Objective: The aim of this study was to compare the anatomic-landmark and ultrasound-guided techniques in the placement of an internal jugular vein port in patients with advanced breast cancer. Methods: Between Marc...Objective: The aim of this study was to compare the anatomic-landmark and ultrasound-guided techniques in the placement of an internal jugular vein port in patients with advanced breast cancer. Methods: Between March 2010 and October 2010, 60 patients with advanced breast cancer underwent central venous port placement for the delivery of chemotherapy, preferably through the internal jugular vein. Patients were randomly assigned to either the anatomic-landmark or the ultrasound-guided group. Failure on first attempt, number of attempts until successful catheterization, time to successful placement, the accordance of the two placement approaches, and the demographics of each patient were recorded. Results: The consistency of the direction of two lines drawn using the anatomic-landmark and ultrasound-guided techniques or of the diameter of the internal jugular vein as determined by the two approaches was 85% (51/60). The rate of successful place- ment at first attempt was higher in the ultrasound group than in the anatomic-landmark group (P 〈 0.05). A greater number of attempts and longer time to successful port placement were needed in the latter (P 〈 0.05). Conclusion: The findings of this study indicate that, in the placement of an internal jugular vein port, the ultrasound (US)-guJded technique has several advantages over the anatomic-landmark technique.展开更多
In order to analyze the possibility of detecting defects in bend pipe using low-frequency ultrasonic guided wave, the propagation of T(0,1) mode and L(0,2) mode through straight-curved-straight pipe sections was studi...In order to analyze the possibility of detecting defects in bend pipe using low-frequency ultrasonic guided wave, the propagation of T(0,1) mode and L(0,2) mode through straight-curved-straight pipe sections was studied. FE(finite element) models of bend pipe without defects and those with defects were introduced to analyze energy distribution, mode transition and defect detection of ultrasonic guided wave. FE simulation results were validated by experiments of four different bend pipes with circumferential defects in different positions. It is shown that most energy of T(0,1) mode or L(0,2) mode focuses on extrados of bend but little passes through intrados of bend, and T(0,1) mode or L(0,2) mode is converted to other possible non-axisymmetric modes when propagating through the bend and the defect after bend respectively. Furthermore, L(0,2) mode is more sensitive to circumferential notch than T(0,1) mode. The results of this work are beneficial for practical testing of pipes.展开更多
We constructed two types of copper-doped metal-organic framework(MOF),i.e.,Cu@UiO-66-NH2 and Cu-UiO-66-NH2.In the former,Cu2+ions are impregnated in the pore space of the amine-functionalized,Zr-based UiO-66-NH2;while...We constructed two types of copper-doped metal-organic framework(MOF),i.e.,Cu@UiO-66-NH2 and Cu-UiO-66-NH2.In the former,Cu2+ions are impregnated in the pore space of the amine-functionalized,Zr-based UiO-66-NH2;while in the latter,Cu^2+ions are incorporated to form a bimetal-center MOF,with Zr^4+being partially replaced by Cu2+in the Zr-O oxo-clusters.Ultrafast spectroscopy revealed that the photoinduced relaxation kinetics associated with the ligand-to-cluster charge-transfer state is promoted for both Cudoped MOFs relative to undoped one,but in a sequence of Cu-UiO-66-NH2>Cu@UiO-66-NH2>UiO-66-NH2.Such a sequence turned to be in line with the trend observed in the visible-light photocatalytic hydrogen evolution activity tests on the three MOFs.These findings highlighted the subtle effect of copper-doping location in this Zr-based MOF system,further suggesting that rational engineering of the specific metal-doping location in alike MOF systems to promote the photoinduced charge separation and hence suppress the detrimental charge recombination therein is beneficial for achieving improved performances in MOF-based photocatalysis.展开更多
AIM:To investigate the variability of the main immunodominant motifs of hepatitis B virus(HBV) core gene by ultra-deep-pyrosequencing(UDPS).METHODS:Four samples(2 genotype A and 2 genotype D) from 4 treatment-na ve pa...AIM:To investigate the variability of the main immunodominant motifs of hepatitis B virus(HBV) core gene by ultra-deep-pyrosequencing(UDPS).METHODS:Four samples(2 genotype A and 2 genotype D) from 4 treatment-na ve patients were assessed for baseline variability.Two additional samples from one patient(patient 4,genotype D) were selected for analysis:one sample corresponded to a 36-mo treatment-free period from baseline and the other to the time of viral breakthrough after 18 mo of lamivudine treatment.The HBV region analyzed covered amino acids 40 to 95 of the core gene,and included the two main epitopic regions,Th50-69 and B74-84.UDPS was carried out in the Genome Sequencer FLX system(454 Life Sciences,Roche).After computer filtering of UDPS data based on a Poisson statistical model,122 813 sequences were analyzed.The most conserved position detected by UDPS was analyzed by site-directed mutagenesis and evaluated in cell culture.RESULTS:Positions with highest variability rates were mainly located in the main core epitopes,confirming their role as immune-stimulating regions.In addition,the distribution of variability showed a relationship with HBV genotype.Patient 1(genotype A) presented the lowest variability rates and patient 2(genotype A) had 3 codons with variability higher than 1%.Patient 3 and 4(both genotype D) presented 5 and 8 codons with variability higher than 1%,respectively.The median baseline frequencies showed that genotype A samples had higher variability in epitopic positions than in the other positions analyzed,approaching significance(P = 0.07,sample 1 and P = 0.05,sample 2).In contrast,there were no significant differences in variability between the epitopic and other positions in genotype D cases.Interestingly,patient 1 presented a completely mutated motif from amino acid 64 to 67(E 64 LMT 67),which is commonly recognized by T helper cells.Additionally,the variability observed in all 4 patients was particularly associated with the E 64 LMT 67 motif.Codons 78 and 79 were highly conserved in all samples,in keeping with their involvement in the interaction between the HBV virion capsid and the surface antigens(HBsAg).Of note,codon 76 was even more conserved than codons 78 and 79,suggesting a possible role in HBsAg interactions or even in hepatitis B e antigen conformation.Sequential analysis of samples from patient 4(genotype D) illustrated the dynamism of the HBV quasispecies,with strong selection of one minor baseline variant coinciding with a decrease in core variability during the treatment-free and lamivudinetreated period.The drop in variability seemed to result from a "steady state" situation of the HBV quasispecies after selection of the variant with greatest fitness.CONCLUSION:Host immune pressure seems to be the main cause of HBV core evolution.UDPS analysis is a useful technique for studying viral quasispecies.展开更多
Traditional chaotic pulse position modulation(CPPM)system has many drawbacks.It introduces delay into the feedback loop,which will lead to divergence of chaotic map easily.The wrong decision of data will cause error p...Traditional chaotic pulse position modulation(CPPM)system has many drawbacks.It introduces delay into the feedback loop,which will lead to divergence of chaotic map easily.The wrong decision of data will cause error propagation.Mismatch of parameters and synchronization error between the receiver and transmitter will arouse high bit error rate.To solve these problems,a demodulation algorithm of CPPM based on particle filtering is proposed.According to the mathematical model of the system,it tracks the real signal by online separation in demodulation.Simulation results show that the proposed method can track the true signal better than the traditional CPPM scheme.What's more,it has good synchronization robustness,reduced error propagation by wrong decision and low bit error rate.展开更多
In order to guarantee reliable data transmission, powerful channel coding techniques are usually required in noncoherent ultra-wideband(UWB) communication systems. Accordingly, several forward error correction(FEC) co...In order to guarantee reliable data transmission, powerful channel coding techniques are usually required in noncoherent ultra-wideband(UWB) communication systems. Accordingly, several forward error correction(FEC) codes, such as Reed-Solomon and convolutional codes have been used in noncoherent UWB systems to improve the bit error rate(BER) performance. In this paper, low-density parity-check(LDPC) codes are further studied as more powerful FEC candidates for noncoherent UWB systems. Two LDPC codes and the corresponding decoding procedures are presented for noncoherent UWB systems. Moreover, performance comparison between the LDPC codes and other FEC codes are provided for three major noncoherent UWB communication systems, namely, noncoherent pulse position modulation(NC-PPM), transmitted reference(TR) and transmitted reference pulse cluster(TRPC). Both theoretical analysis and simulation results show that the two investigated LDPC codes outperform other existing FEC codes with limited penalty in terms of complexity and therefore they are promising FEC candidates for noncoherent UWB systems with low-cost and low-power consumption.展开更多
Approximate analytical solutions of the D-dimensional Klein-Gordon equation are obtained for the scalarand vector general Hulthen-type potential and position-dependent mass with any l by using the concept of supersymm...Approximate analytical solutions of the D-dimensional Klein-Gordon equation are obtained for the scalarand vector general Hulthen-type potential and position-dependent mass with any l by using the concept of supersymmetricquantum mechanics (SUSYQM).The problem is numerically discussed for some cases of parameters.展开更多
In order to achieve greater pressure ratios, compressor designers have the opportunity to use transonic configurations. In the supersonic part of the incoming flow, shock waves appear in the front part of the blades a...In order to achieve greater pressure ratios, compressor designers have the opportunity to use transonic configurations. In the supersonic part of the incoming flow, shock waves appear in the front part of the blades and propagate in the upstream direction. In case of multiple blade rows, steady simulations have to impose an azimuthal averaging (mixing plane) which prevents these shock waves to extend upstream. In the present paper, several mixing plane locations are numerically tested and compared in a supersonic configuration. An analytical method is used to describe the shock pattern. It enables to take a critical look at the CFD (computational fluid dynamics) steady results. Based on this method, the shock losses are also evaluated. The good agreement between analytical and numerical values shows that this method can be useful to wisely forecast the mixing plane location and to evaluate the shift in performances due to the presence of the mixing plane.展开更多
The supersonic mixing layer flow,consisting of a relatively cold,slow diluted hydrogen stream and a hot,faster air stream,is numerically simulated with detailed transport properties and chemical reaction mechanisms.Th...The supersonic mixing layer flow,consisting of a relatively cold,slow diluted hydrogen stream and a hot,faster air stream,is numerically simulated with detailed transport properties and chemical reaction mechanisms.The evolution of the combustion process in the supersonic reacting mixing layer is observed and unsteady phenomena of ignition,flame propagation and extinction are successfully captured.The ignition usually takes place at the air stream side of braid regions between two vortexes due to much higher temperature of premixed gases.After ignition,the flame propagates towards two vortexes respectively located on the upstream and downstream of the ignition position.The apparent flame speed is 1569.97 m/s,which is much higher than the laminar flame speed,resulting from the effects of expansion,turbulence,vortex stretching and consecutive ignition.After the flame arrives at the former vortex,the flame propagates along the outer region of the vortex in two branches.Then the upper flame branch close to fuel streamside distinguishes gradually due to too fuel-riched premixed mixtures in the front of the flame and the strong cooling effect of the adjacent cool fuel flow,while the lower flame branch continues to propagate in the vortex.展开更多
When an aircraft flies at a hypersonic speed,the temperature of gas inner boundary layer near the wall is so high that the specific heat is no longer a constant but dependent upon the temperature.It is necessary to co...When an aircraft flies at a hypersonic speed,the temperature of gas inner boundary layer near the wall is so high that the specific heat is no longer a constant but dependent upon the temperature.It is necessary to consider its effect on transition location.In this paper,the transition locations of hypersonic plane boundary layer are predicted with the improved e N method,and the results of the specific heat dependent upon temperature are compared with those of constant specific heat.The flow parameters are taken as those corresponding to the condition at a height of 40 km and the Mach numbers of oncoming flow are 6,7,and 8,respectively.It is found that the transition locations calculated by the variable specific heat are closer to the leading edge than those by the constant specific heat.The deviations in most cases are around 30 percent.All the results prove that the real gas effect should be taken into consideration when one predicts transition location for hypersonic flow.Whether the first or second mode wave determines the transition location relies on the oncoming flow Mach number and the wall condition.展开更多
文摘Objective: The aim of this study was to compare the anatomic-landmark and ultrasound-guided techniques in the placement of an internal jugular vein port in patients with advanced breast cancer. Methods: Between March 2010 and October 2010, 60 patients with advanced breast cancer underwent central venous port placement for the delivery of chemotherapy, preferably through the internal jugular vein. Patients were randomly assigned to either the anatomic-landmark or the ultrasound-guided group. Failure on first attempt, number of attempts until successful catheterization, time to successful placement, the accordance of the two placement approaches, and the demographics of each patient were recorded. Results: The consistency of the direction of two lines drawn using the anatomic-landmark and ultrasound-guided techniques or of the diameter of the internal jugular vein as determined by the two approaches was 85% (51/60). The rate of successful place- ment at first attempt was higher in the ultrasound group than in the anatomic-landmark group (P 〈 0.05). A greater number of attempts and longer time to successful port placement were needed in the latter (P 〈 0.05). Conclusion: The findings of this study indicate that, in the placement of an internal jugular vein port, the ultrasound (US)-guJded technique has several advantages over the anatomic-landmark technique.
基金Project(51265044)supported by the National Natural Science Foundation of ChinaProject(2013TT2028)supported by the Science and Technology Project of Hunan Province of ChinaProject(2012QK162)supported by the Science and Technology Project of General Administration of Quality Supervision,Inspection and Quarantine of China
文摘In order to analyze the possibility of detecting defects in bend pipe using low-frequency ultrasonic guided wave, the propagation of T(0,1) mode and L(0,2) mode through straight-curved-straight pipe sections was studied. FE(finite element) models of bend pipe without defects and those with defects were introduced to analyze energy distribution, mode transition and defect detection of ultrasonic guided wave. FE simulation results were validated by experiments of four different bend pipes with circumferential defects in different positions. It is shown that most energy of T(0,1) mode or L(0,2) mode focuses on extrados of bend but little passes through intrados of bend, and T(0,1) mode or L(0,2) mode is converted to other possible non-axisymmetric modes when propagating through the bend and the defect after bend respectively. Furthermore, L(0,2) mode is more sensitive to circumferential notch than T(0,1) mode. The results of this work are beneficial for practical testing of pipes.
基金the National Key Research and Development Program on Nano Science and Technology of the Ministry of Science and Technology of China(No.2016YFA0200602 and No.2018YFA0208702)the National Natural Science Foundation of China(No.21573211 and No.21633007)the Anhui Initiative in Quantum Information Technologies(No.AHY090200)。
文摘We constructed two types of copper-doped metal-organic framework(MOF),i.e.,Cu@UiO-66-NH2 and Cu-UiO-66-NH2.In the former,Cu2+ions are impregnated in the pore space of the amine-functionalized,Zr-based UiO-66-NH2;while in the latter,Cu^2+ions are incorporated to form a bimetal-center MOF,with Zr^4+being partially replaced by Cu2+in the Zr-O oxo-clusters.Ultrafast spectroscopy revealed that the photoinduced relaxation kinetics associated with the ligand-to-cluster charge-transfer state is promoted for both Cudoped MOFs relative to undoped one,but in a sequence of Cu-UiO-66-NH2>Cu@UiO-66-NH2>UiO-66-NH2.Such a sequence turned to be in line with the trend observed in the visible-light photocatalytic hydrogen evolution activity tests on the three MOFs.These findings highlighted the subtle effect of copper-doping location in this Zr-based MOF system,further suggesting that rational engineering of the specific metal-doping location in alike MOF systems to promote the photoinduced charge separation and hence suppress the detrimental charge recombination therein is beneficial for achieving improved performances in MOF-based photocatalysis.
基金Supported by A Grant from the Spanish Ministry of Health and Consumer Affairs,No. FIS PS09/00899 and SAF 2009-10403CIBERehd Funded by Instituto CarlosⅢ,Ministry of Health and Consumer Affairs
文摘AIM:To investigate the variability of the main immunodominant motifs of hepatitis B virus(HBV) core gene by ultra-deep-pyrosequencing(UDPS).METHODS:Four samples(2 genotype A and 2 genotype D) from 4 treatment-na ve patients were assessed for baseline variability.Two additional samples from one patient(patient 4,genotype D) were selected for analysis:one sample corresponded to a 36-mo treatment-free period from baseline and the other to the time of viral breakthrough after 18 mo of lamivudine treatment.The HBV region analyzed covered amino acids 40 to 95 of the core gene,and included the two main epitopic regions,Th50-69 and B74-84.UDPS was carried out in the Genome Sequencer FLX system(454 Life Sciences,Roche).After computer filtering of UDPS data based on a Poisson statistical model,122 813 sequences were analyzed.The most conserved position detected by UDPS was analyzed by site-directed mutagenesis and evaluated in cell culture.RESULTS:Positions with highest variability rates were mainly located in the main core epitopes,confirming their role as immune-stimulating regions.In addition,the distribution of variability showed a relationship with HBV genotype.Patient 1(genotype A) presented the lowest variability rates and patient 2(genotype A) had 3 codons with variability higher than 1%.Patient 3 and 4(both genotype D) presented 5 and 8 codons with variability higher than 1%,respectively.The median baseline frequencies showed that genotype A samples had higher variability in epitopic positions than in the other positions analyzed,approaching significance(P = 0.07,sample 1 and P = 0.05,sample 2).In contrast,there were no significant differences in variability between the epitopic and other positions in genotype D cases.Interestingly,patient 1 presented a completely mutated motif from amino acid 64 to 67(E 64 LMT 67),which is commonly recognized by T helper cells.Additionally,the variability observed in all 4 patients was particularly associated with the E 64 LMT 67 motif.Codons 78 and 79 were highly conserved in all samples,in keeping with their involvement in the interaction between the HBV virion capsid and the surface antigens(HBsAg).Of note,codon 76 was even more conserved than codons 78 and 79,suggesting a possible role in HBsAg interactions or even in hepatitis B e antigen conformation.Sequential analysis of samples from patient 4(genotype D) illustrated the dynamism of the HBV quasispecies,with strong selection of one minor baseline variant coinciding with a decrease in core variability during the treatment-free and lamivudinetreated period.The drop in variability seemed to result from a "steady state" situation of the HBV quasispecies after selection of the variant with greatest fitness.CONCLUSION:Host immune pressure seems to be the main cause of HBV core evolution.UDPS analysis is a useful technique for studying viral quasispecies.
基金Supported by the National Natural Science Foundation of China(No.41074090)Henan Science and Technology Key Project(No.092102210360)+1 种基金Henan Provincial Department of Education Science ang Technology Key Project(No.13A510330)Doctorate Program of Henan Polytechnic University(No.B2009-27)
文摘Traditional chaotic pulse position modulation(CPPM)system has many drawbacks.It introduces delay into the feedback loop,which will lead to divergence of chaotic map easily.The wrong decision of data will cause error propagation.Mismatch of parameters and synchronization error between the receiver and transmitter will arouse high bit error rate.To solve these problems,a demodulation algorithm of CPPM based on particle filtering is proposed.According to the mathematical model of the system,it tracks the real signal by online separation in demodulation.Simulation results show that the proposed method can track the true signal better than the traditional CPPM scheme.What's more,it has good synchronization robustness,reduced error propagation by wrong decision and low bit error rate.
基金supported in part by the National Natural Science Foundation of China under Grant 61271262, 61473047 and 61572083Shaanxi Provincial Natural Science Foundation under Grant 2015JM6310the Special Fund for Basic Scientific Research of Central Colleges, Chang’an University under Grant 310824152010 and 00092014G1241043
文摘In order to guarantee reliable data transmission, powerful channel coding techniques are usually required in noncoherent ultra-wideband(UWB) communication systems. Accordingly, several forward error correction(FEC) codes, such as Reed-Solomon and convolutional codes have been used in noncoherent UWB systems to improve the bit error rate(BER) performance. In this paper, low-density parity-check(LDPC) codes are further studied as more powerful FEC candidates for noncoherent UWB systems. Two LDPC codes and the corresponding decoding procedures are presented for noncoherent UWB systems. Moreover, performance comparison between the LDPC codes and other FEC codes are provided for three major noncoherent UWB communication systems, namely, noncoherent pulse position modulation(NC-PPM), transmitted reference(TR) and transmitted reference pulse cluster(TRPC). Both theoretical analysis and simulation results show that the two investigated LDPC codes outperform other existing FEC codes with limited penalty in terms of complexity and therefore they are promising FEC candidates for noncoherent UWB systems with low-cost and low-power consumption.
文摘Approximate analytical solutions of the D-dimensional Klein-Gordon equation are obtained for the scalarand vector general Hulthen-type potential and position-dependent mass with any l by using the concept of supersymmetricquantum mechanics (SUSYQM).The problem is numerically discussed for some cases of parameters.
文摘In order to achieve greater pressure ratios, compressor designers have the opportunity to use transonic configurations. In the supersonic part of the incoming flow, shock waves appear in the front part of the blades and propagate in the upstream direction. In case of multiple blade rows, steady simulations have to impose an azimuthal averaging (mixing plane) which prevents these shock waves to extend upstream. In the present paper, several mixing plane locations are numerically tested and compared in a supersonic configuration. An analytical method is used to describe the shock pattern. It enables to take a critical look at the CFD (computational fluid dynamics) steady results. Based on this method, the shock losses are also evaluated. The good agreement between analytical and numerical values shows that this method can be useful to wisely forecast the mixing plane location and to evaluate the shift in performances due to the presence of the mixing plane.
文摘The supersonic mixing layer flow,consisting of a relatively cold,slow diluted hydrogen stream and a hot,faster air stream,is numerically simulated with detailed transport properties and chemical reaction mechanisms.The evolution of the combustion process in the supersonic reacting mixing layer is observed and unsteady phenomena of ignition,flame propagation and extinction are successfully captured.The ignition usually takes place at the air stream side of braid regions between two vortexes due to much higher temperature of premixed gases.After ignition,the flame propagates towards two vortexes respectively located on the upstream and downstream of the ignition position.The apparent flame speed is 1569.97 m/s,which is much higher than the laminar flame speed,resulting from the effects of expansion,turbulence,vortex stretching and consecutive ignition.After the flame arrives at the former vortex,the flame propagates along the outer region of the vortex in two branches.Then the upper flame branch close to fuel streamside distinguishes gradually due to too fuel-riched premixed mixtures in the front of the flame and the strong cooling effect of the adjacent cool fuel flow,while the lower flame branch continues to propagate in the vortex.
基金supported by the National Natural Science Foundation of China (Grant Nos. 10772134 and 11172203)the National Basic Research Program of China (Grant No. 2009CB724103)
文摘When an aircraft flies at a hypersonic speed,the temperature of gas inner boundary layer near the wall is so high that the specific heat is no longer a constant but dependent upon the temperature.It is necessary to consider its effect on transition location.In this paper,the transition locations of hypersonic plane boundary layer are predicted with the improved e N method,and the results of the specific heat dependent upon temperature are compared with those of constant specific heat.The flow parameters are taken as those corresponding to the condition at a height of 40 km and the Mach numbers of oncoming flow are 6,7,and 8,respectively.It is found that the transition locations calculated by the variable specific heat are closer to the leading edge than those by the constant specific heat.The deviations in most cases are around 30 percent.All the results prove that the real gas effect should be taken into consideration when one predicts transition location for hypersonic flow.Whether the first or second mode wave determines the transition location relies on the oncoming flow Mach number and the wall condition.