Objective The present study attempted to evaluate the value of neoadjuvant chemotherapy in limiteddisease small cell lung cancer(LD-SCLC),and to identify the predictive value of the tumor regression grading(TRG) syste...Objective The present study attempted to evaluate the value of neoadjuvant chemotherapy in limiteddisease small cell lung cancer(LD-SCLC),and to identify the predictive value of the tumor regression grading(TRG) system in LD-SCLC treatment-response and prognosis.Methods The records of patients with LD-SCLC(p-Stage I–IIIa) who underwent definitive radical resection at Shaanxi Provincial People's Hospital between March 1,2000 and March 31,2014 were retrospectively analyzed.We compared the disease-free survival(DFS) and overall survival(OS) rates between Group A patients(patients who underwent surgery combined with pre-and post-operative chemotherapy) and Group B patients(patients who underwent surgery combined with adjuvant chemotherapy only) using the Kaplan-Meier method and the Mantel-Cox test.The specimens of patients who received neoadjuvant chemotherapy were reassessed according to the TRG system.Results The median DFS for 27 patients was 16.267 months and the median OS was 81.167 months(1-year OS,74.07%;3-year OS,22.22%;5-year OS,14.81%).Thirteen patients received neoadjuvant chemotherapy,and their specimens were reassessed by TRG(pathological complete remission,3/13,23.08%).Patients in group A had a longer OS than those in group B(mean,93.782 months versus 42.322 months,P = 0.025),although there was no significant difference in DFS between the two groups(median 20.100 months versus 14.667 months,P = 0.551).Statistical analysis revealed that TRG Grade(G) 0(mean,61.222 months) was associated with better OS than G1-2(mean,31.213 months)(P = 0.311).Conclusion Our study indicated that neoadjuvant chemotherapy combined with surgical resection may represent a feasible treatment method for patients with LD-SCLC.The TRG system may be a valuable prediction tool to assess neoadjuvant chemotherapeutic efficacy,especially in patients with G0 disease as determined by TRG;these patients may attain an improved survival benefit with neoadjuvant chemotherapy.展开更多
Overabundance of phosphorus (P) in soils and water is of great concern and has received much attention in Florida, USA. Therefore, it is essential to analyze and predict the distribution of P in soils across large are...Overabundance of phosphorus (P) in soils and water is of great concern and has received much attention in Florida, USA. Therefore, it is essential to analyze and predict the distribution of P in soils across large areas. This study was undertaken to model the variation of soil total phosphorus (TP) in Florida. A total of 448 soil samples were collected from different soil types. Soil samples were analyzed by chemical reference method and scanned in the visible/near-infrared (VNIR) region of 350-2 500 nm. Partial least squares regression (PLSR) calibration model was developed between chemical reference values and VNIR values. The coefficient of determination (R2) and the root mean squares error (RMSE) of calibration and validation sets, and the residual prediction deviation (RPD) were used to evaluate the models. The R2in calibration and validation for log-transformed TP (log TP) were 0.69 and 0.65, respectively, indicating that VNIR calibration obtained in this study accounted for at least 65% of the variance in log TP using only VNIR spectra, and the high RPD of 2.82 obtained suggested that the spectral model derived in this study was suitable and robust to predict TP in a wide range of soil types, being representative of Florida soil conditions.展开更多
文摘Objective The present study attempted to evaluate the value of neoadjuvant chemotherapy in limiteddisease small cell lung cancer(LD-SCLC),and to identify the predictive value of the tumor regression grading(TRG) system in LD-SCLC treatment-response and prognosis.Methods The records of patients with LD-SCLC(p-Stage I–IIIa) who underwent definitive radical resection at Shaanxi Provincial People's Hospital between March 1,2000 and March 31,2014 were retrospectively analyzed.We compared the disease-free survival(DFS) and overall survival(OS) rates between Group A patients(patients who underwent surgery combined with pre-and post-operative chemotherapy) and Group B patients(patients who underwent surgery combined with adjuvant chemotherapy only) using the Kaplan-Meier method and the Mantel-Cox test.The specimens of patients who received neoadjuvant chemotherapy were reassessed according to the TRG system.Results The median DFS for 27 patients was 16.267 months and the median OS was 81.167 months(1-year OS,74.07%;3-year OS,22.22%;5-year OS,14.81%).Thirteen patients received neoadjuvant chemotherapy,and their specimens were reassessed by TRG(pathological complete remission,3/13,23.08%).Patients in group A had a longer OS than those in group B(mean,93.782 months versus 42.322 months,P = 0.025),although there was no significant difference in DFS between the two groups(median 20.100 months versus 14.667 months,P = 0.551).Statistical analysis revealed that TRG Grade(G) 0(mean,61.222 months) was associated with better OS than G1-2(mean,31.213 months)(P = 0.311).Conclusion Our study indicated that neoadjuvant chemotherapy combined with surgical resection may represent a feasible treatment method for patients with LD-SCLC.The TRG system may be a valuable prediction tool to assess neoadjuvant chemotherapeutic efficacy,especially in patients with G0 disease as determined by TRG;these patients may attain an improved survival benefit with neoadjuvant chemotherapy.
基金Supported by the National Natural Science Foundation of China (No. 41071159)the Cooperative Ecosystem Studies UnitNational Resources Conservation Service (NRCS), USA
文摘Overabundance of phosphorus (P) in soils and water is of great concern and has received much attention in Florida, USA. Therefore, it is essential to analyze and predict the distribution of P in soils across large areas. This study was undertaken to model the variation of soil total phosphorus (TP) in Florida. A total of 448 soil samples were collected from different soil types. Soil samples were analyzed by chemical reference method and scanned in the visible/near-infrared (VNIR) region of 350-2 500 nm. Partial least squares regression (PLSR) calibration model was developed between chemical reference values and VNIR values. The coefficient of determination (R2) and the root mean squares error (RMSE) of calibration and validation sets, and the residual prediction deviation (RPD) were used to evaluate the models. The R2in calibration and validation for log-transformed TP (log TP) were 0.69 and 0.65, respectively, indicating that VNIR calibration obtained in this study accounted for at least 65% of the variance in log TP using only VNIR spectra, and the high RPD of 2.82 obtained suggested that the spectral model derived in this study was suitable and robust to predict TP in a wide range of soil types, being representative of Florida soil conditions.
