The high-resolution nonlinear simultaneous inversion of petrophysical parameters is based on Bayesian statistics and combines petrophysics with geostatistical a priori information. We used the fast Fourier transform–...The high-resolution nonlinear simultaneous inversion of petrophysical parameters is based on Bayesian statistics and combines petrophysics with geostatistical a priori information. We used the fast Fourier transform–moving average（FFT–MA） and gradual deformation method（GDM） to obtain a reasonable variogram by using structural analysis and geostatistical a priori information of petrophysical parameters. Subsequently, we constructed the likelihood function according to the statistical petrophysical model. Finally, we used the Metropolis algorithm to sample the posteriori probability density and complete the inversion of the petrophysical parameters. We used the proposed method to process data from an oil fi eld in China and found good match between inversion and real data with high-resolution. In addition, the direct inversion of petrophysical parameters avoids the error accumulation and decreases the uncertainty, and increases the computational effi ciency.展开更多
In 2000 and 2001, 1-year-old seedlings of 7 economic tree species including chestnut, apricot, persimmon, peach, walnut, pear and apple were cultured in garden pots that had a diameter of 40 cm and were filled with cl...In 2000 and 2001, 1-year-old seedlings of 7 economic tree species including chestnut, apricot, persimmon, peach, walnut, pear and apple were cultured in garden pots that had a diameter of 40 cm and were filled with clean sand. The major components of exudates released from their roots were isolated and analysed by GC-MS. Totally 200 kinds of organic chemicals were isolated, of which 3 kinds i.e. naphthalene, dimethylbenzene and dibutyl phthalate were principally controlled pollutants according to 'Blacklist of Principal Environment Pollutants in China' and the standard of U.S. Environmental Protection Agency (EPA). The research result provided theoretical evidence for selecting low-pollution economic forest crops in the water source protection area in Miyun Reservoir.展开更多
To determine the role of hepatitis B virus X protein (HBx), HBx in regulating hepatic progenitor cell (HPC)-like features in hepatocellular carcinoma (HCC) and the underlying molecular mechanisms.METHODSWe used a retr...To determine the role of hepatitis B virus X protein (HBx), HBx in regulating hepatic progenitor cell (HPC)-like features in hepatocellular carcinoma (HCC) and the underlying molecular mechanisms.METHODSWe used a retrovirus vector to introduce wild type HBx or empty vector into HepG2 cells. We then used these cells to analyze cell proliferation, senescence, transformation, and stem-like features. Gene expression profiling was carried out on Affymetrix GeneChip Human U133A2.0 ver.2 arrays according to the manufacturer’s protocol. Unsupervised hierarchical clustering analysis and Class Comparison analysis were performed by BRB-Array Tools software Version 4.2.2. A total of 238 hepatitis B virus (HBV)-related HCC patients’ array data were used for analyzing clinical features.RESULTSThe histone demethylase KDM5B was significantly highly expressed in HBV-related HCC cases (P < 0.01). In HBV proteins, only HBx up-regulated KDM5B by activating c-myc. Hepatic stem cell (HpSC) markers (EpCAM, AFP, PROM1, and NANOG) were significantly highly expressed in KDM5B-high HCC cases (P < 0.01). KDM5B played an important role in maintaining HpSC-like features and was associated with a poor prognosis. Moreover, inhibition of KDM5B suppressed spheroid formation and cell invasion in vitro.CONCLUSIONHBx activates the histone demethylase KDM5B and induces HPC-like features in HCC. Histone demethylases KDM5B may be an important therapeutic target against HBV-related HCC cases.展开更多
To improve the detection and identification performance of the Statistical Quality Monitoring （SQM） system, a novel quality based Prioritized Sensor-Fault Detection （PSFD） methodology is proposed. Weighted by the ...To improve the detection and identification performance of the Statistical Quality Monitoring （SQM） system, a novel quality based Prioritized Sensor-Fault Detection （PSFD） methodology is proposed. Weighted by the Vp （variable importance in projection） index, which indicates the importance of the sensor variables to the quality variables, the new monitoring statistic, Qv, is developed toensure that the most vital sensor faults be detected successfully. Subsequently, the ratio between the Detectable Minimum Faulty Magnitude （DMFM） of the most important sensor and of the least important sensor is only gpmin/gpmax 〈〈 1. The Structured Residuals are designed according to the Vp index to identify and then isolate them. The theoretical findings are fully supported by simulation studies performed on the Tennessee Eastman process.展开更多
(m, k)-firm real-time or weakly hard real-time (WHRT) guarantee is becoming attractive as it closes the gap between hard and soft (or probabilistic) real-time guarantee, and enables finer granularity of real-time QoS ...(m, k)-firm real-time or weakly hard real-time (WHRT) guarantee is becoming attractive as it closes the gap between hard and soft (or probabilistic) real-time guarantee, and enables finer granularity of real-time QoS through adjusting m and k. For multiple streams with (m, k)-firm constraint sharing a single server, an on-line priority assignment policy based on the most recent k-length history of each stream called distance based priority (DBP) has been proposed to assign priority.In case of priority equality among these head-of-queue instances, Earliest Deadline First (EDF) is used. Under the context of WHRT schedule theory, DBP is the most popular, gets much attention and has many applications due to its straightforward priority assignment policy and easy implementation. However, DBP combined with EDF cannot always provide good performance, mainly because the initial DBP does not underline the rich information on deadline met/missed distribution,specially streams in various failure states which will travel different distances to restore success states. Considering how to effectively restore the success state of each individual stream from a failure state, an integrated DBP utilizing deadline met/missed distribution is proposed in this paper. Simulation results validated the performance improvement of this pro-posal.展开更多
基金sponsored by the National Basic Research Program of China(No.2013CB228604)the Major National Science and Technology Projects(No.2011ZX05009)+1 种基金the Natural Science Foundation of Shandong Province(No.ZR2011DQ013)the National Science Foundation of China(No.41204085)
文摘The high-resolution nonlinear simultaneous inversion of petrophysical parameters is based on Bayesian statistics and combines petrophysics with geostatistical a priori information. We used the fast Fourier transform–moving average（FFT–MA） and gradual deformation method（GDM） to obtain a reasonable variogram by using structural analysis and geostatistical a priori information of petrophysical parameters. Subsequently, we constructed the likelihood function according to the statistical petrophysical model. Finally, we used the Metropolis algorithm to sample the posteriori probability density and complete the inversion of the petrophysical parameters. We used the proposed method to process data from an oil fi eld in China and found good match between inversion and real data with high-resolution. In addition, the direct inversion of petrophysical parameters avoids the error accumulation and decreases the uncertainty, and increases the computational effi ciency.
基金The study was supported by Natural Science Foundation of Beijing to Wang Yuzhu (No. 6992013).
文摘In 2000 and 2001, 1-year-old seedlings of 7 economic tree species including chestnut, apricot, persimmon, peach, walnut, pear and apple were cultured in garden pots that had a diameter of 40 cm and were filled with clean sand. The major components of exudates released from their roots were isolated and analysed by GC-MS. Totally 200 kinds of organic chemicals were isolated, of which 3 kinds i.e. naphthalene, dimethylbenzene and dibutyl phthalate were principally controlled pollutants according to 'Blacklist of Principal Environment Pollutants in China' and the standard of U.S. Environmental Protection Agency (EPA). The research result provided theoretical evidence for selecting low-pollution economic forest crops in the water source protection area in Miyun Reservoir.
基金Supported by Grant-in-Aid for Scientific Research(KAKENHI)(C),No.15K08992(to Oishi N)Core-to-Core Program,B.Asia-Africa Science Platforms,the Japan Society for the Promotion of Science(to Kaneko S)
文摘To determine the role of hepatitis B virus X protein (HBx), HBx in regulating hepatic progenitor cell (HPC)-like features in hepatocellular carcinoma (HCC) and the underlying molecular mechanisms.METHODSWe used a retrovirus vector to introduce wild type HBx or empty vector into HepG2 cells. We then used these cells to analyze cell proliferation, senescence, transformation, and stem-like features. Gene expression profiling was carried out on Affymetrix GeneChip Human U133A2.0 ver.2 arrays according to the manufacturer’s protocol. Unsupervised hierarchical clustering analysis and Class Comparison analysis were performed by BRB-Array Tools software Version 4.2.2. A total of 238 hepatitis B virus (HBV)-related HCC patients’ array data were used for analyzing clinical features.RESULTSThe histone demethylase KDM5B was significantly highly expressed in HBV-related HCC cases (P < 0.01). In HBV proteins, only HBx up-regulated KDM5B by activating c-myc. Hepatic stem cell (HpSC) markers (EpCAM, AFP, PROM1, and NANOG) were significantly highly expressed in KDM5B-high HCC cases (P < 0.01). KDM5B played an important role in maintaining HpSC-like features and was associated with a poor prognosis. Moreover, inhibition of KDM5B suppressed spheroid formation and cell invasion in vitro.CONCLUSIONHBx activates the histone demethylase KDM5B and induces HPC-like features in HCC. Histone demethylases KDM5B may be an important therapeutic target against HBV-related HCC cases.
基金Supported by the National Natural Science Foundation of China （20776128） and the Natural Science Foundation of Zhejiang Province （Y 107032）.
文摘To improve the detection and identification performance of the Statistical Quality Monitoring （SQM） system, a novel quality based Prioritized Sensor-Fault Detection （PSFD） methodology is proposed. Weighted by the Vp （variable importance in projection） index, which indicates the importance of the sensor variables to the quality variables, the new monitoring statistic, Qv, is developed toensure that the most vital sensor faults be detected successfully. Subsequently, the ratio between the Detectable Minimum Faulty Magnitude （DMFM） of the most important sensor and of the least important sensor is only gpmin/gpmax 〈〈 1. The Structured Residuals are designed according to the Vp index to identify and then isolate them. The theoretical findings are fully supported by simulation studies performed on the Tennessee Eastman process.
基金Project supported by the National Natural Science Foundation ofChina (No. 60203030) and Advanced Research Program of France-China (Nos. PRA SI01-04 PRA SI03-02)
文摘(m, k)-firm real-time or weakly hard real-time (WHRT) guarantee is becoming attractive as it closes the gap between hard and soft (or probabilistic) real-time guarantee, and enables finer granularity of real-time QoS through adjusting m and k. For multiple streams with (m, k)-firm constraint sharing a single server, an on-line priority assignment policy based on the most recent k-length history of each stream called distance based priority (DBP) has been proposed to assign priority.In case of priority equality among these head-of-queue instances, Earliest Deadline First (EDF) is used. Under the context of WHRT schedule theory, DBP is the most popular, gets much attention and has many applications due to its straightforward priority assignment policy and easy implementation. However, DBP combined with EDF cannot always provide good performance, mainly because the initial DBP does not underline the rich information on deadline met/missed distribution,specially streams in various failure states which will travel different distances to restore success states. Considering how to effectively restore the success state of each individual stream from a failure state, an integrated DBP utilizing deadline met/missed distribution is proposed in this paper. Simulation results validated the performance improvement of this pro-posal.
