目的:探讨发生慢性肾脏病基础上急性肾损伤(acute kidney injury on chronic kidney disease,A on C)的诱因、疗效和预后。方法:回顾性分析62例A on C患者的临床资料,对诱发病因、基础肾脏病、治疗、疗效和预后进行统计分析。结果:62例A...目的:探讨发生慢性肾脏病基础上急性肾损伤(acute kidney injury on chronic kidney disease,A on C)的诱因、疗效和预后。方法:回顾性分析62例A on C患者的临床资料,对诱发病因、基础肾脏病、治疗、疗效和预后进行统计分析。结果:62例A on C患者中主要基础肾脏病有糖尿病肾病18例(29.03%),良性小动脉肾硬化症17例(27.42%),慢性间质性肾炎10例(16.13%),慢性肾小球肾炎9例(14.52%),梗阻性肾病5例(8.07%),原发性肾病综合征2例(3.22%),多囊肾1例(1.61%)。发生A on C主要诱因有感染23例(37.10%),肾毒性药物使用12例(19.36%),原发病加重10例(16.13%),其次的诱因有急、慢性心衰6例(9.68%)、尿路梗阻5例(8.07%)、严重高血压2例(3.22%)、血管介入性治疗或手术2例(3.22%)、外伤1例(1.61%)、酮症酸中毒1例(1.61%)。经过对症内科药物治疗或药物治疗+血液透析,有效率为70.97%。肾功能恢复25例(40.32%),部分恢复19例(30.65%),无恢复8例(12.90%),慢性化6例(9.68%),死亡4例(6.45%)。结论:部分A on C患者肾功能存在可逆性,及早发现和诊断A on C,早期明确其诱因,及时控制各种感染,尽量避免使用肾毒性药物,加强原发病的整体治疗,是改善患者肾功能,降低病死率,延长患者生命的重要措施。展开更多
Hepatic portal venous gas is most often associated with extensive bowel necrosis due to mesenteric infarction.Mortality exceeds 75% with this condition.The most common precipitating factors include ischemia,intra-abdo...Hepatic portal venous gas is most often associated with extensive bowel necrosis due to mesenteric infarction.Mortality exceeds 75% with this condition.The most common precipitating factors include ischemia,intra-abdominal abscesses and inflammatory bowel disease.In this report,we present a 75-year-old woman with extensive hepatic portal and mesenteric venous gas due to colonic diverticulitis.She had a 10-year history of type diabetes mellitus and hypertension.She was treated by sigmoid resection and Hartmann's procedure and discharged from the hospital without any complications.展开更多
Bleeding from the gastrointestinal tract and its management are associated with significant morbidity and mortality.The predisposing factors that led to the occurrence of these hemorrhagic instances are largely linked...Bleeding from the gastrointestinal tract and its management are associated with significant morbidity and mortality.The predisposing factors that led to the occurrence of these hemorrhagic instances are largely linked to the life style of the affected persons.Designing a new strategy aimed at educating the publics and improving their awareness of the problem could effectively help in eradicating this problem with no associated risks and in bringing the mortality rates down to almost zero.展开更多
Sorafenib,a multitargeted tyrosine kinase inhibitor,has been shown to improve survival in patients with advanced hepatocellular carcinoma(HCC).As the clinical use of sorafenib increases,many adverse effects have been ...Sorafenib,a multitargeted tyrosine kinase inhibitor,has been shown to improve survival in patients with advanced hepatocellular carcinoma(HCC).As the clinical use of sorafenib increases,many adverse effects have been reported,such as hand-foot skin reaction,diarrhea,anorexia,asthenia,alopecia,weight loss,hypertension and arterial thromboembolism.However,there are no prior reports of splenic infarction as an adverse effect of sorafenib.Here,a case of splenic infarction in a patient with HCC who was treated with sorafenib is reported. The patient had no other predisposing factors to explain the splenic infarction except for the administration of sorafenib.The splenic infarction improved after sorafenib was discontinued;however,the HCC progressed.展开更多
The AtTOM1 gene of Arabidopsis thaliana had been shown to be essential for the efficient multiplication of Tobacco mosaic virus(TMV) in A.thaliana.In this study,we cloned an AtTOM1-like gene from Nicotiana benthamiana...The AtTOM1 gene of Arabidopsis thaliana had been shown to be essential for the efficient multiplication of Tobacco mosaic virus(TMV) in A.thaliana.In this study,we cloned an AtTOM1-like gene from Nicotiana benthamiana named as NbTOM1.Sequence alignment showed that NbTOM1 is closely related to AtTOM1 homologues of N.tabacum and Lycopersicon esculentum with 97.2% and 92.6% nucleotide sequence identities,respectively.Silencing of NbTOM1 by a modified viral satellite DNA-based vector resulted in complete inhibition of the multiplication of TMV in N.benthamiana.The result suggests that inhibition of NbTOM1 via RNA silencing is a potentially useful method for generating TMV-resistant plants.展开更多
文摘目的:探讨发生慢性肾脏病基础上急性肾损伤(acute kidney injury on chronic kidney disease,A on C)的诱因、疗效和预后。方法:回顾性分析62例A on C患者的临床资料,对诱发病因、基础肾脏病、治疗、疗效和预后进行统计分析。结果:62例A on C患者中主要基础肾脏病有糖尿病肾病18例(29.03%),良性小动脉肾硬化症17例(27.42%),慢性间质性肾炎10例(16.13%),慢性肾小球肾炎9例(14.52%),梗阻性肾病5例(8.07%),原发性肾病综合征2例(3.22%),多囊肾1例(1.61%)。发生A on C主要诱因有感染23例(37.10%),肾毒性药物使用12例(19.36%),原发病加重10例(16.13%),其次的诱因有急、慢性心衰6例(9.68%)、尿路梗阻5例(8.07%)、严重高血压2例(3.22%)、血管介入性治疗或手术2例(3.22%)、外伤1例(1.61%)、酮症酸中毒1例(1.61%)。经过对症内科药物治疗或药物治疗+血液透析,有效率为70.97%。肾功能恢复25例(40.32%),部分恢复19例(30.65%),无恢复8例(12.90%),慢性化6例(9.68%),死亡4例(6.45%)。结论:部分A on C患者肾功能存在可逆性,及早发现和诊断A on C,早期明确其诱因,及时控制各种感染,尽量避免使用肾毒性药物,加强原发病的整体治疗,是改善患者肾功能,降低病死率,延长患者生命的重要措施。
文摘Hepatic portal venous gas is most often associated with extensive bowel necrosis due to mesenteric infarction.Mortality exceeds 75% with this condition.The most common precipitating factors include ischemia,intra-abdominal abscesses and inflammatory bowel disease.In this report,we present a 75-year-old woman with extensive hepatic portal and mesenteric venous gas due to colonic diverticulitis.She had a 10-year history of type diabetes mellitus and hypertension.She was treated by sigmoid resection and Hartmann's procedure and discharged from the hospital without any complications.
文摘Bleeding from the gastrointestinal tract and its management are associated with significant morbidity and mortality.The predisposing factors that led to the occurrence of these hemorrhagic instances are largely linked to the life style of the affected persons.Designing a new strategy aimed at educating the publics and improving their awareness of the problem could effectively help in eradicating this problem with no associated risks and in bringing the mortality rates down to almost zero.
文摘Sorafenib,a multitargeted tyrosine kinase inhibitor,has been shown to improve survival in patients with advanced hepatocellular carcinoma(HCC).As the clinical use of sorafenib increases,many adverse effects have been reported,such as hand-foot skin reaction,diarrhea,anorexia,asthenia,alopecia,weight loss,hypertension and arterial thromboembolism.However,there are no prior reports of splenic infarction as an adverse effect of sorafenib.Here,a case of splenic infarction in a patient with HCC who was treated with sorafenib is reported. The patient had no other predisposing factors to explain the splenic infarction except for the administration of sorafenib.The splenic infarction improved after sorafenib was discontinued;however,the HCC progressed.
基金Project supported by the Cultivation Fund of the Key Scientific and Technical Innovation Project, Ministry of Education of China (No. 705025) the National Natural Science Foundation of China (No. 30530520)
文摘The AtTOM1 gene of Arabidopsis thaliana had been shown to be essential for the efficient multiplication of Tobacco mosaic virus(TMV) in A.thaliana.In this study,we cloned an AtTOM1-like gene from Nicotiana benthamiana named as NbTOM1.Sequence alignment showed that NbTOM1 is closely related to AtTOM1 homologues of N.tabacum and Lycopersicon esculentum with 97.2% and 92.6% nucleotide sequence identities,respectively.Silencing of NbTOM1 by a modified viral satellite DNA-based vector resulted in complete inhibition of the multiplication of TMV in N.benthamiana.The result suggests that inhibition of NbTOM1 via RNA silencing is a potentially useful method for generating TMV-resistant plants.
