus,it remains an important public health burden worldwide,especially in developing countries.The remarkable geographic variations in the rates of stomach cancer indicate that dietary factors,including a range of food groups to which salt and/or nitrates have been added,may affect stomach cancer risk.In this paper,we review the results from ecologic,case-control and cohort studies on the relationship between salt or salted foods and stomach cancer risk.The majority of ecological studies indicated that the average salt intake in each population was closely correlated with gastric cancer mortality.Most case-control studies showed similar results,indicating a moderate to high increase in risk for the highest level of salt or salted food consumption.The overall results from cohort studies are not totally consistent,but are suggestive of a moderate direct association.Since salt intake has been correlated with Helicobacter pylori(H pylori) infection,it is possible that these two factors may synergize to promote the development of stomach cancer.Additionally,salt may also cause stomach cancer through directly damaging gastric mucus,improving temporary epithelial proliferation and the incidence of endogenous mutations,and inducing hypergastrinemia that leads to eventual parietal cell loss and progression to gastric cancer.Based on the considerable evidence from ecological,case-control and cohort studies worldwide and the mechanistic plausibility,limitation on salt and salted food consumption is a practical strategy for preventing gastric cancer.展开更多
Geological data are usually of the characteristics of multi-source, large amount and multi-scale. The construction of Spatial Information Grid overcomes the shortages of personal computers when dealing with geological...Geological data are usually of the characteristics of multi-source, large amount and multi-scale. The construction of Spatial Information Grid overcomes the shortages of personal computers when dealing with geological data. The authors introduce the definition, architecture and flow of mineral resources assessment by weights of evidence model based on Spatial Information Grid (SIG). Meanwhile, a case study on the prediction of copper mineral occurrence in the Middle-Lower Yangtze metallogenic belt is given. The results show that mineral resources assessement based on SIG is an effective new method which provides a way of sharing and integrating distributed geospatial information and improves the efficiency greatly.展开更多
The aerosol effect on clouds was explored using remote sensing of aerosol and cloud data at Shouxian, China. Non-precipitation, ice-free, and overcast clouds were firstly chosen by a combination of sky im- ages from t...The aerosol effect on clouds was explored using remote sensing of aerosol and cloud data at Shouxian, China. Non-precipitation, ice-free, and overcast clouds were firstly chosen by a combination of sky im- ages from the Total Sky Imager (TSI), cloud base heights from the Ceilometer, and vertical temperature profiles from the Balloon-Borne Sounding System (BBSS). Six cases were chosen in summer, and seven in autumn. The averaged cloud effective radii (re), cloud optical depth (COD), aerosol total light scattering coefficient (a), and liquid water path (LWP) are, respectivey, 6.47 μm, 35.4, 595.9 mm-1, 0.19 mm in summer, and 6.07 μm, 96.0, 471.7 mm-1, 0.37 mm in autumn. The correlation coefficient between re and tc was found to change from negative to positive value as LWP increases.展开更多
OBJECTIVE The current retrospective study aims to evaluate the management of non-functioning the assessment of experience on pituitary macroadenoma through clinical, biochemical, radiological features, and treatment o...OBJECTIVE The current retrospective study aims to evaluate the management of non-functioning the assessment of experience on pituitary macroadenoma through clinical, biochemical, radiological features, and treatment outcome of patients, and to identify prognostic factors affecting progression-free survival (PFS). METHODS Data of 55 patients macroadenoma presented to the with non-functioning pituitary Clinical Oncology and Nuclear Medicine department between 1998 and 2009 were investigated. RESULTS The most common symptom was visual disturbance (38.2%) followed by headache (27.3%). The presence of male predominance was observed (1.4:1). Ten patients received radio-therapy (RT) only. Extrasellar extension was the more common treatment. The overall response rate was 72.8% with completed response at 16.4%. Memory and intellectual sequelae were the most common late complications of treatment (14%). The ten-year PFS was at 84.6%. PFS was found to be significantly better with higher dose of RT (up to 54 Gy), treatment by both surgery and RT, absence of visual field defect, and tumor localized to sella, whereas it was not significantly affected by age and sex. CONCLUSION The data confirmed that the prevalence of mass effect and hypopituitarism in patients with non-functioning pituitary macroadenoma is elevated. Conventional external RT up to 54 Gy is safe and effective in controlling non-functioning pituitary macro- adenoma with tolerable and acceptable morbidity.展开更多
In the paper, an iterative method is presented to the optimal control of batch processes. Generally it is very difficult to acquire an accurate mechanistic model for a batch process. Because support vector machine is ...In the paper, an iterative method is presented to the optimal control of batch processes. Generally it is very difficult to acquire an accurate mechanistic model for a batch process. Because support vector machine is powerful for the problems characterized by small samples, nonlinearity, high dimension and local minima, support vector regression models are developed for the optimal control of batch processes where end-point properties are required. The model parameters are selected within the Bayesian evidence framework. Based on the model, an iterative method is used to exploit the repetitive nature of batch processes to determine the optimal operating policy. Numerical simulation shows that the iterative optimal control can improve the process performance through iterations.展开更多
The study provides one of the first lines of evidence showing linkages between Antarctic phytoplankton abundance and composition in response to ENSO, based on historical reconstruction of sediment biomarkers. In addit...The study provides one of the first lines of evidence showing linkages between Antarctic phytoplankton abundance and composition in response to ENSO, based on historical reconstruction of sediment biomarkers. In addition to sediment biomarkers, field measured and remote sensing data of phytoplankton abundance were also recorded from Prydz Bay, Eastern Antarctica. Com-munity structure of field measured phytoplankton showed significant El Ni?o/La Ni?a-related succession during 1990 to 2002. In general, the number of algae species decreased during El Ni?o and La Ni?a years compared to normal years. Austral summer monthly variation of remotely sensed chlorophyll-a (Chl-a), particulate organic carbon (POC), and sea surface temperature (SST) indicated that ENSO impacted the timing of phytoplankton blooms during 2007 to 2011. Phytoplankton blooms (indicated by Chl-a and POC) preceded the increases in SST during El Ni?o years, and lagged behind the SST increases during La Ni?a years. Stratigraphic record of marine sedimentary lipid (brassicasterol, dinosterol and alkenones) biomarkers inferred that the proportions of different algae (diatoms, dinoflagellates and haptophytes) changed significantly between El Ni?o and La Ni?a events. The relative proportion of diatoms increased, with that of dinoflagellates being decreased during El Ni?o years, while it was reversed during La Ni?a years.展开更多
A variable weight approach was proposed to handle the probability deficiency problem in the evidential reasoning (ER) approach. The probability deficiency problem indicated that the inadequate information in the ass...A variable weight approach was proposed to handle the probability deficiency problem in the evidential reasoning (ER) approach. The probability deficiency problem indicated that the inadequate information in the assessment result should be less than that in the input. However, it was proved that under certain circumstances, the ER approach could not solve the probability deficiency problem. The variable weight approach was based on two assumptions: 1) the greater weight should be given to the rule with more adequate information; 2) the greater weight should be given to the rules with less disparate information. Assessment results of two notional case studies show that 1) the probability deficiency problem is solved using the proposed variable weight approach, and 2) the information with less inadequacy and more disparity is provided for the decision makers to help reach a consensus.展开更多
The aim of this study is to investigate whether the comprehensive income (CI) and its individual components are useful in assessing the future cash flows for Italian listed companies. In addition, we verify whether ...The aim of this study is to investigate whether the comprehensive income (CI) and its individual components are useful in assessing the future cash flows for Italian listed companies. In addition, we verify whether the recent requirement of International Accounting Standard (IAS) 1 (r2011) of providing the other comprehensive income (OCI) separates in two sub-totals (recycling and non-recycling items groups) is useful to explain the expected cash flows. We consider a sample of 121 Italian non-financial companies listed on the Italian Stock Exchange for the testing period of 2008-2011, employing a fixed-effect regression model, and we test the relationship between the changes in the variables considered and not the relative absolute value reducing, in this way, the risk of not grasping a report if the independent variable and the response variable do not have the same sign. Our results stress that CI and the two new sub-aggregates are not relevant to explain future cash flows, while net income (NI) and OC1 as a whole seem to be more relevant to make explicit the future financial position. The study contributes, as a sort of post-implementation review, to the current debate on the ability of Cl to predict the future cash flows and on the real usefulness of the CI and the sub-aggregate identified by the IAS 1 revised as well.展开更多
The aim of this study is to investigate the effect of auditor type and eamings reporting lag on the cost of debt for the Tunisian setting. Our sample consists of 32 Tunisian companies for the period of 2003-2012. Audi...The aim of this study is to investigate the effect of auditor type and eamings reporting lag on the cost of debt for the Tunisian setting. Our sample consists of 32 Tunisian companies for the period of 2003-2012. Audit quality is measured by auditor size (Big 4 versus non-Big 4) and timely disclosure is proxied by earnings reporting lag. Results show that auditor type is negatively associated with the cost of debt. By contrast, the association between earnings announcement lag and the cost of debt is positive and significant. When testing for the moderating effects of industry and listing status, we document that these associations are more pronounced for industrial companies and listed firms. Finally, the period of investigation slightly moderates the examined associations, since financial institutions become more sensitive to the tardy communication of information and less concerned with auditor type following some economic and political troubles in Tunisia between 2010 and 2012. Our findings have policy implications for managers in the Tunisian setting and other developing economies similar to Tunisia given the crucial role played by debt as an important source of external finance for companies.展开更多
This study examines the relationship between earnings quality and insider trading. Using downward earnings restatement firms to identify low-quality earnings, we find that insiders outsell non-earnings restatement fir...This study examines the relationship between earnings quality and insider trading. Using downward earnings restatement firms to identify low-quality earnings, we find that insiders outsell non-earnings restatement firms of their holdings over the period from two years before to one year after the beginning of the restatement period. In addition, the amounts of restatement are positively associated with the excess insider selling. We also provide evidence that excess insider selling predicts excessive earnings manipulations that eventually lead to GAAP (Generally Accepted Accounting Principles) violation. Some researchers argued that insider trading can be an efficient way of transferring insider information to the capital markets. Our evidence of intensive insider selling in the context of earnings restatements implies that insiders disregard their fiduciary duties to the shareholders during the periods of deteriorating financial performance.展开更多
The introduction of the New Public Management (NPM) has not bridged the differences among the various European accounting traditions. In Italy, in particular, there are still different accounting methods in all publ...The introduction of the New Public Management (NPM) has not bridged the differences among the various European accounting traditions. In Italy, in particular, there are still different accounting methods in all public sectors. In the healthcare system, these differences have emerged more strongly. The recent Italian reform on accounting harmonization seems to be the answer to this accounting disharmony and represents a means of controlling public expenditure. This study aims to analyze the consolidated financial statement and the consolidated cash flow statement of the regional healthcare system as a new tool for the accounting harmonization. This paper is divided into two logical parts: In the first part, the authors analyze how the new accounting model is evolving under the current reform; in the second part, the authors analyze the consolidated financial statement and the consolidated cash flow statement that has been applied experimentally over the last two years in the Umbria Region.展开更多
基金supported by the National Basic Research Program of China (973 Program) (No. 2009CB219603)Key Special National Project (No. 2008ZX05035)Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘D-S evidence theory provides a good approach to fuse uncertain inlbrmation. In this article, we introduce seismic multi-attribute fusion based on D-S evidence theory to predict the coalbed methane (CBM) concentrated areas. First, we choose seismic attributes that are most sensitive to CBM content changes with the guidance of CBM content measured at well sites. Then the selected seismic attributes are fused using D-S evidence theory and the fusion results are used to predict CBM-enriched area. The application shows that the predicted CBM content and the measured values are basically consistent. The results indicate that using D-S evidence theory in seismic multi-attribute fusion to predict CBM-enriched areas is feasible.
基金Project(2017yfc0602901)supported by the National Key R&D Program of China during the Thirteenth Five-Year Plan PeriodProject(2017zzts204)supported by the Fundamental Research Funds for the Central Universities of Central South University,China
文摘In order to overcome the limitation that rock mass instability warnings are caused by a lack of deep consideration of the inherent mechanism of disaster formation, early warning signs of rock mass instability were detected and multi-field coupling was analyzed. A multi-field coupling model of a damaged rock mass was established. The relationship between microseismic activity parameters and rock mass stability was analyzed, and a multi-parameter early warning index system was established and its solution program was compiled. Based on the D-S data fusion theory,an early warning model of rock mass instability combining multi-field coupling analysis and microseismic monitoring was constructed. Taking an underground mine stope as an object, the multi-field coupling model and its solution program were used to analyze mining response characteristics. The seismic field data were used to verify the accuracy of the multi-field coupling analysis. The early warning model was used to predict the instability of stope rock mass,and the early warning result is consistent with a real-world scenario.
文摘Stomach cancer is still the fourth most common cancer;thus,it remains an important public health burden worldwide,especially in developing countries.The remarkable geographic variations in the rates of stomach cancer indicate that dietary factors,including a range of food groups to which salt and/or nitrates have been added,may affect stomach cancer risk.In this paper,we review the results from ecologic,case-control and cohort studies on the relationship between salt or salted foods and stomach cancer risk.The majority of ecological studies indicated that the average salt intake in each population was closely correlated with gastric cancer mortality.Most case-control studies showed similar results,indicating a moderate to high increase in risk for the highest level of salt or salted food consumption.The overall results from cohort studies are not totally consistent,but are suggestive of a moderate direct association.Since salt intake has been correlated with Helicobacter pylori(H pylori) infection,it is possible that these two factors may synergize to promote the development of stomach cancer.Additionally,salt may also cause stomach cancer through directly damaging gastric mucus,improving temporary epithelial proliferation and the incidence of endogenous mutations,and inducing hypergastrinemia that leads to eventual parietal cell loss and progression to gastric cancer.Based on the considerable evidence from ecological,case-control and cohort studies worldwide and the mechanistic plausibility,limitation on salt and salted food consumption is a practical strategy for preventing gastric cancer.
基金Supported by the National High Technology Research and Development Programof China(863 Program) Nos .2002AA134010 and 2002AA131010
文摘Geological data are usually of the characteristics of multi-source, large amount and multi-scale. The construction of Spatial Information Grid overcomes the shortages of personal computers when dealing with geological data. The authors introduce the definition, architecture and flow of mineral resources assessment by weights of evidence model based on Spatial Information Grid (SIG). Meanwhile, a case study on the prediction of copper mineral occurrence in the Middle-Lower Yangtze metallogenic belt is given. The results show that mineral resources assessement based on SIG is an effective new method which provides a way of sharing and integrating distributed geospatial information and improves the efficiency greatly.
基金supported by the Knowledge Innovation Program of the Chinese Academy of Sciences(KZCX2-YW-QN201)the National Basic Research Program of China(973 Program)(2006CB403706 and 2010CB950804)the National Natural Science Foundation of China(40775009 and 40875084)
文摘The aerosol effect on clouds was explored using remote sensing of aerosol and cloud data at Shouxian, China. Non-precipitation, ice-free, and overcast clouds were firstly chosen by a combination of sky im- ages from the Total Sky Imager (TSI), cloud base heights from the Ceilometer, and vertical temperature profiles from the Balloon-Borne Sounding System (BBSS). Six cases were chosen in summer, and seven in autumn. The averaged cloud effective radii (re), cloud optical depth (COD), aerosol total light scattering coefficient (a), and liquid water path (LWP) are, respectivey, 6.47 μm, 35.4, 595.9 mm-1, 0.19 mm in summer, and 6.07 μm, 96.0, 471.7 mm-1, 0.37 mm in autumn. The correlation coefficient between re and tc was found to change from negative to positive value as LWP increases.
文摘OBJECTIVE The current retrospective study aims to evaluate the management of non-functioning the assessment of experience on pituitary macroadenoma through clinical, biochemical, radiological features, and treatment outcome of patients, and to identify prognostic factors affecting progression-free survival (PFS). METHODS Data of 55 patients macroadenoma presented to the with non-functioning pituitary Clinical Oncology and Nuclear Medicine department between 1998 and 2009 were investigated. RESULTS The most common symptom was visual disturbance (38.2%) followed by headache (27.3%). The presence of male predominance was observed (1.4:1). Ten patients received radio-therapy (RT) only. Extrasellar extension was the more common treatment. The overall response rate was 72.8% with completed response at 16.4%. Memory and intellectual sequelae were the most common late complications of treatment (14%). The ten-year PFS was at 84.6%. PFS was found to be significantly better with higher dose of RT (up to 54 Gy), treatment by both surgery and RT, absence of visual field defect, and tumor localized to sella, whereas it was not significantly affected by age and sex. CONCLUSION The data confirmed that the prevalence of mass effect and hypopituitarism in patients with non-functioning pituitary macroadenoma is elevated. Conventional external RT up to 54 Gy is safe and effective in controlling non-functioning pituitary macro- adenoma with tolerable and acceptable morbidity.
基金Project supported by the National Natural Science Foundation of China(Grant No.60504033)
文摘In the paper, an iterative method is presented to the optimal control of batch processes. Generally it is very difficult to acquire an accurate mechanistic model for a batch process. Because support vector machine is powerful for the problems characterized by small samples, nonlinearity, high dimension and local minima, support vector regression models are developed for the optimal control of batch processes where end-point properties are required. The model parameters are selected within the Bayesian evidence framework. Based on the model, an iterative method is used to exploit the repetitive nature of batch processes to determine the optimal operating policy. Numerical simulation shows that the iterative optimal control can improve the process performance through iterations.
基金financially supported by the National Natural Science Foundation of China (NSFC) (40876104, 41306202, 41376193, 41076134 and 41006118)the scientific research fund of Second Institute of Oceanography, SOA (JT1208 and JG1218)+1 种基金Chinese Arctic and Antarctic Administration Foundation (20110208)the special fund for polar environment comprehensive investigation and assessment (CHINARE 2014-04-04, 2014-01-04 and 2014-04-01)
文摘The study provides one of the first lines of evidence showing linkages between Antarctic phytoplankton abundance and composition in response to ENSO, based on historical reconstruction of sediment biomarkers. In addition to sediment biomarkers, field measured and remote sensing data of phytoplankton abundance were also recorded from Prydz Bay, Eastern Antarctica. Com-munity structure of field measured phytoplankton showed significant El Ni?o/La Ni?a-related succession during 1990 to 2002. In general, the number of algae species decreased during El Ni?o and La Ni?a years compared to normal years. Austral summer monthly variation of remotely sensed chlorophyll-a (Chl-a), particulate organic carbon (POC), and sea surface temperature (SST) indicated that ENSO impacted the timing of phytoplankton blooms during 2007 to 2011. Phytoplankton blooms (indicated by Chl-a and POC) preceded the increases in SST during El Ni?o years, and lagged behind the SST increases during La Ni?a years. Stratigraphic record of marine sedimentary lipid (brassicasterol, dinosterol and alkenones) biomarkers inferred that the proportions of different algae (diatoms, dinoflagellates and haptophytes) changed significantly between El Ni?o and La Ni?a events. The relative proportion of diatoms increased, with that of dinoflagellates being decreased during El Ni?o years, while it was reversed during La Ni?a years.
基金Foundation item: Projects(70901074, 71001104, 71201168) supported by the National Natural Science Foundation of China
文摘A variable weight approach was proposed to handle the probability deficiency problem in the evidential reasoning (ER) approach. The probability deficiency problem indicated that the inadequate information in the assessment result should be less than that in the input. However, it was proved that under certain circumstances, the ER approach could not solve the probability deficiency problem. The variable weight approach was based on two assumptions: 1) the greater weight should be given to the rule with more adequate information; 2) the greater weight should be given to the rules with less disparate information. Assessment results of two notional case studies show that 1) the probability deficiency problem is solved using the proposed variable weight approach, and 2) the information with less inadequacy and more disparity is provided for the decision makers to help reach a consensus.
文摘The aim of this study is to investigate whether the comprehensive income (CI) and its individual components are useful in assessing the future cash flows for Italian listed companies. In addition, we verify whether the recent requirement of International Accounting Standard (IAS) 1 (r2011) of providing the other comprehensive income (OCI) separates in two sub-totals (recycling and non-recycling items groups) is useful to explain the expected cash flows. We consider a sample of 121 Italian non-financial companies listed on the Italian Stock Exchange for the testing period of 2008-2011, employing a fixed-effect regression model, and we test the relationship between the changes in the variables considered and not the relative absolute value reducing, in this way, the risk of not grasping a report if the independent variable and the response variable do not have the same sign. Our results stress that CI and the two new sub-aggregates are not relevant to explain future cash flows, while net income (NI) and OC1 as a whole seem to be more relevant to make explicit the future financial position. The study contributes, as a sort of post-implementation review, to the current debate on the ability of Cl to predict the future cash flows and on the real usefulness of the CI and the sub-aggregate identified by the IAS 1 revised as well.
文摘The aim of this study is to investigate the effect of auditor type and eamings reporting lag on the cost of debt for the Tunisian setting. Our sample consists of 32 Tunisian companies for the period of 2003-2012. Audit quality is measured by auditor size (Big 4 versus non-Big 4) and timely disclosure is proxied by earnings reporting lag. Results show that auditor type is negatively associated with the cost of debt. By contrast, the association between earnings announcement lag and the cost of debt is positive and significant. When testing for the moderating effects of industry and listing status, we document that these associations are more pronounced for industrial companies and listed firms. Finally, the period of investigation slightly moderates the examined associations, since financial institutions become more sensitive to the tardy communication of information and less concerned with auditor type following some economic and political troubles in Tunisia between 2010 and 2012. Our findings have policy implications for managers in the Tunisian setting and other developing economies similar to Tunisia given the crucial role played by debt as an important source of external finance for companies.
文摘This study examines the relationship between earnings quality and insider trading. Using downward earnings restatement firms to identify low-quality earnings, we find that insiders outsell non-earnings restatement firms of their holdings over the period from two years before to one year after the beginning of the restatement period. In addition, the amounts of restatement are positively associated with the excess insider selling. We also provide evidence that excess insider selling predicts excessive earnings manipulations that eventually lead to GAAP (Generally Accepted Accounting Principles) violation. Some researchers argued that insider trading can be an efficient way of transferring insider information to the capital markets. Our evidence of intensive insider selling in the context of earnings restatements implies that insiders disregard their fiduciary duties to the shareholders during the periods of deteriorating financial performance.
文摘The introduction of the New Public Management (NPM) has not bridged the differences among the various European accounting traditions. In Italy, in particular, there are still different accounting methods in all public sectors. In the healthcare system, these differences have emerged more strongly. The recent Italian reform on accounting harmonization seems to be the answer to this accounting disharmony and represents a means of controlling public expenditure. This study aims to analyze the consolidated financial statement and the consolidated cash flow statement of the regional healthcare system as a new tool for the accounting harmonization. This paper is divided into two logical parts: In the first part, the authors analyze how the new accounting model is evolving under the current reform; in the second part, the authors analyze the consolidated financial statement and the consolidated cash flow statement that has been applied experimentally over the last two years in the Umbria Region.