AIM: To investigate the angiogenesis-related protein expression profile characterizing metastatic colorectal cancer (mCRC) with the aim of identifying prognostic markers.METHODS: The expression of 44 angiogenesis-...AIM: To investigate the angiogenesis-related protein expression profile characterizing metastatic colorectal cancer (mCRC) with the aim of identifying prognostic markers.METHODS: The expression of 44 angiogenesis- secreted factors was measured by a novel cytokine antibody array methodology. The study evaluated vas- cular endothelial growth factor (VEGF) and its soluble vascular endothelial growth factor receptor (sVEGFR)-I protein levels by enzyme immunoassay (EIA) in a panel of 16 CRC cell lines, mRNA VEGF and VEGF-A isoforms were quantified by quantitative reverse-transcription polymerase chain reaction (Q-RT-PCR) and vascular en- dothelial growth factor receptor (VEGFR)-2 expressionwas analyzed by flow cytometry.展开更多
Background: Regular physical activity(PA) has documented effects in prevention and treatment of many non-communicable diseases(NCDs).Physical inactivity is recognized as the fourth leading risk factor for premature de...Background: Regular physical activity(PA) has documented effects in prevention and treatment of many non-communicable diseases(NCDs).Physical inactivity is recognized as the fourth leading risk factor for premature death, worldwide. Despite these facts, physical inactivity is increasing,not only in high-income, but also in middle-and low-income countries. To address this negative trend, evidence-based methods to increase PA are needed. The purpose of this paper is to describe the implementation and assessment of 4 strategies designed to increase PA in Vietnam.Methods: Four strategies were used: i) introduction and evaluation of an education and training program on the Swedish method of Physical Activity on Prescription(PAP) among health care professionals, ii) translation of the PAP evidence-based handbook, Physical Activity in the Prevention and Treatment of Disease(called FYSS in Swedish) into Vietnamese, iii) launch of a mass-media campaign to promote PA, and iv)advocacy to support development of PA guidelines in Vietnam.Results: The evaluation indicated that the participating health care professionals had a positive attitude to PAP. However, they also reported uncertainty in prescribing PA. FYSS was translated and disseminated successfully to health care professionals. A mass-media campaign identified the beneficial effects of PA to health care professionals, journalists, policy makers, and the public. Last, the process of developing national guidelines on PA was initiated.Conclusion: This project led to enhanced awareness and appreciation of PA in the prevention and treatment of NCDs among health care professionals as well as initiation of national PA guidelines. Important lessons also were learned in the presentation of PAP, which will be considered when designing similar projects in the future.展开更多
This paper shows an overview of the academic and vocational training of the Mexican university coaches. Professional sports in Mexico are not sufficiently organized in all disciplines and the Olympic sporting system d...This paper shows an overview of the academic and vocational training of the Mexican university coaches. Professional sports in Mexico are not sufficiently organized in all disciplines and the Olympic sporting system does not consider the university sports as a hotbed of world-class athletes. Coaches' academic and vocational training is one of the variables to analyze university-sporting level. A quantitative model was used to approach the topic through an adapted and validated version of a questionnaire used in Spanish populations. The sample consisted of 326 participant's coaches at the 2013 National Student Games. Among the findings, observed there are some aspects revealed related to the training, the domain of knowledge and the existing relationship between an empirical coach and a trained one. In conclusion, therefore, it is important to emphasize that the non-skilled trainer finds it difficult to achieve the optimum sport development, the fulfillment of the assigned tasks, the selection, the dosage, the linking of different means, and the assessment of achievement. According to the national sport level, the university trainer's profile neither allows the consolidation of practice nor these ages and sport levels.展开更多
The value identity emphasizes the harmony and consistency between the different value concepts. In general, it includes three stages, namely cognition, internalization and externalization. By the investigation on the ...The value identity emphasizes the harmony and consistency between the different value concepts. In general, it includes three stages, namely cognition, internalization and externalization. By the investigation on the present situation of college students' socialist core value system identity, it can be found that, at present, there is a good development momentum of our country's higher vocational school students' thoughts in general. But it also exists some problems that can't be ignored. Therefore, the top priority should be focused on the students' physical and mental characteristics. We should reform the current education methods gradually, steadily enhance the college students' identity, emotion and behavior cognition of socialist core value system, and gradually strengthen the ideological construction of college students, so as to make them better serve the socialist modernization.展开更多
Modern Chinese Buddhist literature of the war of resistance against Japanese aggression is a unique literary phenomenon written in a unique era.Thematically,it combines the modern Buddhist consciousness of citizenship...Modern Chinese Buddhist literature of the war of resistance against Japanese aggression is a unique literary phenomenon written in a unique era.Thematically,it combines the modern Buddhist consciousness of citizenship and the traditional spirit of the Way of the Bodhisattva.In terms of individual life experience,it responds to the spirit of the times through the conscious and innovative use of Buddhist conceptions introduced in a modern manner;in terms of identifying a social role,its artistic practice consciously and actively answers the call of China’s wartime cultural strategy;and in terms of artistic production,it vigorously promotes modernization of expression and popular participation.These new elements and tendencies offer a perspective that cannot be overlooked if we are to gain an in-depth and comprehensive appreciation and evaluation of the role of wartime Buddhist literature in China’s national war of resistance.展开更多
基金Supported by A grant of "Department of Health,Government of Navarra,Spain (23/2009)"
文摘AIM: To investigate the angiogenesis-related protein expression profile characterizing metastatic colorectal cancer (mCRC) with the aim of identifying prognostic markers.METHODS: The expression of 44 angiogenesis- secreted factors was measured by a novel cytokine antibody array methodology. The study evaluated vas- cular endothelial growth factor (VEGF) and its soluble vascular endothelial growth factor receptor (sVEGFR)-I protein levels by enzyme immunoassay (EIA) in a panel of 16 CRC cell lines, mRNA VEGF and VEGF-A isoforms were quantified by quantitative reverse-transcription polymerase chain reaction (Q-RT-PCR) and vascular en- dothelial growth factor receptor (VEGFR)-2 expressionwas analyzed by flow cytometry.
基金funded by the Swedish International Development Cooperation Agency (Sida), Department for Development Partnership (No. AKT-2010-045)
文摘Background: Regular physical activity(PA) has documented effects in prevention and treatment of many non-communicable diseases(NCDs).Physical inactivity is recognized as the fourth leading risk factor for premature death, worldwide. Despite these facts, physical inactivity is increasing,not only in high-income, but also in middle-and low-income countries. To address this negative trend, evidence-based methods to increase PA are needed. The purpose of this paper is to describe the implementation and assessment of 4 strategies designed to increase PA in Vietnam.Methods: Four strategies were used: i) introduction and evaluation of an education and training program on the Swedish method of Physical Activity on Prescription(PAP) among health care professionals, ii) translation of the PAP evidence-based handbook, Physical Activity in the Prevention and Treatment of Disease(called FYSS in Swedish) into Vietnamese, iii) launch of a mass-media campaign to promote PA, and iv)advocacy to support development of PA guidelines in Vietnam.Results: The evaluation indicated that the participating health care professionals had a positive attitude to PAP. However, they also reported uncertainty in prescribing PA. FYSS was translated and disseminated successfully to health care professionals. A mass-media campaign identified the beneficial effects of PA to health care professionals, journalists, policy makers, and the public. Last, the process of developing national guidelines on PA was initiated.Conclusion: This project led to enhanced awareness and appreciation of PA in the prevention and treatment of NCDs among health care professionals as well as initiation of national PA guidelines. Important lessons also were learned in the presentation of PAP, which will be considered when designing similar projects in the future.
文摘This paper shows an overview of the academic and vocational training of the Mexican university coaches. Professional sports in Mexico are not sufficiently organized in all disciplines and the Olympic sporting system does not consider the university sports as a hotbed of world-class athletes. Coaches' academic and vocational training is one of the variables to analyze university-sporting level. A quantitative model was used to approach the topic through an adapted and validated version of a questionnaire used in Spanish populations. The sample consisted of 326 participant's coaches at the 2013 National Student Games. Among the findings, observed there are some aspects revealed related to the training, the domain of knowledge and the existing relationship between an empirical coach and a trained one. In conclusion, therefore, it is important to emphasize that the non-skilled trainer finds it difficult to achieve the optimum sport development, the fulfillment of the assigned tasks, the selection, the dosage, the linking of different means, and the assessment of achievement. According to the national sport level, the university trainer's profile neither allows the consolidation of practice nor these ages and sport levels.
文摘The value identity emphasizes the harmony and consistency between the different value concepts. In general, it includes three stages, namely cognition, internalization and externalization. By the investigation on the present situation of college students' socialist core value system identity, it can be found that, at present, there is a good development momentum of our country's higher vocational school students' thoughts in general. But it also exists some problems that can't be ignored. Therefore, the top priority should be focused on the students' physical and mental characteristics. We should reform the current education methods gradually, steadily enhance the college students' identity, emotion and behavior cognition of socialist core value system, and gradually strengthen the ideological construction of college students, so as to make them better serve the socialist modernization.
文摘Modern Chinese Buddhist literature of the war of resistance against Japanese aggression is a unique literary phenomenon written in a unique era.Thematically,it combines the modern Buddhist consciousness of citizenship and the traditional spirit of the Way of the Bodhisattva.In terms of individual life experience,it responds to the spirit of the times through the conscious and innovative use of Buddhist conceptions introduced in a modern manner;in terms of identifying a social role,its artistic practice consciously and actively answers the call of China’s wartime cultural strategy;and in terms of artistic production,it vigorously promotes modernization of expression and popular participation.These new elements and tendencies offer a perspective that cannot be overlooked if we are to gain an in-depth and comprehensive appreciation and evaluation of the role of wartime Buddhist literature in China’s national war of resistance.