Aim To improve the efficiency of fatigue material tests and relevant statistical treatment of test data. Methods\ Least square approach and other special treatments were used. Results and Conclusion\ The concepts...Aim To improve the efficiency of fatigue material tests and relevant statistical treatment of test data. Methods\ Least square approach and other special treatments were used. Results and Conclusion\ The concepts of each phase in fatigue tests and statistical treatment are clarified. The method proposed leads to three important properties. Reduced number of specimens brings to the advantage of lowering test expenditures. The whole test procedure has more flexibility for there is no need to conduct many tests at the same stress level as in traditional cases.展开更多
AIM: To evaluate the sensitivity and specificity of transfesrrin dipstick test (Tf) in colorectal cancer (CRC) screening and precancerous lesions screening. METHODS: Eight hundreds and sixty-one individuals at high-ri...AIM: To evaluate the sensitivity and specificity of transfesrrin dipstick test (Tf) in colorectal cancer (CRC) screening and precancerous lesions screening. METHODS: Eight hundreds and sixty-one individuals at high-risk for CRC were recruited. Six hundreds and eleven subsequently received the three fecal occult blood tests and colonoscopy with biopsy performed as needed. Fecal samples were obtained on the day before colonoscopy. Tf, immuno fecal occult blood test (IFOBT) and guaiac fecal occult blood test (g-FOBT) were performed simultaneously on the same stool. To minimize false-negative cases, all subjects with negative samples were asked to provide an additional stool specimen for a second test even a third test. If the results were all negative after testing three repeated samples, the subject was considered a true negative. The performance characteristics of Tf for detecting CRC and precancerous lesions were examined and compared to those of IFOBT and the combination of Tf, IFOBT and g-FOBT. RESULTS: A total of six hundreds and eleven subjects met the study criteria including 25 with CRC and 60 with precancerous lesions. Sensitivity for detecting CRC was 92% for Tf and 96% for IFOBT, specificities of Tf and IFOBT were both 72.0% (95% CI: 68.2%-75.5%; χ2 = 0.4, P > 0.05); positive likelihood ratios of those were 3.3 (95% CI: 2.8-3.9) and 3.4 (95% CI: 2.9-4.0), respectively. In precancerous lesions, sensitivities for Tf and IFOBT were 50% and 58%, respectively (χ 2 = 0.8, P > 0.05); specificities of Tf and IFOBT were 71.5% (95% CI: 67.6%-75.1%) and 72.2% (95% CI: 68.4%-75.8%); positive likelihood ratios of those were 1.8 (95% CI: 1.3-2.3) and 2.1 (95% CI: 1.6-2.7), respectively; compared to IFOBT, g-FOBT+ Tf+ IFOBT had a significantly higher positive rate for precancerous lesions (83% vs 58%, respectively; χ 2 = 9.1, P < 0.05). In patients with CRC and precancerous lesions, the sensitivities of Tf and IFOBT were 62% and 69% (χ 2 = 0.9, P > 0.05); specificities of those were 74.5% (95% CI: 70.6%-78.1%) and 75.5% (95% CI: 71.6%-79.0%); positive likelihood ratios of those were 2.5 (95% CI: 2.0-3.1) and 2.8 (95% CI: 2.3-3.5). Compared to IF-OBT alone, combining g-FOBT, IFOBT and Tf led to significantly increased sensitivity for detecting CRC and cancerous lesions (69% vs 88%, respectively; χ 2 = 9.0, P < 0.05). CONCLUSION: Tf dipstick test might be used as an ad- ditional tool for CRC and precancerous lesions screening in a high-risk cohort.展开更多
A data processing method was proposed for eliminating the end restraint in triaxial tests of soil. A digital image processing method was used to calculate the local deformations and local stresses for any region on th...A data processing method was proposed for eliminating the end restraint in triaxial tests of soil. A digital image processing method was used to calculate the local deformations and local stresses for any region on the surface of triaxial soil specimens. The principle and implementation of this digital image processing method were introduced as well as the calculation method for local mechanical properties of soil specimens. Comparisons were made between the test results calculated by the data from both the entire specimen and local regions, and it was found that the deformations were more uniform in the middle region compared with the entire specimen. In order to quantify the nonuniform characteristic of deformation, the non-uniformity coefficients of strain were defined and calculated. Traditional and end-lubricated triaxial tests were conducted under the same condition to investigate the effects of using local region data for deformation calculation on eliminating the end restraint of specimens. After the statistical analysis of all test results, it was concluded that for the tested soil specimen with the size of 39.1 mm × 80 ram, the utilization of the middle 35 mm region of traditional specimens in data processing had a better effect on eliminating end restraint compared with end lubrication. Furthermore, the local data analysis in this paper was validated through the comparisons with the test results from other researchers.展开更多
The World Health Organization （WHO） standard assay for determining antibody level is the rapid fluorescent focus inhibition test （RFFIT） and is used to determine the degree of immunity after vaccination against ra...The World Health Organization （WHO） standard assay for determining antibody level is the rapid fluorescent focus inhibition test （RFFIT） and is used to determine the degree of immunity after vaccination against rabies. To compare the difference in RFFIT results between the laboratories of The National Institute of Infectious Disease in Japan （NIID） and the Chinese Centre for Disease Control （CCDC） as well the influence of the choice of standard serum （STD） for the detection, the two laboratories detection methods were simultaneously manipulated by RFFIT. The reference serums used in NIID and the WHO standard serum used in CCDC were compared in the same RFFIT detection to determine the titer of four sera samples C1, Sl, S2 and S4 in parallel, and the titers of the detected sera samples were calculated using the standard formula for neutralizing antibody titer. No significant difference was found in RFFIT methods from the two laboratories and the RFFIT testing procedures of the two laboratories have good consistency. However, different titers were obtained with the tentative internal standard serum （TI-STD） produced by adjusting to 2.0 IU of WHO standard serum in NIID and the WHO STD. The titer determined with the TI-STD was higher than that determined with WHO STD, This difference appears to be significant and requires further investigation展开更多
A series of compression tests were conducted on 150 groups of cement paste specimens with side lengths ranging from 40 mm to 200 mm. The specimens include cube specimens and prism specimens with height to width ratio ...A series of compression tests were conducted on 150 groups of cement paste specimens with side lengths ranging from 40 mm to 200 mm. The specimens include cube specimens and prism specimens with height to width ratio of 2. The experiment results show that size effect exists in the cubic compressive strength and prismatic compressive strength of the cement paste, and larger specimens resist less in terms of strength than smaller ones. The cubic compressive strength and the prismatic compressive strength of the specimens with side length of 200 mm are respectively about 91% and 89% of the compressive strength of the specimens with the side length of 40 mm. Water to binder ratio has a significant influence on the size effect of the compressive strengths of the cement paste. With a decrease in the water to binder ratio, the size effect is significantly enhanced. When the water to binder ratio is 0.2, the size effects of the cubic compressive strength and the prismatic compressive strength of the cement paste are 1.6 and 1.4 times stronger than those of a water to binder ratio of 0.6. Furthermore, a series of formulas are proposed to calculate the size effect of the cubic compressive strength and the prismatic compressive strength of cement paste, and the results of the size effect predicted by the formulas are in good agreement with the experiment results.展开更多
The research object was high 120 m concrete gravity dam of the Angara Bratsk hydroelectric power plant. The state of the concrete dam is estimated based on the results of continuous supervision performed by site perso...The research object was high 120 m concrete gravity dam of the Angara Bratsk hydroelectric power plant. The state of the concrete dam is estimated based on the results of continuous supervision performed by site personnel as well as periodic monitoring. According to the classification of the interrelations in the system ＂concrete-environment＂, there were selected some important parts of dams and a comprehensive analysis of concrete was executed on these parts. Concerning the complex research of concrete, a combination of full-scale tests with core-sampling has been proposed. Core samples tests had an object to study the deep concrete layers and to determine the specific indicators such as strength, density, porosity, comparative diameter of capillary pores, CaO content in cement stone and others. Obtained findings and recommended criteria can be applied when selecting technologies for constructing dams that guarantee their durability in the north.展开更多
文摘Aim To improve the efficiency of fatigue material tests and relevant statistical treatment of test data. Methods\ Least square approach and other special treatments were used. Results and Conclusion\ The concepts of each phase in fatigue tests and statistical treatment are clarified. The method proposed leads to three important properties. Reduced number of specimens brings to the advantage of lowering test expenditures. The whole test procedure has more flexibility for there is no need to conduct many tests at the same stress level as in traditional cases.
基金Supported by National Natural Science Foundation of China,No. 81071832the Key Scientific Research Project of the Health Bureau of Hubei Province, No. JX5A01
文摘AIM: To evaluate the sensitivity and specificity of transfesrrin dipstick test (Tf) in colorectal cancer (CRC) screening and precancerous lesions screening. METHODS: Eight hundreds and sixty-one individuals at high-risk for CRC were recruited. Six hundreds and eleven subsequently received the three fecal occult blood tests and colonoscopy with biopsy performed as needed. Fecal samples were obtained on the day before colonoscopy. Tf, immuno fecal occult blood test (IFOBT) and guaiac fecal occult blood test (g-FOBT) were performed simultaneously on the same stool. To minimize false-negative cases, all subjects with negative samples were asked to provide an additional stool specimen for a second test even a third test. If the results were all negative after testing three repeated samples, the subject was considered a true negative. The performance characteristics of Tf for detecting CRC and precancerous lesions were examined and compared to those of IFOBT and the combination of Tf, IFOBT and g-FOBT. RESULTS: A total of six hundreds and eleven subjects met the study criteria including 25 with CRC and 60 with precancerous lesions. Sensitivity for detecting CRC was 92% for Tf and 96% for IFOBT, specificities of Tf and IFOBT were both 72.0% (95% CI: 68.2%-75.5%; χ2 = 0.4, P > 0.05); positive likelihood ratios of those were 3.3 (95% CI: 2.8-3.9) and 3.4 (95% CI: 2.9-4.0), respectively. In precancerous lesions, sensitivities for Tf and IFOBT were 50% and 58%, respectively (χ 2 = 0.8, P > 0.05); specificities of Tf and IFOBT were 71.5% (95% CI: 67.6%-75.1%) and 72.2% (95% CI: 68.4%-75.8%); positive likelihood ratios of those were 1.8 (95% CI: 1.3-2.3) and 2.1 (95% CI: 1.6-2.7), respectively; compared to IFOBT, g-FOBT+ Tf+ IFOBT had a significantly higher positive rate for precancerous lesions (83% vs 58%, respectively; χ 2 = 9.1, P < 0.05). In patients with CRC and precancerous lesions, the sensitivities of Tf and IFOBT were 62% and 69% (χ 2 = 0.9, P > 0.05); specificities of those were 74.5% (95% CI: 70.6%-78.1%) and 75.5% (95% CI: 71.6%-79.0%); positive likelihood ratios of those were 2.5 (95% CI: 2.0-3.1) and 2.8 (95% CI: 2.3-3.5). Compared to IF-OBT alone, combining g-FOBT, IFOBT and Tf led to significantly increased sensitivity for detecting CRC and cancerous lesions (69% vs 88%, respectively; χ 2 = 9.0, P < 0.05). CONCLUSION: Tf dipstick test might be used as an ad- ditional tool for CRC and precancerous lesions screening in a high-risk cohort.
基金Supported by Major State Basic Research Development Program of China("973" Program,No.2010CB731502)
文摘A data processing method was proposed for eliminating the end restraint in triaxial tests of soil. A digital image processing method was used to calculate the local deformations and local stresses for any region on the surface of triaxial soil specimens. The principle and implementation of this digital image processing method were introduced as well as the calculation method for local mechanical properties of soil specimens. Comparisons were made between the test results calculated by the data from both the entire specimen and local regions, and it was found that the deformations were more uniform in the middle region compared with the entire specimen. In order to quantify the nonuniform characteristic of deformation, the non-uniformity coefficients of strain were defined and calculated. Traditional and end-lubricated triaxial tests were conducted under the same condition to investigate the effects of using local region data for deformation calculation on eliminating the end restraint of specimens. After the statistical analysis of all test results, it was concluded that for the tested soil specimen with the size of 39.1 mm × 80 ram, the utilization of the middle 35 mm region of traditional specimens in data processing had a better effect on eliminating end restraint compared with end lubrication. Furthermore, the local data analysis in this paper was validated through the comparisons with the test results from other researchers.
基金Grant from National Institute of Infectious Diseases(NIID)National Department Public Benefit Research Foundation (201103032)
文摘The World Health Organization （WHO） standard assay for determining antibody level is the rapid fluorescent focus inhibition test （RFFIT） and is used to determine the degree of immunity after vaccination against rabies. To compare the difference in RFFIT results between the laboratories of The National Institute of Infectious Disease in Japan （NIID） and the Chinese Centre for Disease Control （CCDC） as well the influence of the choice of standard serum （STD） for the detection, the two laboratories detection methods were simultaneously manipulated by RFFIT. The reference serums used in NIID and the WHO standard serum used in CCDC were compared in the same RFFIT detection to determine the titer of four sera samples C1, Sl, S2 and S4 in parallel, and the titers of the detected sera samples were calculated using the standard formula for neutralizing antibody titer. No significant difference was found in RFFIT methods from the two laboratories and the RFFIT testing procedures of the two laboratories have good consistency. However, different titers were obtained with the tentative internal standard serum （TI-STD） produced by adjusting to 2.0 IU of WHO standard serum in NIID and the WHO STD. The titer determined with the TI-STD was higher than that determined with WHO STD, This difference appears to be significant and requires further investigation
基金Project(51408213)supported by the National Natural Science Foundation of China
文摘A series of compression tests were conducted on 150 groups of cement paste specimens with side lengths ranging from 40 mm to 200 mm. The specimens include cube specimens and prism specimens with height to width ratio of 2. The experiment results show that size effect exists in the cubic compressive strength and prismatic compressive strength of the cement paste, and larger specimens resist less in terms of strength than smaller ones. The cubic compressive strength and the prismatic compressive strength of the specimens with side length of 200 mm are respectively about 91% and 89% of the compressive strength of the specimens with the side length of 40 mm. Water to binder ratio has a significant influence on the size effect of the compressive strengths of the cement paste. With a decrease in the water to binder ratio, the size effect is significantly enhanced. When the water to binder ratio is 0.2, the size effects of the cubic compressive strength and the prismatic compressive strength of the cement paste are 1.6 and 1.4 times stronger than those of a water to binder ratio of 0.6. Furthermore, a series of formulas are proposed to calculate the size effect of the cubic compressive strength and the prismatic compressive strength of cement paste, and the results of the size effect predicted by the formulas are in good agreement with the experiment results.
文摘The research object was high 120 m concrete gravity dam of the Angara Bratsk hydroelectric power plant. The state of the concrete dam is estimated based on the results of continuous supervision performed by site personnel as well as periodic monitoring. According to the classification of the interrelations in the system ＂concrete-environment＂, there were selected some important parts of dams and a comprehensive analysis of concrete was executed on these parts. Concerning the complex research of concrete, a combination of full-scale tests with core-sampling has been proposed. Core samples tests had an object to study the deep concrete layers and to determine the specific indicators such as strength, density, porosity, comparative diameter of capillary pores, CaO content in cement stone and others. Obtained findings and recommended criteria can be applied when selecting technologies for constructing dams that guarantee their durability in the north.
