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化妆品长期人体试用试验安全性评价的现状与挑战
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作者 闫钇岑 李航 田燕 《中华预防医学杂志》 CAS CSCD 北大核心 2023年第12期2220-2223,共4页
化妆品在人群中的使用具有长期性的特点。既往国际上的化妆品不良反应案例提示,对于风险较高的化妆品新原料,人体斑贴试验、短期的人体试用试验可能不足以评估其安全性,而应进行长期的人体试用试验加以评价。故此,本文回顾了影响长期人... 化妆品在人群中的使用具有长期性的特点。既往国际上的化妆品不良反应案例提示,对于风险较高的化妆品新原料,人体斑贴试验、短期的人体试用试验可能不足以评估其安全性,而应进行长期的人体试用试验加以评价。故此,本文回顾了影响长期人体试用试验的关键因素,如使用部位、单次使用量、使用频率、持续使用时间、受试者条件等,从而为标准化的化妆品长期人体试用试验安全性评价规范的撰写提供证据支持。 展开更多
关键词 化妆品 长期 人体试用试验 安全性评价
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新型树脂基制动闸片的装车试用研究 被引量:1
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作者 王海庆 王成国 +3 位作者 庄光山 孙毅 姚永强 郑树伟 《工程塑料应用》 CAS CSCD 北大核心 2010年第4期50-53,共4页
采用新型配方体系制备了列车客车车辆用制动闸片并进行了装车试用试验,测量了闸片的磨耗值和摩擦表面形貌,对制动盘的工作表面状况也进行了观测。结果表明,试制的闸片在使用过程中制动平稳,线磨耗值较低,摩擦工作面良好,对偶制动盘也无... 采用新型配方体系制备了列车客车车辆用制动闸片并进行了装车试用试验,测量了闸片的磨耗值和摩擦表面形貌,对制动盘的工作表面状况也进行了观测。结果表明,试制的闸片在使用过程中制动平稳,线磨耗值较低,摩擦工作面良好,对偶制动盘也无热斑和微裂纹等异常。试制闸片制动性能良好且与制动盘的匹配性佳。 展开更多
关键词 闸片 制动 试用试验
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新型多功能模块化航标灯的试用评估分析
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作者 徐晓菲 施浩亮 《中国水运》 2023年第S01期44-49,共6页
为统一长江干线航道航标灯技术规格,解决现有航标灯产品通用性差、备品配件品种规格繁杂、均衡性差、仓储率高、难以统一管理等问题,2021年底由长江航道局联合各单位、厂家共同研制了一款新型多功能模块化航标灯。为验证新型多功能模块... 为统一长江干线航道航标灯技术规格,解决现有航标灯产品通用性差、备品配件品种规格繁杂、均衡性差、仓储率高、难以统一管理等问题,2021年底由长江航道局联合各单位、厂家共同研制了一款新型多功能模块化航标灯。为验证新型多功能模块化航标灯在长江航道的适应性,从2021年末至2022年初共选取7处长江航道区域局(处)开展了试用试验。本文通过分析长江数字航道综合平台遥测和日常巡航观测方式,对灯器的电气性能、电池容量、遥测遥控功能、视距等参数进行试用评估,由此对新型多功能模块化航标灯在长江航道的可推广性和应用前景进行评价。 展开更多
关键词 新型航标 多光源 模块化 试用试验
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化妆品抗皱功效评价方法 被引量:13
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作者 刘洋 邓影妹 赵华 《日用化学品科学》 CAS 2015年第4期18-21,共4页
介绍了各种抗皱功效评价方法的原理和应用,并对其优缺点进行了简要分析,为合理选择和使用功效评价方法提供参考。
关键词 功效评价 生物化学法 细胞实验法 人体试用试验
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Experimental study of pavement performance of basalt fiber-modified asphalt mixture 被引量:17
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作者 范文孝 康海贵 郑元勋 《Journal of Southeast University(English Edition)》 EI CAS 2010年第4期614-617,共4页
To discuss the pavement performance of basalt fiber-modified asphalt mixtures,the optimum dosages of asphalt and fibers are studied by the Marshall test and the rutting test.The results demonstrate that the optimum do... To discuss the pavement performance of basalt fiber-modified asphalt mixtures,the optimum dosages of asphalt and fibers are studied by the Marshall test and the rutting test.The results demonstrate that the optimum dosages of asphalt and fibers are 4.63% and 0.3%,respectively.Then the pavement performances of basalt(polyester,xylogen)fiber-modified asphalt mixtures are investigated through high temperature stability tests,water stability tests and low temperature crack resistance tests.It indicates that the pavement performances of the fiber-modified asphalt mixtures such as rutting dynamic stability,freezing splitting tensile strength,low temperature crack resistance and so on are improved compared with control asphalt mixture.The results show that the pavement performances of asphalt mixtures can be improved by fiber-modifiers.Besides,the improvement effects of basalt fiber are superior to polyester fiber and xylogen fiber. 展开更多
关键词 asphalt mixture basalt fiber Marshall test high temperature stability test pavement performance
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Research on theory and application of landslide model test 被引量:3
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作者 CHENG Sheng-guo LUO Xian-qi 《Journal of Coal Science & Engineering(China)》 2010年第2期140-143,共4页
In this paper, a theory of landslide model testing and application in Three Gorges reservoir area were introduced.Based on geo-mechanical model tests, the similarity ratio of similar material parameters, component of ... In this paper, a theory of landslide model testing and application in Three Gorges reservoir area were introduced.Based on geo-mechanical model tests, the similarity ratio of similar material parameters, component of similar material and the boundary friction coefficient of the 2D earth landslide model test were derived and stated by theoretical and experimental methods.A model test of the Qianjiangping landslide in Three Gorges reservoir area reveal a two-step trigger mechanism of coexistence between retrogressive landslide and thrust load caused land-slide. 展开更多
关键词 LANDSLIDE model test Three Gorges reservoir area
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Mechanical property of calcareous sand under action of compaction 被引量:4
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作者 JIANG Lu FAN Jianhua +1 位作者 WANG Zhengjin HUO Zhensheng 《Global Geology》 2015年第3期183-187,共5页
Calcareous sand is a kind of special medium which is composed of calcium carbonate and other difficult soluble carbonate substances. Because of its rich in inner pore space and easy crashed,the mechanical property is ... Calcareous sand is a kind of special medium which is composed of calcium carbonate and other difficult soluble carbonate substances. Because of its rich in inner pore space and easy crashed,the mechanical property is very different from conventional quartz sand. Based on the compaction test and direct shear test of calcareous sand,by means of data fitting,the coupling relationship between compaction density and mechanical property under different water contents was obtained; meanwhile,the shear strength expression was built on the basis of the relationship between water content and dry density. 展开更多
关键词 calcareous sand compaction test direct shear test mechanical property
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Chitosan that Dissolves in Hard Water Represses Mutagenicity
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作者 K. Yoshikaw D.M. Shankel 《Journal of Environmental Science and Engineering》 2011年第3期241-246,共6页
Chitosan is derived by deacetylation of chitin, a major component of the shells of crustacea such as crabs and shrimps. In this experiment using the Ames test, there was antimutagenic effect by the water-soluble chito... Chitosan is derived by deacetylation of chitin, a major component of the shells of crustacea such as crabs and shrimps. In this experiment using the Ames test, there was antimutagenic effect by the water-soluble chitosan that dissolved in hard water (CHW). The Ames test was performed using Salmonella typhimurium TA98 and TA100. For the antimutagenic test, and the desmutagenic and bioantimutagenic tests, Trp-P-2, 2AA and AF-2 were used as mutagens. Tests for spontaneous mutation rate without mutagens were performed using S. typhimurium TA98 and TA100. When several concentrations of CHW were directly added to Minimal Glucose Plates, there were no changes in the number of His+ revertants of TA98 and TA100. In desmutagenic and bioantimutagenic tests, the number of His^+ revertants of TA98 and TA100 decreased. In the test for spontaneous mutation rate, the number of His+ revertants of TA98 and TA 100 decreased slightly. When a concentration of CHW was added to examine antimutagenic effects, there was no change in the viable cell count of TA98 and TA100. From these results, AF-2 that is a direct mutagen may combine with CHW, and that may also be carrying out the inactivation. CHW possibly acts directly on the DNA by decreasing the rate at which mutation is caused to the strain's promutagens, Trp-P-2 and 2AA. This is evident from the decreased spontaneous mutation rate without a decreased viable cell count. 展开更多
关键词 CHITOSAN antimutagen anticareinogen CHEMOPREVENTION ames test.
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Accelerated Luminous Depreciation Testing for LED Lighting Products
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作者 钱诚 孙博 曹峻松 《China Standardization》 2014年第5期74-79,共6页
With the application of energy-saving, environmental and durable LED lighting products, the reliability testing has become a pivot point for the large scale industrialization and popularization. The paper briefly intr... With the application of energy-saving, environmental and durable LED lighting products, the reliability testing has become a pivot point for the large scale industrialization and popularization. The paper briefly introduces two methods to be respectively applied in the accelerated depreciatinn lesting for the luminous flex of LED lighting products and the life of outdoor LED-driving power, which can sharply shorten the time for lifetime lest. providing references for the LED lighting products' reliability evaluation. 展开更多
关键词 LED lighting products outdoor LED driving power accelerated attenuation
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美乳类化妆品人体安全性和美乳作用检验方法
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《中国化妆品》 2001年第2期30-31,共2页
1应用范围本方法适用于正常人群试用美乳类化妆品后,对其安全性和美乳作用的检验和评价。 2检验目的通过正常人体试用试验和一系列观察指标,检验和评价受试化妆品引起人体不良反应的可能性以及是否具有样品所宣称的功效作用。
关键词 化妆品 受试者 安全性评价 不良反应 检验方法 乳房体 观察指标 正常人群 正常人体 试用试验
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