In the previous research, we found that anticancer agent LS-1-2 F could cause the vacuolation of tumor cells. Herein we investigated the effect of compound LS-1-2 F on the endocytosis of macromolecules, including fluo...In the previous research, we found that anticancer agent LS-1-2 F could cause the vacuolation of tumor cells. Herein we investigated the effect of compound LS-1-2 F on the endocytosis of macromolecules, including fluorescence quantum dots, human serum albumin, single-stranded RNA, and monoclonal antibody, into tumor cells. We found that LS-1-2 F could accelerate the endocytosis of these large molecules by laser confocal microscope and flow cytometry. The effect of LS-1-2 F on the improvement of the internalization efficiency of Herceptin biosimilar was particularly significant. Promoting endocytosis will help increase the efficiency of liquid-phase drug uptake in drug-resistant cancer cells and could potentially facilitate the use of drugs in nanoparticle delivery vehicles.展开更多
基金National Natural Science Foundation of China(Grant No.81573272)
文摘In the previous research, we found that anticancer agent LS-1-2 F could cause the vacuolation of tumor cells. Herein we investigated the effect of compound LS-1-2 F on the endocytosis of macromolecules, including fluorescence quantum dots, human serum albumin, single-stranded RNA, and monoclonal antibody, into tumor cells. We found that LS-1-2 F could accelerate the endocytosis of these large molecules by laser confocal microscope and flow cytometry. The effect of LS-1-2 F on the improvement of the internalization efficiency of Herceptin biosimilar was particularly significant. Promoting endocytosis will help increase the efficiency of liquid-phase drug uptake in drug-resistant cancer cells and could potentially facilitate the use of drugs in nanoparticle delivery vehicles.
