Pre-coding aided quadrature spatial modulation(PQSM) is a promising multiple input multiple output(MIMO) transmission technology. The multiuser(MU) detection in PQSM system is investigated in this paper. Based on the ...Pre-coding aided quadrature spatial modulation(PQSM) is a promising multiple input multiple output(MIMO) transmission technology. The multiuser(MU) detection in PQSM system is investigated in this paper. Based on the known channel state information, pre-coding matrix is designed to pre-process the in-phase and quadrature signals of quadrature spatial modulation(QSM) to reduce the inter-channel interference. In order to lower the complexity at the receiver brought by the orthogonality of the PQSM system, an orthogonal matching pursuit(OMP) detection algorithm and a reconstructed model are proposed. The analysis and simulation results show that the proposed algorithm can obtain a similar bit error rate(BER) performance as the maximum likelihood(ML) detection algorithm with more than 80% reduction of complexity.展开更多
Myogenesis is a complex process required for skeletal muscle formation during embryonic development and for regeneration and growth of myofibers in adults. Accumulating evidence suggests that long non-coding RNAs （In...Myogenesis is a complex process required for skeletal muscle formation during embryonic development and for regeneration and growth of myofibers in adults. Accumulating evidence suggests that long non-coding RNAs （IncRNAs） play key roles in regulating cell fate decision and function in various tissues. However, the role of IncRNAs in the regulation of myogenesis remains poorly understood. In this study, we identifed a novel muscle-enriched IncRNA called ＇Myolinc （AK142388）＇, which we functionally characterized in the C2C12 myoblast cell line. Myolinc is predominately localized in the nucleus, and its levels increase upon induction of the differ-entiation. Knockdown of Myolinc impairs the expression of myogenic regulatory factors and formation of multi-nucleated myotubes in cultured myoblasts. Myolinc also regulates the expression of Filipl in a cis-manner. Similar to MyoUnc, knockdown of FiUpl inhi-bits myogenic differentiation. Furthermore, Myolinc binds to TAR DNA-binding protein 43 （TDP-43）, a DNA/RNA-binding protein that regulates the expression of muscle genes （e.g. Actal and MyoD）. Knockdown of TDP-43 inhibits myogenic differentiation. We also show that Myolinc-TDP-43 interaction is essential for the binding of TDP-43 to the promoter regions of muscle marker genes. Finally, we show that silencing of Myolinc inhibits skeletal muscle regeneration in adult mice. Altogether, our study identifies a novel IncRNA that controls key regulatory networks of myogenesis.展开更多
Rather than random degradation products, the 18 to 40 nucleotides(nt) transfer RNA-derived small RNAs(tsRNAs) are RNA species generated specifically from pre-RNAs or mature tRNAs in archaea, bacteria and eukaryotes. R...Rather than random degradation products, the 18 to 40 nucleotides(nt) transfer RNA-derived small RNAs(tsRNAs) are RNA species generated specifically from pre-RNAs or mature tRNAs in archaea, bacteria and eukaryotes. Recent studies from animal systems have shown that tsRNAs are important non-coding RNAs that regulate gene expression at the transcriptional and/or post-transcriptional levels. They are involved in various biological processes, such as cell proliferation, tumor genesis, stress response and intergenerational epigenetic inheritance. In this review, we will summarize the discovery, biogenesis, and function of tsRNAs in higher plants. In addition, analysis on tsRNAs from lower plants is shown.展开更多
基金partially supported by the National Natural Science Foundation of China (Grant No. 61701063)Scientific and Technological Research Program of Chongqing Municipal Education Commission (No. KJ1600435)
文摘Pre-coding aided quadrature spatial modulation(PQSM) is a promising multiple input multiple output(MIMO) transmission technology. The multiuser(MU) detection in PQSM system is investigated in this paper. Based on the known channel state information, pre-coding matrix is designed to pre-process the in-phase and quadrature signals of quadrature spatial modulation(QSM) to reduce the inter-channel interference. In order to lower the complexity at the receiver brought by the orthogonality of the PQSM system, an orthogonal matching pursuit(OMP) detection algorithm and a reconstructed model are proposed. The analysis and simulation results show that the proposed algorithm can obtain a similar bit error rate(BER) performance as the maximum likelihood(ML) detection algorithm with more than 80% reduction of complexity.
文摘Myogenesis is a complex process required for skeletal muscle formation during embryonic development and for regeneration and growth of myofibers in adults. Accumulating evidence suggests that long non-coding RNAs （IncRNAs） play key roles in regulating cell fate decision and function in various tissues. However, the role of IncRNAs in the regulation of myogenesis remains poorly understood. In this study, we identifed a novel muscle-enriched IncRNA called ＇Myolinc （AK142388）＇, which we functionally characterized in the C2C12 myoblast cell line. Myolinc is predominately localized in the nucleus, and its levels increase upon induction of the differ-entiation. Knockdown of Myolinc impairs the expression of myogenic regulatory factors and formation of multi-nucleated myotubes in cultured myoblasts. Myolinc also regulates the expression of Filipl in a cis-manner. Similar to MyoUnc, knockdown of FiUpl inhi-bits myogenic differentiation. Furthermore, Myolinc binds to TAR DNA-binding protein 43 （TDP-43）, a DNA/RNA-binding protein that regulates the expression of muscle genes （e.g. Actal and MyoD）. Knockdown of TDP-43 inhibits myogenic differentiation. We also show that Myolinc-TDP-43 interaction is essential for the binding of TDP-43 to the promoter regions of muscle marker genes. Finally, we show that silencing of Myolinc inhibits skeletal muscle regeneration in adult mice. Altogether, our study identifies a novel IncRNA that controls key regulatory networks of myogenesis.
基金supported by the General Program of National Natural Science Foundation of China (31471165 to Zhicheng Dong)
文摘Rather than random degradation products, the 18 to 40 nucleotides(nt) transfer RNA-derived small RNAs(tsRNAs) are RNA species generated specifically from pre-RNAs or mature tRNAs in archaea, bacteria and eukaryotes. Recent studies from animal systems have shown that tsRNAs are important non-coding RNAs that regulate gene expression at the transcriptional and/or post-transcriptional levels. They are involved in various biological processes, such as cell proliferation, tumor genesis, stress response and intergenerational epigenetic inheritance. In this review, we will summarize the discovery, biogenesis, and function of tsRNAs in higher plants. In addition, analysis on tsRNAs from lower plants is shown.
