鱼肝油与蒙脱石散混合调制异常分析

口腔溃疡是一种最常见的口腔黏膜疾病，在人群中患病率一般超过10％［1］。儿童因免疫功能尚不健全，加上外界各种诱因的影响，易发生口腔溃疡。其病因多为B族维生素缺乏（如偏食）、损伤（如咬伤）、口腔卫生差、菌群失调等，常伴有细菌感染。发病机制可能与免疫、心理、遗传、营养和感染等因素有关，有学者认为L型链球菌与该病有紧密关联，且在溃疡面也培养出该细菌［2］。儿童患病后，口腔各部位均可发生溃疡，常见于舌、唇内及颊黏膜等处，可蔓延至唇及咽喉部。表现为口腔黏膜充血、水肿，表面出现大小不等、边界清楚的糜烂面，并有纤维素渗出物形成的假膜，剥脱假膜则出现出血面，不久又有假膜覆盖。患处疼痛或极痛，流涎增多，伴有口臭、拒食、烦躁不安，甚至发热等全身症状，严重影响进食和日常生活，且家长亦身心疲惫，十分焦虑。因此，及时消除患儿口腔疼痛，使溃疡尽快愈合、恢复进食，对减轻病儿痛苦和家长的心理负担有着十分重要的临床意义。有很多文献报道给予蒙脱石散（思密达）、鱼肝油局部涂抹治疗效果较好［3］。笔者发现两种药在混合调制过程中出现了呈色反应，可能存在配伍禁忌，现报道如下。

辽宁地区固体潮调制比空间异常特征震例“回溯性”研究

通过对辽宁地区1970年以来的11次Ms≥4.6地震的小震调制比的时空变化分析,发现在11次中强震例中,有4次地震表现出调制比异常,震中位于异常区域150km范围内,异常通常会在主震一年前出现,对辽宁地区中强地震预测发生有一定的指示意义,地震发生对应率为44.4%,小震调制比异常空间演化过程中,表现出高值异常显著强度减弱、异常区域收缩的现象。

黑龙江省及邻区中强震前固体潮调制比特征分析

基于黑龙省及邻区浅源地震目录,通过固体潮调制比的时空分析方法回顾性地研究了黑龙江省及邻区1970年以来发生的5级以上地震,发现在12次中强震震例中,有7次地震前出现调制比异常,地震发生对应率为58.33%,异常区域分布在距震中150 km内的区域,异常通常在主震前一年出现,呈现高值异常,并在震前消失或减弱。因此,固体潮调制比分析方法对黑龙江省及邻区中强地震预测具有一定的指示意义。

Orlistat-lnduced Modulation of Plasma Metabolites Independent of Weight Loss in Overweight Females

Orlistat-induced weight loss results in amelioration in several comorbidities including obesity-related dyslipidemia. The aim of the present study was to characterize the changes in the blood plasma metabolic profile from overweight women treated with Orlistat, a lipase inhibitor. A metabonomic approach employing LHNMR was applied to the access metabolic profile in lean and overweight women after a 120 day treatment with 120 mg of Orlistat three times daily. Twenty overweight women （BMI： 32.8 ± 2.9 kg/m2） were evaluated before and after Orlistat treatment and seven normal weight women （BMh 21.8 ± 1.4 kg/m2） were taken as control. After 120 days of treatment with Orlistat, no significant weight changes were observed. However, Orlistat-induced metabolic changes in overweight subjects decreased the profile differences between lean and obese individuals, independent of weight loss. These were associated to decreasing levels of lactate and calcium. Higher levels of lactate, alanine and lipids from overweight subjects were detected in comparison to lean individuals. These results show that a lipase inhibitor shifts the metabolic profile of overweight subjects towards normality, independent of weight loss.