Bleeding from the gastrointestinal tract and its management are associated with significant morbidity and mortality.The predisposing factors that led to the occurrence of these hemorrhagic instances are largely linked...Bleeding from the gastrointestinal tract and its management are associated with significant morbidity and mortality.The predisposing factors that led to the occurrence of these hemorrhagic instances are largely linked to the life style of the affected persons.Designing a new strategy aimed at educating the publics and improving their awareness of the problem could effectively help in eradicating this problem with no associated risks and in bringing the mortality rates down to almost zero.展开更多
The assessment of rainfall-induced shallow landslide hazards is a significant issue in the Three Gorges Reservoir area in China due to the rapid development of land in the past two decades. In this study, a probabilis...The assessment of rainfall-induced shallow landslide hazards is a significant issue in the Three Gorges Reservoir area in China due to the rapid development of land in the past two decades. In this study, a probabilistic analysis method that combines TRIGRS and the point-estimate method for evaluating the hazards of shallow landslides have been proposed under the condition of rainfall over a large area. TRIGRS provides the transient infiltration model to analyze the pore water pressure during a rainfall. The point-estimate method is used to analyze the uncertainty of the soil parameters, which is performed in the geographic information system(GIS). In this paper, we use this method to evaluate the hazards of shallow landslides in Badong County,Three Gorges Reservoir, under two different types of rainfall intensity, and the results are compared with the field investigation. The results showed that the distribution of the hazard map is consistent with the observed landslides. To some extent, the distributionof the hazard map reflects the spatial and temporal distribution of the shallow landslide caused by rainfall.展开更多
Sorafenib,a multitargeted tyrosine kinase inhibitor,has been shown to improve survival in patients with advanced hepatocellular carcinoma(HCC).As the clinical use of sorafenib increases,many adverse effects have been ...Sorafenib,a multitargeted tyrosine kinase inhibitor,has been shown to improve survival in patients with advanced hepatocellular carcinoma(HCC).As the clinical use of sorafenib increases,many adverse effects have been reported,such as hand-foot skin reaction,diarrhea,anorexia,asthenia,alopecia,weight loss,hypertension and arterial thromboembolism.However,there are no prior reports of splenic infarction as an adverse effect of sorafenib.Here,a case of splenic infarction in a patient with HCC who was treated with sorafenib is reported. The patient had no other predisposing factors to explain the splenic infarction except for the administration of sorafenib.The splenic infarction improved after sorafenib was discontinued;however,the HCC progressed.展开更多
文摘Bleeding from the gastrointestinal tract and its management are associated with significant morbidity and mortality.The predisposing factors that led to the occurrence of these hemorrhagic instances are largely linked to the life style of the affected persons.Designing a new strategy aimed at educating the publics and improving their awareness of the problem could effectively help in eradicating this problem with no associated risks and in bringing the mortality rates down to almost zero.
基金The National Natural Science Foundation of China(SN:41572292)the follow-up work of geological disaster prevention projects in Three Gorges Reservoir supported the research in thispaper(SN:0001212015CC60005)
文摘The assessment of rainfall-induced shallow landslide hazards is a significant issue in the Three Gorges Reservoir area in China due to the rapid development of land in the past two decades. In this study, a probabilistic analysis method that combines TRIGRS and the point-estimate method for evaluating the hazards of shallow landslides have been proposed under the condition of rainfall over a large area. TRIGRS provides the transient infiltration model to analyze the pore water pressure during a rainfall. The point-estimate method is used to analyze the uncertainty of the soil parameters, which is performed in the geographic information system(GIS). In this paper, we use this method to evaluate the hazards of shallow landslides in Badong County,Three Gorges Reservoir, under two different types of rainfall intensity, and the results are compared with the field investigation. The results showed that the distribution of the hazard map is consistent with the observed landslides. To some extent, the distributionof the hazard map reflects the spatial and temporal distribution of the shallow landslide caused by rainfall.
文摘Sorafenib,a multitargeted tyrosine kinase inhibitor,has been shown to improve survival in patients with advanced hepatocellular carcinoma(HCC).As the clinical use of sorafenib increases,many adverse effects have been reported,such as hand-foot skin reaction,diarrhea,anorexia,asthenia,alopecia,weight loss,hypertension and arterial thromboembolism.However,there are no prior reports of splenic infarction as an adverse effect of sorafenib.Here,a case of splenic infarction in a patient with HCC who was treated with sorafenib is reported. The patient had no other predisposing factors to explain the splenic infarction except for the administration of sorafenib.The splenic infarction improved after sorafenib was discontinued;however,the HCC progressed.
