In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutama...In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat’s excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of δ1 and δ2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased β2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitoty effects.展开更多
This paper presents the changes of landscape structure in the Demanovská Valley which ranks among the most valuable protected areas of Slovakia. The area was selected on the basis of changes associated with the r...This paper presents the changes of landscape structure in the Demanovská Valley which ranks among the most valuable protected areas of Slovakia. The area was selected on the basis of changes associated with the rapidly growing tourism industry and the rise of an important destination in the center of Low Tatras National Park, Slovakia. To document any changes, we visually interpreted data from aerial and satellite images in three periods（1949, 2007 and 2013） and for predicting future changes we used land use planning documentation. Interpreted data were analyzed using overlay analysis and landscape metrics. Results showed extensive changes in the landscape structure mainly connected with the development of tourism infrastructure. We also identified long-term changes whose causes stem from the transformation of society and forest management in the past. The dynamics and extent of these changes may increase in the future. We propose to stop future development of ski slopes and expansion of related infrastructure, to focus on sustainability and environmentally friendly operation of the existing ski resort and to invest a substantial portion of profits to support projects aimed to preserve surrounding lands and wildlife.展开更多
Beijing’s Silicon Valley is encouraging startups to push the boundaries Located in northwest Beijing,Zhongguancun is often referred to as China’s very own Silicon Valley. However,the current reputation of this neigh...Beijing’s Silicon Valley is encouraging startups to push the boundaries Located in northwest Beijing,Zhongguancun is often referred to as China’s very own Silicon Valley. However,the current reputation of this neighborhood as a hub of advanced Chinese technology contrasts sharply with its traditional image.展开更多
基金Project supported by the National Natural Science Foundation ofChina (No. 30170275) and the Key Laboratory for Biomedical En-gineering of the Ministry of Education of China and Science andTechnology Department of Zhejiang Province (No. 011106239)
文摘In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal Glutamate (Glu) were monitored simultaneously in vivo as indicators of rat’s excitatory state. Power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of δ1 and δ2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). Diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased β2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitoty effects.
基金the support of the Scientific Grant Agency of the Slovak Republic through the research grant:"Adaptation strategies to natural and social disturbancies in the forestlandscape"(no.2/0038/14)
文摘This paper presents the changes of landscape structure in the Demanovská Valley which ranks among the most valuable protected areas of Slovakia. The area was selected on the basis of changes associated with the rapidly growing tourism industry and the rise of an important destination in the center of Low Tatras National Park, Slovakia. To document any changes, we visually interpreted data from aerial and satellite images in three periods（1949, 2007 and 2013） and for predicting future changes we used land use planning documentation. Interpreted data were analyzed using overlay analysis and landscape metrics. Results showed extensive changes in the landscape structure mainly connected with the development of tourism infrastructure. We also identified long-term changes whose causes stem from the transformation of society and forest management in the past. The dynamics and extent of these changes may increase in the future. We propose to stop future development of ski slopes and expansion of related infrastructure, to focus on sustainability and environmentally friendly operation of the existing ski resort and to invest a substantial portion of profits to support projects aimed to preserve surrounding lands and wildlife.
文摘Beijing’s Silicon Valley is encouraging startups to push the boundaries Located in northwest Beijing,Zhongguancun is often referred to as China’s very own Silicon Valley. However,the current reputation of this neighborhood as a hub of advanced Chinese technology contrasts sharply with its traditional image.
