理中丸含药血清对中焦湿阻证Cajal间质细胞代谢作用的影响

目的:初步探索理中丸含药血清对体外中焦湿阻证Cajal间质细胞(ICC)的代谢作用的影响,进一步探索理中丸在治疗胃肠动力障碍性疾病中的作用机制。方法:采用本实验室建立的湿困脾胃证大鼠模型造模方法造模,分别取湿阻模型动物血清、正常组动物血清、给药组动物血清及自然恢复组血清,采用Ⅱ胶原酶消化法体外培养ICC,鉴定成功后,用湿阻模型组血清建立"中焦湿阻证Cajal间质细胞模型",模拟湿证大鼠模型体内ICC的生长,通过细胞造模后给药(含药血清)与细胞不造模给药(含药血清)两种给药法的对比,观察细胞内LDH和SDH活力的影响。结果:(1)细胞内LDH活力结果提示:细胞造模后给药和细胞不造模给药后,与正常血清和自然恢复血清比较,理中丸含药血清均能降低ICC细胞内LDH活力(P<0.01);(2)细胞内SDH活力结果提示:细胞造模后给药和细胞不造模给药(即含药血清直接给药)后,与正常血清和自然恢复血清比较,理中丸含药血清均能提高ICC细胞内SDH活力(P<0.01);结论:通过理中丸降低中焦湿阻证Cajal间质细胞模型细胞内LDH和提高其细胞内的SDH活力,说明理中丸含药血清能提高体外湿阻中焦证Cajal间质细胞的有氧代谢。

基于~1H-NMR的干寒性气质失调证糖尿病大鼠肝组织代谢变化研究

目的:观察干寒性气质失调证糖尿病模型大鼠肝脏组织的代谢变化。方法:对模型肝脏组织进行核磁共振检测,并对其代谢轮廓变化进行分析。结果:与健康组比较,干寒性气质失调证大鼠肝组织中β-羟基丁酸、肌酸、氧化三甲胺、苏氨酸和胆碱等代谢物含量明显升高,而乳酸、肌酸肝、葡萄糖和肌醇等含量明显降低;干寒性气质失调糖尿病大鼠肝组织中β-羟基丁酸、肌酸、肌醇和葡萄糖等含量明显升高,但异亮氨酸、亮氨酸、缬氨酸、乳酸、丙氨酸、鸟氨酸、瓜氨酸、蛋氨酸、谷氨酰胺、谷氨酸、α-酮戊二酸、乙酰天冬氨酸、甲胺、肌氨酸、肌酸肝、组氨酸、色氨酸、甘氨酸、苏氨酸、胆碱、酪氨酸、苯丙氨酸、烟酸和马尿酸等含量均明显降低。结论:干寒性气质失调证的发生伴随有多种能量代谢的变化。

中焦湿阻证Cajal细胞内乳酸脱氢酶和琥珀酸脱氢酶活力变化及平胃散的干预研究

目的探索中焦湿阻证模型ICC细胞和原代ICC细胞的差异,建立湿阻ICC细胞模型,和经平胃散干预后细胞内乳酸脱氢酶(LDH)和琥珀酸脱氢酶(SDH)活力的变化反证模型细胞和原代ICC存在差异。方法湿阻中焦动物模型建立及动物血清制备;采用Ⅱ胶原酶消化法体外培养ICC,建立"中焦湿阻证Cajal间质细胞模型",给细胞加入湿阻动物含药血清模拟湿阻大鼠模型体内ICC的生长;通过给ICC细胞加入动物血清,观察平胃散对ICC细胞内LDH和SDH活力的影响。结果中焦湿阻证ICC细胞模型的评价:模型细胞与原代细胞有差异。细胞内LDH活力结果提示,与原代ICC+模型血清组及原代ICC+2次模型血清组比较,平胃散含药血清能降低加入1次血清组及加入2次血清组细胞内LDH活力(P<0.01)。细胞内SDH活力结果提示:平胃散含药血清能升高加入1次血清组细胞内SDH活力(P<0.01),而对加入2次血清组细胞内SDH活力有升高趋势。结论平胃散能降低中焦湿阻证Cajal间质细胞模型细胞内LDH活力和升高SDH活力,抑制细胞内无氧代谢增强细胞内有氧代谢。

对当庭认证的重新思考

自民事审判方式改革一开始,当庭认证便作为一个重要目标被提出来。我们把当庭认证理解为:一切证据必须在庭审中举证、质证、并由法官当庭确定是否采信,把当庭认证片面地理解为在法庭调查阶段完成。

Importance of Proficiency Testing in Water Quality Monitoring

The monitoring data is undoubtedly important to the water quality monitor- ing department. The proficiency testing is an important way to improve the monitor- ing capacity and enhance the quality management of laboratories. It plays an impor- tant role in ensuring the accuracy, integrity and comparability of monitoring data. In this paper, the positive role of proficiency testing in the water quality monitoring was analyzed. In addition, how to improve the water quality monitoring capacity and the quality management level of laboratories through the proficiency testing was also discussed.

Admission Control Based on QoS for Third Generation Broadband Mobile Communication Systems

In this paper, a novel admission scheme is proposed which provides high degrees of quality of service (QoS) guarantees for multimedia traffic carried in mobile networks. The proposed scheme combines the admission control and bandwidth reservation to guarantee QoS requirements. It considers both local information and remote information to determine whether to accept or reject a connection. In order to embody the characteristics of the algorithms proposed in the article, two traditional algorithms of admission control are used for comparison. In the end of the paper the simulation analyses are given and the results show that the proposed algorithm can adjust the bandwidth according to the current status of networks and decrease the probability of connections forcibly dropped. The most important thing is that the algorithm is based on the multimedia communications and can guarantee the QoS of real time connections through decreasing the bandwidth of non real time connections.

QUALITY ASSURANCE INFORMATION SYSTEM FOR AGILE MANUFACTURING

The customer driven dynamic global market and geographical distribution of collaborating partners bring new challenges to the development of quality assurance information system (QAIS) for agile manufacturing. With recent dramatic advances in information technology, firstly the requirements of QAIS are examined in agile manufacturing environment, then a new implementation framework of a distributed QAIS is presented, where a deve loping environment of QAIS is established and some critical techniques are studied. Finally a prototype system based on world wide web (WWW) is accomplished.

肠易激综合征的辨体论治

肠易激综合征是临床上常见的一种功能性疾病,以腹痛或腹部不适为主要症状,常伴有排便习惯改变,缺乏可解释症状的形态学和生化学异常。中医多将其分为肝郁气滞、肝气乘脾、脾胃虚弱、寒热错杂、大肠燥热等证型,治疗主要从疏肝健脾入手。现从中医体质角度来探讨肠易激综合征的辨证论治,将"辨质论治"作为一大辨证要点,使质-证结合、质-病结合,为肠易激综合征的辨证论治提供新的思路。

干寒属性食物与干寒环境因素对小鼠生物表征的影响

目的:观察干寒属性食物与干寒环境双因素对小鼠生物表征的影响。方法:将健康雄性ICR小鼠30只随机分为对照组和干预组各15只,每日称体质量、测进食量、饮水量、大便量、小便量并观察各种生物表征的变化。结果:生物表征方面,与对照组相比,干预组生物表征第14天表现出舌质暗红,少津,皮毛稀疏,少光泽,蜷缩少动,倦怠,淡漠,反应迟钝,扎堆眯眼,嗜睡,大便半成形、半湿,小便色清长;第21天表现出青紫舌,皮毛松弛,暗淡无光泽,蜷缩少动,倦怠淡漠,反应迟钝,扎堆眯眼,大便不成形、黏糊状,小便色清量少。体质量方面,与对照组相比,第7天干预组小鼠体质量减轻,但差异无统计学意义(P>0.05);第14天体质量增长缓慢,差异明显(P<0.05);第21天干预组较对照组体质量增长缓慢,具有显著性差异(P<0.01)。出入量方面,与对照组相比,干预组小鼠饮水量明显增加,具有显著性差异(P<0.01);而饮食量、小便量,大便量2组比较差异无统计学意义(P>0.05)。结论:干寒属性食物和干寒环境两种因素施加于小鼠后,可以使小鼠产生体质量减轻、饮水量增加等一系列生物表征改变,随着时间的延长或强度增加,干寒属性食物和干寒环境最终可能导致维吾尔医学干寒性气质失调证。

Authentication masking code against DoS of T-MAC protocol

Security vulnerability of denial of service (DoS) in time out-medium access control (T-MAC) protocol was discussed and analysis of power consumption at each stage of T-MAC protocol was carried out. For power efficient authentication scheme which can provide reliability, efficiency, and security for a general T-MAC communication, a novel synchronization and authentication scheme using authentication masking code was proposed. Authentication data were repeated and masked by PN sequence. The simulation results show that the proposed approach can provide synchronization and authentication simultaneously for nodes in wireless sensor network (WSN). 63 bits AMC code gives above 99.97% synchronization detection and 93.98% authentication data detection probability in BER 0.031 7.

Effect of electro-acupuncture on substance P, its receptor and corticotropin-releasing hormone in rats with irritable bowel syndrome

AIM： To investigate the effect and mechanism of electro-acupuncture lEA） at ST25 and ST37 on irritable bowel syndrome （IBS） of rats. METHODS： A total of 21 male Sprague-Dawley rats were randomly divided into normal group, model group and EA group. A rat model of IBS was established by constraining the limbs and distending the colorectum of rats. Rats in EA group received bilateral EA at ST25 and ST37 with a sparse and intense waveform at a frequency of 2/50 Hz for 15 min, once a day for 7 d as a course. Rats in normal and model groups were stimulated by distending colorectum （CR）. An abdominal withdrawal reflex （AWR） scoring system was used to evaluate improvements in visceral hypersensitivity. Toluidine blue-improved method, immunohistochemistry and radioimmunoassay were used to observe mucosal mast cells （MC）, changes of substance P （SP） and substance P receptor （SPR） in colon and change of corticotropin-releasing hormone （CRH） in hypothalamus. RESULTS： The threshold of visceral sense was significantly lower in model group than in normal group,and significantly higher in EA group than in model group. The number of mucosal MC was greater in model group than in normal group and significantly smaller in EA group than in model group. The CRH level in hypothalamus of rats was significantly higher in model group than in normal group, which was remarkably decreased after electro-acupuncture treatment. The SP and SPR expression in colon of rats in model group was decreased after electro-acupuncture treatment. CONCLUSION： EA at ST25 and ST37 can decrease the number of mucosal MC and down-regulate the expression of CRH in hypothalamus, and the expression of SP and SPR in colon of rats with IBS.

Radiotherapy in Non-Functioning Pituitary Macroadenoma： Mansoura Experience

OBJECTIVE The current retrospective study aims to evaluate the management of non-functioning the assessment of experience on pituitary macroadenoma through clinical, biochemical, radiological features, and treatment outcome of patients, and to identify prognostic factors affecting progression-free survival （PFS）. METHODS Data of 55 patients macroadenoma presented to the with non-functioning pituitary Clinical Oncology and Nuclear Medicine department between 1998 and 2009 were investigated. RESULTS The most common symptom was visual disturbance （38.2%） followed by headache （27.3%）. The presence of male predominance was observed （1.4：1）. Ten patients received radio-therapy （RT） only. Extrasellar extension was the more common treatment. The overall response rate was 72.8% with completed response at 16.4%. Memory and intellectual sequelae were the most common late complications of treatment （14%）. The ten-year PFS was at 84.6%. PFS was found to be significantly better with higher dose of RT （up to 54 Gy）, treatment by both surgery and RT, absence of visual field defect, and tumor localized to sella, whereas it was not significantly affected by age and sex. CONCLUSION The data confirmed that the prevalence of mass effect and hypopituitarism in patients with non-functioning pituitary macroadenoma is elevated. Conventional external RT up to 54 Gy is safe and effective in controlling non-functioning pituitary macro- adenoma with tolerable and acceptable morbidity.

Quality assurance for computed-tomography simulator: In home Z-phantom for mechanical tests of the couch and the gantry

Objective:The main purpose of this work was to present a Z-phantom manufactured in home (at National Cancer Institute Cairo University) and it's use in a simple way to check the accuracy of the computed-tomography (CT) table movement and CT gantry tilt, also the other general quality control (QC) tests of the CT simulator used at radiotherapy department. Methods:The laser phantom was used to check the external mobile laser position accuracy, for internal image indicator laser beam (light field) the coincidence between light field and radiation exposure at CT simulator was checked using X-Omat ready back film. The Z-phantom was used to check the slice thickness and the table movement and so the gantry tilts. The image quality testes were checked using the CT image quality phantom. TLDs were inserted to the Cicil phantom at the center of each scan volume to estimate the patient dose. Results:The results showed that the difference in the fixed distance between the external mobile laser and the internal image indicator laser beam was less than ± 1 mm; the orientation of the two mobile lateral lasers was coincident. The mechanical movement and the image quality of the CT simulator were within the tolerances and the results were 0.5 mm, 0.2% and 0.6% for the mechanical movement, noise and image uniformity respectively. Conclusion:A CT simulator with a good performance is important for the radiotherapy treatment planning specially with the extremely revolution in radiotherapy techniques, also a rotten quality assurance (QA) program is very important to be shore about the reproducibility of the CT performance. The use of Z-phantom to check the gantry tilt and the table movement is faster than the use of ready back films in these tests.

HONG KONG HOUSING AUTHORITY ——THE EVOLUTION OF QUALITY

The Hong Kong housing authority houses a half po pulation of Hong Kong. It constructs and manages pro perty on a massive scale. In 1989, the housing authority makes the decision that by 1993, its construction project management arm, and all construction companies working for the Housing Authority would be certified to the ISO 9000 standard. This decision is to have a profound and lasting impact on the construction industry in Hong Kong. In 1996, a management enhancement programme is launched. Targeting all 15 000 staff in the housing department, the programme aims at changing the culture of the organization and its partners in delivering high calibre services to customers. This paper examines the motivation and reasons behind the initiatives. It outlines the approach and framework used as the authority changes the mindset of a large department of the civil service.

Development and Challenge of HIV/AIDS Testing Laboratory Network and Quality Assurance System in China

This paper describes the development and challenge of HIV/AIDS testing laboratory network and quality assurance system in China. At present,the HIV/AIDS testing laboratories includes three classes,the National AIDS Reference Laboratory,HIV/AIDS confirmatory laboratories and HIV/AIDS screening laboratories. All of them are accredited by the health authorities,and each class of laboratories take charge of their function strictly according to the "National Management of HIV/AIDS Detection (2006)". A complete quality assurance and quality control system for HIV/AIDS testing has been developed,which includes technical training,strict laboratory monitoring and approval,examination or proficiency testing on HIV/AIDS detection,and quality evaluation and supervision of HIV/AIDS diagnostic kits. Besides conduct the routine anti-HIV antibody test,more and more laboratories began to conduct other tests,such as CD4+ T lymphocyte cell counting,HIV viral load,HIV DNA PCR,genotyping,drug resistance,and HIV-1 recent infection test. The primary challenges faced by the HIV/AIDS testing laboratory network are in the areas of laboratory management and quality control. For example,the provincial PT program is inefficient,the internal quality control is conducted perfunctorily,personnel training can not met the needs of the workplace,which need to be improved.

AN ADAPTIVE AQM TO PROVIDE DELAY GUARANTEES FOR DIFFERENTIATED SERVICES

RIO(RED with IN and OUT) is the primary queue management mechanism proposed for assured forwarding in the DiffServ (Differentiated Service) framework. Although RIO can generally provide bandwidth guarantees, its queuing delay is sensitive to the traffic load. This paper presents a qualitative explanation for its origin. As a solution, an Adaptive RIO for Delay (ARIO-D) is proposed to provide guaranteed delay for multimedia traffic. Simulation results show that by trading loss for delay, ARIO-D can effectively improve the robustness of RIO under different and dynamic traffic, and provide stable and differentiated performance of queuing delay without any degradation in performance of throughput.

现行刑诉法适用中几个问题的探讨

修改后的刑诉法是一部进步性、科学性含量很高的好法。其主要表现在：确立了“疑罪从无”的人权思想观念，摒弃了“疑罪从有”的传统作法；在庭前审查阶段，实现了对案件实体性事实审查向程序性法律审查的转变，为防止法官“先入为主、先定后审”打下了良好基础；在法庭辩论中，充分体现了分散辩论与集中辩论相结合的原则。以查清事实为核心，增强庭审透明度和民主性，以利保证办案质量。修改后的刑诉法中所确定的这些新思想观念，通过在适用中不断总结、发展和完善，将会对我国诉讼法制建设起到巨大的推动作用。

S100B protein in the gut:The evidence for enteroglial-sustained intestinal inflammation

Glial cells in the gut represent the morphological and functional equivalent of astrocytes and microglia in the central nervous system （CNS）. In recent years, the role of enteric glial cells （EGCs） has extended from that of simple nutritive support for enteric neurons to that of being pivotal participants in the regulation of inflammatory events in the gut. Similar to the CNS astrocytes, the EGCs physiologically express the SIOOB protein that exerts either trophic or toxic effects depending on its concentration in the extracellular milieu. In the CNS, SIOOB overexpression is responsible for the initiation of a gliotic reaction by the release of pro-inflammatory mediators, which may have a deleterious effect on neighboring cells. SlOOB-mediated pro-inflammatory effects are not limited to the brain： SIOOB overexpression is associated with the onset and maintenance of inflammation in the human gut too. In this review we describe the major features of EGCs and SIOOB protein occurring in intestinal inflammation deriving from such.

Geological Evidence and Characteristics of Activity of the Wuhe-Mingguang Section of Tancheng-Lujiang Fault Zone in Late Pleistocene

As the most influential strike-slip fault in East China,the Tancheng-Lujiang fault zone draws scholars attention for its strong seismic activity. Nevertheless,most research has been conducted along segments in Shandong Province and Bohai Bay where huge earthquakes occur frequently. Meanwhile,it is generally believed that segments lying to the south of Huaihe River have been inactive since the late Quaternary and thus it is incapable of generating moderate or strong earthquakes. However,these understandings about the Tancheng-Lujiang fault have been questioned by our recent work for part of the fault south to the Huaihe River. Based on interpretation of high-resolution satellite images,detailed field investigations near Wuhe county and Mingguang City in northern Anhui Province and elaborate microstructure analysis, we come to the conclusion that the Tancheng-Lujiang fault zone mainly consists of four branches and at least one should be active since the late Pleistocene for the Wuhe-Mingguang section. This segment is monopolized by dextral strike-slip motion in late Quaternary. Different from obvious faults in bed rocks or consolidated sediments,the latest activity trace in Quaternary loose sediment revealed by trench excavation is not obvious or even invisible to visual observation. According to our recent work and previous studies, we call for more attention to be paid to invisible faults in young sediment and also suggest that more research be conducted along this seemingly placid segment.