In this paper, let T be a bounded linear operator on a complex Hilbert H. We give and prove that every p-w-hyponormal operator has Bishop's property(β) and spectral properties; Quasi-similar p-w-hyponormal operat...In this paper, let T be a bounded linear operator on a complex Hilbert H. We give and prove that every p-w-hyponormal operator has Bishop's property(β) and spectral properties; Quasi-similar p-w-hyponormal operators have equal spectra and equal essential spectra. Finally, for p-w-hyponormal operators, we give a kind of proof of its normality by use of properties of partial isometry.展开更多
Two trace impurities in the bulk drug lisinopril were detected by means of high-performance liquid chromatography coupled with mass spectrometry （HPLC/MS） with a simple and sensitive method suitable for HPLC/MSn ana...Two trace impurities in the bulk drug lisinopril were detected by means of high-performance liquid chromatography coupled with mass spectrometry （HPLC/MS） with a simple and sensitive method suitable for HPLC/MSn analysis. The fragmentation behavior of lisinopfil and the impurities was investigated, and two unknown impurities were elucidated as 2-（6-amino- l-（l-carboxyethylamino）- l-oxohexan-2-ylamino）-4-phenylbutanoic acid and 6-amino-2-（l-carboxy-3-phenylpropylamino）-hexanoic acid on the basis of the multi-stage mass spectrometry and exact mass evidence, The proposed structures of the two unknown impurities were further confirmed by nuclear magnetic resonance （NMR） experiments after preparative isolation.展开更多
A highly sensitive SPE-liquid/liquid extraction RPLC method has been developed for the analysis of 6β-hydroxycortisol and cortisol in the urine of cancer patients. Methods： After SPE column purification and liquid-l...A highly sensitive SPE-liquid/liquid extraction RPLC method has been developed for the analysis of 6β-hydroxycortisol and cortisol in the urine of cancer patients. Methods： After SPE column purification and liquid-liquid extraction, the sample test solutions were analyzed with RPLC using a C18 analytical column. This improved analytical method has been validated for linearity, accuracy （recovery from urine）, repeatability （within-day and between-day precision）, specificity, sensitivity, and stability. This SPE-liquid/liquid extraction-RPLC is rapid, simple, accurate and reproducible. The technique is particularly useful for monitoring the CYP3A activity of cancer patients in clinical settings. The results are expressed as the ratio of 6β-hydroxycortisol to cortisol. Results： The CYP3A activity from a total of 153 samples was measured using this improved method. Considerable variation in the CYP3A activity of different cancer patients has been documented. Thus, personalized medical treatment based on the individual metabolic enzyme activity level is necessary. Conclusion： This new analytical method facilitates such individualized medical treatments.展开更多
The purpose of this study is to design a tool, adapted to students＇ individual contexts and to enable students to reflect on their understanding of media characteristics. AHP （analytic hierarchy process） is a struc...The purpose of this study is to design a tool, adapted to students＇ individual contexts and to enable students to reflect on their understanding of media characteristics. AHP （analytic hierarchy process） is a structured technique for organizing and analyzing complex decisions. Using AHP, students have to define appropriate criteria and priorities for using media. It is expected that students＂ understanding of the characteristics of different types of media will emerge through reflection. Seventy two university students took part in this research. They were asked to prioritize their ways.of obtaining information about current affairs using sets of media such as TV, books, newspapers and web pages, Twitter and Facebook. AHP enables us to visualize a ＂real＂ understanding of media characteristics and students can reflect on that basis. As far as ＂information sources and media＂ is concerned, a few students indicated that it was the information source itself that was important rather than the type of media. Our tool fulfils the role of encouraging this type of reflection.展开更多
Based on chromatographic theory, the moment method and the time-domain fitting analysis were applied to measure and evaluate the adsorption equilibrium constant and mass transfer properties (axial dispersion coefficie...Based on chromatographic theory, the moment method and the time-domain fitting analysis were applied to measure and evaluate the adsorption equilibrium constant and mass transfer properties (axial dispersion coefficient and effective intra-particle diffusivity) for toluene and p-dichlorobenzene on silica gel adsorbent in the subcritical and supercritical CO2. An apparatus based on supercritical fluid chromatography was established and the experiments were performed at temperatures of 298.15-318.15 K and pressures of 7.5-17.8 MPa. The two methods have been compared. The results show that for the systems studied here the moment method can give reasonable values for both adsorption equilibrium constant and mass transfer properties, but the time-domain analysis only can obtain the adsorption equilibrium constant. The dependence of adsorption equilibrium constant and mass transfer properties on temperature and pressure was investigated.展开更多
Formulation of poorly water-soluble crystalline drugs in their amorphous counterpart is a common approach to enhance their biodisponibility. In this study, the amorphous forms of ketoprofen and flurbiprofen were obtai...Formulation of poorly water-soluble crystalline drugs in their amorphous counterpart is a common approach to enhance their biodisponibility. In this study, the amorphous forms of ketoprofen and flurbiprofen were obtained by supercooling of the melt in a DSC （differential scanning calorimetry） apparatus and then investigated, especially under the stability point of view. The average rate of molecular motions at any given temperature is probably the most important parameter to know for amorphous pharmaceutical materials, and it was used to explain and predict the stability of ketoprofen and flurbiprofen. A quantitative estimate of the product＇s behaviour upon storage is obtained with additional data, such as the heat capacity of crystalline and amorphous samples and the distribution of molecular relaxation times. Amorphous flurbiprofen demonstrated greater physical stability at any aging temperature tested, when compared to ketoprofen and a different dependence from aging temperature. Both amorphous drugs could he classified as ＂fragile＂ ones.展开更多
When evaluating Nuclear Waste DGR Safety, it is necessary to confirm its safety in a long run and above all its safety towards the biosphere which is more precisely that the biosphere will not be in any hazard caused ...When evaluating Nuclear Waste DGR Safety, it is necessary to confirm its safety in a long run and above all its safety towards the biosphere which is more precisely that the biosphere will not be in any hazard caused by radioactive substances, With the aid of geologists, a model of a hypothetical area was elaborated and described with the use of geological and hydrogeological parameters. The volume of isotopes released out of the massif at the borderline of the near/far field from the DGR was determined. The paper results showed that ground water flow and transport of substances within the area were first to be determined. The Flow123D SW was used for the determination. The resulting outcome represents a determination of transported substances concentration depending on time. The disadvantage of the model is the fact that all the input parameters were set deterministically. The problem is solved by using the sensitivity analysis （changing the input parameters） or using the Monte Carlo Method. The major results are： calculations of the radionuclide concentrations in the elements depending on time and determination of parameters that have the biggest impact on the sensitivity of the whole model.展开更多
基金Natural Science and Education Foundation of Henan Province(2007110016)
文摘In this paper, let T be a bounded linear operator on a complex Hilbert H. We give and prove that every p-w-hyponormal operator has Bishop's property(β) and spectral properties; Quasi-similar p-w-hyponormal operators have equal spectra and equal essential spectra. Finally, for p-w-hyponormal operators, we give a kind of proof of its normality by use of properties of partial isometry.
基金Project (No. 20772109) supported by the National Natural ScienceFoundation of China
文摘Two trace impurities in the bulk drug lisinopril were detected by means of high-performance liquid chromatography coupled with mass spectrometry （HPLC/MS） with a simple and sensitive method suitable for HPLC/MSn analysis. The fragmentation behavior of lisinopfil and the impurities was investigated, and two unknown impurities were elucidated as 2-（6-amino- l-（l-carboxyethylamino）- l-oxohexan-2-ylamino）-4-phenylbutanoic acid and 6-amino-2-（l-carboxy-3-phenylpropylamino）-hexanoic acid on the basis of the multi-stage mass spectrometry and exact mass evidence, The proposed structures of the two unknown impurities were further confirmed by nuclear magnetic resonance （NMR） experiments after preparative isolation.
基金supported by the Shanghai Pharmaceutical Association
文摘A highly sensitive SPE-liquid/liquid extraction RPLC method has been developed for the analysis of 6β-hydroxycortisol and cortisol in the urine of cancer patients. Methods： After SPE column purification and liquid-liquid extraction, the sample test solutions were analyzed with RPLC using a C18 analytical column. This improved analytical method has been validated for linearity, accuracy （recovery from urine）, repeatability （within-day and between-day precision）, specificity, sensitivity, and stability. This SPE-liquid/liquid extraction-RPLC is rapid, simple, accurate and reproducible. The technique is particularly useful for monitoring the CYP3A activity of cancer patients in clinical settings. The results are expressed as the ratio of 6β-hydroxycortisol to cortisol. Results： The CYP3A activity from a total of 153 samples was measured using this improved method. Considerable variation in the CYP3A activity of different cancer patients has been documented. Thus, personalized medical treatment based on the individual metabolic enzyme activity level is necessary. Conclusion： This new analytical method facilitates such individualized medical treatments.
文摘The purpose of this study is to design a tool, adapted to students＇ individual contexts and to enable students to reflect on their understanding of media characteristics. AHP （analytic hierarchy process） is a structured technique for organizing and analyzing complex decisions. Using AHP, students have to define appropriate criteria and priorities for using media. It is expected that students＂ understanding of the characteristics of different types of media will emerge through reflection. Seventy two university students took part in this research. They were asked to prioritize their ways.of obtaining information about current affairs using sets of media such as TV, books, newspapers and web pages, Twitter and Facebook. AHP enables us to visualize a ＂real＂ understanding of media characteristics and students can reflect on that basis. As far as ＂information sources and media＂ is concerned, a few students indicated that it was the information source itself that was important rather than the type of media. Our tool fulfils the role of encouraging this type of reflection.
基金Supported by research grant 02KJB530002 from Jiangsu Provincial Committee of Education.
文摘Based on chromatographic theory, the moment method and the time-domain fitting analysis were applied to measure and evaluate the adsorption equilibrium constant and mass transfer properties (axial dispersion coefficient and effective intra-particle diffusivity) for toluene and p-dichlorobenzene on silica gel adsorbent in the subcritical and supercritical CO2. An apparatus based on supercritical fluid chromatography was established and the experiments were performed at temperatures of 298.15-318.15 K and pressures of 7.5-17.8 MPa. The two methods have been compared. The results show that for the systems studied here the moment method can give reasonable values for both adsorption equilibrium constant and mass transfer properties, but the time-domain analysis only can obtain the adsorption equilibrium constant. The dependence of adsorption equilibrium constant and mass transfer properties on temperature and pressure was investigated.
文摘Formulation of poorly water-soluble crystalline drugs in their amorphous counterpart is a common approach to enhance their biodisponibility. In this study, the amorphous forms of ketoprofen and flurbiprofen were obtained by supercooling of the melt in a DSC （differential scanning calorimetry） apparatus and then investigated, especially under the stability point of view. The average rate of molecular motions at any given temperature is probably the most important parameter to know for amorphous pharmaceutical materials, and it was used to explain and predict the stability of ketoprofen and flurbiprofen. A quantitative estimate of the product＇s behaviour upon storage is obtained with additional data, such as the heat capacity of crystalline and amorphous samples and the distribution of molecular relaxation times. Amorphous flurbiprofen demonstrated greater physical stability at any aging temperature tested, when compared to ketoprofen and a different dependence from aging temperature. Both amorphous drugs could he classified as ＂fragile＂ ones.
文摘When evaluating Nuclear Waste DGR Safety, it is necessary to confirm its safety in a long run and above all its safety towards the biosphere which is more precisely that the biosphere will not be in any hazard caused by radioactive substances, With the aid of geologists, a model of a hypothetical area was elaborated and described with the use of geological and hydrogeological parameters. The volume of isotopes released out of the massif at the borderline of the near/far field from the DGR was determined. The paper results showed that ground water flow and transport of substances within the area were first to be determined. The Flow123D SW was used for the determination. The resulting outcome represents a determination of transported substances concentration depending on time. The disadvantage of the model is the fact that all the input parameters were set deterministically. The problem is solved by using the sensitivity analysis （changing the input parameters） or using the Monte Carlo Method. The major results are： calculations of the radionuclide concentrations in the elements depending on time and determination of parameters that have the biggest impact on the sensitivity of the whole model.
