在美国,阿片类药物和苯二氮?类药物的联合处方非常常见。虽然所有阿片类药物的说明书上都有类似"使用中枢神经系统抑制药物时,应谨慎使用阿片类镇痛药"的警示,但疾病控制中心(Centers for Disease Control,CDC)的数据表明,2012年每...在美国,阿片类药物和苯二氮?类药物的联合处方非常常见。虽然所有阿片类药物的说明书上都有类似"使用中枢神经系统抑制药物时,应谨慎使用阿片类镇痛药"的警示,但疾病控制中心(Centers for Disease Control,CDC)的数据表明,2012年每100名美国人中卫生保健专业人员为其开出了82.5张阿片类药物处方以及37.6张苯二氮[艹卓]类处方。展开更多
BACKGROUND: Herceptin (trastuzumab), a new achemotherapeutic agent, is a monoclonal antibody that blocks the human epidermal growth factor receptor 2 protein. There is no reported experience with use of this agent dur...BACKGROUND: Herceptin (trastuzumab), a new achemotherapeutic agent, is a monoclonal antibody that blocks the human epidermal growth factor receptor 2 protein. There is no reported experience with use of this agent during pregnancy and possible effects on the fetus. CASE: A patient with breast cancer was treated with Herceptin during pregnancy. This treatment was associated with anhydramnios, which resolved slowly after the drug was discontinued. CONCLUSION: Although listed as a category B drug, experience with Herceptin in human pregnancy is limited, and it should be used with caution. Investigation of the role of human epidermal growth factor receptor 2 protein in the embryonic kidney may further our understanding of amniotic fluid dynamics.展开更多
文摘在美国,阿片类药物和苯二氮?类药物的联合处方非常常见。虽然所有阿片类药物的说明书上都有类似"使用中枢神经系统抑制药物时,应谨慎使用阿片类镇痛药"的警示,但疾病控制中心(Centers for Disease Control,CDC)的数据表明,2012年每100名美国人中卫生保健专业人员为其开出了82.5张阿片类药物处方以及37.6张苯二氮[艹卓]类处方。
文摘BACKGROUND: Herceptin (trastuzumab), a new achemotherapeutic agent, is a monoclonal antibody that blocks the human epidermal growth factor receptor 2 protein. There is no reported experience with use of this agent during pregnancy and possible effects on the fetus. CASE: A patient with breast cancer was treated with Herceptin during pregnancy. This treatment was associated with anhydramnios, which resolved slowly after the drug was discontinued. CONCLUSION: Although listed as a category B drug, experience with Herceptin in human pregnancy is limited, and it should be used with caution. Investigation of the role of human epidermal growth factor receptor 2 protein in the embryonic kidney may further our understanding of amniotic fluid dynamics.