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基于网络药理学和分子对接技术的调压方治疗原发性高血压的作用机制
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作者 张骞 李秀育 +1 位作者 田佰福 唐震 《宁夏医科大学学报》 2024年第11期1173-1179,共7页
目的通过网络药理学方法和分子对接技术探究调压方治疗原发性高血压的作用机制。方法利用TCMSP、TCM中药数据库及文献获取中药成分;Super-PRED分析药物活性成分的靶点;通过GeneCards、NCBI、OMIM、PharmGKB疾病数据库检索获取原发性高... 目的通过网络药理学方法和分子对接技术探究调压方治疗原发性高血压的作用机制。方法利用TCMSP、TCM中药数据库及文献获取中药成分;Super-PRED分析药物活性成分的靶点;通过GeneCards、NCBI、OMIM、PharmGKB疾病数据库检索获取原发性高血压的疾病靶点;选择药物—疾病交集靶点通过Cytoscape软件分析获取药物核心作用靶点和核心成分;利用DAVID数据库完成核心靶点的GO和KEGG富集分析;通过CB-Dock2在线分子对接调压方核心成分与核心靶点。结果筛选获取得到调压方药物活性成分284个;调压方活性成分靶点311个;原发性高血压疾病靶点1550个;药物—疾病交集靶点107个;核心作用靶点NFKB1、KDR、STAT3、TP53、PTGS2、TLR4等19个;GO富集分析显示,调压方通过多种生物学过程参与抗原发性高血压;KEGG富集分析显示,调压方通过癌症蛋白聚糖、脂质和动脉粥样硬化等途径调控原发性高血压;分子对接结果显示,调压方核心成分与核心靶点之间有较好的结合活性。结论调压方可通过“多成分—多靶点-多途径”方式作用于NFKB1、KDR、STAT3、CXCR4、TLR4、SRC等靶点参与脂质与动脉粥样硬化信号通路、MAPK信号通路、PI3K-AKT信号通路等途径发挥治疗原发性高血压作用。 展开更多
关键词 调压方 原发性高血 网络药理学 分子对接 作用机制
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清眩调压方治疗更年期女性高血压病的临床研究 被引量:14
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作者 陶丽丽 马晓昌 陈可冀 《中国中西医结合杂志》 CAS CSCD 北大核心 2009年第8期680-684,共5页
目的探讨清眩调压方对更年期女性高血压病的降压效果及作用机理。方法将87例患者随机分为对照组(43例)和试验组(44例),对照组给予培哚普利片加中药模拟剂,试验组给予培哚普利片加清眩调压方颗粒剂,疗程2个月,治疗前后分别检测患者动态血... 目的探讨清眩调压方对更年期女性高血压病的降压效果及作用机理。方法将87例患者随机分为对照组(43例)和试验组(44例),对照组给予培哚普利片加中药模拟剂,试验组给予培哚普利片加清眩调压方颗粒剂,疗程2个月,治疗前后分别检测患者动态血压(ABMP)、心率、相关临床症状、血脂、血清雌二醇(E2)、超敏C反应蛋白(Hs-CRP)、同型半胱氨酸(HCY)、血管紧张素Ⅱ(AngⅡ)的水平。结果治疗后,试验组可显著降低血压变异性和夜间血压下降率,且优于对照组(P<0.05),降压的总有效率和显效率也优于对照组(P<0.05);试验组对头痛、腰酸、膝软、失眠症状改善明显(P<0.05);在降低心率、总胆固醇(TC)、低密度脂蛋白(LDL-C)方面明显优于对照组(P<0.05);内源性血浆E2水平较治疗前上升(P<0.05),而对照组治疗前后变化无统计学意义;试验组降低血浆Hs-CRP、AngⅡ水平,升高内源性血浆E2水平优于对照组(P<0.05)。结论清眩调压方对更年期女性高血压患者具有较好的降压作用,能降低更年期女性高血压的血压变异性,改善患者更年期综合征症状、血脂代谢及血浆E2、Hs-CRP、AngⅡ水平,提示其作用机理可能与调节交感-迷走神经功能、神经-内分泌-免疫功能及抑制循环肾素-血管紧张素-醛固酮系统(RAAS)活性有关。 展开更多
关键词 清眩调压方 高血 更年期女性 临床研究
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调压方治疗老年单纯收缩期高血压阳亢络阻证疗效观察 被引量:8
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作者 张骞 张敏 +2 位作者 朱思敏 李志明 杨学信 《宁夏医科大学学报》 2014年第4期461-463,共3页
目的观察调压方治疗老年单纯收缩期高血压阳亢络阻证的临床疗效。方法将入选患者180例随机分为单纯西药组、治疗组、对照组3组,每组60例,基础治疗均单纯口服非洛地平缓释片,2.5mg·d-1;治疗组加服调压方颗粒剂,对照组加服清脑降压... 目的观察调压方治疗老年单纯收缩期高血压阳亢络阻证的临床疗效。方法将入选患者180例随机分为单纯西药组、治疗组、对照组3组,每组60例,基础治疗均单纯口服非洛地平缓释片,2.5mg·d-1;治疗组加服调压方颗粒剂,对照组加服清脑降压片,3组疗程均为4周,治疗后观察疗效。结果治疗后,三组患者24h动态血压比较平均收缩压降低差异无统计学意义(P>0.05),治疗组白天和夜间平均收缩压均明显低于单纯西药组(P<0.05);治疗组用药后降压及中医证候疗效总有效率均优于单纯西药组(P均<0.05)。三组患者治疗前后血、尿、便常规及肝、肾功能检查均未见明显改变,用药过程中无明显不良反应。结论调压方是治疗老年单纯收缩期高血压阳亢络阻证的有效方药,值得推广。 展开更多
关键词 老年单纯收缩期高血 阳亢络阻证 调压方
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调压方对高血压病阳亢络阻证患者动脉僵硬度的影响 被引量:1
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作者 王辉 张骞 +2 位作者 刘丽梅 李志明 杨学信 《宁夏医科大学学报》 2015年第3期346-349,共4页
目的观察调压方对高血压病阳亢络阻证患者外周动脉僵硬度的影响。方法纳入符合条件的高血压病患者100例,依据治疗分为西药对照组和调压方治疗组各50例,两组均进行常规治疗,治疗组在常规治疗基础上加用调压方,两组均治疗2个月。观察治疗... 目的观察调压方对高血压病阳亢络阻证患者外周动脉僵硬度的影响。方法纳入符合条件的高血压病患者100例,依据治疗分为西药对照组和调压方治疗组各50例,两组均进行常规治疗,治疗组在常规治疗基础上加用调压方,两组均治疗2个月。观察治疗前后踝肱脉搏波传导速度(ba PWV)和踝臂指数(ABI)的变化。结果治疗后两组患者ba PWV均下降(P均<0.05),治疗组下降程度更明显(P<0.05);治疗后调压方治疗组外周动脉僵硬度改善程度优于单纯西药组(P<0.05)。结论在常规治疗基础上加用调压方能进一步降低高血压病患者ba PWV,对改善其外周动脉僵硬度有一定效果。 展开更多
关键词 高血 阳亢络阻证 中医治疗 调压方 动脉僵硬度
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调压方治疗老年单纯收缩期高血压阳亢络阻证90例 被引量:1
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作者 张骞 刘丽梅 +2 位作者 朱思敏 李志明 杨学信 《中医研究》 2013年第9期8-10,共3页
目的:观察调压方治疗老年单纯收缩期高血压阳亢络阻证的临床疗效。方法:将180例老年单纯收缩期高血压阳亢络阻证患者采用随机数字表法随机分为治疗组和对照组各90例,两组均给予非洛地平缓释片基础治疗,对照组给予清脑降压片,4片/次,3次... 目的:观察调压方治疗老年单纯收缩期高血压阳亢络阻证的临床疗效。方法:将180例老年单纯收缩期高血压阳亢络阻证患者采用随机数字表法随机分为治疗组和对照组各90例,两组均给予非洛地平缓释片基础治疗,对照组给予清脑降压片,4片/次,3次/d,口服;治疗组给予调压方颗粒剂,每日1剂,开水冲服,150 mL/次,分2次口服。两组均以10 d为1个疗程,共治疗4个疗程。结果:治疗组显效36例,有效48例,无效6例,有效率占93.3%;对照组显效28例,有效45例,无效17例,有效率占81.1%。两组对比,差别有统计学意义(P<0.05)。结论:调压方治疗老年单纯收缩期高血压阳亢络阻证具有良好的疗效。 展开更多
关键词 老年单纯收缩期高血 中医药疗法 阳亢络阻证 中医药疗法 临床观察 调压方 治疗应用
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苯磺酸左旋氨氯地平联合滋阴补阳调压方治疗阴阳两虚型老年性高血压患者的临床疗效研究 被引量:1
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作者 周萍 胡芳 张咏梅 《海峡药学》 2020年第7期96-98,共3页
目的研究滋阴补阳调压方联合苯磺酸左旋氨氯地平治疗阴阳两虚型老年性高血压患者的临床疗效。方法本次研究对象为醴陵市中医院自2019年阴阳两虚型老年性高血压患者60例,根据治疗方法不同将其等分为实验组和对照组,每组各30例。对照组采... 目的研究滋阴补阳调压方联合苯磺酸左旋氨氯地平治疗阴阳两虚型老年性高血压患者的临床疗效。方法本次研究对象为醴陵市中医院自2019年阴阳两虚型老年性高血压患者60例,根据治疗方法不同将其等分为实验组和对照组,每组各30例。对照组采用苯磺酸左旋氨氯地平治疗,实验组在对照组基础上加用滋阴补阳调压方治疗,比较两患者治疗效果。结果实验组总有效率(96.7%)高于对照组总有效率(76.7%),差异显著(P<0.05)。实验组不良反应发生率(6.7%)略高于对照组(3.3%),差异不大(P>0.05)。结论滋阴补阳调压方联合苯磺酸左旋氨氯地平治疗阴阳两虚型老年性高血压患者安全有效,值得在临床中推广。 展开更多
关键词 滋阴补阳调压方 苯磺酸左旋氨氯地平 阴阳两虚型 老年性高血 临床疗效
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滋阴补阳调压方联合氨氯地平治疗老年性高血压疗效观察
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作者 周萍 胡芳 张咏梅 《内蒙古中医药》 2020年第7期14-15,共2页
目的:观察滋阴补阳调压方联合氨氯地平治疗老年性高血压的疗效及对24 h动态血压平滑指数的影响。方法:采用随机数表法将2017年6月—2019年9月我院收治的86例老年性高血压患者分为观察组(n=43)和对照组(n=43)。对照组予以苯磺酸左旋氨氯... 目的:观察滋阴补阳调压方联合氨氯地平治疗老年性高血压的疗效及对24 h动态血压平滑指数的影响。方法:采用随机数表法将2017年6月—2019年9月我院收治的86例老年性高血压患者分为观察组(n=43)和对照组(n=43)。对照组予以苯磺酸左旋氨氯地平治疗,观察组在对照组基础上加用滋阴补阳调压方治疗,比较两组疗效及24 h动态血压平滑指数(SI)。结果:观察组有效率(95.4%,41/43)显著高于对照组(79.1%,34/43),差异有统计学意义(P<0.05)。观察组SISBP、SIDBP明显高于对照组,差异显著(P<0.05)。结论:滋阴补阳调压方联合氨氯地平治疗老年性高血压疗效确切,可显著提高24 h动态SI,平稳降压,值得在临床上推广。 展开更多
关键词 滋阴补阳调压方 氨氯地平 高血 平滑指数
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调压活络方治疗H型高血压的疗效及机制研究 被引量:3
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作者 卢艳 王艳辉 王海涛 《世界中医药》 CAS 2017年第2期310-314,共5页
目的:观察调压活络方治疗H型高血压的疗效,初步探讨其机制。方法:将2015年3月至2016年2月就治的H型高血压患者94例采用随机数字表法分为2组,每组47例,对照组给予依叶片口服,1片/d;治疗组给予依叶片+调压活络方治疗,1剂/d,持续治疗2个疗... 目的:观察调压活络方治疗H型高血压的疗效,初步探讨其机制。方法:将2015年3月至2016年2月就治的H型高血压患者94例采用随机数字表法分为2组,每组47例,对照组给予依叶片口服,1片/d;治疗组给予依叶片+调压活络方治疗,1剂/d,持续治疗2个疗程。观察2组治疗效果,检测血管活性物质、血液流变学、氧化应激指标及肾素-血管紧张素Ⅱ-醛固酮(Renin AngiotensinⅡAldosterone System,RAAS)系统变化。结果:1)治疗组治疗后除了气短、乏力、善忘积分外,其余症候积分及总分下降幅度均大于对照组,差异有统计学意义(P<0.05);2)治疗后治疗组日间收缩压、舒张压及晚间收缩压、舒张压下降幅度大于对照组,差异有统计学意义(P<0.05);2组治疗后高同型半胱氨酸(Homocysteine,Hcy)浓度比较差异无统计学意义(P>0.05);3)治疗组治疗后RA、AngⅡ低于对照,差异有统计学意义(P<0.05);4)2组治疗后丙二醛(Malondialdehyde,MDA)、髓过氧化物酶(myeloperoxidase,MPO)、氧化物歧化酶(Superoxide Dismutase,SOD)与治疗前比较差异无统计学意义(P>0.05);5)治疗组治疗后前列环素(Prostacyclin,PGI2)低于对照组,而血栓素(Thromboxane A2,TXA2)高于对照组,差异有统计学意义(P<0.05);6)治疗组治疗后血小板活化因子、血小板凝聚率、全血黏度高切均低于对照组,差异有统计学意义(P<0.05)。结论:调压活络方可有效控制H型高血压患者血压,改善症状,值得临床推广适用;其机制可能与调节RAAS系统、保护内皮细胞及减少血液黏稠度有关。 展开更多
关键词 H型高血 活络 血液流变学 肾素-血管紧张素Ⅱ-醛固酮系统
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杨学信经验方治疗肝阳上亢型高血压病50例临床观察 被引量:1
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作者 张骞 徐娟 +2 位作者 李防栋 师常喜 杨学信 《中医药临床杂志》 2013年第5期385-386,共2页
目的:观察杨学信经验方(调压方)治疗肝阳上亢型高血压病的临床疗效。方法:将100例入选患者随机分为治疗组和对照组各50例,对照组予清脑降压片口服治疗,治疗组予调压方汤剂治疗,2组疗程均为4周,治疗后观察血压、临床症状的改善情况以及... 目的:观察杨学信经验方(调压方)治疗肝阳上亢型高血压病的临床疗效。方法:将100例入选患者随机分为治疗组和对照组各50例,对照组予清脑降压片口服治疗,治疗组予调压方汤剂治疗,2组疗程均为4周,治疗后观察血压、临床症状的改善情况以及有无不良反应,进行疗效判定。结果:2组显效率及有效率差异均无统计学意义(χ2分别为2.15、2.99,P>0.05)。结论:调压方治疗肝阳上亢型高血压病具有良好的疗效。 展开更多
关键词 高血 肝阳上亢型 杨学信 调压方 名老中医经验传承
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Proximal gastric motility in critically ill patients with type 2 diabetes mellitus 被引量:3
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作者 Nam Q Nguyen Robert J Fraser +2 位作者 Laura K Bryant Marianne Chapman Richard H Holloway 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第2期270-275,共6页
AIM: To investigate the proximal gastric motor response to duodenal nutrients in critically ill patients with longstanding type 2 diabetes mellitus.METHODS: Proximal gastric motility was assessed (using a barostat... AIM: To investigate the proximal gastric motor response to duodenal nutrients in critically ill patients with longstanding type 2 diabetes mellitus.METHODS: Proximal gastric motility was assessed (using a barostat) in 10 critically ill patients with type 2 diabetes mellitus (59±3 years) during two 60-min duodenal infusions of Ensure (1 and 2 kcal/min), in random order, separated by 2h fasting. Data were compared with 15 non-diabetic critically ill patients (48 ± 5 years) and 10 healthy volunteers (28 ±3 years). RESULTS: Baseline proximal gastric volumes were similar between the three groups. In diabetic patients, proximal gastric relaxation during I kcal/min nutrient infusion was similar to non-diabetic patients and healthy controls. In contrast, relaxation during 2 kcal/ min infusion was initially reduced in diabetic patients (P 〈 0.05) but increased to a level similar to healthy humans, unlike non-diabetic patients where relaxation was impaired throughout the infusion. Duodenal nutrient stimulation reduced the fundic wave frequency in a dose-dependent fashion in both the critically ill diabetic patients and healthy subjects, but not in critically ill patients without diabetes. Fundic wave frequency in diabetic patients and healthy subjects was greater than in non-diabetic patients.CONCLUSION: In patients with diabetes mellitus, proximal gastric motility is less disturbed than nondiabetic patients during critical illness, suggesting that these patients may not be at greater risk of delayed gastric emptying. 展开更多
关键词 Proximal gastric function Diabetes mellitus type 2 Critical illness Enteral nutrition
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An Analytical Approach to Thermal and Electrical Transport in a Mesoscopic Conductor
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作者 WANG Zheng-Chuan SU Gang +1 位作者 LI Ling GAO Jie 《Communications in Theoretical Physics》 SCIE CAS CSCD 2005年第4X期735-742,共8页
In order to consider the thermal and electrical coherent transport in a mesoscopic conductor under the influence of electron-electron interaction, in this paper, we establish a method in terms of which one can analyti... In order to consider the thermal and electrical coherent transport in a mesoscopic conductor under the influence of electron-electron interaction, in this paper, we establish a method in terms of which one can analytically obtain the Hartree self-consistent potential instead of computing it by the numerical iterative procedure as usual, which is convenient for us to describe the thermal and electric current flow through a mesoscopic conductor. If we study the electron-electron interaction at the Hartree approximation level, the Hartree potential satisfies the Poisson equation and Schroedinger equation, so when we expand the action function S(x) by Planck constant h, the self-consistent potential and the wavefunction can be solved analytically order by order, and the thermal and electrical conductance can thus be obtained readily. However, we just show the quantum corrections up to the second order. 展开更多
关键词 mesoscopic conductor thermal and electrical transport
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埋地式燃气调压装置的应用 被引量:2
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作者 吴胜雷 孙浩 《煤气与热力》 2012年第6期39-42,共4页
论述了圆筒式埋地燃气调压装置、方箱式埋地燃气调压装置、集成式埋地燃气调压装置的结构特点、安装方式、具体安装做法,分析了使用中应注意的问题。
关键词 地下燃气装置 埋地式燃气装置 圆筒式埋地燃气装置 箱式埋地燃气装置 集成式埋地燃气装置
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A Parameter Determination Method of Distribution Voltage Regulators Considering Tap Change and Voltage Profile
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作者 Yuji Hanai Yasuhiro Hayashi +2 位作者 Junya Matsuki Yoshiaki Fuwa Kenjiro Mori 《Journal of Energy and Power Engineering》 2012年第1期117-125,共9页
This paper proposes a parameter determination method of distribution voltage regulators load ratio control transformers (LRT) and step voltage regulators (SVR) considering the tap change and voltage profile. The m... This paper proposes a parameter determination method of distribution voltage regulators load ratio control transformers (LRT) and step voltage regulators (SVR) considering the tap change and voltage profile. The method takes two procedures in order to simplify the optimization problem and to reduce calculation time. One is to simultaneously determine the control parameters of LRT and SVR minimizing voltage violations and voltage variations. The algorithm is based on particle swarm optimization (PSO), which is one of non-linear optimization methods by using a concept of swarm intelligence. Another is to determine the dead-band width of LRT and SVR on the basis of bi-evaluation of tap change and voltage margin. The concept of a Pareto optimal solution is used for the decision of the best dead-band width. As the results of numerical simulations using distribution network model, the validity of the proposed method has been affirmed. 展开更多
关键词 Distribution network voltage control LRT SVR control parameter deadband PSO.
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Deterministic Quantum Key Distribution Using Gaussian-Modulated Squeezed States 被引量:1
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作者 何广强 朱俊 曾贵华 《Communications in Theoretical Physics》 SCIE CAS CSCD 2011年第10期664-668,共5页
A continuous variable ping-pong scheme, which is utilized to generate deterministic private key, is proposed. The proposed scheme is implemented physically by using Ganssian-modulated squeezed states. The deterministi... A continuous variable ping-pong scheme, which is utilized to generate deterministic private key, is proposed. The proposed scheme is implemented physically by using Ganssian-modulated squeezed states. The deterministic char- acteristic, i.e., no basis reconciliation between two parties, leads a nearly two-time efficiency comparing to the standard quantum key distribution schemes. Especially, the separate control mode does not need in the proposed scheme so that it is simpler and more available than previous ping-pong schemes. The attacker may be detected easily through the fidelity of the transmitted signal, and may not be successful in the beam splitter attack strategy. 展开更多
关键词 Gaussian-modulated squeezed state quantum key distribution deterministic private key
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Methodology Approach Using Harmonic Synthesis as Simulation Method for Investigation of Power Network with Non-Linear Loads 被引量:2
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作者 M. Befiova B. Dobrucky M. Pokorny 《Journal of Energy and Power Engineering》 2010年第11期36-42,共7页
The paper deals with analysis and synthesis of non-harmonic and non-linear sources and appliances, and their interaction with harmonic power supply network. Basic idea is based on knowledge of harmonic spectrum of the... The paper deals with analysis and synthesis of non-harmonic and non-linear sources and appliances, and their interaction with harmonic power supply network. Basic idea is based on knowledge of harmonic spectrum of the sources and/or appliances, respectively. Obviously, one need to know voltage harmonic components of voltage sources (renewable with inverters,...), and current harmonic components generated by non-linear appliances (rectifiers,...). Method of investigation lies on decomposition of real electric circuit into n-harmonic separated equivalent schemes for each harmonic component. Then transient analysis will be done for each scheme separately using "impedance harmonic matrices". The important fact is that each equivalent scheme is now linearized and therefore easily calculated. Finally, the effects of each investigated schemes arc summed into resulting quantities of real non-linear electric circuit. 展开更多
关键词 HARMONICS MODELING SIMULATION converter circuits single phase systems Fourier analysis.
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Using the EMD Method to Determine Fault Criterion for Medium-low Pressure Gas Regulators 被引量:11
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作者 HAO Xuejun LIU Qiang +1 位作者 YANG Guobin DU Yi 《Journal of Thermal Science》 SCIE EI CAS CSCD 2015年第6期557-561,共5页
By extracting the outlet pressure data of gas regulators,this paper uses the EMD toolbox of the MATLAB software,which can perform data decomposition and the Hilbert-Huang Transform to find the rules with fault data.Ev... By extracting the outlet pressure data of gas regulators,this paper uses the EMD toolbox of the MATLAB software,which can perform data decomposition and the Hilbert-Huang Transform to find the rules with fault data.Eventually,the medium-low pressure gas regulator fault criterion can be established. 展开更多
关键词 medium-low pressure gas regulator EMD decomposition fault criterion
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Advances and New Applications Using the Acousto-Optic Effect in Optical Fibers 被引量:1
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作者 Alexandre A. P. POHL Roberson A. OLIVEIRA +5 位作者 Ricardo E. DA SILVA Carlos A. F. MARQUES Paulo de Tarso NEVES JR. Kevin COOK John CANNING Rogério N. NOGUEIRA3 《Photonic Sensors》 SCIE EI CAS 2013年第1期1-25,共25页
This work presents a short review of the current research on the acousto-optic mechanism applied to optical fibers. The role of the piezoelectric element and the acousto-optic modulator in the excitation of flexural a... This work presents a short review of the current research on the acousto-optic mechanism applied to optical fibers. The role of the piezoelectric element and the acousto-optic modulator in the excitation of flexural and longitudinal acoustic modes in the frequency range up to 1.2 MHz is highlighted. A combination of the finite elements and the transfer matrix methods is used to simulate the interaction of the waves with Bragg and long period gratings. Results show a very good agreement with experimental data. Recent applications such as the writing of gratings under the acoustic excitation and a novel viscometer sensor based on the acousto-optic mechanism are discussed. 展开更多
关键词 ACOUSTO-OPTICS fiber gratings optical fibers optical sensors
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