Objective To assess the prevalence of the bleeding complications in pacemaker implanted patients receiving different antiplatelet regimens, and the influence of each regimen on hospital stays after device implantation...Objective To assess the prevalence of the bleeding complications in pacemaker implanted patients receiving different antiplatelet regimens, and the influence of each regimen on hospital stays after device implantation. Methods We prospectively enrolled 364 patients receiving the cardiac rhythm device implantations in Fuwai Hospital from July 2012 to December 2013. Bleeding complications including pocket hematoma, hemothorax, cardiac tamponade and blood transfusion requirement were measured as endpoints. Post operation hospital stay was also included in the endpoints. Results Bleeding complications were detected in 15 patients （14 with hematoma, one with hemothorax） out of all 364 patients （4.12%）. Dual antiplatelet therapy （DAT） significantly increased hematoma （19.3%） compared with aspi- fin treatment （ASA） （3.2%, P = 0.001） and no antiplatelet therapy （1.9%, P 〈 0.001）. There was no significant difference in incidence of pocket hematoma between the ASA group and the control group （P = 0.45）. The post procedure hospital stay was longer in DAT group （5.45 ± 2.01 days） compared to those in the ASA group （3.65 ± 1.37 days, P 〈 0.05） or control group （3.99 ± 2.27 days, P 〈 0.05）. Pocket hema- toma was considered an independent predictor of hospital stay prolongation （OR： 5.26; 95% CI： 1.56-16.64; P = 0.007）. Conclusions Among the Chinese patients undergoing device implantation in this study, the use of dual antiplatelet agents significantly increased the risk of pocket hematoma complications and led to a longer hospital stay. Use of aspirin alone did not increase the risk.展开更多
Synchronization is considered to be a crucial mechanism that maintains respiratory rhythm.For understanding the effect of electrical coupling on the transition of the firing patterns and synchronization,we coupled two...Synchronization is considered to be a crucial mechanism that maintains respiratory rhythm.For understanding the effect of electrical coupling on the transition of the firing patterns and synchronization,we coupled two inspiratory pacemaker neurons together,and studied various synchronous behaviors between them.We firstly compared the bifurcation diagrams between the coupled neurons and single neuron,and found that the coupled neurons had a more complicated bifurcation mode.By increasing the coupling strength,the regular variation of phase differences was illustrated so that asynchronous and some synchronous states could be observed.These synchronous states were also shown in detail by phase portraits and firing series.In addition,we explored the ranges of different synchronous states,which attributed to different ranges of membrane capacitance and coupling strength.展开更多
文摘Objective To assess the prevalence of the bleeding complications in pacemaker implanted patients receiving different antiplatelet regimens, and the influence of each regimen on hospital stays after device implantation. Methods We prospectively enrolled 364 patients receiving the cardiac rhythm device implantations in Fuwai Hospital from July 2012 to December 2013. Bleeding complications including pocket hematoma, hemothorax, cardiac tamponade and blood transfusion requirement were measured as endpoints. Post operation hospital stay was also included in the endpoints. Results Bleeding complications were detected in 15 patients （14 with hematoma, one with hemothorax） out of all 364 patients （4.12%）. Dual antiplatelet therapy （DAT） significantly increased hematoma （19.3%） compared with aspi- fin treatment （ASA） （3.2%, P = 0.001） and no antiplatelet therapy （1.9%, P 〈 0.001）. There was no significant difference in incidence of pocket hematoma between the ASA group and the control group （P = 0.45）. The post procedure hospital stay was longer in DAT group （5.45 ± 2.01 days） compared to those in the ASA group （3.65 ± 1.37 days, P 〈 0.05） or control group （3.99 ± 2.27 days, P 〈 0.05）. Pocket hema- toma was considered an independent predictor of hospital stay prolongation （OR： 5.26; 95% CI： 1.56-16.64; P = 0.007）. Conclusions Among the Chinese patients undergoing device implantation in this study, the use of dual antiplatelet agents significantly increased the risk of pocket hematoma complications and led to a longer hospital stay. Use of aspirin alone did not increase the risk.
基金supported by the National Natural Science Foundation of China(Grant No.11172103)
文摘Synchronization is considered to be a crucial mechanism that maintains respiratory rhythm.For understanding the effect of electrical coupling on the transition of the firing patterns and synchronization,we coupled two inspiratory pacemaker neurons together,and studied various synchronous behaviors between them.We firstly compared the bifurcation diagrams between the coupled neurons and single neuron,and found that the coupled neurons had a more complicated bifurcation mode.By increasing the coupling strength,the regular variation of phase differences was illustrated so that asynchronous and some synchronous states could be observed.These synchronous states were also shown in detail by phase portraits and firing series.In addition,we explored the ranges of different synchronous states,which attributed to different ranges of membrane capacitance and coupling strength.
