This paper presents one of many possible applications of Bayesian inference predictive context of planned tests. We are particularly interested in the use of predictive Bayesian approach in clinical trials or objectiv...This paper presents one of many possible applications of Bayesian inference predictive context of planned tests. We are particularly interested in the use of predictive Bayesian approach in clinical trials or objective is the development of important evidence of an effect of interest We offer the procedure based on the notion of satisfaction index which is a function of the p-value and we look forward, given the available data to calculate a forecast for future satisfaction data as predictive Bayesian hope this index conditional on previous observations. To illustrate the proposed procedure, several models have been studied by choosing the prior distribution justify the reasons of objectivity or neutrality that underlie the analysis of experimental data.展开更多
Objective To observe and evaluate the clinical efficacy of acupuncture and Chinese massage on knee osteoarthritis and conduct the analysis on the functions of knee flexors and extensors in patients. Methods Eighty cas...Objective To observe and evaluate the clinical efficacy of acupuncture and Chinese massage on knee osteoarthritis and conduct the analysis on the functions of knee flexors and extensors in patients. Methods Eighty cases were randomly divided into an observation group and a control group, 40 cases in each one. In observation group, acupuncture combined with Chinese massage was applied. The main acupoints for acupuncture were Nèixīyǎn （内膝眼 EX-LE 4）, Hèdǐng （鹤顶 EX-LE 2）, Dúbí （犊鼻 ST 35）, etc. In Chinese massage, gun-fa （rolling）, rou-fa （kneading）, na-fa （grasping）, ca-fa （rubbing） and passive movements of joints were applied. In control group, Fenbid was administered orally. The efficacy evaluation, JOA score and the result of isokinetic testing were compared before and after treatment in two groups. Results ① The total effective rate was 90.0% （36/40） in observation group and was 87.5% （35/40） in control group, indicating equivalent efficacy between two groups （P0.05）. JOA score after treatment increased remarkably compared with that before treatment in two groups （both P0.01）. ② It was indicated in isokinetic test of two groups that peak torque （PT）, total work （TW） and average power （AP） after treatment were all improved in comparison with those before treatment （P0.05, P0.01） and the improvement after treatment in observation group was much more remarkable as compared with that in control group （all P0.05）. Conclusion Acupuncture and Chinese massage can improve significantly in the symptoms, the muscle strength of the flexors and extensors as well as motor function of the patients with knee osteoarthritis, which is superior to that achieved with Fenbid.展开更多
We consider the statistical inference for right-censored data when censoring indicators are missing but nonignorable, and propose an adjusted imputation product-limit estimator. The proposed estimator is shown to be c...We consider the statistical inference for right-censored data when censoring indicators are missing but nonignorable, and propose an adjusted imputation product-limit estimator. The proposed estimator is shown to be consistent and converges to a Gaussian process. Furthermore, we develop an empirical processbased testing method to check the MAR (missing at random) mechanism, and establish asymptotic properties for the proposed test statistic. To determine the critical value of the test, a consistent model-based bootstrap method is suggested. We conduct simulation studies to evaluate the numerical performance of the proposed method and compare it with existing methods. We also analyze a real data set from a breast cancer study for an illustration.展开更多
文摘This paper presents one of many possible applications of Bayesian inference predictive context of planned tests. We are particularly interested in the use of predictive Bayesian approach in clinical trials or objective is the development of important evidence of an effect of interest We offer the procedure based on the notion of satisfaction index which is a function of the p-value and we look forward, given the available data to calculate a forecast for future satisfaction data as predictive Bayesian hope this index conditional on previous observations. To illustrate the proposed procedure, several models have been studied by choosing the prior distribution justify the reasons of objectivity or neutrality that underlie the analysis of experimental data.
基金Supported by Shanghai Municipal Key Discipline Construction Project: T0302-A17Project of "Science and Technology Innovation Program" of Shanghai Science Committee: 08411961100
文摘Objective To observe and evaluate the clinical efficacy of acupuncture and Chinese massage on knee osteoarthritis and conduct the analysis on the functions of knee flexors and extensors in patients. Methods Eighty cases were randomly divided into an observation group and a control group, 40 cases in each one. In observation group, acupuncture combined with Chinese massage was applied. The main acupoints for acupuncture were Nèixīyǎn （内膝眼 EX-LE 4）, Hèdǐng （鹤顶 EX-LE 2）, Dúbí （犊鼻 ST 35）, etc. In Chinese massage, gun-fa （rolling）, rou-fa （kneading）, na-fa （grasping）, ca-fa （rubbing） and passive movements of joints were applied. In control group, Fenbid was administered orally. The efficacy evaluation, JOA score and the result of isokinetic testing were compared before and after treatment in two groups. Results ① The total effective rate was 90.0% （36/40） in observation group and was 87.5% （35/40） in control group, indicating equivalent efficacy between two groups （P0.05）. JOA score after treatment increased remarkably compared with that before treatment in two groups （both P0.01）. ② It was indicated in isokinetic test of two groups that peak torque （PT）, total work （TW） and average power （AP） after treatment were all improved in comparison with those before treatment （P0.05, P0.01） and the improvement after treatment in observation group was much more remarkable as compared with that in control group （all P0.05）. Conclusion Acupuncture and Chinese massage can improve significantly in the symptoms, the muscle strength of the flexors and extensors as well as motor function of the patients with knee osteoarthritis, which is superior to that achieved with Fenbid.
基金supported by National Natural Science Foundation of China (Grant Nos. 10901162 and 10926073)China Postdoctoral Science Foundation and Foundation of the Key Laboratory of Random Complex Structures and Data Science, Chinese Academy of Sciences+2 种基金supported by National Natural Science Foundation of China (Grant Nos. 10971007 and 11101015)the fund from the government of Beijing (Grant No. 2011D005015000007)supported by National Science Foundation of US (Grant Nos. DMS0806097 and DMS1007167)
文摘We consider the statistical inference for right-censored data when censoring indicators are missing but nonignorable, and propose an adjusted imputation product-limit estimator. The proposed estimator is shown to be consistent and converges to a Gaussian process. Furthermore, we develop an empirical processbased testing method to check the MAR (missing at random) mechanism, and establish asymptotic properties for the proposed test statistic. To determine the critical value of the test, a consistent model-based bootstrap method is suggested. We conduct simulation studies to evaluate the numerical performance of the proposed method and compare it with existing methods. We also analyze a real data set from a breast cancer study for an illustration.
