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表观遗传结合免疫治疗——肿瘤治疗的新策略 被引量:1
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作者 何滔 郭明洲 《胃肠病学和肝病学杂志》 CAS 2017年第4期361-364,共4页
表观遗传异常频繁发生于各种肿瘤,表观遗传改变可能成为肿瘤的诊断、预后和化疗敏感性的标志物。DNA甲基化、组蛋白修饰和非编码RNA能够调控许多基因的表达,且这些表观遗传学改变在一定条件下逆转,为肿瘤的治疗提供新的机遇。近年来,随... 表观遗传异常频繁发生于各种肿瘤,表观遗传改变可能成为肿瘤的诊断、预后和化疗敏感性的标志物。DNA甲基化、组蛋白修饰和非编码RNA能够调控许多基因的表达,且这些表观遗传学改变在一定条件下逆转,为肿瘤的治疗提供新的机遇。近年来,随着对免疫耐受机制的深入研究,针对免疫检查点的抗体应运而生,以CTLA-4、PD-1、PD-L1抗体为代表的"免疫检查点阻断治疗"取得了突出的进展。肿瘤细胞通过表观遗传调控,直接或间接下调肿瘤细胞与宿主免疫系统相互作用的关键分子的表达,影响免疫系统识别或损害免疫系统的活性。因此,表观遗传治疗结合免疫检查点阻断治疗有望获得进一步的突破。 展开更多
关键词 表观遗传学 调节性免疫治疗 免疫检查点阻断 肿瘤
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中西医结合肾本质研究回顾 被引量:100
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作者 沈自尹 《中国中西医结合杂志》 CAS CSCD 北大核心 2012年第3期304-306,共3页
中西医结合,概言之是各取所长、优势互补。中医的长处是整体着眼,针对功能采取调节性治疗;西医的长处是从局部出发,针对功能采取拮抗性治疗,从研究的角度是与时俱进,使中西医有高起点的结合。
关键词 中西医结合 肾本质 调节性治疗 优势互补 与时俱进 拮抗性
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Depressive Neurosis Treated by Acupuncture for Regulating the Liver―A Report of 176 Cases 被引量:7
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作者 符文彬 樊莉 +9 位作者 朱晓平 何青 王玲 庄礼兴 刘远声 唐纯志 李颖文 蒙昌荣 张洪来 严洁 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2009年第2期83-86,共4页
Objective: To observe therapeutic effect of acupuncture for regulating the liver on depressive neurosis. Methods: In a multi-center randomized controlled trial, 440 patients were divided into 3 groups: Acupuncture gro... Objective: To observe therapeutic effect of acupuncture for regulating the liver on depressive neurosis. Methods: In a multi-center randomized controlled trial, 440 patients were divided into 3 groups: Acupuncture group for regulating the liver (Acup., 176 cases) was treated by acupuncture at Siguan Points, i.e. bilateral Hegu (LI 4) and Taichong (LR 3), Baihui (GV 20) and Yintang (EX-HN3) plus ear-acupuncture, Prozac group (P., 176 cases) by oral administration of Prozac, and Non-acupoint needling group (NAN, 88 cases) by acupuncture at non-acupoints as acupuncture placebo. Self-rating Depression Scale (SDS) was examined before treatment, and one month, two and three months after treatment respectively to evaluate therapeutic effect, and Rating Scale for Side Effects (SERS) was used to evaluate the safety. Results: After one month of treatment, SDS scores in Acup. Group were significantly lower than that in P. Group (P<0.05) and than that in NAN Group (P<0.01), and SDS scores in P. Group were lower than that in NAN Group (P<0.05), showing the SDS scores in Acup. Group <P. Group <NAN Group. After 2 months of treatment, SDS scores in Acup. Group were also significantly lower than that in P. Group (P<0.01) and than that in NAN Group (P<0.01), and SDS scores in P. Group were also lower than that in NAN Group (P<0.05), showing the SDS scores in Acup. Group <P. Group <NAN Group. After 3 months of treatment, SDS scores in Acup. Group were also significantly lower than that in P. Group (P<0.01) and than that in NAN Group (P<0.01), and SDS scores in P. Group were also lower than that in NAN Group (P<0.01), showing the SDS score in Acup. Group <P. Group <NAN Group. After treatment, SERS scores were 0.16±0.95, 6.51±5.09 and 0.23±1.36 in Acup. Group, P. Group and NAN Group respectively. A significant difference existed between Acup. Group and P. Group (P<0.05), but no significant difference between Acup. Group and NAN Group (P>0.05), showing the SERS scores in Acup. Group <NAN Group <P. Group. No side effect was found in Acup. and NAN groups. Conclusion: The therapeutic effect of acupuncture on depressive neurosis is better than or similar to that of Prozac but with less side effect. 展开更多
关键词 DEPRESSION regulating the liver acupuncture therapy investigation
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The Qi-regulating Massotherapy for Treatment of Tonic Headache in 150 Cases
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作者 谭涛 王金贵 +2 位作者 孙庆 石玉生 王新中 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2009年第1期13-18,共6页
Objective: To observe the therapeutic effects of the qi-regulating massotherapy (通脉调气推拿法) for treatment of tonic headache. Methods: According to different clinical types, 150 cases of tonic headache were treate... Objective: To observe the therapeutic effects of the qi-regulating massotherapy (通脉调气推拿法) for treatment of tonic headache. Methods: According to different clinical types, 150 cases of tonic headache were treated by the qi-regulating massotherapy. Evaluations were done according to the scores for physiology, behavior, intensity of pain, and the therapeutic effects. Results: After treatment, the total score in the 150 cases significantly decreased as compared with that before treatment (P<0.01). The total effective rate was 93.3%, and the effective rates for all the types were over 90%. Conclusion: The qi-regulating massotherapy is indicated for all types of tonic headache with obvious therapeutic effects. 展开更多
关键词 tonic headache massage therapy qi-regulating massotherapy
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