气举设计适应性评价新方法——气举工况诊断节点分析法

在气举装置投入生产前,分析连续气举设计装置对目标油井含水率、气油比、地层压力、产液指数、注气压力和注气量等重要参数的适应范围,评估出气举设计的适应性,进而优化或优选出最佳的气举设计方案是非常必要的。将气举工况诊断与节点分析进行有机结合,分析气举设计对目标油井各重要参数的适应范围,进而制作出不同的含水率、气油比条件下气举地层压力、产液指数适应性图版,得到了气举设计适应性评价新方法。实例分析表明,新方法制作气举设计适应性图版与现场测试判断结果较吻合,可以评价气举设计方案在油井生产中的适应性。

自动变速器故障的系统分析诊断法

介绍了用系统分析法诊断汽车电控自动变速器故障的方法，并给出了应用案例。

旅游企业财务预警:TCG公司破产的启示

旅游企业作为旅游业的主体,容易受到环境不确定性的影响,财务危机无处不在。财务预警作为企业财务管理的关键环节,做好财务预警工作具有重要意义。文章结合托马斯·库克公司2011—2018年上市数据及公开资料,使用改进的Z值模型,运用四阶段诊断分析与Z值财务预警模型相结合的方法,对公司破产倒闭进行了验证性分析,提出旅游企业财务风险防控的策略,以促进旅游业健康稳步发展。

南极海冰的时空变化特征

依据Hadley中心提供的全球海冰密集度格点资料 ,利用诊断分析方法 ,对近 35年来南极海冰的时空变化特征进行了研究。研究表明 ,在南极地区 ,海冰平均北界和海冰总面积的变化基本一致 ,可以用海冰北界来研究南极海冰的时空变化特征。南极海冰最多和最少期分别出现在 9月和 2月 ;威德尔海和罗斯海地区海冰最多、变化最大 ,南极半岛地区海冰最少 ,变化也小 ;近 35年来环南极地区的海冰有明显的减少趋势。南极海冰变化的时空多样性十分明显 ,存在着 5个变化不同的区域 ,其中有两个区域近 35年来海冰范围扩大 ,面积增加 ,而另三个区域则海冰范围缩小 ,面积减少。不同区域的海冰都存在着较明显的 2— 3年和 5— 7年主振荡周期。南极海冰时空变化特征的研究对进一步认识南极地区海 冰 气相互作用的物理过程 。

低液量定向井综合提效技术创新与应用

机采系统作为长庆油田生产的核心业务，近几年耗电、修井费用均超过20亿元，降本增效的潜力巨大，长庆油田将“提高系统效率、降低作业频次”作为油田降本增效的一项重点工作。2016年以来，长庆油田紧密结合生产实际，一方面形成了油井间开的数学模型和优化模板、管杆失效“1234”分析诊断法、组合管柱中和点修正方法等技术集成创新；另外创建了井筒管理微平台监控、“两交叉、三对口、一验证”的监管和井筒预警平台＋微降井现场精细管理模式。2016年综合提效技术在油田进行了规模应用，累计节约成本、创造效益超过7000万元，现场应用效果显著。

Measurement of Serum Total and Free Prostate-Specific Antigen for Breast Cancer Diagnosis in Women

Objective: To investigate the diagnostic value and the relationship between the clinicopathological features and the levels of total and free prostate-specific antigen (PSA) in women with breast cancer.Methods: Using the microparticle enzyme immunoassay system, we measured the concentrations of these markers in the sera of 85 women with breast cancer and in 30 healthy women.Rseults: The lowest detection level for both markers was 0.01 ng/ml. Free PSA levels were significantly higher in women with breast cancer than that in healthy women (P<0.05). The percentage of free PSA predominant subjects was 37.6% in breast cancer patients and 3.3% in healthy women. Cut-off values were 0.36 ng/ml for total PSA and 0.02 ng/ml for free PSA. In women with breast cancer, total PSA positivity was 23.5% and free PSA positivity was 27.1%. Compared to negatives, total PSA positive patients had a higher percentage of lymph node involvement tumours (P>0.05). However, patients with predominant free PSA had a higher percentage of early stage than patients with predominant PSA-ACT.Conclusion: Although the sensitivity of free PSA predominance is low (37.6%) in distinguishing women with breast cancer from healthy women, its specificity is high (97.0%).Free PSA predominance tends to be present in early stage tumours. These findings may indicate clinical significance of preoperative measurement of serum total and free PSA in women with breast cancer.

Total thyroidectomy is safer with identification of recurrent laryngeal nerve

Objective:To investigate the effect of recurrent laryngeal nerve(RLN)identification on the complications after total thyroidectomy and lobectomy.Methods:Total 134 consecutive patients undergoing total thyroidectomy or thyroid lobectomy from January 2003 to November 2004 were investigated retrospectively.Patients were divided into two groups:RLN identified (Group A)or not(Group B).The two groups were compared for RLN injury and hypocalcaemia.Results:The numbers of patients and nerves at risk were 71 and 129 in Group A,and 63 and 121 in Group B,respectively.RLN injury in Group A(0)was sig- nificantly lower than that in Group B(57.9%)patients,75.8%nerves)for the numbers of patients(P=0.016)and nerves at risk (P=0.006).Temporary hypocalcaemia was significantly higher in Group A than in Group B(1424.1%vs 610.3%,P=0.049). Permanent complications in Group B were significantly higher than those in Group A(1320.6%vs 45.6%,P=0.009).Con- clusion:RLN injury was prevented and permanent complications were decreased by identifying the whole course and branches of the recurrent laryngeal nerve during total thyroidectomy.

Fault Diagnosis in Chemical Process Based on Self-organizing Map Integrated with Fisher Discriminant Analysis

Fault diagnosis and monitoring are very important for complex chemical process. There are numerous methods that have been studied in this field, in which the effective visualization method is still challenging. In order to get a better visualization effect, a novel fault diagnosis method which combines self-organizing map (SOM) with Fisher discriminant analysis (FDA) is proposed. FDA can reduce the dimension of the data in terms of maximizing the separability of the classes. After feature extraction by FDA, SOM can distinguish the different states on the output map clearly and it can also be employed to monitor abnormal states. Tennessee Eastman (TE) process is employed to illustrate the fault diagnosis and monitoring performance of the proposed method. The result shows that the SOM integrated with FDA method is efficient and capable for real-time monitoring and fault diagnosis in complex chemical process.

Treatment regimen design in clinical radiotherapy for hepatoma

Recently, the paper by Wang et at published in World Journal of Gastroenterology has given rise to great interest of many researchers. It is well known that hepatoma is one of the lethal diseases with a high incidence in the world, especially in Asia. Radiotherapy is the main treatment modality of hepatoma in clinical practice. Unfortunately, intrinsic radiosensitivity of cancer cells is not fully understood, though a large number of papers on it are now available. Yang and colleagues 21 have developed the premature chromosome condensation technique for clinical radiotherapy of hepatoma. A precise and quick measurement of cell radiosensitivity can detect the highrisk results after exposure to a large dose.

Independent component analysis approach for fault diagnosis of condenser system in thermal power plant

A statistical signal processing technique was proposed and verified as independent component analysis(ICA) for fault detection and diagnosis of industrial systems without exact and detailed model.Actually,the aim is to utilize system as a black box.The system studied is condenser system of one of MAPNA's power plants.At first,principal component analysis(PCA) approach was applied to reduce the dimensionality of the real acquired data set and to identify the essential and useful ones.Then,the fault sources were diagnosed by ICA technique.The results show that ICA approach is valid and effective for faults detection and diagnosis even in noisy states,and it can distinguish main factors of abnormality among many diverse parts of a power plant's condenser system.This selectivity problem is left unsolved in many plants,because the main factors often become unnoticed by fault expansion through other parts of the plants.

A local and global statistics pattern analysis method and its application to process fault identification

Traditional principal component analysis （PCA） is a second-order method and lacks the ability to provide higherorder representations for data variables. Recently, a statistics pattern analysis （SPA） framework has been incorporated into PCA model to make full use of various statistics of data variables effectively. However, these methods omit the local information, which is also important for process monitoring and fault diagnosis. In this paper, a local and global statistics pattern analysis （LGSPA） method, which integrates SPA framework and locality pre- serving projections within the PCK is proposed to utilize various statistics and preserve both local and global in- formation in the observed data. For the purpose of fault detection, two monitoring indices are constructed based on the LGSPA model. In order to identify fault variables, an improved reconstruction based contribution （IRBC） plot based on LGSPA model is proposed to locate fault variables. The RBC of various statistics of original process variables to the monitoring indices is calculated with the proposed RBC method. Based on the calculated RBC of process variables＇ statistics, a new contribution of process variables is built to locate fault variables. The simula- tion results on a simple six-variable system and a continuous stirred tank reactor system demonstrate that the proposed fault diagnosis method can effectively detect fault and distinguish the fault variables from normal variables.

Diagnosis and treatment of prolactinoma:clinical analysis of 124 prolactinomas

Objective： To study the diagnostic and therapeutic features of prolactinoma. Methods： 124 patients with prolactinoma were studied in clinical manifestation, pathologic, endocrinological, radiographic and therapeutic features. Results： The average age of the male patients was 41.6 years, 32.3 years of females. The major clinical manifestation in males were sexual and visual disfunction. In females, disfunction of menstruates and galactorrhea. Average serum prolactin was 1875.22 in males, 376.6 ng/mL in females. Average diameter of the tumors was 38.05 mm in males, and 83.3% of the tumors were invasive, in females were 15.25 mm and 49%. After surgery, the average serum prolactin decreased to 385.84 ng/mL （P〈 0.05）, 13 of 15 patients improved in sexual function, 82.6% patients improved in eyesight and visual field. In females prolactin decreased to 23.93 ng/mL （P 〈 0.05）, and 81.25% infertility with microprolactinoma got pregnancy, higher than controls of drug therapy （P 〈 0.05）. Conclusion： In males, the tumors were usually larger and more invasive, and serum prolactin levels were higher. The patients were elder. But in females, much younger than males, most of the tumors were microadenoma, and after operation the prolactin usually decrease to normal level and more chance of pregnancy. Results of a single therapy were with less satisfaction, we advocate integrated therapy around operation.

The diagnosis and differential diagnosis of granulocytic sarcoma

Objective： To discuss the diagnosis and differential diagnosis of granulocytic sarcoma （GS）. Methods： Six cases were reported in this paper. They were assessed by pathologists. Immunohistochemistry （IHC） stain and routine hematoxylin and eosin （H＆E） stain were applied. Results： All patients involved in different anatomic sites respectively including skin, lymph node, soft tissue, breast, cervix and penis. All cases were previously error diagnoses. Three of them were initially diagnosed as non-Hodgkin lymphoma （NHL）. One case of cervical lymph node lesion was first considered as metastasized carcinoma by clinician. One biopsied skin sample was initially reported as Karposi＇s sarcoma. And one breast case was suspicious of the Iobular carcinoma with the frozen samples without antecedent clinical history information. GS was accompanied with acute myeloid leukemia （AML） in one case and with acute lymphocytic leukemia （ALL） in one case. Histopathologically, blastic, immature and differentiated variants were found in four, one and one, respectively. Immunohistochemistry （IHC） showed that myeloperoxidase （MPO） and lysozyme were both found to be positive in all cases, CD43 was found in 5 of 6 cases. Three of six cases were CD68, CD15 and LCA positive. CD34 and CDl17 were positive in 1/5 and 1/6 cases, respectively. However, CD20 and CD3 were negative in all cases. Conclusion： GS was uncommon and it may be misdiagnosed easily in routine practice. Each area had its own character, but they had the common features too. It can be correctly diagnosed by combination of H＆E stain, IHC stain, peripheral blood and bone marrow. MPO and Lysozyme were necessary for the nature of granulocytes. In addition, CD43, CD68 and CD15 were very helpful.

Correlation Analysis between TCM Syndromes and Physicochemical Parameters

Traditionally, differentiation of syndromes of Traditional Chinese Medicine (TCM) mainly depends on the information obtained from four diagnosis methods. Now many physicochemical parameters are available in clinic. There exists great correlation between TCM syndromes and physicochemical parameters. The objective of the paper is to analyze the correlation between TCM syndromes and physicochemical parameters quantitatively. Correlation analysis has been widely studied and many analysis methods have been developed. Mutual information based on entropy can measure arbitrary dependence between variables. It has been applied to many kinds of fields, especially to pattern recognition. But most works are restricted to discrete variables and little work has been done to study the relation between discrete and continuous variables. A novel algorithm is proposed to calculate the mutual information between discrete and continuous variables. It is used to analyze the correlation between TCM syndromes and physicochemical parameters.

A smartphone-based calibration-free portable urinalysis device

As one of the most common medical diagnosis methods, urinalysis is a highly demanded technique for screening tests or daily monitoring of various diseases. With the rapid development of POC(point-of-care) systems, a convenient house-using urinalysis device is widely needed. However, considering the difference of onboard systems and multiple test indicators in urinalysis, the design of such an intelligent device is still challenging. In this paper, a smartphone-based portable urinalysis system has been developed and applied for the colorimetric analysis of routine urine examination indices using an Android app. By integrating the test paper sensor in the portable device for urinalysis,our system significantly improves the instability of conventional dipstick-based manual colorimetry, and the smartphone application used for color discrimination enhances the accuracy of the visual assessment of sample strips. Using a simple operation approach that takes ~ 2 min per test, our system can be applied as rapid urinalysis for routine check-ups.

夏季对流层臭氧辐射强迫对华北地区天气和空气质量的影响

自2013年我国实施《大气污染防治行动计划》以来,大气颗粒物浓度显著降低,但臭氧(O_(3))污染日益严峻,同时对流层O_(3)作为一种重要的温室气体,其辐射强迫能够影响天气和空气质量.利用双向耦合的区域空气质量模型WRF-Chem,再现2017年6月发生在华北地区的一次O_(3)污染事件,通过敏感性试验分析对流层臭氧辐射强迫(TORF)对当地气象场的影响,以及改变的气象变量对O_(3)空气质量的反馈作用.结果表明,WRF-Chem模式在气象要素的模拟上表现出较好的性能,并且能够很好地捕捉到O_(3)浓度的时空演变特征.TORF使北京-天津-河北-山东地区的近地面气温平均升高0.23 K(最大增温可达0.8 K)、近地面相对湿度降低1.84%、边界层高度增加27.73 m.TORF对风速的影响较弱(-0.02 m·s^(-1)),但产生的西南风异常容易将上游污染地区的O_(3)和其前体物输送至华北地区.在臭氧辐射反馈的影响下,研究区域内φ(O_(3))平均增加1.7%(1.23×10^(-9)),而在污染严重的北京和天津地区,φ(O_(3))增加量最高可达5×10^(-9).进一步利用过程诊断分析法可以发现,增强的气相化学反应是TORF恶化近地面O_(3)污染的主导原因.