超声内镜引导细针穿刺抽吸术(EUS-FNA)在胰腺占位性病变中的诊断价值研究进展

胰腺占位性病变是常见的胰腺疾病,其中以胰腺癌最为常见。胰腺癌起病隐匿,早期缺乏典型的临床表现,大部分患者就诊时已失去了手术机会,只10%~20%的患者可以行手术切除,且5年生存率较低。因此,对胰腺微小占位的定性诊断尤为重要。胰腺是后腹膜脏器,位置较深,传统的B超、CT、MRI等影像学检查常由于受到腹壁脂肪及肠道气体的干扰,对胰腺的良恶性诊断敏感度低、特异度差。超声内镜可以清晰地显示病灶图像。超声内镜引导细针穿刺抽吸术(Endoscopic Ultraonography-Guided Fine-Needle Aspiration, EUS-FNA)可以将抽得的病变组织液和组织条送检做病理、生化和免疫学分析,为胰腺占位性病变的定性诊断提供重要的帮助。本文主要通过查阅近年来发表的文献分析近年来超声内镜引导细针穿刺抽吸术(EUS-FNA)在胰腺占位性病变中的诊断中的应用价值。

超声内镜引导细针穿刺对胰腺占位病变诊断的影响因素

超声内镜及其引导的细针穿刺技术已广泛用于胰腺疾病的诊断,但仍存在一定的误诊和漏诊。研究表明,穿刺针及活检钳、穿刺方法、超声内镜辅助技术、标本的实时评估及病理学标准等因素均可影响超声内镜穿刺对胰腺占位病变的诊断效能。本文就上述影响超声内镜引导细针穿刺对胰腺病变诊断的因素作一综述。

超声内镜引导细针穿刺细胞学联合组织病理学对胰腺占位病变的诊断价值

目的探讨超声内镜引导下细针穿刺抽吸活检(endoscopic ultrasound-guided fine-needle aspiration,EUS-FNA)细胞学联合组织病理学对胰腺占位性病变的诊断价值。方法选取经EUS-FNA检查同时行细胞学和组织病理学检测的51例胰腺占位性病例资料,将细胞学、组织病理学及联合诊断结果与最终诊断结果进行比较,分析不同诊断方法的应用价值。结果细胞学诊断胰腺占位的敏感性、特异性和曲线下面积(AUC)分别为91.11%、100.00%和0.981;组织病理学对应的指标为75.56%、83.33%和0.852;两者联合检测的指标为95.56%、83.33%和0.987。两者联合诊断效能优于组织病理学(χ^(2)=4.55,P=0.03),差异有统计学意义。结论超声内镜引导细针穿刺细胞学联合组织病理学可提高胰腺占位病变的诊断率,且具有较高的安全性。

超声内镜引导细针穿刺诊断肝尾状叶肿瘤4例

目的:复习肝脏尾状叶肿瘤的病例资料,评价内镜超声引导下细针穿刺(endoscopic ultrasound-guided fine needle aspiration,EUS-FNA)肝尾状叶对恶性肿瘤的诊断价值.方法:4例患者其他影像学检查发现肝脏占位,并行相应的辅助检查.总结其主要临床特点.肝脏尾状叶占位和相关部位行EUS-FNA,穿刺物行细胞学检查和组织学检查.内镜超声在食管胃连接处探头指向右侧扫查到肝尾状叶,穿刺肝尾状叶.结果:4例患者,男3例,女1例,年龄50岁-69岁.穿刺9个部位(肝尾状叶4,肝左叶1,胰腺2,肝门淋巴结1,腹膜后淋巴结1).9个穿刺部位中,肝门部淋巴结未获得足够的组织学标本,仅作细胞学涂片诊断腺癌转移;其他8个病灶均获得足够的组织学标本进行细胞学涂片和组织学检查,均获得明确的病理学诊断和临床诊断.所有患者均未出现并发症.诊断胰头癌并肝转移2例,胆管细胞癌并肝门淋巴结转移1例,原发性肝癌并腹腔转移1例.结论:内镜超声在食管胃连接处探头指向右侧可非常容易扫查到肝尾状叶,行EUS-FNA路径短,可精准穿刺到肝尾状叶的占位,安全性高,EUS-FNA肝尾状叶肿瘤有重要的临床价值.

超声内镜引导细针穿刺抽吸术精准诊断胃癌术后胰腺转移癌一例

胰腺转移癌在临床上十分罕见,并且其诊断和治疗较为复杂,往往不易被发现。但近年来随着人民生活水平的提高以及各种精密诊断仪器和精准诊断方法的不断发展,特别是超声内镜引导细针穿刺抽吸术(EUS-FNA)的飞速发展,胰腺转移癌的检出率有逐渐上升的趋势。EUS-FNA技术具有创伤小、恢复快、诊断精准度高的优势。该文报道了1例67岁男性,8年前确诊胃癌,7个月前确诊胃癌食管转移,现发现胰腺占位的患者,经EUS-FNA获取病理后,确诊为胃癌胰腺转移,为后续指导治疗提供循证医学证据。

超声内镜引导细针穿刺活检对胰腺占位性病变的诊断价值

目的探讨超声内镜引导下细针穿刺活检(EUS-FNA)对胰腺占位性病变的诊断价值。方法回顾分析2009年1月至2010年1月间行EUS-FNA的35例胰腺占位病例,与CT、B超、临床表现等进行对比分析,依病理学和细胞学检查或随访结果确诊。结果在所有35例患者中,最后确诊胰腺癌23例、慢性胰腺炎9例、导管内黏液性乳头状瘤1例、胰腺假性囊肿1例、浆液性囊腺瘤1例。B超共检出胰腺病变22例,CT29例,EUS发现35例可疑胰腺病变。对所有患者均行EUS-FNA检查,获得满意标本34例,取材满意率97.14%。EUS-FNA诊断胰腺癌17例,敏感性为73.91%,EUS-FNA总准确率为82.86%。5例患者EUS-FNA后出现淀粉酶及脂肪酶轻度升高,治疗后很快恢复正常。结论 EUS-FNA是病理学诊断胰腺占位性病变安全而有效的方法,应作为首选。

超声内镜引导细针穿刺活检对胰腺占位性疾病的诊断价值

目的评价超声内镜引导细针穿刺活检(endoscopic ultrasonography-guided fine needle aspiration,EUS-FNA)对胰腺占位性疾病的诊断价值。方法收集西安交通大学第一附属医院2013年6月至2018年7月影像学(CT/MRI/经腹B超)提示胰腺占位性疾病的患者,行EUS-FNA检查,观察EUS-FNA穿刺情况与病理报告结果,分析诊断灵敏度与特异度,并将超声内镜(endoscopic ultrasonography,EUS)与影像学检查的诊断结果相关指标进行比较。结果患者共96例,男性69例,女性27例,平均年龄(60.5±11.9)岁。EUS-FNA诊断的灵敏度为91.9%,特异度为100.0%,准确率为93.8%。EUS对胰腺占位性疾病诊断的灵敏度、特异度及准确率均高于CT、MRI及经腹B超。所有患者仅有1例穿刺点少量出血,给予200 mL/L孟氏液20 mL喷洒后无出血,其余均未出现并发症。结论EUS-FNA是一项灵敏度、准确性、安全性均较高的诊断技术,有助于早期诊断胰腺肿瘤。

超声内镜引导细针穿刺活检诊断胰腺占位性病变临床意义

目的:探究超声内镜引导细针穿刺活检诊断胰腺占位性病变效果。方法:采用茂名市人民医院最新引进的奥利巴斯超声内镜对5例胰腺占位性病变患者进行超声内镜引导细针穿刺活检,并据此进行诊断,将诊断结果与临床最终诊断结果对比,分析超声内镜引导细针穿刺活检诊断胰腺占位性病变的准确性。结果:病灶部位、病灶大小、病理阳性率对比无明显差异,不同性质瘤体穿刺病理阳性率对比差异显著(P<0.05)。临床诊断结果与超声内镜引导细针穿刺活检结果对比,差异不明显。结论:超声内镜引导细针穿刺活检能对胰腺占位性病变进行有效诊断,便于及时采取治疗,有临床推广价值。

超声内镜引导细针穿刺诊断胰腺癌的效果

目的观察临床诊断胰腺癌采用超声内镜引导细针穿刺的效果。方法选取2016年1月至2018年5月本院收治的胰腺占位性病变患者54例进行研究,回顾性分析患者的临床特点和超声内镜引导细针穿刺诊断结果,统计该诊断技术的灵敏性、特异性、阳性检出率。结果 54例患者病理学阳性检出率为87.0%,细胞学阳性检出率为38.9%,超声内镜引导细针穿刺灵敏性为94.3%,特异性为100.0%。结论超声内镜引导细针穿刺在胰腺癌诊断中的灵敏性和特异性较高,可提高阳性检出率,降低误诊、漏诊风险,且安全性较高。

评估Barrett食管和重度不典型增生及建议接受内镜下切除的黏膜内腺癌患者:常规超声内镜与超声内镜引导细针穿刺的临床意义

Background and Study Aims: Endoscopic mucosal resection and photodynamic therapy are exciting, minimally invasive curative techniques that represent an alternative to surgery in patients with Barrett’s esophagus and high-grade dysplasia or intramucosal adenocarcinoma. However, there is lack of uniformity regarding which staging method should be used prior to therapy, and some investigators even question whether staging is required prior to ablation. We report our experience with a protocol of conventional endoscopic ultrasound staging prior to endoscopic therapy. Patients and Methods: A total of 25 consecutive patients with a diagnosis of high-grade dysplasia or intramucosal adenocarcinoma in Barrett’s esophagus who had been referred to the University of Chicago for staging in preparation for endoscopic therapy between March 2002 and November 2004 were included in the study. All 25 patients underwent repeat diagnostic endoscopy and conventional endosonography with a radial echo endoscope. Any suspicious lymph nodes that were detected were sampled using endoscopic ultrasound-guided fine-needle aspiration. Results: Baseline pathology in the 25 patients (mean age 70, range 49- 85) revealed high-grade dysplasia in 12 patients and intramucosal carcinoma in 13 patients. Five patients were found to have submucosal invasion on conventional endosonography. Seven patients had suspicious adenopathy, six regional (N1) and one metastatic to the celiac axis (M1a). Fine-needle aspiration confirmed malignancy in five of these seven patients. Based on these results, five patients (20% ) were deemed to be unsuitable candidates for endoscopic therapy. Conclusions: By detecting unsuspected malignant lymphadenopathy, conventional endosonography and endoscopic ultrasound with fine-needle aspiration dramatically changed the course of management in 20% of patients referred for endoscopic therapy of Barrett’s esophagus with high-grade dysplasia or intramucosal carcinoma. Based on our results, we believe that conventional endosonography and endoscopic ultrasound with fine-needle aspiration when nodal disease is present should be performed routinely in all patients referred for endoscopic therapy in this setting.

超声内镜引导细针穿刺检测端粒酶活性:辅助诊断胰腺癌

Background:Telomerase activity is up-regulated in pancreatic cancer.Hence,measurement of telomerase activity in pancreatic needle-biopsy specimens could assist in establishing a positive diagnosis in specimens that are inadequate for cytology.Objective:To determine the sensitivity and specificity of telomerase activity for neoplasia in a series of EUS-guided fine-needle aspirate(EUS-FNA)biopsies of pancreatic mass lesions.Design:Prospective,consecutive,nonrandomized cohort.Setting:Academic hospital,tertiary referral center.Patients:Seventy-one patients with a pancreatic mass diagnosed by cross-sectional imaging.Interventions:EUS-FNA of 52 solid and 18 cystic pancreatic lesions.Main Outcome Measurements:(1)Cytologic diagnosis;(2)tissue telomerase activity by semi-quantitative polymerase chain reaction;(3)patient demographics;(4)clinical outcomes.Results:Cytology results were positive for adenocarcinoma in 40 patients with a solid pancreatic mass;of these,telomerase activity was detected in 31.There were no telomerase false-positive results.Telomerase results were positive in 6 of the 7 patients(86%)who had negative cytology results and who eventually were found to have biopsy-proven adenocarcinoma.The sensitivity and specificity of telomerase activity for detecting pancreatic adenocarcinoma in solid masses was 79%(95%CI,64%-89%)and 100%(95%CI,55%-100%).Limitations:Extremely high sensitivity and specificity of EUS-FNA cytology in solid lesions minimized the incremental benefit of telomerase.Conclusions:Telomerase activity can be measured readily in specimens obtained at EUS-FNA and accurately predicts malignancy.Used in combination with cytology,telomerase increased the sensitivity from 85%to 98%while maintaining the specificity at 100%.Lesions with negative cytology result and positive telomerase activity should be evaluated aggressively to exclude malignancy.

超声内镜引导细针穿刺和支气管内超声引导的经支气管针吸:在纵隔病变中的联合检测

Background and study aims: It would be desirable to develop minimally invasive methods of tissue diagnosis from lymph nodes as well as solid lesions in the mediastinum. The aim of the present study was to test the combined method of transesophageal endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA)and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the evaluation of mediastinal lesions. Patients and methods: EUS-FNA and EBUS-TBNA were compared in 33 patients, for the staging of lung cancer in patients with an established diagnosis of nonsmall-cell lung cancer (n = 20) or for diagnosis of a suspicious mediastinal lesion in patients with suspected lung cancer (n = 13). E-BUS-TBNA and EUS-FNA were unsuccessful in one patient each. The diagnoses were verified in 28 of the remaining 31 patients either at thoracotomy (n = 9) or during the clinical follow-up (n = 19). Results: A total of 119 lesions were sampled by EUS-FNA (n = 59) and EBUS-TBNA (n = 60). EUS-FNA and EBUS-TBNA demonstrated cancer in 26 and 28 lesions, respectively, and benign cytology in 30 and 28 lesions, respectively. Suspicious cells were found in three and four lesions by EUS-FNA and EBUS-TBNA, respectively. When the 60 EBUS-TBNA samples were compared with the 59 EUS-FNA samples, 11 additional cancer diagnoses and three samples with suspicious cells were obtained by EBUS-TBNA that had not been obtained by EUS-FNA. Conversely, EUSFNA diagnosed 12 additional cancer diagnoses, one suspicious and one specific benign diagnosis (sarcoidosis) in addition to EBUS-TBNA.With a combined approach (EUS-FNA+ EBUS-TBNA) in 28 of the 31 patients in whom a final diagnosis was obtained in the evaluation of mediastinal cancer, 20 patients were found to have mediastinal involvement, whereas no mediastinal metastases were found in eight patients. The accuracy of EUS-FNA and EBUS-TBNA, in combination, for the diagnosis of mediastinal cancer was 100% (95% CI, 83-100% ). Conclusions: EUS-FNA and EBUS-TBNA appear to be complementary methods. A combined approach with both EUS-FNA and EBUS-TBNA may be able to replace more invasive methods for evaluating lung cancer patients with suspected hilar or mediastinal metastases, as well as for evaluating unclear mediastinal or hilar lesions.

胰腺实性占位超声内镜引导细针穿刺抽吸/活检术中内镜医师快速病理评估价值的研究进展

为提高超声内镜引导细针穿刺抽吸/活检术(endoscopic ultrasound-guided fine-needle aspiration/biopsy,EUS-FNA/B)诊断准确率,快速现场评估(rapid on site evaluation,ROSE)被应用于该操作中,通过细胞病理医师现场评估标本取材满意度及标本的良恶性,让内镜医师及时获得反馈,以提高诊断准确率、减少不必要的穿刺。由于许多内镜中心无法实现细胞病理医师进行ROSE,目前逐渐出现内镜医师进行ROSE。内镜医师能否胜任ROSE,其诊断效能能否与细胞病理医师相媲美值得探讨。文中结合近年来文献进展,对内镜医师在胰腺实性占位EUS-FNA/B标本快速评估中的作用进行了综述。

超声内镜引导细针穿刺抽吸术在胰腺占位中应用的安全性分析

目的探讨超声内镜引导细针穿刺抽吸术(endoscopic ultrasound-guided fine-needle aspiration,EUS-FNA)在胰腺占位性病变中应用的安全性及其风险因素。方法选择2012年1月至2022年12月于复旦大学附属肿瘤医院内镜科行EUS-FNA的5160例患者作为回顾性研究对象,计算操作相关并发症的发生率,利用单因素和logistic回归分析并发症发生的独立风险指标。结果术后胰腺炎发生率为1.38%(68/4930),术中出血发生率为0.82%(42/5143),术后出血发生率为0.78%(40/5143),无直接相关的消化道穿孔和死亡事件发生。年龄>60岁(OR=0.581,95%CI:0.356~0.946,P=0.029)、颈体尾部肿瘤(OR=0.355,95%CI:0.194~0.652,P=0.001)、病灶长径>20~40 mm(OR=0.450,95%CI:0.227~0.893,P=0.023)和病灶长径>40 mm(OR=0.382,95%CI:0.168~0.869,P=0.022)为术后胰腺炎发生的独立保护因素,经十二指肠穿刺(OR=2.435,95%CI:1.319~4.496,P=0.005)是术后胰腺炎独立危险因素。穿刺3~4次(OR=0.439,95%CI:0.235~0.821,P=0.010)、病灶长径>20~40 mm(OR=0.154,95%CI:0.069~0.341,P<0.001)、病灶长径>40 mm(OR=0.326,95%CI:0.143~0.743,P=0.008)是术中出血的独立保护因素。细针穿刺活检(fine-needle biopsy,FNB)针(OR=2.314,95%CI:1.189~4.502,P=0.014)为术后出血的独立危险因素。结论EUS-FNA是一项安全的操作,总体并发症发生率低。术后胰腺炎和术中出血的发生主要与病变临床特征有关,而术后出血与穿刺针类型有关。

超声内镜引导细针穿刺抽吸/活检术诊断胆囊癌的研究进展

胆囊癌侵袭性强,进展速度快,早期诊断胆囊癌是提升预后的关键。本综述回顾了以胆囊为靶点的超声内镜引导细针穿刺抽吸/活检术(endoscopic ultrasound-guided fine needle aspiration/biopsy,EUS-FNA/B)诊断胆囊癌的研究,总结了EUS-FNA/B对胆囊癌的诊断效能、可能影响诊断率的因素以及不良事件。

二维超声与应力式弹性成像联合超声引导下甲状腺细针穿刺活检术在甲状腺结节诊断中的临床应用价值

目的:探讨应用二维超声与应力式弹性成像(SE)联合超声引导下甲状腺细针穿刺活检术(FNAB)诊断甲状腺结节(TN)的价值。方法:选取2020年1月—2023年12月高州市人民医院收治的70例TN患者(共82个结节),全部患者均进行二维超声、SE、FNAB检查,对比不同方法单一诊断、SE联合FNAB诊断在TN良恶性鉴别诊断中的效能。结果:二维超声检查中,良性结节形态规则率、包膜完整率以及边界清楚率均高于恶性结节(P<0.05);SE检查中良性结节检出50个,其中1分8个、2分29个、3分13个,恶性结节检出32个,其中4分21个、5分11个;FNAB细胞学检查中良性结节检出54个,其中Ⅰ级0个、Ⅱ级24个、Ⅲ级21个、Ⅳ级9个,恶性结节检出28个,其中Ⅴ级12个、Ⅵ级16个。二维超声诊断TN良恶性准确率为78.05%,特异度为78.18%,灵敏度为77.78%,与病理结果一致性一般(Kappa值=0.529);SE诊断准确率为81.71%,特异度为81.82%,灵敏度为81.48%,与病理结果一致性尚可(Kappa值=0.604);FNAB诊断准确率为91.46%,特异度为92.73%,灵敏度为88.89%,与病理结果一致性较好(Kappa值=0.808);SE联合FNAB诊断方面准确率为96.34%、特异度为96.36%、灵敏度为96.30%,与病理结果一致性极好(Kappa值=0.917)。显示联合诊断的诊断效能更高。结论:SE联合FNAB检查对TN进行鉴别诊断,具有更高的诊断效能,相比于单一诊断,更加具备优势。

超声引导下甲状腺结节细针穿刺术的护理方法与效果

在本文中针对性对超声引导下甲状腺结节细针穿刺术患者的护理工作方法和效果进行探究和分析。方法 选择回顾分析法,随机抽取我院的真实病案资料,具体为2022年1月到2024年1月期间我院确诊并且收治的58例甲状腺结节FNAC检查的患者,将其区分为观察组和对照组两组,分组依据为目前临床中主要采取和应用的入院时间基准,其中入院时间的前者为本文对照组,后者为本文的观察组,本文对照组患者应用我院针对此类患者的常规临床护理方式,观察组患者则在对照组常规护理基础之上的综合护理,在护理工作过程中针对两组患者的穿刺成功率等等护理效果进行探究和分析,并且形成书面记录。结果 针对本文的观察组和对照组甲状腺结节患者实施超声引导下的细针穿刺术护理采取不同方法之下,取得了差异性的护理成效,其中观察组患者的穿刺成功率达到100%,远高于本文对照组患者,另外在并发症的控制方面,也是观察组患者采取的综合护理更具优势,组间差异比较相对显著,存在通缉学意义,P<0.05.结果 针对超声引导下甲状腺结节细针穿刺术患者应用综合护理干预具有显著作用和效果,可以提升患者的细针穿刺术成功率和控制并发症,值得在临床中进行推广和应用。

超声引导细针穿刺鉴别甲状腺结节良恶性的价值分析

目的:探讨甲状腺结节患者应用超声引导细针穿刺(US-FNAC)检查的价值。方法:选取2021年1月—2022年12月东台市中医院收治的50例甲状腺结节患者作为研究对象,均接受超声检查、US-FNAC检查、病理检查,以病理检查结果为“金标准”,比较超声检查、US-FNAC检查诊断甲状腺结节良恶性的效能。结果:超声检查、US-FNAC检查诊断甲状腺结节良恶性的灵敏度比较,差异无统计学意义(P>0.05);US-FNAC检查诊断甲状腺结节良恶性的特异度、准确度高于超声检查,差异有统计学意义(P<0.05)。结论:US-FNAC检查鉴别甲状腺结节良恶性的特异度、准确度较高,值得临床应用。

超声引导下甲状腺细针穿刺检查在甲状腺肿瘤诊断中的应用价值

目的分析超声引导甲状腺细针穿刺用于甲状腺肿瘤的诊断价值。方法纳入2022年1月至2022年12月安阳市肿瘤医院收入的甲状腺肿瘤患者共82例(110个结节),均先后予以超声引导甲状腺细针穿刺、无超声引导甲状腺细针穿刺检查,将最终的术后病理结果当作金标准,统计结节有关超声表现,并比较两项检查的诊断效能(准确度、特异度、敏感度、阳性预测值及阴性预测值)。结果82例患者的110个结节,经过手术病理检查显示恶性结节42个,包含乳头状癌28个、滤泡状癌11个、髓样癌2个及未分化癌1个;良性结节68个,包含结节甲状腺肿35个、甲状腺腺瘤20个及桥本甲状腺炎13个。110个结节中,40个形态缺乏规则性,35个边界不清;51个为实性低回声,8个为混合回声,51个为中高回声;42个结节中存在微钙化征象,同时结节为中央型血供。超声引导甲状腺细针穿刺显示恶性结节41个,良性结节69个;无超声引导甲状腺细针穿刺显示恶性结节34个,良性结节76个。超声引导甲状腺细针穿刺的诊断准确度、敏感度以及阴性预测值为97.27%、95.24%、97.10%高于无超声引导甲状腺细针穿刺的83.64%、69.05%、82.89%,差异有统计学意义(P<0.05),两项检查的诊断特异度、阳性预测值相比差异无统计学意义(P>0.05)。结论超声引导甲状腺细针穿刺用于甲状腺肿瘤良恶性诊断不仅操作方便、定位准确,同时诊断准确度以及敏感度较高,对明确肿瘤性质和制定后续治疗方案有着重要价值。

超声引导下甲状腺细针穿刺细胞学检查下传统涂片联合液基制片在甲状腺结节诊断中的价值

目的:分析超声引导下甲状腺细针穿刺细胞学检查下使用传统涂片联合液基制片对甲状腺结节患者进行诊断的应用价值。方法:选取2019年1月至2023年6月钦州市第一人民医院收治的进行超声引导下甲状腺细针穿刺细胞学检查呈阳性且进行病理组织学检查为恶性的33例甲状腺结节患者作为研究对象。使用传统涂片与液基制片对这些患者的细胞穿刺样本进行细胞学检查。以进行病理组织学检查结果为金标准。比较使用传统涂片、液基制片及传统涂片联合液基制片对甲状腺结节患者进行诊断的准确率及检出率。结果:使用传统涂片联合液基制片诊断甲状腺结节的准确率和检出率均高于使用传统涂片、液基制片(P<0.05)。使用传统涂片与液基制片诊断甲状腺结节的准确率和检出率相比,差异无统计学意义(P>0.05)。结论:在甲状腺结节的诊断中,超声引导下甲状腺细针穿刺细胞学检查下使用传统涂片联合液基制片进行诊断的准确率较高,为临床治疗提供依据。