AIM： To evaluate the effect of propolis administration on the healing of colon anastomosis with light and transmission electron microscopes. METHODS： Forty-eight Wistar-AIbino female rats were divided into two group...AIM： To evaluate the effect of propolis administration on the healing of colon anastomosis with light and transmission electron microscopes. METHODS： Forty-eight Wistar-AIbino female rats were divided into two groups and had colon resection and anastomosis. In group Ⅰ, rats were fed with standard rat chow pre- and postoperatively. The rats in group Ⅱ were fed with standard rat chow and began receiving oral supplementation of propolis 100 mg/kg per day beginning 7 d before the operation and continued until they were sacrificed. Rats were sacrificed 1, 3, 7 and 14 d after operation, and anastomotic bursting pressures measured. After the resection of anastomotic segments, histopathological examination was performed with light and transmission electron microscopes by two blinded histologists and photographed. RESULTS： The colonic bursting pressures of the propolis group were statistically significantly better than the control group. UItrastructural histopathological analysis of the colon anastomosis revealed that propotis accelerated the phases of the healing process and stimulated mature granulation tissue formation and collagen synthesis of fibroblasts. CONCLUSION： Bursting pressure measurements and ultra structural histopathological evaluation showed that administration of propolis accelerated the healing of colon anastomosis following surgical excision.展开更多
Focusing on African American novelist Gloria Naylor’s fiction Mama Day, this article intends to analyze Mama Day and George’s distinctive relationships with maternal spaces, particularly based on French philosopher ...Focusing on African American novelist Gloria Naylor’s fiction Mama Day, this article intends to analyze Mama Day and George’s distinctive relationships with maternal spaces, particularly based on French philosopher Luce Irigaray’s philosophy concerning maternal spaces and a feminine way of communication. It is to argue that the two characters’ different ways of communicating with the maternal spaces result in their different endings in the narrative, as well as their different degrees of healing, either healing their own wounded relationships with their mothers or healing the disconnection between men and women. This finding unravels Naylor’s implicit ethical and philosophical messages in writing George’s mystic and tragic death. In addition, by engaging Mama Day in active and feminine communication with maternal spaces, Naylor successfully re-establishes “the missing pillar” of the female ancestry that Irigaray observes on Western civilization, thus offering a possibility for a woman to construct her female subjectivity with reference to her maternal origin.展开更多
What is a lie？ Why do people tell lies？ What compels them to make false utterances？ How do people treat lie, deception or fudge？ Is the attitude to them the same in different cultures？ If not, what differences ar...What is a lie？ Why do people tell lies？ What compels them to make false utterances？ How do people treat lie, deception or fudge？ Is the attitude to them the same in different cultures？ If not, what differences are there？ An answer to these and some other questions is being sought in the paper. Producing a false utterance, the sender deprives the communication partner of the right to receive full information. The article presents views of Russians and representatives of Anglo-American culture on telling lies drawing the readers＇ attention to very serious situations, such as family conflicts between spouses, aggravated with lies. The material for analysis is taken from the texts by Russian playwright Anton Chekhov and the American novel writer Irwin Shaw. The analysis is based on the study of verbal and non-verbal markers of false utterances generated by quarreling spouses. A complex method of researching the literary material combining linguistic, extra-linguistic, and paralinguistic analysis of conflict speech acts with false utterances of different kinds is applied.展开更多
Hannah Arendt＇s 1963 study ＂Eichmann in Jerusalem＂, based on the former Nazi＇s 1961 trial, broached two highly controversial topics： The first was her theory of the banality of evil--the uncomfortable moral scena...Hannah Arendt＇s 1963 study ＂Eichmann in Jerusalem＂, based on the former Nazi＇s 1961 trial, broached two highly controversial topics： The first was her theory of the banality of evil--the uncomfortable moral scenario that leads ordinary individuals, for the most trivial and arbitrary reasons, to commit heinous atrocities; and the second was her fierce condemnation of Jewish collaboration with the Nazis. This paper argues that the novelist Jonathan Littell＇s critically acclaimed best-seller The Kindly Ones （2010） provocatively revalorizes and builds upon these two aspects of Arendt＇s study： Firstly, it posits her theory of banality as a challenge to the comforting presupposition that terrible evils can only be committed by a minority of monstrous individuals, by suggesting instead that ＂normal＂ readers share the same capacity to commit atrocities as Nazis such as Eichmann. Secondly, the novel nuances Arendt＇s damning indictment of Jewish collaboration by regarding it as the inevitable consequence of the terrible predicament faced by Jews at that time. Finally, the paper concludes with Littell＇s consideration of banality as a phenomenon that not only invites an uncomfortable moral self-analysis, but also legitimises a return to a justice system based on the ancient Greek model.展开更多
Pancreatic ductal adenocarcinoma is a devastating disease with a poor prognosis regardless of stage. To date the mainstay of therapy for advanced disease has been chemotherapy with little incremental im-provements in ...Pancreatic ductal adenocarcinoma is a devastating disease with a poor prognosis regardless of stage. To date the mainstay of therapy for advanced disease has been chemotherapy with little incremental im-provements in outcome. Despite extensive research investigating new treatment options the current practices continue to utilise fluorouracil or gemcitabine containing combinations. The need for novel the-rapeutic approaches is mandated by the ongoing poor survival rates associated with this disease. One such approach may include manipulation of ribosome biogenesis and the nucleolar stress response, which has recently been applied to haematological malignancies such as lymphoma and prostate cancer with promising results. This review will focus on the current therapeutic options for pancreatic ductal adenocarcinoma and the complexities associated with developing novel treatments, with a particular emphasis on the role of the nucleolus as a treatment strategy.展开更多
Preparation of biodiesel from waste oils containing 72% of free fatty acids catalyzed by a novel Br?nsted acidic ionic liquid 1-sulfobutyl-3-methylimidazolium hydrosulfate([BHSO_3MIM][HSO_4]) was systematically invest...Preparation of biodiesel from waste oils containing 72% of free fatty acids catalyzed by a novel Br?nsted acidic ionic liquid 1-sulfobutyl-3-methylimidazolium hydrosulfate([BHSO_3MIM][HSO_4]) was systematically investigated.The optimum molar ratio of methanol to waste oils,catalyst amount,reaction temperature and reaction time were 8/1,10%(based on the mass of waste oils),140°C and 6 h,respectively,under which the obtained yield of biodiesel reached 94.9%.Also,[BHSO_3MIM][HSO_4] as a catalyst still retained around 97% of its original catalytic activity after successive re-use of 5 batches(6 h per batch),showing the excellent operational stability.Moreover,the acidic IL [BHSO_3MIM][HSO_4] was able to ef ficiently catalyze conversions of waste oils with different amounts of FFAs(free fatty acids) into biodiesel,and showed tremendous application potential.Therefore,an ef ficient and environmentally friendly catalyst is provided for the synthesis of biodiesel from waste oils with high acid value.展开更多
The HINT project is a four-country collective of Global heritage interpretation. HINT is a two-year project part funded Geoparks researching the uses and benefits of new technologies in by the European Leader Programm...The HINT project is a four-country collective of Global heritage interpretation. HINT is a two-year project part funded Geoparks researching the uses and benefits of new technologies in by the European Leader Programme. The partners are Geopark Shetland （Scotland）, Chablais Geopark （France）, North Pennines Area of Outstanding Natural Beauty （England） and Geopark de Hondsrug （The Netherlands）. Each partner has developed a pilot project to investigate the practicalities of interpreting and communicating heritage, especially geological heritage, using a particular technology. An overview of each of the four pilot projects is given. The overall aim of the pilot projects is to develop best practice in using new technologies for heritage interpretation and to share information and ideas within the project partnership and with geoparks and heritage organizations around the world. This paper, developed by the HINT partners, aims to give an insight into the practical process of developing interpretive tools using new technologies. Some common problems are highlighted and some ways in which these can be addressed are shown.展开更多
Cationic polymerization of styrene has been achieved using several novel acidic initiators in room temperature ionic liquids (ILs) under mild reaction conditions to obtain polymers of low molecular weight with narrow ...Cationic polymerization of styrene has been achieved using several novel acidic initiators in room temperature ionic liquids (ILs) under mild reaction conditions to obtain polymers of low molecular weight with narrow polydispersity. Both strong protic acids such as bis(trifluoromethanesulfonyl) amide acid (HTFSA) and a moderately weak acid such as bisoxalato phosphorous acid (HBOP) have been studied as initiators. It has been observed that HTFSA initiates the polymerization rapidly even at room temperature and below, as compared to HBOP which produces a slower polymerization requiring elevated temperatures to complete. The relative difference in reactivity of the initiators as compared to the previously described HBOB initiator is discussed in terms of the difference in their proton acidity and the consequential basicity of the anions. The efficiency of different ILs as the reaction solvent is also presented.展开更多
Rhetorical features of Chinese writers’essays have been studied for decades but inconsistent interpretations of deduction and induction lead to controversial results.Taking a comparative rhetoric perspective,this pap...Rhetorical features of Chinese writers’essays have been studied for decades but inconsistent interpretations of deduction and induction lead to controversial results.Taking a comparative rhetoric perspective,this paper clarifies the notions of deduction and induction and investigates what rhetorical features characterize Chinese expository paragraphs besides deduction and induction and whether Chinese EFL learners’English paragraphs have similar features.Two kinds of data sources were used—29 full-score Chinese expositions in College Entrance Examinations and 29 English expositions written by Chinese EFL learners.The results show that deduction is preferred in both Chinese and EFL writing,and that rhetorical paragraphs and coordinate paragraphs are particular to Chinese writing while the EFL learners’paragraphs display hybrid rhetoric such as semi-coordination.It is concluded that neither Chinese paragraphs nor EFL ones are similar to the modern English rhetorical paradigm,and English rhetoric instruction will facilitate the introspection of the two kinds of rhetoric.展开更多
Coordination polymeric solid, {[Ag 2 (bpp) 2 (H 2 O) 2 ](chd)·9H 2 O} n (1) (bpp = 1,3-bis(4-pyridyl) propane, H 2 chd = 1,4-cyclo-hexanedicarboxylic acid), has been obtained by the solution phase ultrasonic synt...Coordination polymeric solid, {[Ag 2 (bpp) 2 (H 2 O) 2 ](chd)·9H 2 O} n (1) (bpp = 1,3-bis(4-pyridyl) propane, H 2 chd = 1,4-cyclo-hexanedicarboxylic acid), has been obtained by the solution phase ultrasonic synthesis techniques. The structure established through X-ray structural analysis shows that the compound traps an interesting 1D water tape built by the alternating "three-pointed star" cage-like pentameric and D 2h tetrameric clusters (C2/c, Z = 4; a = 30.37(2) , b = 9.271(5) , and c = 18.89(1) ; β = 128.47°; V = 4164(4) 3 ). The novelty of the present complex is the rarely crystallographic example of the cage-shaped water pentamer, which is usually ascribed to a less-stable species. A first-principle density functional theory (DFT) calculation demonstrates that the interconnectivity between cage-like pentamers and D 2h tetramers is beneficial for contribution to the structural stabilization of these less-stable water cluster species.展开更多
The statistical inference for generalized mixed-effects state space models （MESSM） are investigated when the random effects are unknown. Two filtering algorithms are designed both of which are based on mixture Kalma...The statistical inference for generalized mixed-effects state space models （MESSM） are investigated when the random effects are unknown. Two filtering algorithms are designed both of which are based on mixture Kalman filter. These algorithms are particularly useful when the longitudinal ts are sparse. The authors also propose a globally convergent algorithm for parameter estimation of MESSM which can be used to locate the initial value of parameters for local while more efficient algorithms. Simulation examples are carried out which validate the efficacy of the proposed approaches. A data set from the clinical trial is investigated and a smaller mean square error is achieved compared to the existing results in literatures.展开更多
文摘AIM： To evaluate the effect of propolis administration on the healing of colon anastomosis with light and transmission electron microscopes. METHODS： Forty-eight Wistar-AIbino female rats were divided into two groups and had colon resection and anastomosis. In group Ⅰ, rats were fed with standard rat chow pre- and postoperatively. The rats in group Ⅱ were fed with standard rat chow and began receiving oral supplementation of propolis 100 mg/kg per day beginning 7 d before the operation and continued until they were sacrificed. Rats were sacrificed 1, 3, 7 and 14 d after operation, and anastomotic bursting pressures measured. After the resection of anastomotic segments, histopathological examination was performed with light and transmission electron microscopes by two blinded histologists and photographed. RESULTS： The colonic bursting pressures of the propolis group were statistically significantly better than the control group. UItrastructural histopathological analysis of the colon anastomosis revealed that propotis accelerated the phases of the healing process and stimulated mature granulation tissue formation and collagen synthesis of fibroblasts. CONCLUSION： Bursting pressure measurements and ultra structural histopathological evaluation showed that administration of propolis accelerated the healing of colon anastomosis following surgical excision.
文摘Focusing on African American novelist Gloria Naylor’s fiction Mama Day, this article intends to analyze Mama Day and George’s distinctive relationships with maternal spaces, particularly based on French philosopher Luce Irigaray’s philosophy concerning maternal spaces and a feminine way of communication. It is to argue that the two characters’ different ways of communicating with the maternal spaces result in their different endings in the narrative, as well as their different degrees of healing, either healing their own wounded relationships with their mothers or healing the disconnection between men and women. This finding unravels Naylor’s implicit ethical and philosophical messages in writing George’s mystic and tragic death. In addition, by engaging Mama Day in active and feminine communication with maternal spaces, Naylor successfully re-establishes “the missing pillar” of the female ancestry that Irigaray observes on Western civilization, thus offering a possibility for a woman to construct her female subjectivity with reference to her maternal origin.
文摘What is a lie？ Why do people tell lies？ What compels them to make false utterances？ How do people treat lie, deception or fudge？ Is the attitude to them the same in different cultures？ If not, what differences are there？ An answer to these and some other questions is being sought in the paper. Producing a false utterance, the sender deprives the communication partner of the right to receive full information. The article presents views of Russians and representatives of Anglo-American culture on telling lies drawing the readers＇ attention to very serious situations, such as family conflicts between spouses, aggravated with lies. The material for analysis is taken from the texts by Russian playwright Anton Chekhov and the American novel writer Irwin Shaw. The analysis is based on the study of verbal and non-verbal markers of false utterances generated by quarreling spouses. A complex method of researching the literary material combining linguistic, extra-linguistic, and paralinguistic analysis of conflict speech acts with false utterances of different kinds is applied.
文摘Hannah Arendt＇s 1963 study ＂Eichmann in Jerusalem＂, based on the former Nazi＇s 1961 trial, broached two highly controversial topics： The first was her theory of the banality of evil--the uncomfortable moral scenario that leads ordinary individuals, for the most trivial and arbitrary reasons, to commit heinous atrocities; and the second was her fierce condemnation of Jewish collaboration with the Nazis. This paper argues that the novelist Jonathan Littell＇s critically acclaimed best-seller The Kindly Ones （2010） provocatively revalorizes and builds upon these two aspects of Arendt＇s study： Firstly, it posits her theory of banality as a challenge to the comforting presupposition that terrible evils can only be committed by a minority of monstrous individuals, by suggesting instead that ＂normal＂ readers share the same capacity to commit atrocities as Nazis such as Eichmann. Secondly, the novel nuances Arendt＇s damning indictment of Jewish collaboration by regarding it as the inevitable consequence of the terrible predicament faced by Jews at that time. Finally, the paper concludes with Littell＇s consideration of banality as a phenomenon that not only invites an uncomfortable moral self-analysis, but also legitimises a return to a justice system based on the ancient Greek model.
文摘Pancreatic ductal adenocarcinoma is a devastating disease with a poor prognosis regardless of stage. To date the mainstay of therapy for advanced disease has been chemotherapy with little incremental im-provements in outcome. Despite extensive research investigating new treatment options the current practices continue to utilise fluorouracil or gemcitabine containing combinations. The need for novel the-rapeutic approaches is mandated by the ongoing poor survival rates associated with this disease. One such approach may include manipulation of ribosome biogenesis and the nucleolar stress response, which has recently been applied to haematological malignancies such as lymphoma and prostate cancer with promising results. This review will focus on the current therapeutic options for pancreatic ductal adenocarcinoma and the complexities associated with developing novel treatments, with a particular emphasis on the role of the nucleolus as a treatment strategy.
基金Supported by the National Natural Science Foundation of China(21676104,21336002,21376096)the Open Funding Project of the State Key Laboratory of Bioreactor Engineeringthe Program of State Key Laboratory of Pulp and Paper Engineering(2017ZD05)
文摘Preparation of biodiesel from waste oils containing 72% of free fatty acids catalyzed by a novel Br?nsted acidic ionic liquid 1-sulfobutyl-3-methylimidazolium hydrosulfate([BHSO_3MIM][HSO_4]) was systematically investigated.The optimum molar ratio of methanol to waste oils,catalyst amount,reaction temperature and reaction time were 8/1,10%(based on the mass of waste oils),140°C and 6 h,respectively,under which the obtained yield of biodiesel reached 94.9%.Also,[BHSO_3MIM][HSO_4] as a catalyst still retained around 97% of its original catalytic activity after successive re-use of 5 batches(6 h per batch),showing the excellent operational stability.Moreover,the acidic IL [BHSO_3MIM][HSO_4] was able to ef ficiently catalyze conversions of waste oils with different amounts of FFAs(free fatty acids) into biodiesel,and showed tremendous application potential.Therefore,an ef ficient and environmentally friendly catalyst is provided for the synthesis of biodiesel from waste oils with high acid value.
文摘The HINT project is a four-country collective of Global heritage interpretation. HINT is a two-year project part funded Geoparks researching the uses and benefits of new technologies in by the European Leader Programme. The partners are Geopark Shetland （Scotland）, Chablais Geopark （France）, North Pennines Area of Outstanding Natural Beauty （England） and Geopark de Hondsrug （The Netherlands）. Each partner has developed a pilot project to investigate the practicalities of interpreting and communicating heritage, especially geological heritage, using a particular technology. An overview of each of the four pilot projects is given. The overall aim of the pilot projects is to develop best practice in using new technologies for heritage interpretation and to share information and ideas within the project partnership and with geoparks and heritage organizations around the world. This paper, developed by the HINT partners, aims to give an insight into the practical process of developing interpretive tools using new technologies. Some common problems are highlighted and some ways in which these can be addressed are shown.
文摘Cationic polymerization of styrene has been achieved using several novel acidic initiators in room temperature ionic liquids (ILs) under mild reaction conditions to obtain polymers of low molecular weight with narrow polydispersity. Both strong protic acids such as bis(trifluoromethanesulfonyl) amide acid (HTFSA) and a moderately weak acid such as bisoxalato phosphorous acid (HBOP) have been studied as initiators. It has been observed that HTFSA initiates the polymerization rapidly even at room temperature and below, as compared to HBOP which produces a slower polymerization requiring elevated temperatures to complete. The relative difference in reactivity of the initiators as compared to the previously described HBOB initiator is discussed in terms of the difference in their proton acidity and the consequential basicity of the anions. The efficiency of different ILs as the reaction solvent is also presented.
基金supported by the Social Science Department of the Ministry of Education of China[Grant No.:16YJA740022].
文摘Rhetorical features of Chinese writers’essays have been studied for decades but inconsistent interpretations of deduction and induction lead to controversial results.Taking a comparative rhetoric perspective,this paper clarifies the notions of deduction and induction and investigates what rhetorical features characterize Chinese expository paragraphs besides deduction and induction and whether Chinese EFL learners’English paragraphs have similar features.Two kinds of data sources were used—29 full-score Chinese expositions in College Entrance Examinations and 29 English expositions written by Chinese EFL learners.The results show that deduction is preferred in both Chinese and EFL writing,and that rhetorical paragraphs and coordinate paragraphs are particular to Chinese writing while the EFL learners’paragraphs display hybrid rhetoric such as semi-coordination.It is concluded that neither Chinese paragraphs nor EFL ones are similar to the modern English rhetorical paradigm,and English rhetoric instruction will facilitate the introspection of the two kinds of rhetoric.
基金supported by the National Natural Science Foundation of China (50971063)the Natural Science Foundation of Fujian Province (2003F006, 2010J01042, 2011J01047)+1 种基金the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry of Chinathe Startup Package Funding of Huaqiao University (10BS210) for supporting
文摘Coordination polymeric solid, {[Ag 2 (bpp) 2 (H 2 O) 2 ](chd)·9H 2 O} n (1) (bpp = 1,3-bis(4-pyridyl) propane, H 2 chd = 1,4-cyclo-hexanedicarboxylic acid), has been obtained by the solution phase ultrasonic synthesis techniques. The structure established through X-ray structural analysis shows that the compound traps an interesting 1D water tape built by the alternating "three-pointed star" cage-like pentameric and D 2h tetrameric clusters (C2/c, Z = 4; a = 30.37(2) , b = 9.271(5) , and c = 18.89(1) ; β = 128.47°; V = 4164(4) 3 ). The novelty of the present complex is the rarely crystallographic example of the cage-shaped water pentamer, which is usually ascribed to a less-stable species. A first-principle density functional theory (DFT) calculation demonstrates that the interconnectivity between cage-like pentamers and D 2h tetramers is beneficial for contribution to the structural stabilization of these less-stable water cluster species.
基金supported by the National Natural Science Foundation of China under Grant No.71271165
文摘The statistical inference for generalized mixed-effects state space models （MESSM） are investigated when the random effects are unknown. Two filtering algorithms are designed both of which are based on mixture Kalman filter. These algorithms are particularly useful when the longitudinal ts are sparse. The authors also propose a globally convergent algorithm for parameter estimation of MESSM which can be used to locate the initial value of parameters for local while more efficient algorithms. Simulation examples are carried out which validate the efficacy of the proposed approaches. A data set from the clinical trial is investigated and a smaller mean square error is achieved compared to the existing results in literatures.
