Aim: To test the hypothesis whether the administration of cytostatic drugs close to surgery in children with malignancies influences the rate of postoperative complications. Method: Included in the study were 27 child...Aim: To test the hypothesis whether the administration of cytostatic drugs close to surgery in children with malignancies influences the rate of postoperative complications. Method: Included in the study were 27 children with malignancies and a control group of 27 neurologically impaired children. All the children had nutritional problems and underwent a video- assisted gastrostomy (VAG) operation during the period 1997- 2002. The children were postoperatively followed up. All complications were documented according to a protocol by a specially trained nurse and correlated to the time elapsed from completion of the last preoperative or the first postoperative cytostatic drug treatment. The complications in the two groups were compared. Results: The children with malignant diseases did not have more postoperative complications of the VAG than those having neurological defects. There was no correlation to complications regarding timing of the operation and administration of cytostatic drugs. Conclusion: This study revealed no aggravated influence of cytostatic drug treatment on early postoperative problems of VAG. The timing of cytostatic drug administration in relation to the surgical intervention did not influence the frequency of postoperative complications.展开更多
Background: In GERD patients, ineffective esophageal motility(IEM), a hypocont ractile disorder, is the most common motor abnormality. IEM has been associated with reflux in both the supine and upright position, prolo...Background: In GERD patients, ineffective esophageal motility(IEM), a hypocont ractile disorder, is the most common motor abnormality. IEM has been associated with reflux in both the supine and upright position, prolonged esophageal cleara nce,and delayed of bolus transport. IEM has been equally present in erosive and in nonerosive GERD. Goal: Considering that reflux has been found to be more seve re in erosive GERD than in nonerosive GERD patients and that IEM delays esophage al clearance, our hypothesis is that patients with erosive GERD have more severe IEM than those with nonerosive disease.Study: A retrospective review of consecu tive manometries of patients with the chief complaint of heartburn and a diagnos is of IEM were performed, and patients with both erosive and nonerosive GERD wer e selected. According to the number of ineffective contractions, IEM was stratif ied into three groups:30%to 40%, mild; 50%to 60%, moderate; and greater than 60%, severe. We also registered the number of low amplitude,failed, and normal waves in each manometry of both groups.We evaluated 110 patients: 70 (64%) wit h erosive GERD and 40 (36%)with nonerosive GERD. The percentage of mild,moderat e and severe IEM was similar in erosive and in nonerosive GERD patients, as well the number of low amplitude, failed or normal waves (P< 0.5). Conclusion: There were no differences between the severity of IEM in erosive and in nonerosive GE RD patients.展开更多
文摘Aim: To test the hypothesis whether the administration of cytostatic drugs close to surgery in children with malignancies influences the rate of postoperative complications. Method: Included in the study were 27 children with malignancies and a control group of 27 neurologically impaired children. All the children had nutritional problems and underwent a video- assisted gastrostomy (VAG) operation during the period 1997- 2002. The children were postoperatively followed up. All complications were documented according to a protocol by a specially trained nurse and correlated to the time elapsed from completion of the last preoperative or the first postoperative cytostatic drug treatment. The complications in the two groups were compared. Results: The children with malignant diseases did not have more postoperative complications of the VAG than those having neurological defects. There was no correlation to complications regarding timing of the operation and administration of cytostatic drugs. Conclusion: This study revealed no aggravated influence of cytostatic drug treatment on early postoperative problems of VAG. The timing of cytostatic drug administration in relation to the surgical intervention did not influence the frequency of postoperative complications.
文摘Background: In GERD patients, ineffective esophageal motility(IEM), a hypocont ractile disorder, is the most common motor abnormality. IEM has been associated with reflux in both the supine and upright position, prolonged esophageal cleara nce,and delayed of bolus transport. IEM has been equally present in erosive and in nonerosive GERD. Goal: Considering that reflux has been found to be more seve re in erosive GERD than in nonerosive GERD patients and that IEM delays esophage al clearance, our hypothesis is that patients with erosive GERD have more severe IEM than those with nonerosive disease.Study: A retrospective review of consecu tive manometries of patients with the chief complaint of heartburn and a diagnos is of IEM were performed, and patients with both erosive and nonerosive GERD wer e selected. According to the number of ineffective contractions, IEM was stratif ied into three groups:30%to 40%, mild; 50%to 60%, moderate; and greater than 60%, severe. We also registered the number of low amplitude,failed, and normal waves in each manometry of both groups.We evaluated 110 patients: 70 (64%) wit h erosive GERD and 40 (36%)with nonerosive GERD. The percentage of mild,moderat e and severe IEM was similar in erosive and in nonerosive GERD patients, as well the number of low amplitude, failed or normal waves (P< 0.5). Conclusion: There were no differences between the severity of IEM in erosive and in nonerosive GE RD patients.
