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高强度聚焦超声热疗联合消积止痛散对胰腺癌患血清血管内皮生长因子的影响及意义
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作者 葛信国 王缨 史兵伟 《中国临床康复》 CSCD 北大核心 2006年第15期82-84,共3页
目的:观察高强度聚焦超声热疗联合中药消积止痛散对胰腺癌患者血管内皮生长因子的影响。方法:纳入2001-01/2004-12常州中医院、常州第一人民医院肿瘤科门诊或入院胰腺癌患者61例,男42例,女19例;随机分为观察组31例和对照组30例。观察组... 目的:观察高强度聚焦超声热疗联合中药消积止痛散对胰腺癌患者血管内皮生长因子的影响。方法:纳入2001-01/2004-12常州中医院、常州第一人民医院肿瘤科门诊或入院胰腺癌患者61例,男42例,女19例;随机分为观察组31例和对照组30例。观察组采用高强度聚焦超声热疗联合中药消积止痛散治疗(中药消积止痛散为天江制药厂提供的配方颗粒,由全蝎0.5g,蛇六谷3.0g,仙鹤草2.0g,土鳖虫1.0g,粉防己0.5g组成)。热疗两次治疗间隔48h以上。每例患者接受3~12次高强度聚焦超声热疗治疗,平均6次;配合服用消积止痛散3.5g/次,2次/d,28d为1周期,连用两周期。对照组30例采用吉西他滨(商品名泽菲,江苏豪森药业股份有限公司生产,批号:040902,1.0g/支,粉针剂)化疗,吉西他滨1.0g/m2(第1,8,15天)或1.0g/m2(第1,8天)加5-FU350mg/m2(第1~5天),每4周重复1次,至少两个周期。采用双抗体夹心ELISA法测定两组患者治疗前后血清血管内皮生长因子的含量,并比较变化。结果:参与观察的胰腺癌患者61例全部进入结果分析。①观察组和对照组治疗前血清血管内皮生长因子含量比较,差异无显著性意义[(531.99±561.67),(491.07±483.68)ng/L;t=0.30,P>0.05]。②治疗后,观察组血清血管内皮生长因子含量较治疗前明显降低,差异有显著性意义[(285.40±323.13)ng/L,t=2.12,P<0.05],对照组较治疗前略上升,但差异无显著性意义[(285.40±323.13)ng/L,t=0.41,P>0.05]。③治疗后观察组血清血管内皮生长因子含量较对照组明显降低,差异有显著性意义(t=2.55,P<0.05)。结论:与吉西他滨化疗比较,高强度聚焦超声热疗联合中药消积止痛散治疗胰腺癌可明显降低患者血清血管内皮生长因子水平。 展开更多
关键词 高温 诱发/方法 肿瘤/治疗 复方合剂 血管内皮生长因子类/代谢 胰腺肿瘤
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周剂量奈达铂同步放疗联合体外高频热疗治疗局部晚期食管癌的疗效 被引量:1
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作者 刘丽华 蔡君东 +3 位作者 刘艳琴 郑玉妹 丁柏英 李晓东 《医学临床研究》 CAS 2017年第8期1643-1645,共3页
【目的】探讨奈达铂同步放疗联合体外高频热疗治疗局部晚期食管癌的临床疗效。【方法】本院收治的75例局部晚期食管癌患者随机分为放化疗标准组(A组)、放化疗试验纽(B纽)、放化热疗试验组(C组),每组25例,比较三组患者的近期疗... 【目的】探讨奈达铂同步放疗联合体外高频热疗治疗局部晚期食管癌的临床疗效。【方法】本院收治的75例局部晚期食管癌患者随机分为放化疗标准组(A组)、放化疗试验纽(B纽)、放化热疗试验组(C组),每组25例,比较三组患者的近期疗效、早期毒副反应和1年生存率。【结果】A组总有效率为60.0%(15/25),B组为64.0%(16/25),两组比较差异无显著性显著(P〉0.05),但均低于C组的88.0%(22/25),且差异有显著性(P〈0.01)。三组患者放射性食管炎总发生率及白细胞下降率比较差异均无显著性(P〉0.05);A组放射性气管炎和胃肠道反应总发生率高于B组(P〈0.05),A,B两组均高于c组,且差异有显著性(P〈0.01)。1年生存率A组(48.0%)与B组(56.0%)均低于C组(84.0%);1年后的KPS评分比较:A组分别低于其他两组,B组低于A组,且各组之间比较差异均有显著性(P〈0.05)。【结论】采用周剂量奈达铂同步放疗联合体外高频热疗治疗局部晚期食管癌的临床效果确切,能有效提高患者的生存率,同时可减轻不良毒副反应的发生;采用奈达铂相比顺铂效果无显著差异,但毒副反应更小,临床建议使用奈达铂化疗,患者依从性更高。 展开更多
关键词 有机铂化合物/投药和剂量 食管肿瘤/药物疗法 食管肿瘤/放射疗法 高温 诱发/方法 存活率
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Dynamic assessment of rainfall-induced shallow landslide hazard 被引量:4
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作者 TANG Yang YIN Kun-long +2 位作者 LIU Lei ZHANG Ling FU Xiao-lin 《Journal of Mountain Science》 SCIE CSCD 2017年第7期1292-1302,共11页
The assessment of rainfall-induced shallow landslide hazards is a significant issue in the Three Gorges Reservoir area in China due to the rapid development of land in the past two decades. In this study, a probabilis... The assessment of rainfall-induced shallow landslide hazards is a significant issue in the Three Gorges Reservoir area in China due to the rapid development of land in the past two decades. In this study, a probabilistic analysis method that combines TRIGRS and the point-estimate method for evaluating the hazards of shallow landslides have been proposed under the condition of rainfall over a large area. TRIGRS provides the transient infiltration model to analyze the pore water pressure during a rainfall. The point-estimate method is used to analyze the uncertainty of the soil parameters, which is performed in the geographic information system(GIS). In this paper, we use this method to evaluate the hazards of shallow landslides in Badong County,Three Gorges Reservoir, under two different types of rainfall intensity, and the results are compared with the field investigation. The results showed that the distribution of the hazard map is consistent with the observed landslides. To some extent, the distributionof the hazard map reflects the spatial and temporal distribution of the shallow landslide caused by rainfall. 展开更多
关键词 Shallow landslide TRIGRS Point-estimate method RAINFALL Hazard assessment
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Single Trial Detection of Visual Evoked Potential by Using EMD and Wavelet Filtering Method
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作者 HE Ke-ren ZOU Ling +2 位作者 TAO Cai-lin MA Zheng-hua ZHOU Tian-tong 《Chinese Journal of Biomedical Engineering(English Edition)》 2011年第3期115-118,124,共5页
Empirical mode decomposition(EMD) is a new signal decomposition method, which could decompose the non-stationary signal into several single-component intrinsic mode functions (IMFs) and each IMF has some physical mean... Empirical mode decomposition(EMD) is a new signal decomposition method, which could decompose the non-stationary signal into several single-component intrinsic mode functions (IMFs) and each IMF has some physical meanings. This paper studies the single trial extraction of visual evoked potential by combining EMD and wavelet threshold filter. Experimental results showed that the EMD based method can separate the noise out of the event related potentials (ERPs) and effectively extract the weak ERPs in strong background noise, which manifested as the waveform characteristics and root mean square error (RMSE). 展开更多
关键词 EMD wavelet threshold ERP single trial extraction
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光动力疗法与经瞳孔温热疗法治疗孤立型脉络膜血管瘤的疗效观察 被引量:2
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作者 宋艳萍 徐东强 +3 位作者 丁琴 赵霞 朱丽 黄志坚 《中华眼底病杂志》 CAS CSCD 北大核心 2009年第4期279-282,共4页
目的观察经瞳孔温热疗法(TTT)和光动力疗法(PDT)治疗孤立型脉络膜血管瘤(CCH)的疗效。方法回顾性分析经眼底检查、荧光素眼底血管造影(FFA)、吲哚青绿血管造影(ICGA)、光相干断层扫描(OCT)、眼部B型超声检查确诊为CCH的患... 目的观察经瞳孔温热疗法(TTT)和光动力疗法(PDT)治疗孤立型脉络膜血管瘤(CCH)的疗效。方法回顾性分析经眼底检查、荧光素眼底血管造影(FFA)、吲哚青绿血管造影(ICGA)、光相干断层扫描(OCT)、眼部B型超声检查确诊为CCH的患者32例33只眼的临床资料。所选病例治疗前最佳矫正视力为指数/眼前~0.2,瘤体大小2~10个视盘直径(DD),均有浆液性视网膜脱离。其中21例22只眼CCH位于除乳斑束及黄斑拱环内区域外的后极部采用经瞳孔温热疗法(TTT)治疗。使用Iris810nm半导体红外激光,能量700~1200mw,时间60S,光斑1~3个不等;11例11只眼CCH位于乳斑束及黄斑拱环以内区域的PDT治疗。经静脉注射维速达尔15min后采用689nm波长半导体激光对病灶进行照射83~123S。随访时间12~48个月,平均随访时间为25.6个月。治疗后复查视力、间接检眼镜、彩色眼底照像、FFA、ICGA、OCT和B型超声波检查,观察其疗效。结果TTT治疗22只眼中,15只眼视力提高,7只眼视力稳定,眼底检查见视网膜平复,瘤体呈灰白色机化瘢痕,造影显示病灶无荧光渗漏,晚期机化瘢痕处呈荧光染色。OCT检查显示22只眼视网膜神经上皮脱离消失,视网膜下积液完全吸收,其瘤体部脉络膜光带反射增强,瘢痕形成;B型超声检查显示22只眼无视网膜脱离,瘤体萎缩。PDT治疗11只眼中9只眼视力提高,2只眼视力稳定,眼底检查见瘤体萎缩,色素沉着,造影显示荧光渗漏消失;OCT显示视网膜下液完全吸收,B型超声检查11只眼瘤体萎缩。结论TTT与PDT治疗CCH有效但适用部位有所不同。两种方法均可使瘤体萎缩,稳定或提高患者的视力。 展开更多
关键词 血管瘤/治疗 高温 诱发/方法 光化学疗法/方法 治疗效果
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经瞳孔温热疗法治疗渗出型老年性黄斑变性合并中心凹下脉络膜新生血管 被引量:1
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作者 杨蕾 忽俊 +2 位作者 秦洁 赵婕 严良 《中华眼底病杂志》 CAS CSCD 北大核心 2009年第4期283-286,共4页
目的观察经瞳孔温热疗法(TTT)治疗渗出型老年性黄斑变性(AMD)合并中心凹下脉络膜新生血管(CNV)的疗效。方法回顾分析经TTT治疗的渗出型AMD患者41例44只眼的临床资料。所有患者均经荧光素眼底血管造影(FFA)检查确诊。其中,隐匿... 目的观察经瞳孔温热疗法(TTT)治疗渗出型老年性黄斑变性(AMD)合并中心凹下脉络膜新生血管(CNV)的疗效。方法回顾分析经TTT治疗的渗出型AMD患者41例44只眼的临床资料。所有患者均经荧光素眼底血管造影(FFA)检查确诊。其中,隐匿性CNV24例26只眼,典型性CNV12例12只眼,微小典型性CNV5例5只眼。采用810nm导体激光进行TTT治疗。根据病灶大小选择光斑直径范围1.0~3.00mm,能量范围160~400mW,时间60S。治疗次数1~3次,平均治疗1.8次,治疗后随访3~24个月,平均随访10.80个月。末次随访者40例42只眼。分别以治疗后1、3个月及末次随访时视力、眼底、FFA及光相干断层扫描(OCT)检查结果作为患眼视功能及病灶变化的观察指标,对比观察治疗前后视力改变、眼底出血渗出吸收、CNV闭合情况。结果末次随访的42只眼中,视力不变或提高者35只眼,占83.34%;视力较治疗前减退者7只眼,占16.67%。OCT检查显示,治疗后1、3个月和末次随访时黄斑区渗液者减少率分别为79.50%、86.40%和88.10%。治疗后3个月,所有患眼黄斑容积较治疗前显著减少,差异有统计学意义(t=1.96,P一0.01);但治疗后1个月和末次随访时黄斑容积较治疗前相比,差异无统计学意义(t=1.17,0.92;P=0.19,0.83)。FFA检查显示,末次随访时隐匿性、典型性和微小典型性CNV的闭合率分别为79.16%、46.15%和60.00%。仅6只眼渗漏较治疗前增加,其中,典型性CNV5只眼,微小典型性CNV1只眼。结论TTT治疗渗出型AMD合并典型性、隐匿型及微小典型性CNV均有一定效果。 展开更多
关键词 黄斑变性/治疗 脉络膜新生血管化/治疗 高温 诱发/方法 治疗效果
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重复加热致肝癌HepG2细胞对化疗药耐受性与细胞凋亡的变化
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作者 秦春宏 李永国 +2 位作者 吴江 何苦寒 费书柯 《中国医师杂志》 CAS 2008年第9期1169-1172,共4页
目的探讨多次加热肝癌HepG2细胞后,残存细胞对化疗药耐受性与细胞凋亡变化的关系。方法HepG2细胞43℃加热,每次80min,每天2次,10个循环后,MTT法分析其对阿霉素的敏感性,试剂盒检测细胞的凋亡,免疫组化法检测细胞Bcl-2蛋白及Bax... 目的探讨多次加热肝癌HepG2细胞后,残存细胞对化疗药耐受性与细胞凋亡变化的关系。方法HepG2细胞43℃加热,每次80min,每天2次,10个循环后,MTT法分析其对阿霉素的敏感性,试剂盒检测细胞的凋亡,免疫组化法检测细胞Bcl-2蛋白及Bax蛋白的表达,RT-PCR法检测细胞Bcl-2mRNA及BaxmRNA的表达,结果热处理后的HepG2细胞对阿霉素的化疗耐受性升高,细胞凋亡率减低,Bcl-2基因/蛋白的表达增强,Bcl-2/Bax值增大。结论热处理后HepG2细胞对化疗药物耐受性增高可能与其凋亡率降低、Bcl-2基因/蛋白的表达增强及Bcl-2/Bax值增大有关。 展开更多
关键词 高温 诱发/方法 肝肿瘤 细胞凋亡 药物耐受性 基因 BCL-2
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内生场热疗联合糖皮质激素治疗放射性肺炎36例分析
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作者 黄建国 王勇强 +1 位作者 董雅璐 赵晓伟 《中国误诊学杂志》 CAS 2012年第16期4375-4376,共2页
目的观察内生场热疗联合糖皮质激素治疗放射性肺炎的临床疗效。方法36例放射性肺炎的患者进行内生场热疗联合糖皮质激素治疗,根据治疗后的症状、体征和影像学检查结果判定疗效。结果36例经内生场热疗联合糖皮质激素治疗后,显效15例,... 目的观察内生场热疗联合糖皮质激素治疗放射性肺炎的临床疗效。方法36例放射性肺炎的患者进行内生场热疗联合糖皮质激素治疗,根据治疗后的症状、体征和影像学检查结果判定疗效。结果36例经内生场热疗联合糖皮质激素治疗后,显效15例,有效17例,有效率88.89A%。患者临床症状改善显著,生活质量明显改善。结论内生场热疗联合糖皮质激素治疗放射性肺炎,疗效显著,值得临床推广应用。 展开更多
关键词 高温 诱发/方法 糖皮质激素类/治疗应用 辐射性肺炎/药物疗法
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Spatio-temporal analysis and simulation on shallow rainfall-induced landslides in China using landslide susceptibility dynamics and rainfall I-D thresholds 被引量:6
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作者 LI WeiYue LIU Chun +7 位作者 Marco SCAIONI SUN WeiWei CHEN Yu YAO DongJing CHEN Sheng HONG Yang ZHANG KaiHang CHENG GuoDong 《Science China Earth Sciences》 SCIE EI CAS CSCD 2017年第4期720-732,共13页
An empirical simulation method to simulate the possible position of shallow rainfall-induced landslides in China has been developed.This study shows that such a simulation may be operated in real-time to highlight tho... An empirical simulation method to simulate the possible position of shallow rainfall-induced landslides in China has been developed.This study shows that such a simulation may be operated in real-time to highlight those areas that are highly prone to rainfall-induced landslides on the basis of the landslide susceptibility index and the rainfall intensity-duration(I-D) thresholds.First,the study on landslide susceptibility in China is introduced.The entire territory has been classified into five categories,among which high-susceptibility regions(Zone 4-'High' and 5-'Very high') account for 4.15%of the total extension of China.Second,rainfall is considered as an external triggering factor that may induce landslide initiation.Real-time satellite-based TMPA3B42 products may provide real rainfall spatial and temporal patterns,which may be used to derive rainfall duration time and intensity.By using a historical record of 60 significant past landslides,the rainfall I-D equation has been calibrated.The rainfall duration time that may trigger a landslide has resulted between 3 hours and 45 hours.The combination of these two aspects can be exploited to simulate the spatiotemporal distribution of rainfall-induced landslide hazards when rainfall events exceed the rainfall I-D thresholds,where the susceptibility category is 'high' or 'very high'.This study shows a useful tool to be part of a systematic landslide simulation methodology,potentially providing useful information for a theoretical basis and practical guide for landslide prediction and mitigation throughout China. 展开更多
关键词 Surface and subsurface runoff Runoff-produced physical and chemical deposits Precipitated salts and water circulation Groundwater supply mechanism Badain Jaran Desert
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Damage-induced material softening and its effect on seismic performance of steel structures 被引量:1
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作者 WANG XinYue SUN Bin LI ZhaoXia 《Science China(Technological Sciences)》 SCIE EI CAS CSCD 2016年第10期1559-1572,共14页
A numerical approach for simulating the seismic performance of steel truss structures, considering damage-induced material softening, is developed based on a ductile damage constitutive model by applying the backward ... A numerical approach for simulating the seismic performance of steel truss structures, considering damage-induced material softening, is developed based on a ductile damage constitutive model by applying the backward Euler explicit algorithm. It is implemented in ABAQUS through a user-defined material subroutine, by which damage evolution could be incorporated into the analysis of seismic performance of steel structures. The case study taken up here is the investigation of a steel connection with a reduced beam section(RBS) and a steel frame with such connections. The material softening effect during the failure process is particularly investigated. The results show that material softening in the vulnerable zone has a significant effect on the distribution of stress and strain fields, as well as on the carrying capacity of the steel connection with RBS. Further, material softening is found to have almost negligible effect on the seismic performance of the steel frame in the early stages of the loading process, but has a large effect when the steel frame is about to fail. These findings offer a practical reference for the assessment of seismic structural failure, and help in understanding the damage mechanism of steel structures under seismic loading. 展开更多
关键词 constitutive model damage evolution damage-induced material softening seismic response steel structure
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Direct numerical simulation of hypersonic transition induced by an isolated cylindrical roughness element 被引量:11
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作者 DUAN Zhi Wei XIAO Zhi Xiang FU Song 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS 2014年第12期2330-2345,共16页
Hypersonic boundary layer transition induced by an isolated cylindrical roughness element is investigated using direct numerical simulation method based on a finite volume formulation.To simulate the transition proced... Hypersonic boundary layer transition induced by an isolated cylindrical roughness element is investigated using direct numerical simulation method based on a finite volume formulation.To simulate the transition procedure by resolving the generation and evolvement of small-scale coherent structures,and capture the shock wave at the same time,high-order minimum dispersion and controllable dissipation scheme is validated and then applied.The results are compared with the available measurements in the quiet wind tunnel,such as the dominated frequency and root mean square of pressure.The computational dominated frequency of 19.23 k Hz is very close to the experimental one,21 k Hz.Also,the disturbances of the roughness are mostly generated by the"jet"just before the roughness,and then they travel and develop downstream with the shear layer and vortex shedding.The transition is mainly dominated by the instabilities of both the horseshoe vortex and the shear layer. 展开更多
关键词 HYPERSONIC boundarry layer transtion ROUGHNESS
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