皮科“调候”法探析

人与天地相参,与日月相应。四时有轮回,人体应自然气候特点,受其寒暖燥湿而影响。出生于立冬-大寒之间者,多寒水当令,土冻柴少火微,体质偏阳虚阴盛;出生于立夏-大暑之间者,多属火土当令,五行火重水死,偏阴虚火旺。人体过寒过暖过燥过湿均易致疾病状态,需施以'调候。'调候者即调控自身环境以适应自然界的万千气象,以图生存发展。文章通过分析调候法的定义、运用原则,归纳调候之法依据,阐述其在皮肤病中的具体体现,旨在为皮肤科辨治体系提供些许新思路。

Climate modulation on sea surface height in China seas

The climate modulation on the sea surface height （SSH） in China seas is investigated using a China Ocean Reanalysis （CORA） dataset from 1958-2008. The dataset is constructed by assimilating the temperature/salinity profiles derived from the satellite altimetry data and historical observational temperature/salinity profiles. Based on the Empirical Orthogonal Function （EOF）, the CORA sea surface height anomaly （SSHa） is decomposed, and the interannual and decadal variability of the first three leading modes are analyzed. On the interannual timescale, the first principal component （PC1） is significant positively correlated with the E1 Nifio/Southern Oscillation （ENSO）. On the decadal timescale, North Pacific Gyre Oscillation （NPGO） has significant negative correlation with PC 1 whereas Pacific Decadal Oscillation （PDO） is in phase with PC3. Analysis shows that the decadal variability of SSH is mainly modulated by the wind stress curl variability related to the NPGO and PDO. In addition, the effect of net heat flux associated to the NPGO and PDO on SSH is also investigated, with net heat flux variability in the Luzon strait and tropic Pacific found to influence the decadal variability of SSH.

Total Occlusion of Anterior Descending Artery （AD） without ST-Segment Elevation： DE Winter Pattern

The recognition of the presence of ST-segment elevation in the context of ACS （acute coronary syndrome） is fundamental for the good outcome of the case. However, some electrocardiographic patterns have been highlighted by the fact that there is no elevation, but they represent a severity similar to ACS with ST elevation. Hence, it is necessary that doctors who do the first service recognize these standards promptly.The electrocardiographic pattern of association between the ST-segment depression and the hyperacute T waves representing myocardial infarction in the anterior wall, localizing more specifically in the anterior descending artery, now known as the De Winter pattern, was first described by Dressler, and then described by Winter six years later. Winter observed that, out of a series of 1,452 cases, 2% of patients with anterior wall infarction had the pattern of ST-segment depression, positive and symmetrical T waves, and occasionally mild ST-segment elevation at AVR derivation. Those patients are admitted to the emergency room with a typical chest pain. However, because the electrocardiographic findings of this syndrome are not known to many health professionals, in many cases the patients do not receive adequate care and have fatal outcome, since mortality is relevant in these cases. Thus, the rapid recognition of this pattern is extremely necessary for the correct and effective intervention.

Exploring the characteristics of inquiry and the correlation with TCM syndromes about the patients with cardiovascular disease

Objective:Inquiry occupies an important position in the Traditional Chinese Medicine(TCM)diagnostic methods.Observing the characteristics of inquiry symptoms and the correlation with TCM syndromes can determine the important guiding significance to build recognition model and diagnostic criteria of syndrome.Methods:In this study,we collected 3707 valid cases,analyzed the inquiry symptoms of patients with cardiovascular disease,then to explore the distribution of inquiry information and the correlation with TCM syndromes based on the methods,such as frequency analysis,expert score,and correlation analysis.Results:We found the symptoms of frequency analysis and expert symptom score all in the top 50,add up to 41.According to the results by correlation analysis,the correlation coefficient between each symptom and each syndrome are sorted from high to low,the same with the experts score to each inquiry symptom basing on its importance of in diagnosing each syndrome.Conclusion:Inquiry occupies an important effect in differentiation syndrome.This research could provide certain objective basis for establishment of TCM syndromes diagnostic criteria of cardiovascular disease,thus provide some ideas and methods for the research of establishing TCM syndrome identification model,then to provide a reference for the syndrome standardization and objectification.

Contraindications for video capsule endoscopy

Video capsule endoscopy(VCE) has been applied in the last 15 years in an increasing field of applications. Although many contraindications have been put into perspective, some precautions still have to be considered. Known stenosis of the gastrointestinal tract is a clear contraindication for VCE unless surgery is already scheduled or at least has been considered as an optional treatment modality. In patients with a higher incidence of stenosis, as in an established diagnosis of Crohn's disease, clinical signs of obstruction, prior radiation or surgical small bowel resection, a preceding test with the self-dissolving patency capsule can override this contraindication. Endoscopic placement of the capsule should be considered in patients with swallowing disorders to avoid aspiration. Esophageal or gastric motility disorders may require endoscopic capsule transport or application of prokinetics if the real-time viewer proofs delayed transit. In pregnant women, VCE should be restricted to urgent cases where diagnosis cannot be postponed after delivery, as data on safety are missing. There is theoretical and clinical evidence that patients with implanted cardiac devices such as a pacemaker, cardioverters or left heart assist devices, can safely undergo VCE in spite of still existing contraindication by manufacturers. Children from the age of 2 years have safely undergone VCE. Although video capsules are not proven safe with magnetic resonance imaging(MRI), first single cases of patients incidentally undergoing MRI with an incorporated capsule have been reported, showing susceptibility artifacts but no signs of clinical harm.

Always-optimally-coordinated candidate selection algorithm for peer-to-peer files sharing system in mobile self-organized networks

In order to improve the performance of peer-to-peer files sharing system under mobile distributed en- vironments, a novel always-optimally-coordinated （AOC） criterion and corresponding candidate selection algorithm are proposed in this paper. Compared with the traditional min-hops criterion, the new approach introduces a fuzzy knowledge combination theory to investigate several important factors that influence files transfer success rate and efficiency. Whereas the min-hops based protocols only ask the nearest candidate peer for desired files, the selection algorithm based on AOC comprehensively considers users＇ preferences and network requirements with flexible balancing rules. Furthermore, its advantage also expresses in the independence of specified resource discovering protocols, allowing for scalability. The simulation results show that when using the AOC based peer selection algorithm, system performance is much better than the rain-hops scheme, with files successful transfer rate improved more than 50% and transfer time re- duced at least 20%.

An Alternative Means of Assessing Climate Models

The authors compared two different sets of assessment of the abilities of contemporary climate models. One group is made of experts, and their results are provided in two expert reports, while the other is the subjective assessment made by ＂physical climate scientists＂ in general, sampled in a series of three survey questionnaires. The expert group is considerably more optimistic than the general group; the former suggesting progress, while the perception of the latter group is more or less stationary.

The Two Main Mechanisms of Glacier Lake Outburst Flood in Tibet,China

With the global warming,the disasters of Glacier Lake Outburst Flood(GLOF) have taken place frequently in Tibet in recent years and attracted more and more attention.A systematic survey was conducted on the 19 GLOFs in Tibet to study their two main mechanisms.Investigations indicated that all the events occurred in end-moraine lakes,and the outburst occurred partially and instantly.And the breach had the shape of an arc or a trapezoid in overflow outburst and its top width was 3-5 times more than the height.The two main mechanisms of GLOFs in Tibetan end-moraine Lake were overflow and piping,and the overflow mechanism caused by iceberg collapse was dominated in most cases.A formula was proposed to calculate the critical thickness of iceberg tongue that determines the collapse.Granular analysis of the moraine materials revealed that seepage deformation is crucial in the outburst process.Finally,we conducted a case study of the Guangxiecuo Lake to show its possible process of outburst and estimated the peak discharge of the resulted flood.

China's low-carbon transition for addressing climate change

This study discusses high-carbon characteristics, the unsustainability of China's development, and the fact that China needs to transform its development mode. China's low-carbon transition must include industry structure adjustment, energy saving and efficiency increases, energy structure improvement, carbon sink development, adaptation capability, and low-carbon pilot schemes.Low-carbon urbanization is a key measure in China's low-carbon transition. China's urbanization faces high-carbon risks. Thus, this study presents a roadmap for transforming urbanization into a low-carbon one. The transition to low-carbon urbanization is a common trend in the developing world. There is a lot of room for international cooperation.

Measurement of public awareness of climate change in China:based on a national survey with 4,025 samples

Just before the new round of UN climate change conference in Bonn, a survey report, named as the Climate Change in the Chinese Mind 2017, was released in Beijing. The investigation was conducted in the form of a computer-assisted telephone survey with a sample size of 4,025 samples, covering 332 prefecture-level administrative units and four municipalities in China.Urban-rural proportion and sex proportion were specially taken into account, so as to demonstrate the Chinese public awareness objectively. The investigation measures the public awareness from six aspects, which includes climate change beliefs, impacts, response, policies, actions, and the assessment of the effectiveness of climate communication. This article presents the key findings of the survey and provides further insights behind the data.

Exploring harmonious development between urbanization and eco-environment based on climate analysis—A study in Changsha, China

The process of urbanization affects the urban warming.The change of urban warming was investigated by several urbanization factors in Changsha,China.The data of surface temperature(minimum,maximum and mean) of Changsha were analyzed to understand the possible effects of urbanization on the climate of this region owing to the population growth,built-up area expansion and energy consumption increases.The weights of these three factors were calculated by the analytical hierarchy process(AHP).Then,three weights were simulated with nonlinear method to obtain the urbanization development rate which was utilized to reveal the influence of the urbanization factors on the surface temperature.The result shows that there is a significant upward trend in the urban temperatures of Changsha.The temperature increase seems to be closely related to the rate of urbanization between 1993 and 2008,and there is an evidential increase trend of the influence on urban temperature by urbanization during 16 years.It is a quantifiable approach measuring the relationship between urbanization and urban eco-environment,and can be applied for the urban sustainability.

Controversy of International Carbon-motivated Border Tax Adjustment and Its Impact on China's Manufacturing Industries

Carbon-motivated border tax adjustment （BTA） aims to compensate for the loss of competitiveness of carbon intensive products due to carbon dioxide abatement actions. Based on the analysis of the international background of carbon-motivated BTAs, this paper discusses the fundamental motivation leading to US policy transformation, the potential impacts of the policy on China＇s manufacturing industries, and the compatibility of the policy to WTO rules. Carbon-motivated BTAs violate the fundamental principle of the UNFCCC, and potentially conflict with the core WTO principle of non-discrimination reflected in the GATT Articles 1 and III. However, Article XX of the GATT may be applicable. Thus, the author suggests several measures to alleviate the impacts of carbon-motivated BTAs, and puts forward countermeasures based on carbon consumption per capita.

Hydrological Responses to Climate Change in the Water Receiving Area of the Middle Route Project for South-to-North Water Transfer

Climate change will lead to a significant alteration in the temporal and spatial pattern variation in the regional hydrological cycle, and the subsequent lack of water, environmental deterioration, floods and droughts etc. And it is especially remarkable in semi-humid and semi-arid region. In this paper, the impacts of climate change on the hydrological cycle were analyzed for the Hai River Basin, a semi-humid and semi-arid basin and also the water receiving area of the middle route of South-to-North Water Diversion project. Meanwhile it is the most vulnerable to climate change. Firstly, the linear regression and Mann-Kendall non-parametric test methods were used to analyze the change characteristics of the hydrological and meteorological elements for the period from 1960 to 2009. The results show a significant increase in temperature, while precipitation decreases slightly, and runoff decreases drastically over the past 50 years. Secondly, the applicability of SWAT （Soil and Water Assessment Tool） model based on the DEM （Digital Elevation Model）, land use and soil type was verified in the basin. Results show the model performs well in this basin. Furthermore, the water balance model, Fu＇s theory and Koichiro＇s theory were used to calculate the actual evaporation, comparing to the simulated actual evaporation by SWAT model to validate the result for the lack of large-scale observed evaporation datasets. Possible reasons were also analyzed to explore the reasonable factor for the decline of the runoff. Finally the precipitation, temperature, runoff and evaporation response processes based on the IPCC AR4 multi-mode climate models and the verified SWAT model under different GHG emission scenarios （SRES-A2, AIB and B1） in the 21st century were discussed in three time periods： 2020s （2011-2040）, 20S0s （2041-2070）, 2080s （2071-2099）. Results show that there are systematic positive trends for precipitation and temperature while the trends for runoff and evaporation will differ among sub-areas. The results will offer some references for adaptive water management in a changing environment, also including adaptation of a cross-basin water transfer project.

“五行流通”理论及其在皮肤科的应用探析

五行之间生克制约循环,如"轮轴"运转,推动生命之流前行。一行之气偏旺则生"克、泄、耗"之疾,一行之气不足则所主脏腑行运不佳,均可影响五行轴运,累及多系统,病情复杂,病机难寻,辨证时需综合考虑五行间的生克联系。"五行流通"之法为治疗五行克耗、偏枯之良方,其通过深入理解生克的本源,用"化泄"的方法平抑强旺、使五行间能量得以传递沟通。此外,人体内在"气候"的寒热在一定程度上受到出生时自然气候寒暖的影响,即所谓天人相应;过寒过暖均会阻碍五行流通,需施以"调候"。"五行流通"理论从多个角度思考临床应用,望可为难治性皮肤病的辨证、论治提供新的思路。

The paleoclimate change of Qaidam Basin during the last 2.85 Ma recorded by Gamma-ray logging

The geographical location of Qaidam Basin corresponds toN36°05′-38°10′ and E90°10′-98°05′. The thickness of the Quaternary deposits in the basin reaches 2000-3000 m. This paper deals mainly with the aspect of paleoclimate change of the basin. The approach used for the study consisted of (1) establishing the paleoclimate curve of the basin according to the climate indices, including the spore-pollen statistics, carbonate content and δ18O, obtained from the samples of the 760 m continuously-cored exploration holes sited in the basin, (2) comparing the paleoclimate curve with the natural gamma-logs of the same exploration holes, and (3) determining the paleoclimatic changes in the last 2.85 Ma on the basis of detailed geochronological calculations. These results are extremely important for comparison with the δ18O-based climate curve derived from the ODP659 in the Atlantic Ocean and with the cycles of paleosol in the Chinese loess.

Porcine FcεRI Mediates Porcine Reproductive and Respiratory Syndrome Virus Multiplication and Regulates the Inflammatory Reaction

Porcine reproductive and respiratory syndrome virus(PRRSV) shows characteristic antibody-dependent enhancement(ADE) of infection and causes porcine systemic inflammation, which is similar to a type I allergic reaction; however, the role of porcine FceεRI in ADE is still unclear. In this study, the expression of different Fc receptors(Fc Rs) on macrophages was investigated in a PRRSV 3D4/21 cell infection model in the presence or absence of PRRSV antibody. The transcription level of Fcc II and FceεRI was significantly up-regulated under PRRSV-antibody complex infection. Internalization and proliferation of PRRSV were promoted by the ADE mechanism when FceεRI was expressed in permissive 3D4/21 cells and the non-permissive cell line HEK 293T. Transcriptome sequencing data showed that the expression levels of AKT,ERK and other signal molecules in the anti-inflammatory pathway were significantly increased, especially in the cells infected with the PRRSV-antibody immune complex. Inflammatory regulatory molecules such as PLA2G6, LOX, TRPM8 and TRPM4 were significantly up-regulated following PRRSV infection but significantly down-regulated in the cells infected with the PRRSV-antibody immune complex. Our results demonstrated that FceεRI could be involved in PRRSV ADE, the antigen presenting process and regulation of the inflammatory response during PRRSV infection, which provides new insights into PRRSV infection mediated by FceεRI and the PRRSV-antibody immune complex.

Climate change and plague history in Europe

Previous research that reported the linkage between climate change and plague activity primarily refers to the immediate effect of short-term climatic variation. Yet, decades of discussion about the climate-plague association cannot determine the precise role of climate in shaping plague dynamics. One reason for this discrepancy originates from the narrow selection of spatio-temporal settings for comprehensive analysis of the correlation, leading to a limited consideration of the complexity of possible dynamics.By analyzing a 414-year long record of plague outbreak in pre-industrial Europe and the corresponding climatic data in multi-scale,we find little evidence to support climate-plague correlation in(1) both climatic variations and large-scale climatic phenomena,(2)both country scale and continental scale,(3) annual to inter-annual scale, and(4) both linear and non-linear analytic approaches. The null-result should not be viewed as a general rejection of other recent findings related to climate-plague association; nevertheless,it suggests that a wider consideration of scales, sensitivity checks and consideration of contexts should be included in explaining and predicting plague transmission under contemporary global climate conditions.

Homogenization of climate series:The basis for assessing climate changes

Long-term meteorological observation series are fundamental for reflecting climate changes.However,almost all meteorological stations inevitably undergo relocation or changes in observation instruments,rules,and methods,which can result in systematic biases in the observation series for corresponding periods.Homogenization is a technique for adjusting these biases in order to assess the true trends in the time series.In recent years,homogenization has shifted its focus from the adjustments to climate mean status to the adjustments to information about climate extremes or extreme weather.Using case analyses of ideal and actual climate series,here we demonstrate the basic idea of homogenization,introduce new understanding obtained from recent studies of homogenization of climate series in China,and raise issues for further studies in this field,especially with regards to climate extremes,uncertainty of the statistical adjustments,and biased physical relationships among different climate variables due to adjustments in single variable series.

EDdb:A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder

Eating disorder is a group of physiological and psychological disorders affecting approximately 1% of the female population worldwide. Although the genetic epidemiology of eating disorder is becoming increasingly clear with accumulated studies, the underlying molecular mechanisms are still unclear. Recently, integration of various high-throughput data expanded the range of candidate genes and started to generate hypotheses for understanding potential pathogenesis in complex diseases. This article presents EDdb （Eating Disorder database）, the first evidence-based gene resource for eating disorder. Fifty-nine experimentally validated genes from the literature in relation to eating disorder were collected as the core dataset. Another four datasets with 2824 candidate genes across 601 genome regions were expanded based on the core dataset using different criteria （e.g., protein-protein interactions, shared cytobands, and related complex diseases）. Based on human protein-protein interaction data, we reconstructed a potential molecular sub-network related to eating disorder. Furthermore, with an integrative pathway enrichment analysis of genes in EDdb, we identified an extended adipocytokine signaling pathway in eating disorder. Three genes in EDdb （AD1PO （adiponectin）, TNF （tumor necrosis factor） and NR3C1 （nuclear receptor subfamily 3, group C, mem- ber 1）） link the KEGG （Kyoto Encyclopedia of Genes and Genomes） ＂adipocytokine signaling pathway＂ with the BioCarta ＂visceral fat deposits and the metabolic syndrome＂ pathway to form a joint pathway. In total, the joint pathway contains 43 genes, among which 39 genes are related to eating disorder. As the first comprehensive gene resource for eating disorder, EDdb （http：//eddb.cbi.pku.edu.cn） enables the exploration of gene-disease relationships and cross-talk mechanisms between related disorders. Through pathway statistical studies, we revealed that abnormal body weight caused by eating disorder and obesity may both be related to dysregulation of the novel joint pathway of adipocytokine signaling. In addition, this joint pathway may be the common pathway for body weight regulation in complex human diseases related to unhealthy lifestyle.

Advance of research on modern soil phytolith

Phytolith study is a new branch of micropaleontology with an increasingly important role in geology, archaeology, and plant taxonomy. Phytoliths have several advantages considering their characteristics of small particle size, high production, wide distribution, anti-decomposition, in situ deposition, distinctive morphologies, and element sequestrating capacity. Phytolith assemblages in modem soil have been found to be closely related to modem vegetation types and climate conditions, which forms the basis for the quantitative study of paleoecology, paleoclimate, and bio-geochemical cycles. At present, phytolith studies generally focus on the following four aspects： （1） Morphology： about 260 unduplicated types of phytoliths have been identified in modem soil, of which 110 types are from grasses, 50 types from ferns, woody plants and other angiosperms, whereas the origin plants of the remaining 100 types are still under investigation. （2） Soil phytolith assemblages and vegetation： phytolith assemblages from the topsoil have been used to distinguish surface vegetation types including different forests and grasslands over a typical region. This model has been applied to restore past vegetation conditions and monitor the dynamic evolution of specific vegetation types at different temporal and spatial scales. （3） Soil phytolith assemblages and climate： quantitative and semi-quantitative relationships between phytolith assemblages and a series of climate parameters, such as annual mean temperature, annual mean precipitation and altitude, have been established through mathematical analysis. In this manner, quantitative reconstruction of paleoclimatic parameters has been achieved through the phytolith-climate transfer function model. （4） Soil phytolith and its sequestered elements： in this topic, the content of soil PhytOC （Phytolith-occluded Organic Carbon） and the importance of PhytOC in the bio-geochemical cycle have been the focus. The study of modem soil phytoliths has provided new approaches and many successful cases for solving specific problems in various fields, such as Earth science and archaeology. This study analyzed existing issues in addition to the abovementioned significant progresses, and provides directions for future research on modem soil phytoliths.