The turbidity and fluorescence of suspended particulate matter (SPM) in the Taiwan Bank and adjacent waters were investigated during July-August, 2004, to examine the effects of the marine sediments re-suspension an...The turbidity and fluorescence of suspended particulate matter (SPM) in the Taiwan Bank and adjacent waters were investigated during July-August, 2004, to examine the effects of the marine sediments re-suspension and sedimentary processes on the turbidity and fluorescence distribution of SPM. The results show that the turbidity of SPM is affected by the re-suspension of marine sediment in the near shore and continental shelf outer fringe, but not obvious in the shoal. The enrichment of phytoplankton has some effects on the turbidity in the continental shelf outer fringe, but not evident in the near shore. This is helpful for better understanding the distribution of turbidity and fluorescence in the adjacent waters of Taiwan Bank.展开更多
Stability assessment of slopes has historically been performed assuming soils to be homogeneous in two-dimensional(2D) cases. In real cases, soils are usually inhomogeneous, and each slope collapse indicates a three-d...Stability assessment of slopes has historically been performed assuming soils to be homogeneous in two-dimensional(2D) cases. In real cases, soils are usually inhomogeneous, and each slope collapse indicates a three-dimensional(3D) nature. Based on a 3D rotational failure mechanism, this work develops an approach to account for the impact of the vertical strength inhomogeneity on the 3D stability of stepped slopes. Seismic actions are taken into account by introducing the concept of a horizontal seismic coefficient. An upper-bound expression for stability factors is derived in the light of the kinematic approach, and the most critical solution is obtained from an optimization programming. In comparison with the previously published solutions, the validity of the proposed method is shown. A sensitivity analysis is carried out to discuss parametric effects on the stability of 3D stepped inhomogeneous slopes.展开更多
[Objective] This study aimed to investigate the improving effect of organic fertilizer on acidified soil as well as their effects on fruit quality and quantity in Yantai orchard.[Method] Plot experiment was conducted ...[Objective] This study aimed to investigate the improving effect of organic fertilizer on acidified soil as well as their effects on fruit quality and quantity in Yantai orchard.[Method] Plot experiment was conducted to investigate the effects of organic fertilizer on fruit yield and quality of Red Fuji and chemical properties of acidified soil.[Result] The apple yield in acidified soil applied with organic fertilizer all increased.Under the application of biological organic fertilizer,the apple yield was higher,and it was 8.92% higher than that in the control group.Under the mixed application of chemical fertilizer and biological organic fertilizer,the growth and development of apple trees were improved,and the total soluble solid(TSS) content,vitamin C(Vc) content and TSS-acid ratio in mature apples all increased.The application of organic fertilizer significantly reduced soil acidity.Compared with those in the control group,the soil p H value,organic matter content and alkali-hydrolyzable nitrogen content under the application of biological organic fertilizer were increased by 8.33%,15.10% and 30.80%,respectively.[Conclusion] The application of biological organic fertilizer could improve the yield of apple in acidified soil.展开更多
With the implementation of the GEOTRACES program, the biogeochemical cycle and distribution of tellurium (Te) in marine environments are becoming increasing environmental concerns. In this study, the concentration o...With the implementation of the GEOTRACES program, the biogeochemical cycle and distribution of tellurium (Te) in marine environments are becoming increasing environmental concerns. In this study, the concentration of dissolved Te in the Changjiang (Yangtze) River estuary and nearby waters was determined in May 2009 by hydride-generation atomic fluorescence spectrometry to elucidate the abundance, dominant species, distribution, and relationship with environmental factors. Results show that: (1) dissolved Te was low owing to its low abundance in the Earth's crust, high insolubility in water, and strong affinity to particulate matter; (2) Te(IV) and Te(VI) predominated in surface water. Te(VI) was the dominant species in bottom water, and Te(IV) was the minor species; (3) Horizontally, resulting from low phytoplankton metabolism and the weak reduction from Te(VI) to Te(IV) in the shore, Te(IV) was concentrated in the central zone instead of the coastal region. However, Te(VI) was abundant near the mouth of the Changjiang River where the Changjiang water is diluted and in the area to the south where the Taiwan Warm Current invaded. In the adsorption-desorption process, Te(IV) was negatively related to suspended paniculate matter (SPM), indicating that it was adsorbed by particulate matter. While for Te(VI), the positive correlation with SPM suggested that it was desorbed from the solid phase. In the estuary, dissolved Te had a negative correlation to salinity. However, it deviated from the dilution line in high-salinity regions due to the invasion of the Taiwan Warm Current and the mineralization of organic matter. The relationship between Te(IV) and SPM nutrients indicated that it was more bioavailable and more related to phosphorus than to nitrogen. Progress in the field is slow and more research is needed to quantify the input of Te to the estuary and evaluate the biochemical role of organisms.展开更多
Based on the principle of fully mechanized backflling and coal mining technology and combined with the Xingtai Coal Mine conditions, we mainly optimized the coal mining equipment and adjusted the coal mining method in...Based on the principle of fully mechanized backflling and coal mining technology and combined with the Xingtai Coal Mine conditions, we mainly optimized the coal mining equipment and adjusted the coal mining method in the Xingtai Coal Mine 7606 working face for implementation this technology. Firstly, we define the practical backfilling process as the "(from backfilling scraper conveyor's) head to tail back- filling, step by step swinging up of the tamping arm, gradual compacting, moving formed backfilling scra- per conveyor when the second tamping arm cannot pass and connecting the immediate roof by back material push front material movement". Meanwhile, the stress changes of backfill body in coal mined out area was monitored by stress sensors, and the roof caving law was analyzed by monitoring the dynamic subsidence of -210 west roadway of this face. The site tests results show that using this new backfilling and coal mining integrated technology, the production capacity in the 7606 working face can reach to 283,000 ton a year, and 282,000 ton of solid materials (waste and fly ash) is backfilled, which meets the needs of high production and efficiency. The goaf was compactly backfilled with solid material and the strata behavior was quite desirable, with an actual maximum vertical stress of the backfill body of 5.5 MPa. Backfill body control the movement of overburden within a certain range, and there is no col- lapses of major areas in the overlying strata upon backfilled gob. The maximum subsidence and speed were 231 mm and 15.75 mm/d respectively, which proved the practical significance of this integrated technology.展开更多
The backward-facing step is a critical problem existing in many engineering and industrial applications.In this study,a semi-porous baffle(the root of the baffle is a porous medium and the tip is solid) is placed behi...The backward-facing step is a critical problem existing in many engineering and industrial applications.In this study,a semi-porous baffle(the root of the baffle is a porous medium and the tip is solid) is placed behind the step.The effects of the length of the porous part,and the baffle location on the energy transfer and pressure drop are studied in different Reynolds numbers(Re=100,200,300,400,500).The effect of the Darcy number of the porous medium on the aforementioned parameters is also investigated.Both the local maximum and average relative Nusselt numbers(divided by the Nusselt of the base case with no baffle at the same Reynolds) and relative pressure drop(calculated as the relative Nusselt number) are reported.The results show that by adoption of the proper length of the porous medium,the average relative and maximum local Nusselt numbers could be enhanced by 20% and 90%,respectively.Low permeable porous media give better energy transfer.For example,porous media with Da=10^(-5) give 30% better maximum local Nusselt number and about 7% higher average Nusselt number with respect to the same case with Da=10^(-2).展开更多
AIM:To report preliminary results of the efficacy and safety of sunitinib in the management of Taiwan Residents gastrointestinal stromal tumors (GIST) patients facing imatinib mesylate (IM) intolerance or failure.METH...AIM:To report preliminary results of the efficacy and safety of sunitinib in the management of Taiwan Residents gastrointestinal stromal tumors (GIST) patients facing imatinib mesylate (IM) intolerance or failure.METHODS:Between 2001 and May 2010,199 Taiwan Residents patients with metastatic GIST were treated at Chang Gung Memorial Hospital.Among them,23 (11.6%) patients receiving sunitinib were investigated.RESULTS:Sixteen male and 7 female patients with a median age of 59 years (range:24-83 years) received sunitinib.Twenty-two GIST patients changed to sunitinib because of IM failure and 1 because of intolerance.The median duration of sunitinib administration was 6.0 mo (range:2-29 mo).The clinical benefit was 65.2% [2 complete response (CR),4 partial response (PR),and 9 stationary disease (SD);15/23].In 12 patients harboring mutations of the kit gene at exon 11,the clinical benefit rate (CR,PR,and SD) was 75.0% and 6 patients with tumors containing kit exon 9 mutations had a clinical benefit of 50.0% (not significant,P=0.344).The progression free survival (PFS) and overall survival (OS) did not differ between patients whose GISTs had wild type,KIT exon 9,or KIT exon 11 mutations.Hand-foot syndrome was the most common cause of grade Ⅲ adverse effect (26.1%),followed by anemia (17.4%),and neutropenia (13.0%).During the median 7.5-mo follow-up after sunitinib use,the median PFS and OS of these 23 GIST patients after sunitinib treatment were 8.4 and 14.1 mo,respectively.CONCLUSION:Sunitinib appears to be an effective treatment for Taiwan Residents with IM-resistant/intolerant GISTs and induced a sustained clinical benefit in more than 50% of Taiwan Residents advanced GIST patients.展开更多
It is still a laborious work to consult massive multidisciplinary geological maps which are scattered in different geological departments,and hard to give full play to the potential application value of geological map...It is still a laborious work to consult massive multidisciplinary geological maps which are scattered in different geological departments,and hard to give full play to the potential application value of geological map. Along with the network,the development of communication and computer technology,especially with the Web2.0 technology arisen,provides opportunities to the web for sharing of geological maps. Web fast sharing platform of massive geological maps( WSPGM) is based on the Flex technology development,using B/S architecture,with map navigation,search,display,security and other functions of the software system. Through the map pretreatment and asynchronous communication the system can display any size of geological map,and through the range limits,rights management,sharing system and watermark logo to take effective security on geological map. On the basis of this system,with the Jilin University web sharing system of geological map,the system can greatly improve the efficiency of using geological map. for research.展开更多
AIM: To determine the effect of body mass index (BMI) on the characteristics and overall outcome of colon cancer in Taiwan. METHODS: From January 1995 to July 2003, 2138 patients with colon cancer were enrolled in...AIM: To determine the effect of body mass index (BMI) on the characteristics and overall outcome of colon cancer in Taiwan. METHODS: From January 1995 to July 2003, 2138 patients with colon cancer were enrolled in this study. BMI categories (in kg/m2) were established according to the classification of the Department of Health of Tai- wan. Postoperative morbidities and mortality, and survival analysis including overall survival (OS), disease- free survival (DFS), and cancer-specific survival (CSS) were compared across the BMI categories.27 kg/m2) patients. Being female, apparently anemic, hypoalbuminemic, and having body weight loss was more likely among underweight patients than among the other patients (P 〈 0.001). Underweight patients had higher mortality rate (P = 0.00.7) and lower OS (P 〈 0.001) and DFS (P = 0.002) than the other pa- tients. OS and DFS did not differ significantly between normal-weight, overweight, and obese patients, while CSS did not differ significantly with the BMI category. CONCLUSION: In Taiwan, BMI does not significantly affect colon-CSS. Underweight patients had a higher rate of surgical mortality and a worse OS and DFS than the other patients. Obesity does not predict a worse survival.展开更多
The purpose of this study is to find "the new theory" in the process of having quality "form" in architecture field which is usually visualized by the ruler through his ideology of his architectural work which is ...The purpose of this study is to find "the new theory" in the process of having quality "form" in architecture field which is usually visualized by the ruler through his ideology of his architectural work which is created by his architects. The study is about an urban design in architectural field related with space-power-knowledge. To reveal the meaning of the architecture objects is need to analyze the architectural object "form" as the culture-material, and to reveal the meaning of the objects through the hidden things related to the presence of the metaphysical data. To find "the new theory" used "grounded theory research", the method is part of qualitative research which refers to Glaser and Strauss. The achievement study is finding the idea of"architecture stage" of the ruler, represented by Soekamo as the first Indonesian President. Through visual observation and spatial experiences in his several architectural works concerning the "Project's Lighthouse" as his architectural work in Jakarta in the 1960s the idea of connectedness was found. He composes his architecture's work by inserted the "architecture drama analogy" as metaphor for representing himself and his ideologist by exploring the Javanese Ancient's as the basic design in the modem architecture at that time the east meet west.展开更多
A geomagnetic observatory was established at Karachi (geog coord: 24.95°N, 167.14° E), Pakistan in 1983 which comprised of AMOS-Ⅲ (Automatic Magnetic Observatory System). In 2006 SUPARCO (Space and Up...A geomagnetic observatory was established at Karachi (geog coord: 24.95°N, 167.14° E), Pakistan in 1983 which comprised of AMOS-Ⅲ (Automatic Magnetic Observatory System). In 2006 SUPARCO (Space and Upper Atmosphere Research Commission) planned to upgrade the old observatory of Karachi in order to qualify it as an IMO (Intermagnet Magnetic Observatory). Dr. Jean Rasson agreed to give support and assist us in the upgradation. BGS (British Geological Survey) provided a complete observatory instrument setup. Due to perturbations traceable to the increased urbanization, the observatory has been shifted to a site "Sonmiani", 80 km north-west of Karachi, where long term protection from cultural noise is offered. This site in a sparsely built research complex was selected after a magnetic survey. A new observatory has also been established at Islamabad (geog cord: 33.75° N, 72.87° E) which is mountainous region. SUPARCO purchased new equipment for the establishment of new observatories. Plan of upgradation of observatory at Quetta is also under consideration in order to improve the monitoring of geomagnetic field on the western part of Pakistan. Repeat station work has been done for the northern part of Pakistan with the collaboration of IRM, Belgium. The obtained results also compared with the global geomagnetic model (IGRF).展开更多
We collected waveforms of a teleseismic event which occurred from January 2007 to October 2011 from 174 broadband seismic stations deployed in Hebei and its adjacent areas. Using the H-k stacking method,the average th...We collected waveforms of a teleseismic event which occurred from January 2007 to October 2011 from 174 broadband seismic stations deployed in Hebei and its adjacent areas. Using the H-k stacking method,the average thickness and Poisson's ratio of the crust are acquired. In order to obtain reliable receiver functions, the broadband seismograms of 488 teleseismic earthquakes occurring in the epicentral distance range from 30° to 90° with magnitudes larger than Mb6. 0 are collected. The results show that crustal thickness have conspicuous lateral heterogeneity and have good correlation to the regional geological tectonic features. Poisson ratio's value is equated with the global models estimates which fluctuate at about 0. 25. Crustal thickness has positive correlation to the topography and the Taihang Mountains form the transition zone of thick and thin crustal thickness. There is an obvious difference in crustal thickness beneath the north and south of the Shanxi earthquake zone and the Poisson ratio of Datong,Ningwu and Anze basins is greater than 0. 3. The crustal thickness beneath the Zhang-Bo( Zhangjiakou-Bohai Sea)earthquake zone decreases from west to north and its Poisson ratio shows conspicuous lateral heterogeneity. The thin crust and low Poisson ratio in the Huabei( North China)basin may correlate with the delamination of the North China craton.展开更多
We apply three methods to relocate 599 earthquake events that occurred from August 2004 to August 2005 in the northeastern Tianshan Mountains area ( 85°30' ~ 88°30'E,43°00' ~ 44°40...We apply three methods to relocate 599 earthquake events that occurred from August 2004 to August 2005 in the northeastern Tianshan Mountains area ( 85°30' ~ 88°30'E,43°00' ~ 44°40' N ) by using travel times recorded by regional seismic network and 10 portable seismic stations deployed around the Urumqi city. By comparing the reliability of different results,we determined a suitable location method,and an improved 1-D crustal velocity model of the study area. The uncertainty of earthquake location is significantly reduced with combined data of seismic network and portable stations. The relocated events are clearly associated with regional tectonics of the northeastern Tianshan Mountains area, and are also in agreement with the existence of active faults imaged by deep seismic reflection profile. The relocated seismicity discovers some potential traces of buried active faults,which need to be validated further.展开更多
With the prevailing and popular entertainment programs, it brought huge benefits to TV stations, but at the same time caused a variety problems of homogenization. The paper analyzes the causes of the entertainment pro...With the prevailing and popular entertainment programs, it brought huge benefits to TV stations, but at the same time caused a variety problems of homogenization. The paper analyzes the causes of the entertainment programs, the root of homogenization, building game theory models between TV stations, TV station and audience to regulate and control the issue of homogeneity about entertainment programs.展开更多
Based on the principle of turned mass damper(TMD) systems,the conceptual design of semi-submersible platform with a moveable heave-plate(MHS) has been put forward.The heave motion response amplitude operator(RAO) and ...Based on the principle of turned mass damper(TMD) systems,the conceptual design of semi-submersible platform with a moveable heave-plate(MHS) has been put forward.The heave motion response amplitude operator(RAO) and viscous damping of the MHS platform are calculated by iteration,and the coupling stiffness between the MHS hull and the heave-plate is optimized to decrease the maximum heave motion response of the MHS hull under 10-year survival conditions in the South China Sea.The nu-merical results indicate that the heave motion RAO of the MHS hull can be decreased in the range of predominant wave frequencies,which may provide some reference to the heave motion control of offshore platforms.展开更多
In order to provide power quality monitoring activities with metrological certification, a DAS (data acquisition system) has been designed, realized and characterized. The system allows acquisition on tri-phases plu...In order to provide power quality monitoring activities with metrological certification, a DAS (data acquisition system) has been designed, realized and characterized. The system allows acquisition on tri-phases plus neutral lines picking up 499 samples per period of the fundamental at 50 Hz. To ensure certified measurements, the system gets external certified time and voltage references. The system uses a FTDI Virtual Com Port Driver to communicate data over High Speed RS232 virtual interface and it does not need any advanced programming skill. The choice to use a virtual serial communication makes the data acquisition software portable over many platforms, regardless by the development environment and by the programming language. To test the proposed device some custom software have been written in many programming language (C^#, VB6, LabView, MatLab), moreover in order to characterize the device the most common ADC (analog to digital converter) performing test have been applied.展开更多
基金supported by the SOA Science Fund for Youths of China(2008316)Fujian Provincial Natural Science Foundation of China(2006J0288)
文摘The turbidity and fluorescence of suspended particulate matter (SPM) in the Taiwan Bank and adjacent waters were investigated during July-August, 2004, to examine the effects of the marine sediments re-suspension and sedimentary processes on the turbidity and fluorescence distribution of SPM. The results show that the turbidity of SPM is affected by the re-suspension of marine sediment in the near shore and continental shelf outer fringe, but not obvious in the shoal. The enrichment of phytoplankton has some effects on the turbidity in the continental shelf outer fringe, but not evident in the near shore. This is helpful for better understanding the distribution of turbidity and fluorescence in the adjacent waters of Taiwan Bank.
基金Project(51378510)supported by the National Natural Science Foundation of China
文摘Stability assessment of slopes has historically been performed assuming soils to be homogeneous in two-dimensional(2D) cases. In real cases, soils are usually inhomogeneous, and each slope collapse indicates a three-dimensional(3D) nature. Based on a 3D rotational failure mechanism, this work develops an approach to account for the impact of the vertical strength inhomogeneity on the 3D stability of stepped slopes. Seismic actions are taken into account by introducing the concept of a horizontal seismic coefficient. An upper-bound expression for stability factors is derived in the light of the kinematic approach, and the most critical solution is obtained from an optimization programming. In comparison with the previously published solutions, the validity of the proposed method is shown. A sensitivity analysis is carried out to discuss parametric effects on the stability of 3D stepped inhomogeneous slopes.
基金Supported by Scientific and Technological Development Plan of Yantai City(2015YD014)
文摘[Objective] This study aimed to investigate the improving effect of organic fertilizer on acidified soil as well as their effects on fruit quality and quantity in Yantai orchard.[Method] Plot experiment was conducted to investigate the effects of organic fertilizer on fruit yield and quality of Red Fuji and chemical properties of acidified soil.[Result] The apple yield in acidified soil applied with organic fertilizer all increased.Under the application of biological organic fertilizer,the apple yield was higher,and it was 8.92% higher than that in the control group.Under the mixed application of chemical fertilizer and biological organic fertilizer,the growth and development of apple trees were improved,and the total soluble solid(TSS) content,vitamin C(Vc) content and TSS-acid ratio in mature apples all increased.The application of organic fertilizer significantly reduced soil acidity.Compared with those in the control group,the soil p H value,organic matter content and alkali-hydrolyzable nitrogen content under the application of biological organic fertilizer were increased by 8.33%,15.10% and 30.80%,respectively.[Conclusion] The application of biological organic fertilizer could improve the yield of apple in acidified soil.
基金Supported by the National Basic Research Program of China(973 Program)(No.2011CB403602)the National Natural Science Foundation of China(No.41121064)
文摘With the implementation of the GEOTRACES program, the biogeochemical cycle and distribution of tellurium (Te) in marine environments are becoming increasing environmental concerns. In this study, the concentration of dissolved Te in the Changjiang (Yangtze) River estuary and nearby waters was determined in May 2009 by hydride-generation atomic fluorescence spectrometry to elucidate the abundance, dominant species, distribution, and relationship with environmental factors. Results show that: (1) dissolved Te was low owing to its low abundance in the Earth's crust, high insolubility in water, and strong affinity to particulate matter; (2) Te(IV) and Te(VI) predominated in surface water. Te(VI) was the dominant species in bottom water, and Te(IV) was the minor species; (3) Horizontally, resulting from low phytoplankton metabolism and the weak reduction from Te(VI) to Te(IV) in the shore, Te(IV) was concentrated in the central zone instead of the coastal region. However, Te(VI) was abundant near the mouth of the Changjiang River where the Changjiang water is diluted and in the area to the south where the Taiwan Warm Current invaded. In the adsorption-desorption process, Te(IV) was negatively related to suspended paniculate matter (SPM), indicating that it was adsorbed by particulate matter. While for Te(VI), the positive correlation with SPM suggested that it was desorbed from the solid phase. In the estuary, dissolved Te had a negative correlation to salinity. However, it deviated from the dilution line in high-salinity regions due to the invasion of the Taiwan Warm Current and the mineralization of organic matter. The relationship between Te(IV) and SPM nutrients indicated that it was more bioavailable and more related to phosphorus than to nitrogen. Progress in the field is slow and more research is needed to quantify the input of Te to the estuary and evaluate the biochemical role of organisms.
基金Financial supports for this work provided by the National Natural Science Foundation of China (No. 51074165)the Key Program of National Natural Science Foundation of China (No.50834004)A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (No.SZBF2011-6-B35)
文摘Based on the principle of fully mechanized backflling and coal mining technology and combined with the Xingtai Coal Mine conditions, we mainly optimized the coal mining equipment and adjusted the coal mining method in the Xingtai Coal Mine 7606 working face for implementation this technology. Firstly, we define the practical backfilling process as the "(from backfilling scraper conveyor's) head to tail back- filling, step by step swinging up of the tamping arm, gradual compacting, moving formed backfilling scra- per conveyor when the second tamping arm cannot pass and connecting the immediate roof by back material push front material movement". Meanwhile, the stress changes of backfill body in coal mined out area was monitored by stress sensors, and the roof caving law was analyzed by monitoring the dynamic subsidence of -210 west roadway of this face. The site tests results show that using this new backfilling and coal mining integrated technology, the production capacity in the 7606 working face can reach to 283,000 ton a year, and 282,000 ton of solid materials (waste and fly ash) is backfilled, which meets the needs of high production and efficiency. The goaf was compactly backfilled with solid material and the strata behavior was quite desirable, with an actual maximum vertical stress of the backfill body of 5.5 MPa. Backfill body control the movement of overburden within a certain range, and there is no col- lapses of major areas in the overlying strata upon backfilled gob. The maximum subsidence and speed were 231 mm and 15.75 mm/d respectively, which proved the practical significance of this integrated technology.
文摘The backward-facing step is a critical problem existing in many engineering and industrial applications.In this study,a semi-porous baffle(the root of the baffle is a porous medium and the tip is solid) is placed behind the step.The effects of the length of the porous part,and the baffle location on the energy transfer and pressure drop are studied in different Reynolds numbers(Re=100,200,300,400,500).The effect of the Darcy number of the porous medium on the aforementioned parameters is also investigated.Both the local maximum and average relative Nusselt numbers(divided by the Nusselt of the base case with no baffle at the same Reynolds) and relative pressure drop(calculated as the relative Nusselt number) are reported.The results show that by adoption of the proper length of the porous medium,the average relative and maximum local Nusselt numbers could be enhanced by 20% and 90%,respectively.Low permeable porous media give better energy transfer.For example,porous media with Da=10^(-5) give 30% better maximum local Nusselt number and about 7% higher average Nusselt number with respect to the same case with Da=10^(-2).
基金Supported by Chang Gung Medical Research Program 380711 Grant to Dr. Yeh CN
文摘AIM:To report preliminary results of the efficacy and safety of sunitinib in the management of Taiwan Residents gastrointestinal stromal tumors (GIST) patients facing imatinib mesylate (IM) intolerance or failure.METHODS:Between 2001 and May 2010,199 Taiwan Residents patients with metastatic GIST were treated at Chang Gung Memorial Hospital.Among them,23 (11.6%) patients receiving sunitinib were investigated.RESULTS:Sixteen male and 7 female patients with a median age of 59 years (range:24-83 years) received sunitinib.Twenty-two GIST patients changed to sunitinib because of IM failure and 1 because of intolerance.The median duration of sunitinib administration was 6.0 mo (range:2-29 mo).The clinical benefit was 65.2% [2 complete response (CR),4 partial response (PR),and 9 stationary disease (SD);15/23].In 12 patients harboring mutations of the kit gene at exon 11,the clinical benefit rate (CR,PR,and SD) was 75.0% and 6 patients with tumors containing kit exon 9 mutations had a clinical benefit of 50.0% (not significant,P=0.344).The progression free survival (PFS) and overall survival (OS) did not differ between patients whose GISTs had wild type,KIT exon 9,or KIT exon 11 mutations.Hand-foot syndrome was the most common cause of grade Ⅲ adverse effect (26.1%),followed by anemia (17.4%),and neutropenia (13.0%).During the median 7.5-mo follow-up after sunitinib use,the median PFS and OS of these 23 GIST patients after sunitinib treatment were 8.4 and 14.1 mo,respectively.CONCLUSION:Sunitinib appears to be an effective treatment for Taiwan Residents with IM-resistant/intolerant GISTs and induced a sustained clinical benefit in more than 50% of Taiwan Residents advanced GIST patients.
文摘It is still a laborious work to consult massive multidisciplinary geological maps which are scattered in different geological departments,and hard to give full play to the potential application value of geological map. Along with the network,the development of communication and computer technology,especially with the Web2.0 technology arisen,provides opportunities to the web for sharing of geological maps. Web fast sharing platform of massive geological maps( WSPGM) is based on the Flex technology development,using B/S architecture,with map navigation,search,display,security and other functions of the software system. Through the map pretreatment and asynchronous communication the system can display any size of geological map,and through the range limits,rights management,sharing system and watermark logo to take effective security on geological map. On the basis of this system,with the Jilin University web sharing system of geological map,the system can greatly improve the efficiency of using geological map. for research.
文摘AIM: To determine the effect of body mass index (BMI) on the characteristics and overall outcome of colon cancer in Taiwan. METHODS: From January 1995 to July 2003, 2138 patients with colon cancer were enrolled in this study. BMI categories (in kg/m2) were established according to the classification of the Department of Health of Tai- wan. Postoperative morbidities and mortality, and survival analysis including overall survival (OS), disease- free survival (DFS), and cancer-specific survival (CSS) were compared across the BMI categories.27 kg/m2) patients. Being female, apparently anemic, hypoalbuminemic, and having body weight loss was more likely among underweight patients than among the other patients (P 〈 0.001). Underweight patients had higher mortality rate (P = 0.00.7) and lower OS (P 〈 0.001) and DFS (P = 0.002) than the other pa- tients. OS and DFS did not differ significantly between normal-weight, overweight, and obese patients, while CSS did not differ significantly with the BMI category. CONCLUSION: In Taiwan, BMI does not significantly affect colon-CSS. Underweight patients had a higher rate of surgical mortality and a worse OS and DFS than the other patients. Obesity does not predict a worse survival.
文摘The purpose of this study is to find "the new theory" in the process of having quality "form" in architecture field which is usually visualized by the ruler through his ideology of his architectural work which is created by his architects. The study is about an urban design in architectural field related with space-power-knowledge. To reveal the meaning of the architecture objects is need to analyze the architectural object "form" as the culture-material, and to reveal the meaning of the objects through the hidden things related to the presence of the metaphysical data. To find "the new theory" used "grounded theory research", the method is part of qualitative research which refers to Glaser and Strauss. The achievement study is finding the idea of"architecture stage" of the ruler, represented by Soekamo as the first Indonesian President. Through visual observation and spatial experiences in his several architectural works concerning the "Project's Lighthouse" as his architectural work in Jakarta in the 1960s the idea of connectedness was found. He composes his architecture's work by inserted the "architecture drama analogy" as metaphor for representing himself and his ideologist by exploring the Javanese Ancient's as the basic design in the modem architecture at that time the east meet west.
文摘A geomagnetic observatory was established at Karachi (geog coord: 24.95°N, 167.14° E), Pakistan in 1983 which comprised of AMOS-Ⅲ (Automatic Magnetic Observatory System). In 2006 SUPARCO (Space and Upper Atmosphere Research Commission) planned to upgrade the old observatory of Karachi in order to qualify it as an IMO (Intermagnet Magnetic Observatory). Dr. Jean Rasson agreed to give support and assist us in the upgradation. BGS (British Geological Survey) provided a complete observatory instrument setup. Due to perturbations traceable to the increased urbanization, the observatory has been shifted to a site "Sonmiani", 80 km north-west of Karachi, where long term protection from cultural noise is offered. This site in a sparsely built research complex was selected after a magnetic survey. A new observatory has also been established at Islamabad (geog cord: 33.75° N, 72.87° E) which is mountainous region. SUPARCO purchased new equipment for the establishment of new observatories. Plan of upgradation of observatory at Quetta is also under consideration in order to improve the monitoring of geomagnetic field on the western part of Pakistan. Repeat station work has been done for the northern part of Pakistan with the collaboration of IRM, Belgium. The obtained results also compared with the global geomagnetic model (IGRF).
基金funded by the Seismic Situation Tracing Orientation Task,China Earthquake Administration(2014020120)the Science and Technology Support Program of Hebei Province(2014020120)
文摘We collected waveforms of a teleseismic event which occurred from January 2007 to October 2011 from 174 broadband seismic stations deployed in Hebei and its adjacent areas. Using the H-k stacking method,the average thickness and Poisson's ratio of the crust are acquired. In order to obtain reliable receiver functions, the broadband seismograms of 488 teleseismic earthquakes occurring in the epicentral distance range from 30° to 90° with magnitudes larger than Mb6. 0 are collected. The results show that crustal thickness have conspicuous lateral heterogeneity and have good correlation to the regional geological tectonic features. Poisson ratio's value is equated with the global models estimates which fluctuate at about 0. 25. Crustal thickness has positive correlation to the topography and the Taihang Mountains form the transition zone of thick and thin crustal thickness. There is an obvious difference in crustal thickness beneath the north and south of the Shanxi earthquake zone and the Poisson ratio of Datong,Ningwu and Anze basins is greater than 0. 3. The crustal thickness beneath the Zhang-Bo( Zhangjiakou-Bohai Sea)earthquake zone decreases from west to north and its Poisson ratio shows conspicuous lateral heterogeneity. The thin crust and low Poisson ratio in the Huabei( North China)basin may correlate with the delamination of the North China craton.
基金supported by the Basic Research Project of Institute of Earthquake Science,CEA (2012IES010103)the National Natural Science Foundation of China (41204037)
文摘We apply three methods to relocate 599 earthquake events that occurred from August 2004 to August 2005 in the northeastern Tianshan Mountains area ( 85°30' ~ 88°30'E,43°00' ~ 44°40' N ) by using travel times recorded by regional seismic network and 10 portable seismic stations deployed around the Urumqi city. By comparing the reliability of different results,we determined a suitable location method,and an improved 1-D crustal velocity model of the study area. The uncertainty of earthquake location is significantly reduced with combined data of seismic network and portable stations. The relocated events are clearly associated with regional tectonics of the northeastern Tianshan Mountains area, and are also in agreement with the existence of active faults imaged by deep seismic reflection profile. The relocated seismicity discovers some potential traces of buried active faults,which need to be validated further.
文摘With the prevailing and popular entertainment programs, it brought huge benefits to TV stations, but at the same time caused a variety problems of homogenization. The paper analyzes the causes of the entertainment programs, the root of homogenization, building game theory models between TV stations, TV station and audience to regulate and control the issue of homogeneity about entertainment programs.
基金supported by the National Basic Research Program of China (No. 2011CB013702)
文摘Based on the principle of turned mass damper(TMD) systems,the conceptual design of semi-submersible platform with a moveable heave-plate(MHS) has been put forward.The heave motion response amplitude operator(RAO) and viscous damping of the MHS platform are calculated by iteration,and the coupling stiffness between the MHS hull and the heave-plate is optimized to decrease the maximum heave motion response of the MHS hull under 10-year survival conditions in the South China Sea.The nu-merical results indicate that the heave motion RAO of the MHS hull can be decreased in the range of predominant wave frequencies,which may provide some reference to the heave motion control of offshore platforms.
文摘In order to provide power quality monitoring activities with metrological certification, a DAS (data acquisition system) has been designed, realized and characterized. The system allows acquisition on tri-phases plus neutral lines picking up 499 samples per period of the fundamental at 50 Hz. To ensure certified measurements, the system gets external certified time and voltage references. The system uses a FTDI Virtual Com Port Driver to communicate data over High Speed RS232 virtual interface and it does not need any advanced programming skill. The choice to use a virtual serial communication makes the data acquisition software portable over many platforms, regardless by the development environment and by the programming language. To test the proposed device some custom software have been written in many programming language (C^#, VB6, LabView, MatLab), moreover in order to characterize the device the most common ADC (analog to digital converter) performing test have been applied.