Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic d...Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.展开更多
This article presents a general form of the estimator for identifying dispersion effects from unreplicated two-level factorial experiments,and shows that the widely used estimators such as the BH,MH,and AMH estimators...This article presents a general form of the estimator for identifying dispersion effects from unreplicated two-level factorial experiments,and shows that the widely used estimators such as the BH,MH,and AMH estimators are all special cases of the proposed one,designated as the G estimator.The unbiased condition of the G estimator is proved,and a lower bound of variance of the G estimator is provided.A simulation based on a realistic design illustrates the variation of the variance and MSE(mean square error) of the G estimator on different coefficients.This estimator may be more flexible and has better performance than other methods such as the BH and MH estimators by appropriately selecting the coefficients.展开更多
基金financially supported by the National Natural Science Foundation of China(No.81303207)CAMS Innovation Fund for Medical Sciences(CIFMS,No.2016-I2M-1-007)
文摘Two new compounds, named lyciumlignan D(1) and lyciumphenyl propanoid A(2), along with seven known compounds, were isolated from the root bark of Lycium chinense. Their structures were elucidated using spectroscopic data(UV, IR, HR-ESI-MS, 1D and 2D NMR, CD), as well as by comparison with those of the literature. Compounds 3–9 were isolated from this genus for the first time. In the in vitro assay, compounds 3, 6, and 7 exhibited stronger anti-inflammatory effects than the positive control curcumin at a concentration of 10 μmol/L.
基金supported by the National Natural Science Fund of China under Grant No.61503228Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi under Grant No.2015106
文摘This article presents a general form of the estimator for identifying dispersion effects from unreplicated two-level factorial experiments,and shows that the widely used estimators such as the BH,MH,and AMH estimators are all special cases of the proposed one,designated as the G estimator.The unbiased condition of the G estimator is proved,and a lower bound of variance of the G estimator is provided.A simulation based on a realistic design illustrates the variation of the variance and MSE(mean square error) of the G estimator on different coefficients.This estimator may be more flexible and has better performance than other methods such as the BH and MH estimators by appropriately selecting the coefficients.
