AIM： To investigate if sildenafil increases splanchnic blood flow and changes the hepatic venous pressure gradient （HVPG） in patients with cirrhosis. Phosphodiesterase type-5 inhibitors are valuable in the treatmen...AIM： To investigate if sildenafil increases splanchnic blood flow and changes the hepatic venous pressure gradient （HVPG） in patients with cirrhosis. Phosphodiesterase type-5 inhibitors are valuable in the treatment of erectile dysfunction and pulmonary hypertension in patients with end-stage liver disease. However, the effect of phosphodiesterase type-5 inhibitors on splanchnic blood flow and portal hypertension remains essentially unknown. METHODS： Ten patients with biopsy proven cirrhosis （five females/five males, mean age 54：1：8 years） and an HVPG above 12 mmHg were studied after informed consent. Measurement of splanchnic blood flow and the HVPG during liver vein catheterization were done before and 80 min after oral administration of 50 mg sildenafil. Blood flow was estimated by use of indocyanine green clearance technique and Fick＇s principle, with correction for non-steady state. RESULTS： The plasma concentration of sildenafil was 222 ± 136 ng/mL 80 min after administration. Mean arterial blood pressure decreased from 77 ±7 mmHg to 66 ± 12 mmHg, P = 0.003, while the splanchnicblood flow and oxygen consumption remained unchanged at 1.14 ± 0.71 L/min and 2.3 ± 0.6 mmol/ min, respectively. Also the HVPG remained unchanged （18 ± 2 mmHg vs 16 ± 2 mmHg） with individual changes ranging from -8 mmHg to ±2 mmHg. In seven patients, HVPG decreased and in three it increased. CONCLUSION： In spite of arterial blood pressure decreases 80 min after administration of the phosphodiesterase type-5 inhibitor sildenafil, the present study could not demonstrate any clinical relevant influence on splanichnic blood flow, oxygen consumption or the HVPG.展开更多
The original or primitive venation of mayflies was not presented clearly upon living materials before,this mostly results from the deform of mayfly imaginal wingbase.Some nymphs of large mayflies of China,like Siphlur...The original or primitive venation of mayflies was not presented clearly upon living materials before,this mostly results from the deform of mayfly imaginal wingbase.Some nymphs of large mayflies of China,like Siphluriscus chinensis,Ephemera pictipennis and Siphlonurus davidi,however,show some clues.Together,they demonstrate that in mayflies,subcostal brace maybe originated from longitudinal vein Anterior Subcostal(ScA),stems of Radius(R)and Media(M)are always fused at base,Media Posterior(MP)leave them first,then the branch of Rs(Radial Section)+MA(Media Anterior),Cubitus(Cu)disconnected to any other veins.Additionally,all longitudinal veins of mayflies fused with their sclerotized base respectively but without any moveable sclerite.Instead,base of R+M of mayflies sclerotized into a single one big plate,and all sclerites of wingbase are fused together rigidly by sclerotized wingbase,which disables any possible folding of mayfly wings.Phylogenetically,in the order Ephemeroptera,the different positions of ScA and Cu leaded to different and diverse venations and lineages of Ephemeroptera.In the Pterygota,the Ephemeroptera has the same fused pattern of R+M and three axillary sclerites as the Neoptera while the Odonata has the fused Cu+M,which disproves the monophyly of Paleoptera.展开更多
This study analyses evidence for reformed basin development and basin-mountain coupling associated with devel- opment of the Ordos Basin and the Laliang Mountains, China. Gaining an improved understanding of the timin...This study analyses evidence for reformed basin development and basin-mountain coupling associated with devel- opment of the Ordos Basin and the Laliang Mountains, China. Gaining an improved understanding of the timing and nature of uplift and evolution of the Ltiliang Mountains is important for the reconstruction of the eastern sedimentary boundary of the Ordos Basin （a major petroliferous basin） as well as for providing insight into the evolution and breakup of the North China Craton （NCC）. Based on systematic sampling for fission track analysis, it is suggested that the main phase of uplift of the Laliang Mountains occurred since later part of the Early Cretaceous. Three evolutionary stages of uplift and development are identified： slow initial uplift （120-65 Ma）, accelerated uplift （65-23 Ma）, and intensive uplift （23 Ma to present）, with the ma- jority of the uplift activity having occurred during the Cenozoic. The history of uplift is non-equilibrium and exhibits complex- ity in temporal and spatial aspects. The middle and northern parts of the Ltiliang Mountains were uplifted earlier than the southern part. The most intensive episode of uplift activity commenced in the Miocene and was associated with a genetic cou- pling relationship with the eastern neighboring Cenozoic Shanxi Grabens. The uplifting and evolutionary processes of the Ltiliang Mountains area since later part of the Early Cretaceous share a unified regional geodynamic setting, which was ac- companied by uplift of the Mesozoic Ordos Basin and development of the neighboring Cenozoic Shanxi Grabens. Collectively, this regional orogenic activity is related principally to the far-field effects of both the compression sourced from the south- western Tibet Plateau and westward subduction of the Pacific Plate in Cenozoic.展开更多
基金Rigshospitalet,University of Copenhagen,The Laerdal Foundation for Acute MedicineSavvaerksejer Jeppe Juhl and wife Ovita Juhls Foundation+2 种基金The Novo Nordisk FoundationThe AP-Mфller Foundationan unrestricted grant from Pfizer,Denmark
文摘AIM： To investigate if sildenafil increases splanchnic blood flow and changes the hepatic venous pressure gradient （HVPG） in patients with cirrhosis. Phosphodiesterase type-5 inhibitors are valuable in the treatment of erectile dysfunction and pulmonary hypertension in patients with end-stage liver disease. However, the effect of phosphodiesterase type-5 inhibitors on splanchnic blood flow and portal hypertension remains essentially unknown. METHODS： Ten patients with biopsy proven cirrhosis （five females/five males, mean age 54：1：8 years） and an HVPG above 12 mmHg were studied after informed consent. Measurement of splanchnic blood flow and the HVPG during liver vein catheterization were done before and 80 min after oral administration of 50 mg sildenafil. Blood flow was estimated by use of indocyanine green clearance technique and Fick＇s principle, with correction for non-steady state. RESULTS： The plasma concentration of sildenafil was 222 ± 136 ng/mL 80 min after administration. Mean arterial blood pressure decreased from 77 ±7 mmHg to 66 ± 12 mmHg, P = 0.003, while the splanchnicblood flow and oxygen consumption remained unchanged at 1.14 ± 0.71 L/min and 2.3 ± 0.6 mmol/ min, respectively. Also the HVPG remained unchanged （18 ± 2 mmHg vs 16 ± 2 mmHg） with individual changes ranging from -8 mmHg to ±2 mmHg. In seven patients, HVPG decreased and in three it increased. CONCLUSION： In spite of arterial blood pressure decreases 80 min after administration of the phosphodiesterase type-5 inhibitor sildenafil, the present study could not demonstrate any clinical relevant influence on splanichnic blood flow, oxygen consumption or the HVPG.
文摘The original or primitive venation of mayflies was not presented clearly upon living materials before,this mostly results from the deform of mayfly imaginal wingbase.Some nymphs of large mayflies of China,like Siphluriscus chinensis,Ephemera pictipennis and Siphlonurus davidi,however,show some clues.Together,they demonstrate that in mayflies,subcostal brace maybe originated from longitudinal vein Anterior Subcostal(ScA),stems of Radius(R)and Media(M)are always fused at base,Media Posterior(MP)leave them first,then the branch of Rs(Radial Section)+MA(Media Anterior),Cubitus(Cu)disconnected to any other veins.Additionally,all longitudinal veins of mayflies fused with their sclerotized base respectively but without any moveable sclerite.Instead,base of R+M of mayflies sclerotized into a single one big plate,and all sclerites of wingbase are fused together rigidly by sclerotized wingbase,which disables any possible folding of mayfly wings.Phylogenetically,in the order Ephemeroptera,the different positions of ScA and Cu leaded to different and diverse venations and lineages of Ephemeroptera.In the Pterygota,the Ephemeroptera has the same fused pattern of R+M and three axillary sclerites as the Neoptera while the Odonata has the fused Cu+M,which disproves the monophyly of Paleoptera.
基金the National Natural Science Foundation of China(Grant Nos.41330315&41002071)MOST Special Funds from the State Key Laboratory of Continental Dynamics(Grant Nos.BJ091354&BJ081334)Special Fund from Ministry of Education for Doctoral Discipline in High School(Grant No.20116101110006)
文摘This study analyses evidence for reformed basin development and basin-mountain coupling associated with devel- opment of the Ordos Basin and the Laliang Mountains, China. Gaining an improved understanding of the timing and nature of uplift and evolution of the Ltiliang Mountains is important for the reconstruction of the eastern sedimentary boundary of the Ordos Basin （a major petroliferous basin） as well as for providing insight into the evolution and breakup of the North China Craton （NCC）. Based on systematic sampling for fission track analysis, it is suggested that the main phase of uplift of the Laliang Mountains occurred since later part of the Early Cretaceous. Three evolutionary stages of uplift and development are identified： slow initial uplift （120-65 Ma）, accelerated uplift （65-23 Ma）, and intensive uplift （23 Ma to present）, with the ma- jority of the uplift activity having occurred during the Cenozoic. The history of uplift is non-equilibrium and exhibits complex- ity in temporal and spatial aspects. The middle and northern parts of the Ltiliang Mountains were uplifted earlier than the southern part. The most intensive episode of uplift activity commenced in the Miocene and was associated with a genetic cou- pling relationship with the eastern neighboring Cenozoic Shanxi Grabens. The uplifting and evolutionary processes of the Ltiliang Mountains area since later part of the Early Cretaceous share a unified regional geodynamic setting, which was ac- companied by uplift of the Mesozoic Ordos Basin and development of the neighboring Cenozoic Shanxi Grabens. Collectively, this regional orogenic activity is related principally to the far-field effects of both the compression sourced from the south- western Tibet Plateau and westward subduction of the Pacific Plate in Cenozoic.
