基于有限元模拟的上饶黏土质切坡抗滑桩加固方案评价与优化

以江西省上饶市典型饱和含水率黏土质切坡为研究对象,建立一组切坡抗滑桩加固有限元模型,分析抗滑桩桩长、桩径以及桩位等因素对切坡稳定性的影响。研究表明,抗滑桩加固能够有效地减少这类黏土质边坡的塑性变形,减小边坡总滑移量,提高边坡的稳定性;在10~18 m桩长范围内,边坡安全系数与桩长呈正相关关系,但当桩长超过18 m后,边坡安全系数增长变缓,抗滑桩加固效果并没有出现明显的变化;当桩径在0~2 m之间递增时,边坡总滑移量呈不断减小,但当桩径超过2 m后,边坡总滑移量变化并不明显,表明此时增加桩径对边坡的抗滑效果增加不明显;随着桩位至边坡坡脚处的距离逐渐减小,边坡的总滑移量也在不断减小。因此在设计抗滑桩时可综合考虑桩长,桩径与桩位,以便在满足边坡加固需求的同时还能达到经济效应,减少对材料的浪费,降低施工的难度。

3D Printing with a 5-Axis FDM Printer Using Bézier Techniques

In the last decade,3D printing,especially fused deposition modeling(FDM),has revolutionized manufacturing with intricate designs.Traditional 3-axis FDM printers face challenges with complex geometries,but 5-axis versions offer more design freedom.However,it requires specialized strategies.This research presents a model for 5-axis FDM printers using Bézier curves with an algorithm to enhance print quality.The result shows significant accuracy improvements,especially for curve-based tasks.In addition,this study deepens the understanding of 5-axis FDM technology,setting a solid basis for further research and potentially refining manufacturing methods.

多西紫杉醇对肺腺癌多药耐药细胞A549/CDDP及其亲代细胞作用机制的初步研究

目的 探讨多西紫杉醇对肺腺癌多药耐药细胞A5 49/CDDP及其亲代细胞的生长抑制作用及其抗肿瘤作用机制。方法 应用MTT比色法和透射电镜等方法,观察A5 49/CDDP及其亲代细胞在多西紫杉醇作用后,细胞生长曲线、生长抑制率及形态学等方面的变化。结果 MTT比色结果表明,多西紫杉醇对A5 49/CDDP细胞及其亲代细胞具有明显的生长抑制作用,并且在0 1～2 μg/ml剂量范围内存在剂量及时间依赖关系。A5 49/CDDP细胞在多西紫杉醇作用12～2 4h较亲代细胞敏感(P <0 0 1) ,在48h开始表现出其药物耐受性(P <0 0 1) ,在72h则与亲代细胞间无显著性差异(P >0 0 5 ) ;透射电镜观察结果发现,A5 49/CDDP细胞及其亲代细胞的胞质内空泡均明显增多,微绒毛减少甚至消失,线粒体出现肿胀甚至空泡化,同时,还存在少数凋亡小体和脱落的不含细胞器成分的细胞质。结论 多西紫杉醇对肺腺癌多药耐药细胞及其亲代细胞均具有明显的生长抑制作用,并可能通过诱导肿瘤细胞坏死、凋亡和胞质自切,从而发挥其细胞毒作用。

多西紫杉醇诱导人肺腺癌细胞A549及其多药耐药细胞A549/CDDP凋亡的研究

目的探讨凋亡在多西紫杉醇对人肺腺癌细胞A549及其多药耐药细胞A549/CDDP作用中的地位及其机制。方法应用透射电镜、流式细胞术、Annexin V/PI和免疫细胞化学等方法,观察多西紫杉醇对A549及A549/CDDP细胞形态学、细胞周期、凋亡以及Fas等蛋白表达的影响。结果多西紫杉醇作用后,A549及A549/CDDP细胞内空泡明显增多,可见少数凋亡小体和脱落的不含细胞器成分的细胞质,后者还出现大量多微核化细胞。多西紫杉醇具有显著的G2期阻滞作用,可同时诱导细胞凋亡、坏死和胞质自切,并以后两者为主。Fas蛋白在多西紫杉醇作用后表达明显增强。结论多西紫杉醇对A549及A549/CDDP细胞均具有显著的G2/M期阻滞作用,能同时诱导其凋亡、坏死和胞质自切,以后两者为主。Fas基因可能在多西紫杉醇抗肿瘤作用中具有重要作用。

FABRICATION OF DLC COATED COBALT-CEMENTED TUNGSTEN CARBIDE MICRO-DRILLS AND THEIR CUTTING PERFORMANCE

In machining the particle reinforced aluminum based composite material with high Si content using the cobalt-cemented tungsten carbide micro cutting tools, diamond like carbon （DLC） films are deposited on cobalt-cemented tungsten carbide micro-drills with two-step pretreatment method. Characteristics of DLC coated tools are investigated in bias-enhanced HFCVD system with the optimized hot filament arrangement. The optimization deposition technology is obtained and the wear mechanism of cutting tools is analyzed. The drilling performance of DLC coated tools is verified by the experiments of cutting particle reinforced aluminum based composite material （Si 15% in volume） compared with uncoated ones. Experimental results show that the two-step pretreatment method is appropriate for complex shaped cemented carbide substrates and ensures the good adhesive strength between the diamond film and the substrate. The cutting performance of DLC coated tool is enhanced 10 times when machining the Si particle reinforced aluminum based metal matrix composite compared with that of uncoated ones under the same cutting conditions.

CUTTING FORCES FOR HIGH-SPEED DRILLING OF COMPOSITES

The thrust and the torque of various carbide drills are studied for the high-speed drilling of fiber reinforced epoxy composites. The orthogonal experiment is carried out with different feed speeds at high rotation speed. Experimental results show that the spindle rotation speed is the most influential factor. The thrust andthe torque decrease under the condition of high rotation rate. With the decrease of the feed speed, the thrust and the torque decrease. But the effect of the feed speed is less than that of the spindle rotation rate. Moreover, the effect of drill materials on the thrust and the torque is more notable than that of the drill geometries and the feed speed. The thrust is greatly affected by the feed speed while the torque is obviously affected by drill geometries.

Studies on Contamination of Cytoplasm DNA and Its Control in Plant Chromosone Microdissection

染色体微切割和微克隆已成为复杂基因组研究的有效途径 ,但是操作过程中的核外DNA的污染一直是令人担心的问题。通过研究植物染色体微切割 (微分离 )和微切割的染色体DNA扩增过程中细胞质DNA的污染问题 ,表明目前常用的植物染色体微切割过程中 ,细胞质DNA的污染几乎难以避免 ,并提出了一个改进的降低细胞质DNA污染的方法 ,对如何控制细胞质DNA的污染进行了详细的讨论。

Effects of Preservatives on the Quality of Ranunculus Cut Flowers

The preservation effects of 9 kinds of preservatives were discussed in this paper. And their effects on ornamental quality of cut Ranunculus asiaticus were in-vestigated. The results showed arranging cut Ranunculus asiaticus in a vase fil ed with 200 mg/L 8-HQC＋1% sucrose＋75 mg/L AgNO3 would effectively slow down the weight loss, promote the rise of flower diameter, prolong life and maintain the chlorophyl and anthocyanin content of cut flower. The preservative had a good fresh-keeping effect and was suitable for promotion in actual production.

基于最优感知的5G多频网策略应用研究

通过对5G网络基于覆盖的业务感知拐点、5G网络基于信道质量切换的策略和门限进行研究,结合2.6 GHz网络和700 MHz网络规模建设现状,制定了基于覆盖切换叠加信道质量切换的5G多频网互操作策略,通过互操作策略的设置实现2.6 GHz与700 MHz多频组网协同优化,达到网络感知最优的效果。

Discovering differential protein expression caused by CagA-induced ERK pathway activation in AGS cells using the SELDI-ProteinChip platform

AIM： To identify the protein expression differences related to the CagA-induced ERK pathway activation in AGS cells. METHODS： Human AGS cells transfected with cagA and blank vector were treated with specific mitogenactivated protein kinase kinase （MEK） inhibitor. Total cell proteins were combined by strong anion exchange （SAX2） and weak cation exchange （CM10） ProteinChip arrays and analyzed using surface-enhanced laser desorption/ ionization time-of-flight mass spectrometry （SELDI-TOF- MS） proteomics technology. Protein expression profiles were compared with those of inhibitor-untreated cagA transfectants. SwissProt/TrEMBL database searching for differentially expressed proteins was carried out using the TagIdent tool with the pI and mass information. RESULTS： When a total of 16 proteins that showed expression differences in inhibitor-untreated cagA transfectants were compared with vector transfectants, three proteins with m/z 4229, 8162 and 9084 were found to have no expression differences after treatment with MEK inhibitor, while the other 13 maintained the same expression differences after inhibitor treatment. Seven pieces of meaningful matching information for the three proteins were obtained from database searching. CONCLUSION： Biomarkers with m/z 4229, 8162 and 9084 are ERKI/2 phosphorylation dependent, andtherefore are the downstream molecules of ERK1/2 in the ERK/MAPK signaling pathway. The three biomarkers may be important cancer-associated proteins according to SwissProt/TrEMBL database information.

Quality of life after three kinds of esophagectomy for cancer

AIM： TO evaluate quality of life （QOL） following Ivor Lewis, left transthoracic, and combined thoracoscopic/ laparoscopic esophagectomy in patients with esopha- geal cancer. METHODS： Ninety patients with esophageal cancer were assigned to Ivor Lewis （/7 = 30）, combined thora- coscopic/laparoscopic （n = 30）, and left transthoracic （n = 30） esophagectomy groups. The QOL-core 30 questionnaire and the supplemental QOL-esophageal module 18 questionnaire for patients with esophageal cancer, both developed by the European Organization for Research and Treatment of Cancer, were used to evaluate patients＇ QOL from 1 wk before to 24 wk after surgery. RESULTS： A total of 324 questionnaires were collect- ed from 90 patients, 36 postoperative questionnaires were not completed because patients could not be contacted for follow-up visits. QOL declined markedly in all patients at 1 wk postoperatively： preoperative and 1-wk postoperative global QOL scores in the Ivor Lewis, combined thoracoscopic/laparoscopic, and left transthoracic groups were 80.8 ± 9.3 vs 32.0 ± 16.1 （P 〈 0.001）, 81.1±9.0 vs 53.3 ± 11.5 （P 〈 0.001）, and 83.6 ± 11.2 vs 46.4 ± 11.3 （P 〈 0.001）, respectively. Thereafter, QOL recovered gradually in all patients. Patients who underwent Ivor Lewis esophagectomy showed the most pronounced decline in QOL; global scores were lower in this group than in the combined thoracoscopic/laparoscopic （P 〈 0.001） and left trans- thoracic （P 〈 0.001） groups at 1 wk postoperatively and was not restored to the preoperative level at 24 wk postoperatively. QOL declined least in patients under- going combined thoracoscopic/laparoscopic esopha- gectomy, and most indices had recovered to preopera- tive levels at 24 wk postoperatively. In the Ivor Lewis and combined thoracoscopic/laparoscopic groups, pain and physical function scores were 78.9 ± 18.5 vs 57.8 ± 19.9 （P 〈 0.001） and 59.3 ± 16.1 vs 70.2 ± 19.2 （P = 0.02）, respectively, at 1 wk postoperatively and 26.1 ± 28.6 vs 9.5 ± 15.6 （P = 0.007） and 88.4 ± 10.5 vs 95.8 ± 7.3 （P = 0.003）, respectively, at 24 wk postop- eratively. Scores in the left transthoracic esophagecto- my group fell between those of the other two groups. CONCLUSION： Compared with Ivor Lewis and left transthoracic esophagectomies, combined thoraco- scopic/laparoscopic esophagectomy enables higher postoperative QOL, making it a preferable surgical ap- proach for esophageal cancer.

INVESTIGATION ON HARDENED STEEL MILLING WITH MICRO-END MILL

Tool wear and breakage of the micro-milling tool is an important problem for high speed machining of hardened steel die and mould. Dry milling of S136 hardened steel is carried out using TiAlN coated carbide micro-end mill (2 mm).The effect of cutting speed, feed per tooth and radial depth of cut on cutting force is analyzed. Cutting parameters adapting to dry machining and strategy optimized for higher rate of material removal with lower cutting force are attained. Results of SEM observation show that the main failure patterns of micro-end mill are breakage of tool tip, wear and drop-off of surface coating, micro-chipping, and breakage of flank.

Health-related quality of life outcomes after cholecystectomy

Gallbladder diseases are very common in developed countries. Complicated gallstone disease represents the most frequent of biliary disorders for which surgery is regularly advocated. As regards, cholecystectomy represents a common abdominal surgical intervention; it can be performed as either an elective intervention or emergency surgery, in the case of gangrene, perforation, peritonitis or sepsis. Nowadays, the laparoscopic approach is preferred over open laparotomy. Globally, numerous cholecystectomies are performed daily; however, little evidence exists regarding assessment of post-surgical quality of life (QOL) following these interventions. To assess post-cholecystectomy QOL, in fact, documentation of high quality care has been subject to extended discussions, and the use of patientreported outcome satisfaction for quality improvement has been advocated for several years. However, there has been little research published regarding QOL out-comes following cholecystectomy; in addition, much of the current literature lacks systematic data on patientcentered outcomes. Then, although several tools have been used to measure QOL after cholecystectomy, diffi culty remains in selecting meaningful parameters in order to obtain reproducible data to reflect postoperative QOL. The aim of this study was to review the impact of surgery for gallbladder diseases on QOL. This review includes Medline searches of current literature on QOL following cholecystectomy. Most studies demonstrated that symptomatic patients profi ted more from surgery than patients receiving an elective intervention. Thus, the gain in QOL depends on the general conditions before surgery, and patients without symptoms profi t less or may even have a reduction in QOL.

Comparison of laparoscopic vs open liver lobectomy(segmentectomy) for hepatocellular carcinoma

AIM:To investigate the effects of laparoscopic hepatectomy for the treatment of hepatocellular carcinoma(HCC) .METHODS:From 2006 to January 2011,laparoscopic hepatectomies were performed on 30 cases of HCC at Northern Jiangsu People's Hospital. During this sametime period,30 patients elected to undergo conventional open hepatectomy over laparoscopic hepatectomy at the time of informed consent. The degree of invasiveness and outcomes of laparoscopic hepatectomy compared to open hepatectomy for HCC were evaluated.RESULTS:Both groups presented with similar bloodloss amounts,operating times and complications. Patients in the laparoscopic hepatectomy group started walking and eating significantly earlier than those inthe open hepatectomy group,and these more rapid recoveries allowed for shorter hospitalizations. There were no significant differences between procedures insurvival rate.CONCLUSION:Laparoscopic hepatectomy is beneficial for patient quality of life if the indications are appropriately based on preoperative liver function and the location and size of the HCC.

Viscosity profile prediction of a heavy crude oil during lifting in two deep artesian wells

It has been known that the productivity of artesian wells is strongly dependent on the rheological properties of crude oils. This work targets two deep artesian wells(>5000 m) that are producing heavy crude oil. The impacts of well conditions including temperature, pressure and shear rate, on the crude oil rheology were comprehensively investigated and correlated using several empirical rheological models. The experimental data indicate that this heavy oil is very sensitive to temperature as result of microstructure change caused by hydrogen bonding. The rheological behavior of the heavy oil is also significantly impacted by the imposed pressure, i.e., the viscosity flow activation energy(Eμ) gently increases with the increasing pressure. The viscosity–shear rate data are well fitted to the power law model at low temperature. However, due to the transition of fluid feature at high temperature(Newtonian fluid), the measured viscosity was found to slightly deviate from the fitting data. Combining the evaluated correlations, the viscosity profile of the heavy crude oil in these two deep artesian wells as a function of well depth was predicted using the oilfield producing data.

Characteristics of late cretaceous faults of the eastern segment of the northern Qaidam basin, NW China

The Late Cretaceous tectonic upheaval was an important event during the evolution of the Qaidam Basin, resulting in the omission of the Upper Cretaceous in the whole basin and unconformities between the Paleogene sequence and pre-K2 strata. Inte-grating geological and geophysical data, two different groups of Late Cretaceous faults were recognized in the study area, one group consisting of E-W extending strike-slip faults (e.g., the Maxian and Yema-Jinan faults in the Mahai area, which caused an E-W omission zone of Mesozoic), while the other one has NW-SE thrust faults, resulting in NW-SE fold-and-thrust belts. Considering the different strikes and scale of these two groups, a simple-shear model has been employed to explain this structural phenomenon. The NW-SE thrust faults were thought to be subsidiary to the E-W strike-slip faults. Putting this into the framework of the Cretaceous paleogeographic environment of central Asia, it is inferred that this tectonic event of the Qaidam Basin is a response to the continuous northward drifting of the India plate.

Frictional characteristics of granular system under high pressure

In order to reveal the force transmission features of the granules in the solid granule medium forming(SGMF) technology,the frictional characteristics of the non-metallic granule medium(NGM) under high pressure were investigated by tests and simulations.And the relevant changing curves of the internal friction coefficient of the granular system under different normal pressures were obtained by self-designed shear test.By the granule volume compression test,the accurate discrete element simulation parameters were obtained,based on this,the discrete element method(DEM) was adopted to reveal the evolution law of the NGM granules movement in the sample shear process from the microscopic view.Based on the DEM,the influence of granule diameter,surface friction coefficient,normal pressure and shear velocity on the internal friction coefficient of the granular system were studied.And the parameters were conducted to be dimensionless by introducing the inertia coefficient.Finally,the expression showing power-law relationship of inertia coefficient,surface friction coefficient and internal friction coefficient is obtained.

A symplectic eigensolution method in transversely isotropic piezoelectric cylindrical media

This paper reports establishment of a symplectic system and introduces a 3D sub-symplectic structure for transversely isotropic piezoelectric media. A complete space of eigensolutions is obtained directly. Thus all solutions of the problem are re- duced to finding eigenvalues and eigensolutions, which include zero-eigenvalue solutions and all their Jordan normal form of the corresponding Hamiltonian matrix and non-zero-eigenvalue solutions. The classical solutions are described by zero-eigen- solutions and non-zero-eigensolutions show localized solutions. Numerical results show some rules of non-zero-eigenvalue and their eigensolutions.

Experimental study on mechanical properties of basalt fiber-reinforced silty clay

Fiber reinforcement technology can significantly improve the mechanical properties of soil and has been increasingly applied in geotechnical engineering.Basalt fiber is a new kind of environment-friendly and highperformance soil reinforcement material,and the mechanical properties of basalt fiber-reinforced soil have become a hot research topic.In this paper,we conducted monotonic triaxial and cyclic triaxial tests,and analyzed the influence of the fiber content,moisture content,and confining pressure on the shear characteristics,dynamic modulus,and damping ratio of basalt fiber-reinforced silty clay.The results illustrate that basalt fiber can enhance the shear strength of silty clay by increasing its cohesion.We find that the shear strength of reinforced silty clay reaches its maximum when the fiber content is approximately 0.2%and the moisture content is 18.5%(optimum moisture content).Similarly,we also find that the dynamic modulus that corresponds to the same strain first increases then decreases with increasing fiber content and moisture content and reaches its maximum when the fiber content is approximately 0.2%and the moisture content is 18.5%.The dynamic modulus is positively correlated with the confining pressure.However,the change in the damping ratio with fiber content,moisture content,and confining pressure is opposite to that of the dynamic modulus.It can be concluded that the optimum content of basalt fiber for use in silty clay is 0.2%.After our experiments,we used scanning electron microscope(SEM)to observe the microstructure of specimens with different fiber contents,and our results show that the gripping effect and binding effect are the main mechanisms of fiber reinforcement.

Effect of NCPB and VSPL on pain and quality of life in chronic pancreatitis patients

AIM: To compare the effects of neurolytic celiac plexus block (NCPB) and videothoracoscopic splanchnicectomy (VSPL) on pain and quality of life of chronic pancreatitis (CP) patients.METHODS: Forty-eight small duct CP patients were treated invasively with NCPB (n = 30) or VSPL (n = 18) in two non-randomized, prospective, case-controlled protocols due to chronic pain syndrome, and compared to a control group who were treated conservatively (n = 32). Visual analog scales were used to assess pain and opioid consumption rate was evaluated. In addition, the quality of life was measured using QLQ C-30 for NCPB and FACIT for VSPL.Although both questionnaires covered similar problems,they could not be compared directly one with another.Therefore, the studies were compared by meta-analysis methodology.RESULTS: Both procedures resulted in a significant positive effect on pain of CP patients. Opioids were withdrawn totally in 47.0% of NCPB and 36.4% of VSPL patients,and reduced in 53.0% and 45.4% of the respective patient groups. No reduction in opioid usage was observed in the control group. In addition, fatigue and emotional well-being showed improvements. Finally, NCPB demonstrated stronger positive effects on social support, which might possibly be attributed to earlier presentation of patients treated with NCPB.CONCLUSION: Both invasive pain treatment methods are effective in CP patients with chronic pain.