黄芪对贝丸洛尔在兔体内处置动力学的影响

本文研究了黄芪对芪贝丸洛尔在兔体内处置动力学的影响。兔单独iv贝丸洛尔后其α,β,K_(10),V。分别为0.19±0.07min^(-1),0.015±0.003min^(-1),0.031±0.01min^(-1), 2.37±0.29L/kg。静脉滴注黄芪30分钟后,再iv贝丸洛尔,其值分别为0.21±0.80min^(-1),0.0049±0.0016min^(-1) ,0.022±0.009min^(-1),1.11±0.33L/kg。结果表明黄芪使贝丸洛尔的中央室分布容积明显减小,从而导致其血药浓度明显升高并使其消除相半衰期明显延长。