目的:探究双盐洗鼻剂鼻腔冲洗用于慢性鼻窦炎(CRS)鼻窦内窥镜术后临床疗效及对血清炎症因子、疼痛视觉模拟量表(VAS)评分的影响。方法:选择2020年3月至2023年5月于唐山中心医院接受鼻窦内镜术的112例CRS患者为研究对象。以随机双盲法分...目的:探究双盐洗鼻剂鼻腔冲洗用于慢性鼻窦炎(CRS)鼻窦内窥镜术后临床疗效及对血清炎症因子、疼痛视觉模拟量表(VAS)评分的影响。方法:选择2020年3月至2023年5月于唐山中心医院接受鼻窦内镜术的112例CRS患者为研究对象。以随机双盲法分为对照组和观察组,每组56例,对照组患者于术后接受300 mL 3%高渗盐水等常规治疗,观察组患者术后联合双盐洗鼻剂鼻腔冲洗治疗。比较两组患者疗效,并分析两组患者治疗前后血清炎性因子、围手术期生活质量(SNOT-20)和VAS评分。结果:治疗后,与对照组总有效率82.14%比较,观察组总有效率94.64%更高,差异有统计学意义(P<0.05);治疗后,观察组治疗后1、2个月的VAS评分[(5.84±1.89)分、(3.98±1.26)分]、SNOT-20评分[(2.77±0.41)分]以及IL-5[(3.28±0.94)ng·mL^(-1)]和IL-6[(85.12±11.24)ng·L^(-1)],低于对照组的[(6.71±1.64)分、(5.12±1.17)分、(4.45±0.72)分、(5.78±1.23)ng·mL^(-1)、(60.84±5.20)ng·L^(-1)],差异有统计学意义(P<0.05);治疗期间,两组患者不良反应事件发生率分别为12.50%、5.36%,差异无统计学意义(P>0.05)。结论:双盐洗鼻剂鼻腔冲洗用于CRS患者鼻窦内镜术后治疗,可显著提升CRS患者疗效,改善疼痛症状和生活质量,稳定患者机体内血清炎性因子水平。展开更多
To evaluate prediction of coronary heart disease(CHD) by quantitative measures of the metabolic syndrome and inflammation in a cohort of high socio-economic status males. Incident CHD was identified in a cohort of 649...To evaluate prediction of coronary heart disease(CHD) by quantitative measures of the metabolic syndrome and inflammation in a cohort of high socio-economic status males. Incident CHD was identified in a cohort of 649 male participants in a company health programme during a mean follow-up of 10.6 years. Using factor analysis, metabolic syndrome and sub-clinical inflammation scores were derived from baseline measurements, which included an oral glucose tolerance test derived measure of insulin resistance. Factor scores were then included as predictor variables in a Cox regression analysis of incident CHD. Forty-two cases of definite CHD were identified on follow-up. The conventional risk factors, cigarette smoking, blood pressure, total cholesterol and low HDL cholesterol were clearly distinguished as significant predictors of incident CHD. Erythrocyte sedimentation rate was also an independent predictor (coefficient 0.0480, z score 2.39, P=0.017). The metabolic syndrome factor included insulin resistance, body mass index, serum triglycerides, glucose tolerance, serum uric acid and fasting plasma glucose. The inflammation factor included serum globulin, blood leukocyte count, low albumin, haemoglobin and cholesterol, but not erythrocyte sedimentation rate. The inflammation factor score was a significant predictor of CHD(coefficient 0.4601, z score 2.43, P=0.015) but the metabolic syndrome factor was not(coefficient 0.2488, z score 1.24, P=0.2). Erythrocyte sedimentation rate and a factor analysis derived measure of sub-clinical inflammation were important in the development of CHD in this relatively low-risk group, but neither metabolic syndrome factor score nor its individual components predicted CHD.展开更多
目的:分析射野角度优化(BAO)布野、均分布野和人工布野3种5野全段食管癌IMRT计划设计方法的剂量学差异,为全段食管癌IMRT计划设计提供临床参考。方法:选取15例行IMRT治疗的全段食管癌患者,分别设计3种5野IMRT(5f-IMRT)计划:基于BAO方法...目的:分析射野角度优化(BAO)布野、均分布野和人工布野3种5野全段食管癌IMRT计划设计方法的剂量学差异,为全段食管癌IMRT计划设计提供临床参考。方法:选取15例行IMRT治疗的全段食管癌患者,分别设计3种5野IMRT(5f-IMRT)计划:基于BAO方法布野计划组(A组)、均分布野计划组(B组)以及人工布野计划组(C组)。用靶区覆盖率、适形度指数(CI)和均匀性指数(HI)以及各危及器官的剂量学参数来比较3组计划方法的剂量学差异,统计分析用配对t检验方法。结果:3组计划的靶区剂量覆盖均能满足临床要求。对于危及器官,A组计划的双肺Dmean和心脏平均值明显低于其他两组计划,差异有统计学意义(P<0.05)。相对于C组计划,A组和B组计划中双肺的V20 Gy和心脏V30 Gy均明显降低(P<0.05),其中A vs C、B vs C的双肺V20 Gy和心脏V30 Gy分别为[(29.15±2.75)%vs(30.03±2.55)%,P=0.005]、[(29.08±2.40)%vs(30.03±2.55)%,P=0.005]和[(45.37±4.59)%vs(48.24±6.45)%,P=0.010]、[(45.79±4.60)%vs(48.24±6.45)%,P=0.040]。最后,对3组计划的剂量学参数进行综合评分,其中A组计划中的靶区PTVx综合评分、危及器官综合评分和计划综合评分得分均为最高,其中计划综合评分CSFTotal为7。C组计划综合评分最差,CSFTotal为-4。结论:相比于人工布野方法与均分布野方法设计的全段食管癌5f-IMRT计划,BAO计划具有明显的剂量学优势,建议在全段食管癌的计划设计中推广应用。展开更多
Selecting six indexs of pH, DO, COD, BOD5, ammonia nitrogen and petroleum hydrocarbons in Haihe River Basin of four seasons in 2012 - 2013 for factor analysis, appling Water Quality Pollution Index （API） to evaluate...Selecting six indexs of pH, DO, COD, BOD5, ammonia nitrogen and petroleum hydrocarbons in Haihe River Basin of four seasons in 2012 - 2013 for factor analysis, appling Water Quality Pollution Index （API） to evaluate DO, COD, BOD5 and ammonia nitrogen, aims for systematic evluation to water quality of Haihe River Basin The results showed that two stations of B J1 and HB2 were the 1V type of water, others were the V type; Water Quality Pollution Index （API） was 1.44, which illustrated Haihe River Basin in the state of contamination that the degree of pollution exceeded the standard of functional areas. Factor Analysis explained that between COD, DO and NH3-N were significant difference （P〈0.05）; principal component analysis showed that, in addition to pH and BOD5, the other indicators were above 0.70; the contribution rate of COD, DO, NH3-N and TPH were higher, petroleum hydrocarbons was 100%, it can be considered that the waters type of pollution was organic pollution, and petroleum hydrocarbon contamination was more prominent.展开更多
文摘目的:探究双盐洗鼻剂鼻腔冲洗用于慢性鼻窦炎(CRS)鼻窦内窥镜术后临床疗效及对血清炎症因子、疼痛视觉模拟量表(VAS)评分的影响。方法:选择2020年3月至2023年5月于唐山中心医院接受鼻窦内镜术的112例CRS患者为研究对象。以随机双盲法分为对照组和观察组,每组56例,对照组患者于术后接受300 mL 3%高渗盐水等常规治疗,观察组患者术后联合双盐洗鼻剂鼻腔冲洗治疗。比较两组患者疗效,并分析两组患者治疗前后血清炎性因子、围手术期生活质量(SNOT-20)和VAS评分。结果:治疗后,与对照组总有效率82.14%比较,观察组总有效率94.64%更高,差异有统计学意义(P<0.05);治疗后,观察组治疗后1、2个月的VAS评分[(5.84±1.89)分、(3.98±1.26)分]、SNOT-20评分[(2.77±0.41)分]以及IL-5[(3.28±0.94)ng·mL^(-1)]和IL-6[(85.12±11.24)ng·L^(-1)],低于对照组的[(6.71±1.64)分、(5.12±1.17)分、(4.45±0.72)分、(5.78±1.23)ng·mL^(-1)、(60.84±5.20)ng·L^(-1)],差异有统计学意义(P<0.05);治疗期间,两组患者不良反应事件发生率分别为12.50%、5.36%,差异无统计学意义(P>0.05)。结论:双盐洗鼻剂鼻腔冲洗用于CRS患者鼻窦内镜术后治疗,可显著提升CRS患者疗效,改善疼痛症状和生活质量,稳定患者机体内血清炎性因子水平。
文摘To evaluate prediction of coronary heart disease(CHD) by quantitative measures of the metabolic syndrome and inflammation in a cohort of high socio-economic status males. Incident CHD was identified in a cohort of 649 male participants in a company health programme during a mean follow-up of 10.6 years. Using factor analysis, metabolic syndrome and sub-clinical inflammation scores were derived from baseline measurements, which included an oral glucose tolerance test derived measure of insulin resistance. Factor scores were then included as predictor variables in a Cox regression analysis of incident CHD. Forty-two cases of definite CHD were identified on follow-up. The conventional risk factors, cigarette smoking, blood pressure, total cholesterol and low HDL cholesterol were clearly distinguished as significant predictors of incident CHD. Erythrocyte sedimentation rate was also an independent predictor (coefficient 0.0480, z score 2.39, P=0.017). The metabolic syndrome factor included insulin resistance, body mass index, serum triglycerides, glucose tolerance, serum uric acid and fasting plasma glucose. The inflammation factor included serum globulin, blood leukocyte count, low albumin, haemoglobin and cholesterol, but not erythrocyte sedimentation rate. The inflammation factor score was a significant predictor of CHD(coefficient 0.4601, z score 2.43, P=0.015) but the metabolic syndrome factor was not(coefficient 0.2488, z score 1.24, P=0.2). Erythrocyte sedimentation rate and a factor analysis derived measure of sub-clinical inflammation were important in the development of CHD in this relatively low-risk group, but neither metabolic syndrome factor score nor its individual components predicted CHD.
文摘目的:分析射野角度优化(BAO)布野、均分布野和人工布野3种5野全段食管癌IMRT计划设计方法的剂量学差异,为全段食管癌IMRT计划设计提供临床参考。方法:选取15例行IMRT治疗的全段食管癌患者,分别设计3种5野IMRT(5f-IMRT)计划:基于BAO方法布野计划组(A组)、均分布野计划组(B组)以及人工布野计划组(C组)。用靶区覆盖率、适形度指数(CI)和均匀性指数(HI)以及各危及器官的剂量学参数来比较3组计划方法的剂量学差异,统计分析用配对t检验方法。结果:3组计划的靶区剂量覆盖均能满足临床要求。对于危及器官,A组计划的双肺Dmean和心脏平均值明显低于其他两组计划,差异有统计学意义(P<0.05)。相对于C组计划,A组和B组计划中双肺的V20 Gy和心脏V30 Gy均明显降低(P<0.05),其中A vs C、B vs C的双肺V20 Gy和心脏V30 Gy分别为[(29.15±2.75)%vs(30.03±2.55)%,P=0.005]、[(29.08±2.40)%vs(30.03±2.55)%,P=0.005]和[(45.37±4.59)%vs(48.24±6.45)%,P=0.010]、[(45.79±4.60)%vs(48.24±6.45)%,P=0.040]。最后,对3组计划的剂量学参数进行综合评分,其中A组计划中的靶区PTVx综合评分、危及器官综合评分和计划综合评分得分均为最高,其中计划综合评分CSFTotal为7。C组计划综合评分最差,CSFTotal为-4。结论:相比于人工布野方法与均分布野方法设计的全段食管癌5f-IMRT计划,BAO计划具有明显的剂量学优势,建议在全段食管癌的计划设计中推广应用。
基金supported by the Key Laboratory of Marine Oil Spill Identification and Damage Assessment Technology, State Oceanic Administration (201214)
文摘Selecting six indexs of pH, DO, COD, BOD5, ammonia nitrogen and petroleum hydrocarbons in Haihe River Basin of four seasons in 2012 - 2013 for factor analysis, appling Water Quality Pollution Index （API） to evaluate DO, COD, BOD5 and ammonia nitrogen, aims for systematic evluation to water quality of Haihe River Basin The results showed that two stations of B J1 and HB2 were the 1V type of water, others were the V type; Water Quality Pollution Index （API） was 1.44, which illustrated Haihe River Basin in the state of contamination that the degree of pollution exceeded the standard of functional areas. Factor Analysis explained that between COD, DO and NH3-N were significant difference （P〈0.05）; principal component analysis showed that, in addition to pH and BOD5, the other indicators were above 0.70; the contribution rate of COD, DO, NH3-N and TPH were higher, petroleum hydrocarbons was 100%, it can be considered that the waters type of pollution was organic pollution, and petroleum hydrocarbon contamination was more prominent.
