Aim To study the pharmacokinetics of remifentanil in Chinese aduh patients undergoing elective surgery and compare the results with the data already published. Methods The pharmacokinetics of remifentanil was determin...Aim To study the pharmacokinetics of remifentanil in Chinese aduh patients undergoing elective surgery and compare the results with the data already published. Methods The pharmacokinetics of remifentanil was determined in 10 aduh patients undergoing elective surgery. Remifentanil 5 - 6 μg·kg^-1 was administered within 1 min after the induction of anesthesia. One point five millilitre of arterial blood samples were collected at 0 (baseline), 1,2, 3, 5,7, 10, 15, 20, 25, 30, 45, 60, and 90 min after drug administration. Remifentanil concentration was assayed by HPLC/MS/MS. Resuits The concentration-time course of remifentanil was best described by a two-compartment model. Total clearance (CL = 2. 149 ± 0. 431 L·min^-1) of remifentanil was greater than the normal hepatic blood flow. The distribution half-life (t1/2α) [ 1.56 ± 0. 52 min (0.73 - 2.31 ) ] and the elimination half-life (t1/2β) [22.07 ± 10.30 min (9, 71 -36.07)] were similar with those in previous reports. Volume of distribution ( Vd = 65. 766 ± 29. 100 L) was about two times greater than that reported in previous studies of other ethnics. Conclusion In the present study, the volume of distribution is significantly greater than thai reported in previous studies of other ethnics, indicating that there are some differences in the pharmacokinetics of remifentanil among different ethnics.展开更多
The effects of different application levels and species of phosphatic fertilizer on Eleocharis dulcis were studied. The results showed that the growth stage of Eleocharis dulcis was not significantly influenced by dif...The effects of different application levels and species of phosphatic fertilizer on Eleocharis dulcis were studied. The results showed that the growth stage of Eleocharis dulcis was not significantly influenced by different levels of phosphatic fertilizer application, with phosphorus level in 195-375 kg/hm^2. With increasing of the phosphorus level, starch and total soluble sugar accumulated, but the yield was not improved significantly. The analysis on the economic benefits showed that the best phosphorus level was 195 kg/hm^2. The growth stage and yield of Eleocharis dulcis were not considerably influenced by different proportions of calcium-magnesia phosphate fertilizer and ammonium dihydrogen phosphate. With increasing of ammonium dihydrogen phosphate, big-fruit rate of Eleocharis dulcis kept growing, but the accumulations of starch and total soluble sugar were decreasing.展开更多
The present work is focused on the relationship between effective segregation coefficient keff and tem- perature of melting zone for purification of phosphorus by zone melting method. Values of keff at four temperatur...The present work is focused on the relationship between effective segregation coefficient keff and tem- perature of melting zone for purification of phosphorus by zone melting method. Values of keff at four temperatures of melting zone are obtained for zone pass n = 1 at travel velocity of molten zone v = 5x 10^-3 m. h^-1 and initial impu- rity concentration C0〈10 μg.g-1, lnkeff is a linear function of 1/T. The keff values of A1, Ca, Cr, Fe, Cd and Sb in- crease with temperatures while that of Mg is almost constant. The purification is acceptable at lower temperature of melting zone such as 323 K. The variations of enthalpy and entropy between impurities and phosphorus in the liq- uid and solid ohases are also 19resented.展开更多
The study was aimed at evaluating growth response of Heteroclarias fingerlings fed diet in which fish meal was substituted with graded levels of earthworm meal. The replacement levels were 0.00%, 25%, 50%, 75% and 100...The study was aimed at evaluating growth response of Heteroclarias fingerlings fed diet in which fish meal was substituted with graded levels of earthworm meal. The replacement levels were 0.00%, 25%, 50%, 75% and 100% designated as Eo, E25, Es0, E75 and El00, respectively. Fingerlings used for the work were obtained through artificial insemination of brood stock (purchased from local farmers) with ovaprim in the laboratory. The resulting fry were reared and fed with cultured plankton for 2 weeks followed by 100% fish meal for another two weeks. Thereafter sixteen fingerlings weighing 4.73 g and measuring 6.512 mm standard length (on the average) were starved over night and reared in five indoors tanks (0.8 ~ 0.5 ~ 0.5 m) in duplicate for eight weeks. Fingerlings were fed on graded earthworm meals of 40% protein twice daily at 08:00 and 16:00. The highest mean weight (6.77 g), specific growth rate (0.86) and protein efficiency ratio (0.6) were obtained at 50% replacement level. Also, Food conversion ratio was the highest at 50% substitution level and lowest at 0.00% substitution, indicating that fingerlings use earthworm containing meal more efficiently. Furthermore, cost benefit analysis revealed that the profit index for 50% inclusion of earthworm meal was the highest (1.71) and the highest net profit of N374.32 (circa $2.3) was achieved at this level. Water quality parameters observed were within tolerable values for the fingerlings well being. Consequently, farmers are advised to use 50% earthworm meal in place of fish meal for formulation of Heteroclarias fingerlings diet. This will drastically reduce production cost, increase farmers profit and enhance the biological value of our menu.展开更多
[Objective] This study aimed to investigate the acaricidal lffect of scopo- letin, and provide the biochemical evidences of scopoletin influencus Ca2+-ATPase activity and gene expressions in the Carmine Spider Mite, ...[Objective] This study aimed to investigate the acaricidal lffect of scopo- letin, and provide the biochemical evidences of scopoletin influencus Ca2+-ATPase activity and gene expressions in the Carmine Spider Mite, Tetranych'us cinnabarinus. in increased protein contents; kinetic analysis showed that the catalytic capability of Ca2+-ATPase was significantly reduced by scopoletin. [Conclusion] Scopoletin exhibits a significant inhibitory effect on Ca2+-ATPase, and its acaricidal effect against T. cinnabarinus might be due to the direct inhibition of Ca2+-ATPase.展开更多
The authors analyzed the engineering geological characteristics of the slope of the study area (K75+840-K76+340). Two typical cross-sections have been chosen to analyze the failure modes after the excavation of the hi...The authors analyzed the engineering geological characteristics of the slope of the study area (K75+840-K76+340). Two typical cross-sections have been chosen to analyze the failure modes after the excavation of the highway. Different types of the failure modes have been calculated and analyzed. The results show that some dealing methods have been advised to ensure the stability of the slopes.展开更多
Saffron, obtained from the flower stigmas of Crocus sativus L., is one of the most expensive food spices. The introduction of saffron in alpine areas could help to broaden and diversify the activities of mountain mult...Saffron, obtained from the flower stigmas of Crocus sativus L., is one of the most expensive food spices. The introduction of saffron in alpine areas could help to broaden and diversify the activities of mountain multifunctional farms, with a positive impact on economy and land management. According to ISO 3632(2010/2011), saffron can be classified into three categories of quality(I, II, III) depending on the concentration of the three main metabolites responsible for its characteristic colour, flavor and aroma: Crocin, Picrocrocin and Safranal. This study represents the first investigation of the quality of saffron produced in the Italian Alps evaluated with spectrophotometry, HPLC, solid-phase microextraction(SPME), and gas chromatographic analysis combined with mass spectrometry(GC/MS). The experiments used Crocus sativus stigmas produced in 2012-2013 in different areas of the Central Italian Alps were located at an altitude between 720 and 1200 m a.s.l.. Results obtained were compared to commercial saffron. The analyses confirmed that all samples can be classified in the first quality category according to the ISO classification. This high quality is also confirmed by HPLC analysis. Moreover, the SPME-GC/MS analysis identified some differences in the aromatic profile of saffron samples, in particular regarding safranal concentration. A preliminary assessment of the economic viability of high quality saffron production for local markets was also performed. Our study provides valid information regarding the quality and economic sustainability of saffron production in the alpine area confirming this crop as a good candidate for a new source of income for multifunctional farms in mountain areas.展开更多
With consideration of the special hydrogeological conditions and layout characteristics of the hydraulic structures, the seepage control measures of dam abutment and underground powerhouse on the right bank of JinPing...With consideration of the special hydrogeological conditions and layout characteristics of the hydraulic structures, the seepage control measures of dam abutment and underground powerhouse on the right bank of JinPing-I hydropower station is drawn up. Based on the three dimensional finite element analysis of seepage control with dry area virtual flow constant mesh analysis method, the rationality of the seepage control measures of dam abutment and underground powerhouse has been verified and the key factors affecting the effect of seepage have been compared. In combination with the curtain of dam abutment, the curtain of underground powerhouse is reasonable. The results showed that the steel liner of penstock after the curtain is necessary.展开更多
A simple, sensible and reliable HPLC-DAD fingerprint analysis method for the raw materials of Oxytropisfalcata and Oxytropis chiliophylla, both of which were used as "Er-Da-Xia" in Tibetan medicines, was developed a...A simple, sensible and reliable HPLC-DAD fingerprint analysis method for the raw materials of Oxytropisfalcata and Oxytropis chiliophylla, both of which were used as "Er-Da-Xia" in Tibetan medicines, was developed and then subsequently applied to analyze samples collected from different locations or times. 19 common fingerprint peaks for O. falcata, 24 for O. chiliophylla, and 11 for the two herbs were designated respectively, including 7 identified characteristic peaks existing in both herbs and 1 uniquely presenting in O. chiliophylla. Although there were some slight differences in the chemicals of O. falcata and O. chiliophylla, the main components of both herbs were consistent generally. The results provided scientific basis, at least from the chemical point of view, for the reasonablity of two herbs being used as the same drug in Tibetan medicines and for the necessary of further investigation on their detailed chemical and pharmacological differences.展开更多
The land fallow policy was adopted by central and local governments to encourage the abandonment of water-intensive crops, such as winter wheat, in groundwater over-exploited areas. At the same time, since the 1990s, ...The land fallow policy was adopted by central and local governments to encourage the abandonment of water-intensive crops, such as winter wheat, in groundwater over-exploited areas. At the same time, since the 1990s, many households in the North China Plain (NCP) have chosen to replace the winter wheat and summer maize double-cropping system with the spring maize single-cropping system. Therefore, it is crucial to identify target land parcels for winter wheat abandonment and to design reasonable and proper standards for ecological compensation prior to the implementation of the land fallow policy in the NCP. In this study, multi-level Iogit models were used with household survey data in order to detect determinants across land parcel, household and village levels on household cropping system decisions; the opportunity costs for winter wheat abandonment were also calculated using cost-benefit analysis. The results show that: (1) land quality and irrigation condition at parcel level are two essential elements influencing household cropping system decisions. Nearly 70% of the total area of poor land and more than 90% of the total area of unirrigated land has suffered winter wheat abandonment. Target land parcels for the land fallow policy should be those that are irrigated and of high quality. (2) There were no significant differences between net profits from spring maize and summer maize under similar farming conditions, and the opportunity cost for winter wheat abandonment should be equal to the net profit of winter wheat. (3) The primary purpose of the land fallow policy is to induce groundwater recovery and restoration as a preliminary stage. A higher level of 350 yuan/mu is recommended as subsidy for ecological compensation at this stage. Later, the primary purpose of the policy should be a transition to a balance between exploitation and supplementation of water resources, and a lower level of 280 yuan/mu is recommended as a subsidy at this stage.展开更多
Applying the economic principles, this article carries out the assessment of economic performancesbrought by forestry research achievement through research and discussion on the assessment method ofeconomic performanc...Applying the economic principles, this article carries out the assessment of economic performancesbrought by forestry research achievement through research and discussion on the assessment method ofeconomic performances of provenance popularization of Pinus massoniana L. The article also brings in theoption method to fully display the value of forest research achievement.展开更多
In this paper, an automatic unstructured focused ion beam (FIB) and scanning electron microscopy (SEM) images induced representative volume element (RVE) finite element (FE) method is developed to predict subm...In this paper, an automatic unstructured focused ion beam (FIB) and scanning electron microscopy (SEM) images induced representative volume element (RVE) finite element (FE) method is developed to predict submicron scale carbonate rock effective Young's and bulk moduli and Poisson's ratio on parallel CPU-GPU platform. Based on high resolution-contrast surface morphology and internal fabric-texture structure images from carbonate rock specimen (covered 0.12-64 μm2 area and 8000 μm3 domain), the cubic RVE FE models are constructed from different sites through Avizo with user-defined parameters Matlab coding. The effective Young's and bulk moduli and Poisson's ratio of the different RVEs and porosity and pore size are computed by using periodic boundary condition in the well-known FE software Abaqus. FE mesh sensitivity analysis has been conducted where all moduli converge to a certain constant value at larger FE mesh density. The effect of fabric-texture (pore size, shape, and distribution) on the elastic properties is discussed. The correlations between the computed effective elastic properties and pore size, porosity, RVE size have been established. The simulation results show that the effective Young's and bulk moduli and Poisson's ratio have strong anisotropic behavior and depend on RVE size, porosity and pore size. The RVE size, porosity and pore size are three independent factors in affecting of the effective elastic moduli, the effect mechanism of porosity and pore size is same while the effect mechanism of RVE size is difference.展开更多
文摘Aim To study the pharmacokinetics of remifentanil in Chinese aduh patients undergoing elective surgery and compare the results with the data already published. Methods The pharmacokinetics of remifentanil was determined in 10 aduh patients undergoing elective surgery. Remifentanil 5 - 6 μg·kg^-1 was administered within 1 min after the induction of anesthesia. One point five millilitre of arterial blood samples were collected at 0 (baseline), 1,2, 3, 5,7, 10, 15, 20, 25, 30, 45, 60, and 90 min after drug administration. Remifentanil concentration was assayed by HPLC/MS/MS. Resuits The concentration-time course of remifentanil was best described by a two-compartment model. Total clearance (CL = 2. 149 ± 0. 431 L·min^-1) of remifentanil was greater than the normal hepatic blood flow. The distribution half-life (t1/2α) [ 1.56 ± 0. 52 min (0.73 - 2.31 ) ] and the elimination half-life (t1/2β) [22.07 ± 10.30 min (9, 71 -36.07)] were similar with those in previous reports. Volume of distribution ( Vd = 65. 766 ± 29. 100 L) was about two times greater than that reported in previous studies of other ethnics. Conclusion In the present study, the volume of distribution is significantly greater than thai reported in previous studies of other ethnics, indicating that there are some differences in the pharmacokinetics of remifentanil among different ethnics.
基金Supported by Key Projects in Hubei Science&Technology Pillar Program in 2015(2015BBA199)Guangxi Agricultural Department Science Research ProgramHubei Agricultural S&T Innovation(2016-620-007-001)
文摘The effects of different application levels and species of phosphatic fertilizer on Eleocharis dulcis were studied. The results showed that the growth stage of Eleocharis dulcis was not significantly influenced by different levels of phosphatic fertilizer application, with phosphorus level in 195-375 kg/hm^2. With increasing of the phosphorus level, starch and total soluble sugar accumulated, but the yield was not improved significantly. The analysis on the economic benefits showed that the best phosphorus level was 195 kg/hm^2. The growth stage and yield of Eleocharis dulcis were not considerably influenced by different proportions of calcium-magnesia phosphate fertilizer and ammonium dihydrogen phosphate. With increasing of ammonium dihydrogen phosphate, big-fruit rate of Eleocharis dulcis kept growing, but the accumulations of starch and total soluble sugar were decreasing.
文摘The present work is focused on the relationship between effective segregation coefficient keff and tem- perature of melting zone for purification of phosphorus by zone melting method. Values of keff at four temperatures of melting zone are obtained for zone pass n = 1 at travel velocity of molten zone v = 5x 10^-3 m. h^-1 and initial impu- rity concentration C0〈10 μg.g-1, lnkeff is a linear function of 1/T. The keff values of A1, Ca, Cr, Fe, Cd and Sb in- crease with temperatures while that of Mg is almost constant. The purification is acceptable at lower temperature of melting zone such as 323 K. The variations of enthalpy and entropy between impurities and phosphorus in the liq- uid and solid ohases are also 19resented.
文摘The study was aimed at evaluating growth response of Heteroclarias fingerlings fed diet in which fish meal was substituted with graded levels of earthworm meal. The replacement levels were 0.00%, 25%, 50%, 75% and 100% designated as Eo, E25, Es0, E75 and El00, respectively. Fingerlings used for the work were obtained through artificial insemination of brood stock (purchased from local farmers) with ovaprim in the laboratory. The resulting fry were reared and fed with cultured plankton for 2 weeks followed by 100% fish meal for another two weeks. Thereafter sixteen fingerlings weighing 4.73 g and measuring 6.512 mm standard length (on the average) were starved over night and reared in five indoors tanks (0.8 ~ 0.5 ~ 0.5 m) in duplicate for eight weeks. Fingerlings were fed on graded earthworm meals of 40% protein twice daily at 08:00 and 16:00. The highest mean weight (6.77 g), specific growth rate (0.86) and protein efficiency ratio (0.6) were obtained at 50% replacement level. Also, Food conversion ratio was the highest at 50% substitution level and lowest at 0.00% substitution, indicating that fingerlings use earthworm containing meal more efficiently. Furthermore, cost benefit analysis revealed that the profit index for 50% inclusion of earthworm meal was the highest (1.71) and the highest net profit of N374.32 (circa $2.3) was achieved at this level. Water quality parameters observed were within tolerable values for the fingerlings well being. Consequently, farmers are advised to use 50% earthworm meal in place of fish meal for formulation of Heteroclarias fingerlings diet. This will drastically reduce production cost, increase farmers profit and enhance the biological value of our menu.
基金Supported by National Natural Science Foundation of China(31272058)Specialized Research Fund for the Doctoral Program of Higher Education(20100182120021)
文摘[Objective] This study aimed to investigate the acaricidal lffect of scopo- letin, and provide the biochemical evidences of scopoletin influencus Ca2+-ATPase activity and gene expressions in the Carmine Spider Mite, Tetranych'us cinnabarinus. in increased protein contents; kinetic analysis showed that the catalytic capability of Ca2+-ATPase was significantly reduced by scopoletin. [Conclusion] Scopoletin exhibits a significant inhibitory effect on Ca2+-ATPase, and its acaricidal effect against T. cinnabarinus might be due to the direct inhibition of Ca2+-ATPase.
文摘The authors analyzed the engineering geological characteristics of the slope of the study area (K75+840-K76+340). Two typical cross-sections have been chosen to analyze the failure modes after the excavation of the highway. Different types of the failure modes have been calculated and analyzed. The results show that some dealing methods have been advised to ensure the stability of the slopes.
基金partly supported by "Accordo di Programma, affermazione in Edolo del Centro di Eccellenza Università della Montagna" MIURUniversità degli Studi di Milano, prot. no. 386 1293-05/08/2011 and by Fondazione della Comunità Bresciana- Onlus
文摘Saffron, obtained from the flower stigmas of Crocus sativus L., is one of the most expensive food spices. The introduction of saffron in alpine areas could help to broaden and diversify the activities of mountain multifunctional farms, with a positive impact on economy and land management. According to ISO 3632(2010/2011), saffron can be classified into three categories of quality(I, II, III) depending on the concentration of the three main metabolites responsible for its characteristic colour, flavor and aroma: Crocin, Picrocrocin and Safranal. This study represents the first investigation of the quality of saffron produced in the Italian Alps evaluated with spectrophotometry, HPLC, solid-phase microextraction(SPME), and gas chromatographic analysis combined with mass spectrometry(GC/MS). The experiments used Crocus sativus stigmas produced in 2012-2013 in different areas of the Central Italian Alps were located at an altitude between 720 and 1200 m a.s.l.. Results obtained were compared to commercial saffron. The analyses confirmed that all samples can be classified in the first quality category according to the ISO classification. This high quality is also confirmed by HPLC analysis. Moreover, the SPME-GC/MS analysis identified some differences in the aromatic profile of saffron samples, in particular regarding safranal concentration. A preliminary assessment of the economic viability of high quality saffron production for local markets was also performed. Our study provides valid information regarding the quality and economic sustainability of saffron production in the alpine area confirming this crop as a good candidate for a new source of income for multifunctional farms in mountain areas.
文摘With consideration of the special hydrogeological conditions and layout characteristics of the hydraulic structures, the seepage control measures of dam abutment and underground powerhouse on the right bank of JinPing-I hydropower station is drawn up. Based on the three dimensional finite element analysis of seepage control with dry area virtual flow constant mesh analysis method, the rationality of the seepage control measures of dam abutment and underground powerhouse has been verified and the key factors affecting the effect of seepage have been compared. In combination with the curtain of dam abutment, the curtain of underground powerhouse is reasonable. The results showed that the steel liner of penstock after the curtain is necessary.
基金National Natural Science Foundation of China (Grant No.21372015 and 20872006)
文摘A simple, sensible and reliable HPLC-DAD fingerprint analysis method for the raw materials of Oxytropisfalcata and Oxytropis chiliophylla, both of which were used as "Er-Da-Xia" in Tibetan medicines, was developed and then subsequently applied to analyze samples collected from different locations or times. 19 common fingerprint peaks for O. falcata, 24 for O. chiliophylla, and 11 for the two herbs were designated respectively, including 7 identified characteristic peaks existing in both herbs and 1 uniquely presenting in O. chiliophylla. Although there were some slight differences in the chemicals of O. falcata and O. chiliophylla, the main components of both herbs were consistent generally. The results provided scientific basis, at least from the chemical point of view, for the reasonablity of two herbs being used as the same drug in Tibetan medicines and for the necessary of further investigation on their detailed chemical and pharmacological differences.
基金National Natural Science Foundation of China,No.41571095,No.41271119
文摘The land fallow policy was adopted by central and local governments to encourage the abandonment of water-intensive crops, such as winter wheat, in groundwater over-exploited areas. At the same time, since the 1990s, many households in the North China Plain (NCP) have chosen to replace the winter wheat and summer maize double-cropping system with the spring maize single-cropping system. Therefore, it is crucial to identify target land parcels for winter wheat abandonment and to design reasonable and proper standards for ecological compensation prior to the implementation of the land fallow policy in the NCP. In this study, multi-level Iogit models were used with household survey data in order to detect determinants across land parcel, household and village levels on household cropping system decisions; the opportunity costs for winter wheat abandonment were also calculated using cost-benefit analysis. The results show that: (1) land quality and irrigation condition at parcel level are two essential elements influencing household cropping system decisions. Nearly 70% of the total area of poor land and more than 90% of the total area of unirrigated land has suffered winter wheat abandonment. Target land parcels for the land fallow policy should be those that are irrigated and of high quality. (2) There were no significant differences between net profits from spring maize and summer maize under similar farming conditions, and the opportunity cost for winter wheat abandonment should be equal to the net profit of winter wheat. (3) The primary purpose of the land fallow policy is to induce groundwater recovery and restoration as a preliminary stage. A higher level of 350 yuan/mu is recommended as subsidy for ecological compensation at this stage. Later, the primary purpose of the policy should be a transition to a balance between exploitation and supplementation of water resources, and a lower level of 280 yuan/mu is recommended as a subsidy at this stage.
文摘Applying the economic principles, this article carries out the assessment of economic performancesbrought by forestry research achievement through research and discussion on the assessment method ofeconomic performances of provenance popularization of Pinus massoniana L. The article also brings in theoption method to fully display the value of forest research achievement.
基金supported by the National Natural Science Foundation of China(Grant No.41404078)
文摘In this paper, an automatic unstructured focused ion beam (FIB) and scanning electron microscopy (SEM) images induced representative volume element (RVE) finite element (FE) method is developed to predict submicron scale carbonate rock effective Young's and bulk moduli and Poisson's ratio on parallel CPU-GPU platform. Based on high resolution-contrast surface morphology and internal fabric-texture structure images from carbonate rock specimen (covered 0.12-64 μm2 area and 8000 μm3 domain), the cubic RVE FE models are constructed from different sites through Avizo with user-defined parameters Matlab coding. The effective Young's and bulk moduli and Poisson's ratio of the different RVEs and porosity and pore size are computed by using periodic boundary condition in the well-known FE software Abaqus. FE mesh sensitivity analysis has been conducted where all moduli converge to a certain constant value at larger FE mesh density. The effect of fabric-texture (pore size, shape, and distribution) on the elastic properties is discussed. The correlations between the computed effective elastic properties and pore size, porosity, RVE size have been established. The simulation results show that the effective Young's and bulk moduli and Poisson's ratio have strong anisotropic behavior and depend on RVE size, porosity and pore size. The RVE size, porosity and pore size are three independent factors in affecting of the effective elastic moduli, the effect mechanism of porosity and pore size is same while the effect mechanism of RVE size is difference.