In order to evaluate all attack paths in a threat tree,based on threat modeling theory,a weight distribution algorithm of the root node in a threat tree is designed,which computes threat coefficients of leaf nodes in ...In order to evaluate all attack paths in a threat tree,based on threat modeling theory,a weight distribution algorithm of the root node in a threat tree is designed,which computes threat coefficients of leaf nodes in two ways including threat occurring possibility and the degree of damage.Besides,an algorithm of searching attack path was also obtained in accordence with its definition.Finally,an attack path evaluation system was implemented which can output the threat coefficients of the leaf nodes in a target threat tree,the weight distribution information,and the attack paths.An example threat tree is given to verify the effectiveness of the algorithms.展开更多
OBJECTIVE： To assess the clinical effectiveness and safety of injections of ginkgo （GI） combined with Western Medicine （WM） for cerebral infarction （C/）. METHODS; Randomized controlled trials （RCTs） of C/trea...OBJECTIVE： To assess the clinical effectiveness and safety of injections of ginkgo （GI） combined with Western Medicine （WM） for cerebral infarction （C/）. METHODS; Randomized controlled trials （RCTs） of C/treated by GI were searched in China National Knowledge Infrastructure Database, Wanfang, China Science and Technology Journal Database, Web of Science, Cochrane library, Embase, PubMed and Chinese Biomedical Literature Database, with the publication data no later than April, 2016. The Co- chrane risk of bias method was used to evaluate the methodological quality of the RCTs. The data were analyzed by Review Manager 5.3, Stata 13.0, and WinBUGS 14 software.RESULTS： Totally 37 RCTs involving 4330 patients were included. By direct comparison, the results of GI group were significantly superior to the routine WM group in the total effective rates [OR = 3.61, 95% CI （2.93, 4.44）, P 〈 0.0001], the neural function defect score （NFDS） [MD = - 4.39, 95% CI （- 5.47, - 3.32）, P 〈 0.0001]. Network Meta-analysis （NMA） results showed that, between S GIs in efficacy, the difference comparing ginaton injections （GbE） to ginkgo-dipyidamolum injections （GD） [OR = 1.74, 95% CI （0.73, 3.65）], shuxuening injections （SXN） [OR = 1.06, 95% CI （0.609, 1.697）] or ginkgolides in- jections （GK） [OR = 4.711, 95% CI （1.178, 13.21）] reach statistical significance; the difference compar- ing GD to GK reach statistical significance [OR = 2.791, 95% CI （0.866, 6.908）]; the difference com- paring SXN to GK reach statistical significance [OR = 4.537, 95% CI （1.203, 12.41）]. Besides, there was no difference between 4 GIs in NFDS. Proba- bility ranking result showed a great possibility for GK [Surface under the Cumulative Ranking curve （SUCRA） = 80.3%] in improving the total effective rates, which were followed by GD （SUCRA = 73.34%）, SXN （SUCRA = 46.59%）, GbE （SUCRA = 45.46%）, floium ginkgo extract and tertram ethy- pyrazine sodium chloride injections （FT） （SU- CRA = 35.64%）. However, GK （SUCRA = 80.3%） or GbE （SUCRA = 69.4%） was better than other GIs in reducing NFDS.GK ＋ WM is the best treatment measures to reduce NFDS in cerebral infarction, which were followed by SXN ＋ WM （SUCRA = 51.6%）, GD ＋ WM （SUCRA = 48.1%）. CONCLUSION： GIs was more effectiveness on CI than the routine Western Medicine. But based on the limitations of the study, more high-quality ran- domized controlled trials will be necessary.展开更多
基金Supported by National Natural Science Foundation of China (No.90718023)National High-Tech Research and Development Program of China (No.2007AA01Z130)
文摘In order to evaluate all attack paths in a threat tree,based on threat modeling theory,a weight distribution algorithm of the root node in a threat tree is designed,which computes threat coefficients of leaf nodes in two ways including threat occurring possibility and the degree of damage.Besides,an algorithm of searching attack path was also obtained in accordence with its definition.Finally,an attack path evaluation system was implemented which can output the threat coefficients of the leaf nodes in a target threat tree,the weight distribution information,and the attack paths.An example threat tree is given to verify the effectiveness of the algorithms.
基金Supported by National Natural Science Foundation of China:Study on the Key Influencing Factors of Anaphylaxis in Traditional Chinese Medicine Injection(No.81473547)Multidimensional Clinical Evaluation Model of Salvia Injection for the Treatment of Unstable Angina Pectoris(No.81673829)
文摘OBJECTIVE： To assess the clinical effectiveness and safety of injections of ginkgo （GI） combined with Western Medicine （WM） for cerebral infarction （C/）. METHODS; Randomized controlled trials （RCTs） of C/treated by GI were searched in China National Knowledge Infrastructure Database, Wanfang, China Science and Technology Journal Database, Web of Science, Cochrane library, Embase, PubMed and Chinese Biomedical Literature Database, with the publication data no later than April, 2016. The Co- chrane risk of bias method was used to evaluate the methodological quality of the RCTs. The data were analyzed by Review Manager 5.3, Stata 13.0, and WinBUGS 14 software.RESULTS： Totally 37 RCTs involving 4330 patients were included. By direct comparison, the results of GI group were significantly superior to the routine WM group in the total effective rates [OR = 3.61, 95% CI （2.93, 4.44）, P 〈 0.0001], the neural function defect score （NFDS） [MD = - 4.39, 95% CI （- 5.47, - 3.32）, P 〈 0.0001]. Network Meta-analysis （NMA） results showed that, between S GIs in efficacy, the difference comparing ginaton injections （GbE） to ginkgo-dipyidamolum injections （GD） [OR = 1.74, 95% CI （0.73, 3.65）], shuxuening injections （SXN） [OR = 1.06, 95% CI （0.609, 1.697）] or ginkgolides in- jections （GK） [OR = 4.711, 95% CI （1.178, 13.21）] reach statistical significance; the difference compar- ing GD to GK reach statistical significance [OR = 2.791, 95% CI （0.866, 6.908）]; the difference com- paring SXN to GK reach statistical significance [OR = 4.537, 95% CI （1.203, 12.41）]. Besides, there was no difference between 4 GIs in NFDS. Proba- bility ranking result showed a great possibility for GK [Surface under the Cumulative Ranking curve （SUCRA） = 80.3%] in improving the total effective rates, which were followed by GD （SUCRA = 73.34%）, SXN （SUCRA = 46.59%）, GbE （SUCRA = 45.46%）, floium ginkgo extract and tertram ethy- pyrazine sodium chloride injections （FT） （SU- CRA = 35.64%）. However, GK （SUCRA = 80.3%） or GbE （SUCRA = 69.4%） was better than other GIs in reducing NFDS.GK ＋ WM is the best treatment measures to reduce NFDS in cerebral infarction, which were followed by SXN ＋ WM （SUCRA = 51.6%）, GD ＋ WM （SUCRA = 48.1%）. CONCLUSION： GIs was more effectiveness on CI than the routine Western Medicine. But based on the limitations of the study, more high-quality ran- domized controlled trials will be necessary.
