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山西定襄地震台SSQ-2I水平摆倾斜仪试记期间资料分析与故障排除 被引量:1
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作者 郭宇 高午原 +3 位作者 刘俊芳 高文玉 刘金柱 宫静芝 《山西地震》 2015年第1期13-16,共4页
介绍了定襄地震台新安装数字化水平摆倾斜仪(SSQ-2I)在试记期间发生的故障及排除方法。并对该仪器观测资料进行了认真分析,对如何识别刮风、气压、雷电、人为等干扰因素总结经验,提高了资料预处理水平。
关键词 水平摆倾斜仪 干扰 试记
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鬼王的试炼——记TeD的巫妖蜘蛛流TR
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《电子竞技》 2009年第5期70-71,共2页
最近新一代鬼王TeD的UD越来越暴力.内战几乎无敌的他在对战其他种族的造诣也越来越高.对战Hum不必多说.有着Sky&lnfi两位世界级的Hum陪练.世界上可以对抗TeD的Hum的其他人类屈指可数——TH000、ToD。对战Orc也不必多说.前段时间Te... 最近新一代鬼王TeD的UD越来越暴力.内战几乎无敌的他在对战其他种族的造诣也越来越高.对战Hum不必多说.有着Sky&lnfi两位世界级的Hum陪练.世界上可以对抗TeD的Hum的其他人类屈指可数——TH000、ToD。对战Orc也不必多说.前段时间TeD就有着打兽最强亡灵之称.虽然近期的TeD打Orc的强势并不是很明显。唯一欠缺的是对抗NE的实力。不过近期的TeD用几次精彩的胜利渐渐克服了这个劣势。 展开更多
关键词 网络游戏 电子游戏 游戏开发 《鬼王的炼——TeD的巫妖蜘蛛流TR》
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Magnetic field properties caused by stress concentration 被引量:14
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作者 黄松岭 李路明 +1 位作者 施克仁 王晓凤 《Journal of Central South University of Technology》 2004年第1期23-26,共4页
Measurements of the effects of tensile stress on magnetic field properties, infrared thermography and (acoustic) emission of a cuboid sample with an elliptical hole in its center were presented. The tensile stress was... Measurements of the effects of tensile stress on magnetic field properties, infrared thermography and (acoustic) emission of a cuboid sample with an elliptical hole in its center were presented. The tensile stress was applied perpendicularly to the sample by electro-tension machine according to a step-loading curve. The changes of the sample temperature was recorded by an infrared thermography system and the noise of domain reversal was inspected by two acoustic probes, which were placed on each end of the sample near the collets of the electro-tension machine, when the sample was in loading process. The magnetic fields on the surface of the sample were inspected with 8 mm lift-off when the loads were held. Valuable information about the changes of domains was obtained from analysis of acoustic emission signals in loading process. Infrared images of the sample provided complementary information about the state of the sample. The results show that stress concentration in ferromagnetic material affects the direction and structure of domain and generates net magnetic moment on its surface. The distribution and magnitude of the net magnetic moment are correlative with those of stress. 展开更多
关键词 magnetic field testing stress concentration THERMOGRAPHY acoustic emission DOMAIN
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Advances in diagnosis, treatment and palliation of pancreatic carcinoma: 1990-2010 被引量:32
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作者 Chakshu Sharma Karim M Eltawil +2 位作者 Paul D Renfrew Mark J Walsh Michele Molinari 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第7期867-897,共31页
Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it ... Several advances in genetics, diagnosis and palliation of pancreatic cancer (PC) have occurred in the last decades. A multidisciplinary approach to this disease is therefore recommended. PC is relatively common as it is the fourth leading cause of cancer related mortality. Most patients present with obstructive jaundice, epigastric or back pain, weight loss and anorexia. Despite improvements in diagnostic modalities, the majority of cases are still detected in advanced stages. The only curative treatment for PC remains surgical resection. No more than 20% of patients are candidates for surgery at the time of diagnosis and survival remains quite poor as adjuvant therapies are not very effective. A small percentage of patients with borderline non-resectable PC might benefit from neo-adjuvant chemoradiation therapy enabling them to undergo resection; however, randomized controlled studies are needed to prove the benefits of this strategy. Patients with unresectable PC benefit from palliative interventions such as biliary decompression and celiac plexus block. Further clinical trials to evaluate new chemo and radiation protocols as well as identification of genetic markers for PC are needed to improve the overall survival of patients affected by PC, as the current overall 5-year survival rate of patients affected by PC is still less than 5%. The aim of this article is to review the most recent high quality literature on this topic. 展开更多
关键词 DIAGNOSIS EPIDEMIOLOGY PALLIATION Pancreatic cancer THERAPY
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Study on EEG power and coherence in patients with mild cognitive impairment during working memory task 被引量:2
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作者 JIANG Zheng-yan(蒋正言) 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2005年第12期1213-1219,共7页
To investigate the features of electroencephalography (EEG) power and coherence at rest and during a working memory task of patients with mild cognitive impairment (MCI). Thirty-five patients (17 males, 18 female... To investigate the features of electroencephalography (EEG) power and coherence at rest and during a working memory task of patients with mild cognitive impairment (MCI). Thirty-five patients (17 males, 18 females; 52-71 years old) and 34 sex- and age-matched controls (17 males, 17 females; 51-63 years old) were recruited in the present study. Mini-Mental State Examination (MMSE) of 35 patients with MCI and 34 normal controls revealed that the scores of MCI patients did not differ significantly from those of normal controls (P〉0.05). Then, EEGs at rest and during working memory task with three levels of working memory load were recorded. The EEG power was computed over 10 channels: fight and left frontal (F3, F4), central (C3, C4), parietal (P3, P4), temporal (T5, T6) and occipital (O1, O2); inter-hemispheric coherences were computed from five electrode pairs of F3-F4, C3-C4, P3-P4, T5-T6 and O1-O2 for delta (1.0-3.5 Hz), theta (4.0-7.5 Hz), alpha-1 (8.0-10.0 Hz), alpha-2 (10.5-13.0 Hz), beta-1 (13.5-18.0 Hz) and beta-2 (18.5-30.0 Hz) frequency bands. All values of the EEG power of MCI patients were found to be higher than those of normal controls at rest and during working memory tasks. Furthermore, the values of EEG power in the theta, alpha-1, alpha-2 and beta-1 bands of patients with MCI were significantly high (P〈0.05) in comparison with those of normal controls. Correlation analysis indicated a significant negative correlation between the EEG powers and MMSE scores. In addition, during working memory tasks, the EEG coherences in all bands were significantly higher in the MCI group in comparison with those in the control group (P〈0.05). However, there was no significant difference in EEG coherences between two groups at rest. These findings comprise evidence that MCI patients have higher EEG power at rest, and higher EEG power and coherence during working conditions. It suggests that MCI may be associated with compensatory processes at rest and during working memory tasks. Moreover, failure of normal cortical connections may be exist in MCI patients. 展开更多
关键词 Mild cognitive impairment (MCI) Electroencephalography (EEG) Spectral power COHERENCE Working memory
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Possibilities for Increasing Sunflower Resistance to Broomrape ( Orobanche cumana Wallr.)
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作者 D. Skoric M. Pacureanu-Joita 《Journal of Agricultural Science and Technology(B)》 2011年第2期151-162,共12页
Broomrape causes economic damage in sunflower production in many countries worldwide, but especially in Central and Eastern Europe, Spain, Turkey, Israel, Iran, Kazakhstan, and China. Sunflower selection for broomrape... Broomrape causes economic damage in sunflower production in many countries worldwide, but especially in Central and Eastern Europe, Spain, Turkey, Israel, Iran, Kazakhstan, and China. Sunflower selection for broomrape resistance uses different methods for testing breeding materials, looks for resistance sources in certain wild species of the genus Helianthus, and has so far produced significant results. Dominant genes for resistance to races A, B, C, D, E and F have been found and incorporated into cultivated sunflower genotypes. In the last two to three years, new broomrape populations have been discovered in several countries. None of the existing commercial hybrids resistant to races A, B, C, D, E and F have proven resistant to these new populations. Greenhouse testing conducted by the Fundulea Institute in Romania in 2009 has managed to identify two restorer lines that are resistant to all the new populations and can be used directly in developing hybrids. Sunflower breeders and geneticists have achieved significant results in the use of molecular markers for identifying new broomrape races. Marker-assisted selection should be used even more in the future search for Orobanche resistance. Broomrape can also be managed by the development of IMl-resistant hybrids or by using biological control. 展开更多
关键词 BREEDING BROOMRAPE molecular markers RACES RESISTANCE sunflower.
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Correlation of microstructural and corrosion characteristics of quaternary shape memory alloys Cu-Al-Ni-X(X=Mn or Ti) 被引量:3
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作者 S.N.SAUD E.HAMZAH +1 位作者 T.ABUBAKAR H.R.BAKHSHESHI-RAD 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2015年第4期1158-1170,共13页
The effects of different contents(0.4%, 0.7%, and 1.0%, mass fraction) of Mn or Ti additions on the micro structure, shape memory effect and the corrosion behaviour of Cu-Al-Ni shape memory alloys were studied by fiel... The effects of different contents(0.4%, 0.7%, and 1.0%, mass fraction) of Mn or Ti additions on the micro structure, shape memory effect and the corrosion behaviour of Cu-Al-Ni shape memory alloys were studied by field emission scanning electron microscopy, transmission electron microscopy, X-ray diffraction, differential scanning calorimetry and electrochemical and immersion tests in NaCl solution. It was observed that the microstructure, shape memory effect and corrosion characteristics are highly sensitive to the composition variations. It was found that the highest strain recovery was with 0.7% addition of Mn or Ti. This may be attributed to the presence of precipitation with a high volume fraction and the grain refinement. The electrochemical test showed that the formation of oxide layers in both Cu-Al-Ni-Mn and Cu-Al-Ni-Ti shape memory alloys(SMAs) provided good passivation which enhanced the corrosion resistance of the alloys. Immersion test showed that in Cu-Al-Ni-Mn SMAs, pitting corrosion occurred through feebleness in the oxide layer. A corrosion product adjacent to the pits was rich in Al/Mn oxide and depleted in Cu while inside of the pit it was rich in Cu. In Cu-Al-Ni-Ti SMAs, localized corrosion occurred on the surface of the specimens and dealuminization attack was also observed in the matrix. 展开更多
关键词 Cu-Al-Ni alloy shape memory effect electrochemical test alloying addition microstructure
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Test Calibration of the Paleoclimatic Proxy Data with Chinese Historical Records
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作者 De'er Zhang 《Advances in Climate Change Research》 SCIE 2011年第1期38-42,共5页
The calibration of paleoclimate proxies is one of the key problems in the study of paleoclimate at present. Historical documentary records of climate are suitable for calibration on dating and the climatic implication... The calibration of paleoclimate proxies is one of the key problems in the study of paleoclimate at present. Historical documentary records of climate are suitable for calibration on dating and the climatic implication of the proxy data in a climatological sense. A test calibration on correcting the Delingha tree ring precipitation series using Chinese historical documentary records shows that among the 44 extreme dry cases in 1401 1950 AD, 42 cases (or 95.5%) are believable. Thus the long series of Delingha rings-denoted precipitation is highly reliable. Another test to validate the monsoon intensity proxy data based on the Zhanjiang Huguangyan sediments using historical records indicates that the years of Lake Maar Ti content series-designated winter monsoon intensities are entirely opposite to historical documents- depicted years of harsh winters in 800-900 AD. As a result, serious doubt is raised about the climatic implication of this paleo-monsoon proxy series. 展开更多
关键词 proxy data calibration PALEOCLIMATE historical documentary records of climate
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TENSILE TEST AND PHYSICAL MODEL OF NiTi SHAPE MEMORY ALLOY 被引量:1
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作者 HUZi-li WANGXin-wei XIONGKe 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2004年第4期267-271,共5页
The tensile stress-strain curves of NiTi wires are obtained by tensile experiments under different heat treatments. A phenomenological physical model based on hysteresis element method is developed to describe the exp... The tensile stress-strain curves of NiTi wires are obtained by tensile experiments under different heat treatments. A phenomenological physical model based on hysteresis element method is developed to describe the experimentally determined stress-strain curves of shape memory alloy (SMA) wires. Numerical simulations are made. Simulation results show that:(1) a series of unusual changes on physical and mechanical properties of SMA wires occur when martensitic, especially R (rhombohedral) phase transformation emerge. The stress-strain relation of SMA wires is highly non-linear; (2) there are no notable yielding phenomena before NiTi wires are broken; (3) numerical results obtained by the physical model are in good agreement with experimental data. 展开更多
关键词 SMA tensile test physical model numerical simulation constitutive relation
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Comparison of the unlabeled and labeled pre-mRNA splicing assays in vitro
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作者 TIAN XU BU JING XIN HONG +1 位作者 ZHI YAO JIE YANG 《Journal of Microbiology and Immunology》 2006年第4期313-317,共5页
Pre-mRNA splicing is a fundamental process required for the expression of most metazoan genes. It is carried out by the spliceosome that catalyzes the removal of non-coding intron sequences to ligate exons into mature... Pre-mRNA splicing is a fundamental process required for the expression of most metazoan genes. It is carried out by the spliceosome that catalyzes the removal of non-coding intron sequences to ligate exons into mature mRNA prior to transport and translation. The purpose of our study is to explore whether the in vitro unlabeled pre-mRNA splicing assay could be performed as an alternative method of splicing reaction other than the radiolabeled one. Two different splicing methods in vitro, 32p labeled and unlabeled pre-mRNA as the substrates in the reaction, were investigated. The radiolabeled products were visualized by autoradiography while the unlabeled products were observed by Ethidium Bromide (EB) staining. As a result, although there are more unspecific bands in the EB staining assay than 32p labeled one, the RNA products of in vitro splicing could be observed clearly. This suggests that the unlabeled pre-mRNA splicing assay can be an optional substitution for the isotope-labeled assay. 展开更多
关键词 Pre-mRNA splicing Spliceoseme Ethidiurn Bromide staining Autoradiography
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Fatigue damage evaluation by metal magnetic memory testing 被引量:5
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作者 王慧鹏 董丽虹 +1 位作者 董世运 徐滨士 《Journal of Central South University》 SCIE EI CAS 2014年第1期65-70,共6页
Tension-compression fatigue test was performed on 0.45% C steel specimens.Normal and tangential components of magnetic memory testing signals,Hp(y) and Hp(x) signals,with their characteristics,K of Hp(y) and Hp(x)M of... Tension-compression fatigue test was performed on 0.45% C steel specimens.Normal and tangential components of magnetic memory testing signals,Hp(y) and Hp(x) signals,with their characteristics,K of Hp(y) and Hp(x)M of Hp(x),throughout the fatigue process were presented and analyzed.Abnormal peaks of Hp(y) and peak of Hp(x) reversed after loading; Hp(y) curves rotated clockwise and Hp(x) curves elevated significantly with the increase of fatigue cycle number at the first a few fatigue cycles,both Hp(y) and Hp(x) curves were stable after that,the amplitude of abnormal peaks of Hp(y) and peak value of Hp(x) increased more quickly after fatigue crack initiation.Abnormal peaks of Hp(y) and peak of Hp(x) at the notch reversed again after failure.The characteristics were found to exhibit consistent tendency in the whole fatigue life and behave differently in different stages of fatigue.In initial and crack developing stages,the characteristics increased significantly due to dislocations increase and crack propagation,respectively.In stable stage,the characteristics remained constant as a result of dislocation blocking,K value ranged from 20 to 30 A/(m·mm)-1,and Hp(x)M ranged from 270 to 300 A/m under the test parameters in this work.After failure,both abnormal peaks of Hp(y) and peak of Hp(x) reversed,K value was 133 A/(m·mm)-1 and Hp(x)M was-640 A/m.The results indicate that the characteristics of Hp(y) and Hp(x) signals were related to the accumulation of fatigue,so it is feasible and applicable to monitor fatigue damage of ferromagnetic components using metal magnetic memory testing(MMMT). 展开更多
关键词 metal magnetic memory testing MMMT signal tension-compression fatigue test feature extraction
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Screening Method for Transgenic Maize with Kanamycin Resistance 被引量:2
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作者 LU Meng-yu DONG Fu-shuang ZHANG Jun-min WANG Hai-bo 《Agricultural Science & Technology》 CAS 2011年第7期954-957,共4页
[Objective]The paper was to establish simple and effective method to screen marker gene in maize with kanamycin resistance.[Method]Using inbred line "Chang 7-2" and hybrid "Zhengdan 958" of maize a... [Objective]The paper was to establish simple and effective method to screen marker gene in maize with kanamycin resistance.[Method]Using inbred line "Chang 7-2" and hybrid "Zhengdan 958" of maize as test materials,their seeds were soaked with different concentrations and volumes of kanamycin for3 and 4 d,respectively,the rate of albino seedlings and average seedling height after sowing for10 d were investigated.[Result]The rate of albino seedlings not only was related to kanamycin concentration,but also had relationship with solution volume during soaking process.The difference between inbred line and hybrid was no significant.When 100 ml of kanamycin solution with concentration of 200 mg/L was used to soak seeds for 3 d,the rate of albino seedlings basically could reach 100%.When 100 ml of kanamycin solution with concentration of 100 mg/L was used to soak 20 seeds for 3 d to carry out resistance screening,the accuracy was up to 84.8% after verifying the screening test of T1 transgenic maize plants.[Conclusion]The method was feasible,which could be used as a simple method for screening transgenic gene maize with kanamycin resistance. 展开更多
关键词 Transgenic maize KANAMYCIN Screening method
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MEXIR: An Implementation of High Performance and High Precision on XML Retrieval
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作者 Tanakom Wichaiwong Chuleerat Jaruskulchai 《Computer Technology and Application》 2011年第4期301-310,共10页
Traditional information retrieval systems respond to user queries with ranked lists of relevant documents. Since, XML (Extensible Markup Language) documents separate content and structure; XML-IR (information retri... Traditional information retrieval systems respond to user queries with ranked lists of relevant documents. Since, XML (Extensible Markup Language) documents separate content and structure; XML-IR (information retrieval) systems are able to retrieve only the relevant portions of documents. Therefore, users who utilize an XML-IR system could potentially receive highly relevant and precise material. We have developed the XML information retrieval system by using MySQL and Sphinx, which we call MEXIR. In our system, XML documents are stored into one table that has fixed relational schema. The schema is independent of the logical structure of XML documents. Each node in XML documents is represented by labels that express the positions in XML tree, namely ADXPI scheme. Our system has performance experiments on INEX collections and shown an average up to four seconds better than GPX. In addition, it has been reduced the size of the data down by 82.29 % compare to GPX system. 展开更多
关键词 XML retrieval information retrieval ranking strategies indexing units.
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A Database Querying Language for Formulating Relational Queries on Small Devices
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作者 Ahmad Rohiza Abdul-Kareem Sameem 《Computer Technology and Application》 2011年第3期172-181,共10页
For small devices like the PDAs and mobile phones, formulation of relational database queries is not as simple as using conventional devices such as the personal computers and laptops. Due to the restricted size and r... For small devices like the PDAs and mobile phones, formulation of relational database queries is not as simple as using conventional devices such as the personal computers and laptops. Due to the restricted size and resources of these smaller devices, current works mostly limit the queries that can be posed by users by having them predetermined by the developers. This limits the capability of these devices in supporting robust queries. Hence, this paper proposes a universal relation based database querying language which is targeted for small devices. The language allows formulation of relational database queries that uses minimal query terms. The formulation of the language and its structure will be described and usability test results will be presented to support the effectiveness of the language. 展开更多
关键词 DATABASE query language relational queries small devices.
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Effects of neurofeedback on the short-term memory and continuous attention of patients with moderate traumatic brain injury: A preliminary randomized controlled clinical trial 被引量:1
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作者 Reza Rostami Payman Salamati +9 位作者 Kourosh Karimi Yarandi Alireza Khoshnevisan Soheil Saadat Zeynab Sadat Kamali Somaie Ghiasi Atefeh Zaryabi Seyed Shahab Ghazi Mir Saeid Mehdi Arjipour Mohammad Saeid Rezaee-Zavareh Vafa Rahimi-Movaghar 《Chinese Journal of Traumatology》 CAS CSCD 2017年第5期278-282,共5页
Purpose: There are some studies which showed neurofeedback therapy (NET) can be effective in clients with traumatic brain injury (TBI) history. However, randomized controlled clinical trials are still needed for ... Purpose: There are some studies which showed neurofeedback therapy (NET) can be effective in clients with traumatic brain injury (TBI) history. However, randomized controlled clinical trials are still needed for evaluation of this treatment as a standard option. This preliminary study was aimed to evaluate the effect of NET on continuous attention (CA) and short-term memory (STM) of clients with moderate TBI using a randomized controlled clinical trial (RCT). Methods: In this preliminary RCT, seventeen eligible patients with moderate TBl were randomly allo- cated in two intervention and control groups. All the patients were evaluated for CA and STM using the visual continuous attention test and Wechsler memory scale-4th edition (WMS-IV) test, respectively, both at the time of inclusion to the project and four weeks later. The intervention group participated in 20 sessions of NFT through the first four weeks. Conversely, the control group participated in the same NF sessions from the fifth week to eighth week of the project. Results: Eight subjects in the intervention group and five subjects in the control group completed the study. The mean and standard deviation of participants' age were (26.75 ~ 15.16) years and (2Z60 +_ 8.17) years in experiment and control groups, respectively. All of the subjects were male. No significant improvement was observed in any variables of the visual continuous attention test and WMS-IV test between two groups (p _~ 0.05). Conclusion: Based on our literature review, it seems that our study is the only study performed on the effect of NET on TBl patients with control group. NET has no effect on CA and STM in patients with moderate TBI. More RCTs with large sample sizes, more sessions of treatment, longer time of follow-up and different orotocols are recommended. 展开更多
关键词 Neurofeedback Brain injuries Attention Short-term memory
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Designing a SCAR molecular marker for monitoring Trichoderma cf. harzianum in experimental communities
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作者 Gabriel PéREZ Valentina VERDEJO +2 位作者 Clarissa GONDIM-PORTO Julieta ORLANDO Margarita CARú 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 SCIE CAS CSCD 2014年第11期966-978,共13页
Several species of the fungal genus Trichoderma establish biological interactions with various micro- and macro-organisms. Some of these interactions are relevant in ecological terms and in biotechnological applicatio... Several species of the fungal genus Trichoderma establish biological interactions with various micro- and macro-organisms. Some of these interactions are relevant in ecological terms and in biotechnological applications, such as biocontrol, where Trichoderma could be considered as an invasive species that colonizes a recipient community. The success of this invasion depends on multiple factors, which can be assayed using experimental communities as study models. Therefore, the aim of this work is to develop a species-specific sequence-characterized amplified region (SCAR) marker to monitor the colonization and growth of T. cf. harzianum when it invades experi- mental communities. For this study, 16 randomly amplified polymorphic DNA (RAPD) primers of 10-mer were used to generate polymorphic patterns, one of which generated a band present only in strains of T. cf. harzianum. This band was cloned, sequenced, and five primers of 20-23 mer were designed. Primer pairs 2F2/2R2 and 2F2/2R3 successfully and specifically amplified fragments of 278 and 448 bp from the T. cf. harzianum BpT10a strain DNA, respectively. Both primer pairs were also tested against the DNA from 14 strains of T. cf. harzianum and several strains of different fungal genera as specificity controls. Only the DNA from the strains of T. cf. hat-zianum was successfully amplified. Moreover, primer pair 2F2/2R2 was assessed by quantitative real-time polymerase chain reaction (PCR) using fungal DNA mixtures and DNA extracted from fungal experimental communities as templates. T. cf. harzianum was detectable even when as few as 100 copies of the SCAR marker were available or even when its population represented only 0.1% of the whole community. 展开更多
关键词 Tnchoderma cf. harzianum Sequence-characterized amplified region (SCAR) Molecular marker Experimental fungal communities
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A systematic study of the determinants of protein abundance memory in cell lineage 被引量:1
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作者 Zongmao Gao Haoyuan Sun +2 位作者 Shanshan Qin Xiaojing Yang Chao Tang 《Science Bulletin》 SCIE EI CSCD 2018年第16期1051-1058,共8页
Proteins are essential players of life activities, lntraceUular protein levels directly affect cellular functions and cell fate. Upon cell division, the proteins in the mother cell are inherited by the daughters. Howe... Proteins are essential players of life activities, lntraceUular protein levels directly affect cellular functions and cell fate. Upon cell division, the proteins in the mother cell are inherited by the daughters. However, what factors and by how much they affect this epigenetic inheritance of protein abundance remains unclear. Using both computational and experimental approaches, we systematically investigated this problem. We derived an analytical expression for the dependence of protein inheritance on various factors and showed that it agreed with numerical simulations of protein production and experimental results. Our work provides a framework for quantitative studies of protein inheritance and for the potential application of protein memory manipulation. 展开更多
关键词 Protein abundance memory Intrinsic noise Extrinsic noise Epigenetic inheritance Cell lineage
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