In this paper,potential use of perfect but delayed channel estimates for variable-power discrete-rate adaptive modulation is explored.Research is concentrated on block by block adaptation.At first,a new quantity-TAUD(...In this paper,potential use of perfect but delayed channel estimates for variable-power discrete-rate adaptive modulation is explored.Research is concentrated on block by block adaptation.At first,a new quantity-TAUD(Tolerable Average Use Delay)is defined,it quantifies the performance of an adaptation scheme in tolerating the delay of channel estimates.Then,the research on TAUD shows that the delay tolerating performance declines with the increase in average power,the scheme working with more modulation modes can tolerate a longer delay,and such improvement will be more significant with the increase of average power.Finally,it shows that,as the delay tolerating performance determines the maximum block length,it has a great effect on the maximum spectral efficiency.The criterion for determining the block length appropriate for the target BER is described and a simple method of calculating the maximum block length is presented.展开更多
Aerobic glycolysis,also known as the Warburg effect,is a hallmark of cancer and essential for metabolism in malignancies,but its regulation and modulation in cancer cells remain poorly understood.Here,using large-scal...Aerobic glycolysis,also known as the Warburg effect,is a hallmark of cancer and essential for metabolism in malignancies,but its regulation and modulation in cancer cells remain poorly understood.Here,using large-scale functional screening,we identified a tumor-associated and broadly expressed oncogenic long noncoding RNA LINC00973.Notably,knocking down LINC00973 significantly inhibits the proliferation of multiple types of cancer cells and reduces tumor growth in vivo.Mechanistically,LINC00973 directly binds to lactate dehydrogenase A(LDHA),an essential glycolytic enzyme,and enhances its enzymatic activity,thereby promoting glycolysis.Clinically,high expression of LINC00973 is significantly associated with poor prognosis in many types of human cancers.This work demonstrates that LINC00973 modulates cancer-specific regulation of the Warburg effect,and may represent a potential target for broad-acting anti-cancer therapies.展开更多
基金supported by National Natural Science Foundation of China(No.61071087)Chun Lei 2009BWZ037 from SDUST,China
文摘In this paper,potential use of perfect but delayed channel estimates for variable-power discrete-rate adaptive modulation is explored.Research is concentrated on block by block adaptation.At first,a new quantity-TAUD(Tolerable Average Use Delay)is defined,it quantifies the performance of an adaptation scheme in tolerating the delay of channel estimates.Then,the research on TAUD shows that the delay tolerating performance declines with the increase in average power,the scheme working with more modulation modes can tolerate a longer delay,and such improvement will be more significant with the increase of average power.Finally,it shows that,as the delay tolerating performance determines the maximum block length,it has a great effect on the maximum spectral efficiency.The criterion for determining the block length appropriate for the target BER is described and a simple method of calculating the maximum block length is presented.
基金This work was supported by the National Natural Science Foundation of China(31371314 and 81673460)Sichuan Youth Science and Technology Innovation Research Team of Experimental Formulology(2020JDTD0022).
文摘Aerobic glycolysis,also known as the Warburg effect,is a hallmark of cancer and essential for metabolism in malignancies,but its regulation and modulation in cancer cells remain poorly understood.Here,using large-scale functional screening,we identified a tumor-associated and broadly expressed oncogenic long noncoding RNA LINC00973.Notably,knocking down LINC00973 significantly inhibits the proliferation of multiple types of cancer cells and reduces tumor growth in vivo.Mechanistically,LINC00973 directly binds to lactate dehydrogenase A(LDHA),an essential glycolytic enzyme,and enhances its enzymatic activity,thereby promoting glycolysis.Clinically,high expression of LINC00973 is significantly associated with poor prognosis in many types of human cancers.This work demonstrates that LINC00973 modulates cancer-specific regulation of the Warburg effect,and may represent a potential target for broad-acting anti-cancer therapies.
